AR041745A1 - Formulacion y forma de dosificacion que provee mayor biodisponibilidad de los farmacos hidrofobos - Google Patents
Formulacion y forma de dosificacion que provee mayor biodisponibilidad de los farmacos hidrofobosInfo
- Publication number
- AR041745A1 AR041745A1 ARP030104008A ARP030104008A AR041745A1 AR 041745 A1 AR041745 A1 AR 041745A1 AR P030104008 A ARP030104008 A AR P030104008A AR P030104008 A ARP030104008 A AR P030104008A AR 041745 A1 AR041745 A1 AR 041745A1
- Authority
- AR
- Argentina
- Prior art keywords
- drug formulation
- dosage form
- dosage
- formulation
- hydrophobic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
Una formulación del fármaco y una forma de dosificación. La formulación del fármaco cumple la función de incrementar la biodisponibilidad de los fármacos hidrófobos administrados al tracto gastrointestinal ("tracto GI") de un sujeto determinado. La formulación del fármaco de la presente se formula como una nanosuspensión auto-emulsionable, que forma una emulsión in situ al introducirse en un medio acuoso. La forma de dosificación, puede formarse utilizando varios materiales diferentes y puede configurarse para administrar la formulación del fármaco al tracto GI de un sujeto utilizando cualquier mecanismo adecuado. Se puede crear una forma de liberación de dosificación controlada para administrar la formulación del fármaco a una velocidad apropiada durante un período de tiempo adecuado. Si se la crea como una forma de dosificación de liberación controlada, puede ser una forma de dosificación osmótica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42318402P | 2002-10-31 | 2002-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR041745A1 true AR041745A1 (es) | 2005-05-26 |
Family
ID=32312618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104008A AR041745A1 (es) | 2002-10-31 | 2003-10-31 | Formulacion y forma de dosificacion que provee mayor biodisponibilidad de los farmacos hidrofobos |
Country Status (11)
Country | Link |
---|---|
US (1) | US20040142040A1 (es) |
EP (1) | EP1556000A1 (es) |
JP (1) | JP2006507309A (es) |
KR (1) | KR20050083875A (es) |
CN (1) | CN1728982A (es) |
AR (1) | AR041745A1 (es) |
AU (1) | AU2003291667A1 (es) |
CA (1) | CA2504031A1 (es) |
TW (1) | TW200423968A (es) |
UY (1) | UY28057A1 (es) |
WO (1) | WO2004041246A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
AU2003230885A1 (en) * | 2002-04-12 | 2003-10-27 | Elan Pharma International Ltd. | Nanoparticulate megestrol formulations |
US20060047025A1 (en) * | 2004-06-29 | 2006-03-02 | Matthew Piazza | Viscous materials and method for producing |
KR20070043894A (ko) * | 2004-08-19 | 2007-04-25 | 알자 코포레이션 | 제어 방출형 나노입자 활성제 제제 제형 및 방법 |
AU2006231967B2 (en) * | 2005-03-31 | 2011-09-15 | Suntory Holdings Limited | Oil-in-water emulsions containing lignan-class compounds and compositions containing the same |
KR100682531B1 (ko) | 2005-04-06 | 2007-02-15 | 유효경 | 양쪽성 계면활성제와 폴리올을 함유하는 가용화용나노조성물 |
EP1933811A2 (en) * | 2005-09-30 | 2008-06-25 | Alza Corporation | Banded controlled release nanoparticle active agent formulation dosage forms and methods |
KR20090045205A (ko) * | 2006-06-26 | 2009-05-07 | 뮤추얼 파마슈티컬 컴퍼니 아이엔씨. | 활성제 제형 및 이의 제조방법 및 사용방법 |
AU2007305614B2 (en) * | 2006-10-04 | 2012-08-23 | Suntory Holdings Limited | O/W/O emulsion containing lignan compounds and composition containing the same |
WO2009042114A2 (en) | 2007-09-21 | 2009-04-02 | The Johns Hopkins University | Phenazine derivatives and uses thereof |
IT1393245B1 (it) * | 2008-07-24 | 2012-04-12 | Universita' Degli Studi Di Milano | Forme farmaceutiche per il rilascio tempo-specifico di farmaci |
US20100159010A1 (en) * | 2008-12-24 | 2010-06-24 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
US20110071090A1 (en) * | 2009-03-11 | 2011-03-24 | Stable Solutions Llc | Method of mitigating adverse drug events using omega-3-fatty acids as a parenteral therapeutic drug vehicle |
US9034389B2 (en) | 2009-03-11 | 2015-05-19 | Stable Solutions Llc | Omega-3 enriched fish oil-in-water parenteral nutrition emulsions |
US8993625B2 (en) | 2009-03-11 | 2015-03-31 | Stable Solutions Llc | Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle |
US9431262B2 (en) | 2014-03-14 | 2016-08-30 | Fujikoshi Machinery Corp. | Method for polishing work and work polishing apparatus |
WO2016071756A1 (en) * | 2014-11-04 | 2016-05-12 | Innopharmax, Inc. | Oral administration of unstable or poorly-absorbed drugs |
GB2541387A (en) * | 2015-08-14 | 2017-02-22 | Res Center Pharmaceutical Eng Gmbh | Self-emulsifying Nanosuspensions as Drug Delivery Systems (SENDDS) |
PL428779A1 (pl) * | 2019-01-31 | 2020-08-10 | Gdański Uniwersytet Medyczny | Kompozycja farmaceutyczna w postaci ciekłej zawierająca jako substancję aktywną substancję leczniczą nietrwałą w środowisku wodnym |
