AR043021A1 - Diacido (4s,8s)- y (4r,8r)-4-p-nitrobencil-8-metil-3,6,9-triaza-3n,6n,9n-tricarboximetil-1,11-undecanoico enantiomericamente puro y sus derivados, procedimiento para su preparacion y uso para preparar agentes farmaceuticos - Google Patents

Diacido (4s,8s)- y (4r,8r)-4-p-nitrobencil-8-metil-3,6,9-triaza-3n,6n,9n-tricarboximetil-1,11-undecanoico enantiomericamente puro y sus derivados, procedimiento para su preparacion y uso para preparar agentes farmaceuticos

Info

Publication number
AR043021A1
AR043021A1 ARP040100339A ARP040100339A AR043021A1 AR 043021 A1 AR043021 A1 AR 043021A1 AR P040100339 A ARP040100339 A AR P040100339A AR P040100339 A ARP040100339 A AR P040100339A AR 043021 A1 AR043021 A1 AR 043021A1
Authority
AR
Argentina
Prior art keywords
groups
preparation
pharmaceutical agents
enantiomerically pure
group
Prior art date
Application number
ARP040100339A
Other languages
English (en)
Inventor
Platzek Johannes Dr
Lehmann Lutz Dr
Friebe Matthias Dr
Brumby Thomas Dr
Suelzle Detlev Dr
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of AR043021A1 publication Critical patent/AR043021A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compuestos enantioméricamente puros de un resto de grupo de fórmula (1), donde: Z es un átomo de hidrógeno o un equivalente de ión metálico de un elemento de número atómico 21-29, 31, 32, 37-39, 42-44, 46, 47, 49, 58-71, 75, 77, 82 u 83, A es un grupo -COO-; R es una biomolécula unida a través de un grupo funcional, o es un radical alquilo C1-25 lineal o ramificado, saturado o insaturado y opcionalmente interrumpido por uno a seis átomos de O, o fenileno, grupos -NHCO-, -CONH-, o un resto de grupo de fórmula (2) y/o -NH-(C=S)-NH-, que opcionalmente está sustituido en cualquier lugar con uno a seis grupos carboxilo, grupos hidroxilo, grupos amino u otros grupos funcionales a través de los cuales pueden estar unidas biomoléculas, así como sus sales con bases orgánicas o inorgánicas, con la condición de que el radical alquilo contenga al menos una biomolécula unida a través de un grupo funcional, y que al menos dos Z sean un equivalente de ión metálico. Procedimientos para la preparación y su uso para preparar agentes farmacéuticos para el radiodiagnóstico, la radioterapia o el diagnóstico por RMN.
ARP040100339A 2003-02-04 2004-02-04 Diacido (4s,8s)- y (4r,8r)-4-p-nitrobencil-8-metil-3,6,9-triaza-3n,6n,9n-tricarboximetil-1,11-undecanoico enantiomericamente puro y sus derivados, procedimiento para su preparacion y uso para preparar agentes farmaceuticos AR043021A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10305463A DE10305463A1 (de) 2003-02-04 2003-02-04 Enantiomerenreines (4S,8S)- und (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triza-3N,6N,9N-tricarboxymethyl-1,11-undecandisäure und deren Abkömmlinge, Verfahren zu deren Herstellung und Verwendung zur Herstellung pharmazeutischer Mittel

Publications (1)

Publication Number Publication Date
AR043021A1 true AR043021A1 (es) 2005-07-13

Family

ID=32695218

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100339A AR043021A1 (es) 2003-02-04 2004-02-04 Diacido (4s,8s)- y (4r,8r)-4-p-nitrobencil-8-metil-3,6,9-triaza-3n,6n,9n-tricarboximetil-1,11-undecanoico enantiomericamente puro y sus derivados, procedimiento para su preparacion y uso para preparar agentes farmaceuticos

Country Status (10)

Country Link
EP (1) EP1590317B1 (es)
JP (1) JP4878119B2 (es)
AR (1) AR043021A1 (es)
AT (1) ATE352538T1 (es)
AU (1) AU2003296740A1 (es)
DE (2) DE10305463A1 (es)
DK (1) DK1590317T3 (es)
ES (1) ES2276168T3 (es)
PT (1) PT1590317E (es)
WO (1) WO2004069787A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
JP6410339B2 (ja) * 2013-03-25 2018-10-24 国立大学法人千葉大学 放射性核種標識オクトレオチド誘導体
WO2014177042A1 (zh) * 2013-04-28 2014-11-06 Qin Gang 一种新型的连接子及其制备方法和用途
JP7395194B2 (ja) * 2018-07-23 2023-12-11 センチュリオン バイオファーマ コーポレイション 外因性および内因性アルブミンを放射性標識するためのイメージング剤
JP2024508976A (ja) 2021-03-08 2024-02-28 ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． 抗体－免疫アゴニストコンジュゲート及びその使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US6207858B1 (en) * 1999-03-03 2001-03-27 Idec Pharmaceuticals Corporation Regioselective synthesis of DTPA derivatives
SE9904507D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
EP1365813A4 (en) * 2001-02-26 2006-03-22 Bristol Myers Squibb Pharma Co ASCORBIC ACID ANALOGUES FOR METALLORADIOPHARMACEUTICAL PRODUCTS

Also Published As

Publication number Publication date
PT1590317E (pt) 2007-02-28
JP4878119B2 (ja) 2012-02-15
DE10305463A1 (de) 2004-08-12
EP1590317A1 (de) 2005-11-02
ATE352538T1 (de) 2007-02-15
DE50306415D1 (de) 2007-03-15
AU2003296740A1 (en) 2004-08-30
JP2006514081A (ja) 2006-04-27
DK1590317T3 (da) 2007-04-30
WO2004069787A1 (de) 2004-08-19
EP1590317B1 (de) 2007-01-24
ES2276168T3 (es) 2007-06-16

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