AR043039A1 - Un proceso microbiano para preparar 5-androsten-3beta, 7alfa, 15alfa-triol-17-ona y analogos relacionados - Google Patents

Un proceso microbiano para preparar 5-androsten-3beta, 7alfa, 15alfa-triol-17-ona y analogos relacionados

Info

Publication number
AR043039A1
AR043039A1 ARP040100366A ARP040100366A AR043039A1 AR 043039 A1 AR043039 A1 AR 043039A1 AR P040100366 A ARP040100366 A AR P040100366A AR P040100366 A ARP040100366 A AR P040100366A AR 043039 A1 AR043039 A1 AR 043039A1
Authority
AR
Argentina
Prior art keywords
15alfa
7alfa
androsten
3beta
ona
Prior art date
Application number
ARP040100366A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AR043039A1 publication Critical patent/AR043039A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Reivindicación 1: Un proceso para la producción de compuestos esteroides de fórmula (2) en la que R es -H o -CO-R1 y R1 es alquilo C1-5, por dihidroxilación fúngica de compuestos esteroides de fórmula (1) caracterizado porque comprende poner en contacto un esteroide de fórmula (19 con un cultivo de biotransformación que contiene una especie del género Fusarium capaz de realizar la 7a,15a-dihidroxilación. Reivindicación 2: Un proceso de acuerdo con la reivindicación 1, para producir esteroides de fórmula (2), caracterizado porque la 7a,15a-dihidroxilación se consigue con la cepa Fusarium culmorum UC 16069.
ARP040100366A 2003-02-07 2004-02-05 Un proceso microbiano para preparar 5-androsten-3beta, 7alfa, 15alfa-triol-17-ona y analogos relacionados AR043039A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44604703P 2003-02-07 2003-02-07

Publications (1)

Publication Number Publication Date
AR043039A1 true AR043039A1 (es) 2005-07-13

Family

ID=32851019

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100366A AR043039A1 (es) 2003-02-07 2004-02-05 Un proceso microbiano para preparar 5-androsten-3beta, 7alfa, 15alfa-triol-17-ona y analogos relacionados

Country Status (4)

Country Link
US (1) US20040171853A1 (es)
AR (1) AR043039A1 (es)
TW (1) TW200427838A (es)
WO (1) WO2004070048A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101961311B (zh) * 2010-09-21 2012-11-21 中山大学 一种5α-雄甾(烷)-3β,5,6β-三醇注射剂及其制备方法
CN102584930B (zh) * 2012-01-17 2015-02-11 北京大学 刺囊酸衍生物及其生物转化方法和用途
CN104673677A (zh) * 2014-04-08 2015-06-03 丽江映华生物药业有限公司 甾体发酵亚麻刺盘孢霉菌株ljyh20130405-1及其应用技术

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2746298A1 (de) * 1977-10-13 1979-04-19 Schering Ag 4-androsten-3,17-dion-derivate, ihre herstellung und verwendung
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3916112A1 (de) * 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
FR2820745A1 (fr) * 2001-02-14 2002-08-16 Oreal Procedes de preparation de la 7alpha-hydroxy- dehydroepiandrosterone

Also Published As

Publication number Publication date
TW200427838A (en) 2004-12-16
US20040171853A1 (en) 2004-09-02
WO2004070048A1 (en) 2004-08-19

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