Family Cites Families (38)
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US534280A (en) * | 1895-02-19 | Hose-leak stop or jacket | ||
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4627850A (en) * | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
US4627851A (en) * | 1984-10-26 | 1986-12-09 | Alza Corporation | Colonic-therapeutic delivery system |
US4915949A (en) * | 1987-07-13 | 1990-04-10 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
US5024842A (en) * | 1988-04-28 | 1991-06-18 | Alza Corporation | Annealed coats |
US5006346A (en) * | 1988-04-28 | 1991-04-09 | Alza Corporation | Delivery system |
US5160743A (en) * | 1988-04-28 | 1992-11-03 | Alza Corporation | Annealed composition for pharmaceutically acceptable drug |
US4931285A (en) * | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
US5126142A (en) * | 1989-07-18 | 1992-06-30 | Alza Corporation | Dispenser comprising ionophore |
US5324280A (en) * | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
US5190765A (en) * | 1991-06-27 | 1993-03-02 | Alza Corporation | Therapy delayed |
US5252338A (en) * | 1991-06-27 | 1993-10-12 | Alza Corporation | Therapy delayed |
EP0656779B1 (en) * | 1992-08-28 | 2000-04-12 | Pharmos Corporation | Submicron emulsions as ocular drug delivery vehicles |
US6113921A (en) * | 1993-03-23 | 2000-09-05 | Pharmos Corp. | Topical and transdermal delivery system utilizing submicron oil spheres |
ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
US5633011A (en) * | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
US5578642A (en) * | 1994-08-17 | 1996-11-26 | Henkel Corporation | Self-emulsifying and/or emollient agents |
US5614578A (en) * | 1994-10-28 | 1997-03-25 | Alza Corporation | Injection-molded dosage form |
WO1996033697A1 (fr) * | 1995-04-24 | 1996-10-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Formulation auto-emulsionnable formant une emulsion huile dans l'eau |
US6245349B1 (en) * | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
UA68350C2 (en) * | 1997-07-01 | 2004-08-16 | Pfizer Prod Inc | Dosage forms of encapsulated sertraline |
CA2313024C (en) * | 1997-12-10 | 2008-06-03 | Severson, Mary L. | Pharmaceutical compositions containing an omega-3 fatty acid oil |
US6245357B1 (en) * | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
US6183466B1 (en) * | 1998-08-21 | 2001-02-06 | Alza Corporation | Dosage form comprising a capsule |
US6551613B1 (en) * | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
US6174547B1 (en) * | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
US6221391B1 (en) * | 1998-11-23 | 2001-04-24 | Accucaps Industries Limited | Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith |
EP1135150B1 (en) * | 1998-12-11 | 2012-10-17 | Tris Pharma, Inc. | Self-emulsifying compositions for drugs poorly soluble in water |
HUP0104721A3 (en) * | 1998-12-17 | 2006-07-28 | Alza Corp Mountain View | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
US6342249B1 (en) * | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
US6057289A (en) * | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
DE60109295T2 (de) * | 2000-07-24 | 2006-04-13 | Sugen, Inc., South San Francisco | Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln |
CA2422580C (en) * | 2000-09-18 | 2011-05-17 | Rpg Life Sciences Limited | Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities |
EP1458353A1 (en) * | 2001-12-19 | 2004-09-22 | ALZA Corporation | Formulation dosage form for the controlled delivery of ther apeutic agents |
-
2003
- 2003-10-31 JP JP2004550348A patent/JP2006507309A/ja not_active Withdrawn
- 2003-10-31 US US10/698,894 patent/US20040142040A1/en not_active Abandoned
- 2003-10-31 CN CNA200380106667XA patent/CN1728982A/zh active Pending
- 2003-10-31 KR KR1020057007599A patent/KR20050083875A/ko not_active Application Discontinuation
- 2003-10-31 UY UY28057A patent/UY28057A1/es unknown
- 2003-10-31 EP EP03768556A patent/EP1556000A1/en not_active Withdrawn
- 2003-10-31 AR ARP030104008A patent/AR041745A1/es not_active Application Discontinuation
- 2003-10-31 TW TW092130379A patent/TW200423968A/zh unknown
- 2003-10-31 AU AU2003291667A patent/AU2003291667A1/en not_active Abandoned
- 2003-10-31 WO PCT/US2003/034703 patent/WO2004041246A1/en active Application Filing
- 2003-10-31 CA CA002504031A patent/CA2504031A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040142040A1 (en) | 2004-07-22 |
KR20050083875A (ko) | 2005-08-26 |
UY28057A1 (es) | 2003-12-31 |
TW200423968A (en) | 2004-11-16 |
AU2003291667A1 (en) | 2004-06-07 |
EP1556000A1 (en) | 2005-07-27 |
WO2004041246A1 (en) | 2004-05-21 |
JP2006507309A (ja) | 2006-03-02 |
CA2504031A1 (en) | 2004-05-21 |
CN1728982A (zh) | 2006-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |