AR040089A1 - Un metodo para usar derivados de piranoindol para el tratamiento de infecciones con el virus de hepatitis c - Google Patents

Un metodo para usar derivados de piranoindol para el tratamiento de infecciones con el virus de hepatitis c

Info

Publication number
AR040089A1
AR040089A1 ARP030101761A ARP030101761A AR040089A1 AR 040089 A1 AR040089 A1 AR 040089A1 AR P030101761 A ARP030101761 A AR P030101761A AR P030101761 A ARP030101761 A AR P030101761A AR 040089 A1 AR040089 A1 AR 040089A1
Authority
AR
Argentina
Prior art keywords
cycloalkyl
substituted
straight chain
aryl
unsubstituted
Prior art date
Application number
ARP030101761A
Other languages
English (en)
Inventor
Stephen M Condon
John W Ellingboe
Matthew G Laporte
Tarek S Mansour
Christopher J Burns
Ariamala Gopalsamy
Original Assignee
Viropharma Inc
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viropharma Inc, Wyeth Corp filed Critical Viropharma Inc
Publication of AR040089A1 publication Critical patent/AR040089A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicación 1: Un método para tratar o prevenir una infección viral de hepatitis C en un mamífero que comprende suministrar al mamífero una cantidad efectiva de un compuesto de fórmula (1): en donde: R1 es H, un alquilo de cadena recta C1-8, un alquilo ramificado C3-12, un cicloalquilo C3-12, un alquenilo C2-7, un alquinilo C2-7, o un arilalquilo o un alquilarilo C7-12; R2 es H, un alquilo de cadena recta C1-12, un alquilo ramificado C3-12, un cicloalquilo C3-12, un alquenilo C2-7, un alquinilo C2-7, un alcoxialquilo C2-12, un arilalquilo o alquilarilo C7-12, un cianoalquilo C1-8, un alquiltioalquilo C2-16, un cicloalquil-alquilo C4-24, un arilo sustituido o no sustituido, o un heteroarilo; R3-R6 son independientemente H, un alquilo de cadena recta C1-8, un alquilo ramificado C3-12, un cicloalquilo C3-12, un alquenilo C2-7, un alquilarilo, arilalquilo, furanilmetilo o arilo, sustituido o no sustituido, C7-12, alquinilo C2-7, o R5 y R6 junto con el átomo de carbono del anillo al cual están unidos forman un grupo carbonilo; R7-R10 son independientemente H, un alquilo de cadena recta C1-8, un alquilo ramificado C3-12, un cicloalquilo C3-12, un alquenilo C2-7, un arilo sustituido o no sustituido, un alquilarilo, arilalquilo, furanilmetilo o heteroarilo, sustituido o no sustituido, de C7-12, alquinilo C2-7, fenilalquinilo, alcoxi C1-8, arilalcoxi C7-12, fluoroalcoxi C1-12, alquiltio C1-8, trifluorometoxi, trifluoroetoxi, trifluorometiltio, trifluoroetiltio, acilo C1-6, COOH, COO-alquilo, CONR11R12, F, Cl, Br, I, CN, CF3, NO2, alquilsulfinilo C1-8, alquilsulfonilo C1-6, pirrolidinilo o tiazolidinilo; R11-R12 son independientemente H, alquilo de cadena recta C1-8, alquilo ramificado C3-12, cicloalquilo C3-12, un heteroarilo o arilo sustituido o no sustituido; Y es un enlace, CH2, CH2CH2, arilo o R2 e Y junto con el átomo de carbono del anillo al cual están unidos pueden formar adicionalmente un anillo cicloalquilo espirocíclico de C3-8; o una forma cristalina o una sal farmacéuticamente aceptable del mismo. Reivindicación 96: El método de acuerdo con la reivindicación 95, que comprende además suministrar al mamífero una cantidad efectiva de por lo menos un agente biológicamente activo. Reivindicación 100: El método de acuerdo con la reivindicación 99, caracterizado porque el por lo menos un agente biológicamente activo es un interferón pegilado.
ARP030101761A 2002-05-21 2003-05-21 Un metodo para usar derivados de piranoindol para el tratamiento de infecciones con el virus de hepatitis c AR040089A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38215402P 2002-05-21 2002-05-21
US45870603P 2003-03-28 2003-03-28

Publications (1)

Publication Number Publication Date
AR040089A1 true AR040089A1 (es) 2005-03-16

Family

ID=29586949

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101761A AR040089A1 (es) 2002-05-21 2003-05-21 Un metodo para usar derivados de piranoindol para el tratamiento de infecciones con el virus de hepatitis c

Country Status (11)

Country Link
US (1) US7217730B2 (es)
EP (1) EP1509225A1 (es)
JP (1) JP2005531572A (es)
CN (1) CN1655778A (es)
AR (1) AR040089A1 (es)
AU (1) AU2003239593A1 (es)
BR (1) BR0311223A (es)
CA (1) CA2485972A1 (es)
MX (1) MXPA04011162A (es)
TW (1) TW200400818A (es)
WO (1) WO2003099275A1 (es)

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TWI368507B (en) 2004-02-20 2012-07-21 Boehringer Ingelheim Int Viral polymerase inhibitors
BRPI0508079A (pt) * 2004-03-01 2007-07-17 Viropharma Inc composto ou uma forma cristalina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos de tratar ou prevenir uma infecção viral com hepatite c em um mamìfero e de inibir replicação de um vìrus da hepatite c
US20080182895A1 (en) * 2006-08-25 2008-07-31 Howe Anita Y M Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto
MX2009011930A (es) 2007-05-04 2009-11-18 Vertex Pharma Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c.
US20120177601A1 (en) * 2009-07-02 2012-07-12 The Usa As Represented By The Secretary Of The Department Of Veterans Affairs Treatment of hepatitis c virus infections
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
EP2864334B1 (en) * 2012-06-25 2017-01-04 Kucukguzel, S. Guniz Thiosemicarbazides and triazoles derived from etodolac and their syntheses
EP2864333B1 (en) * 2012-06-25 2017-07-19 Kucukguzel, S. Guniz Etodolac derivatives as hcv ns5b polymerase inhibitors
EP2738173A1 (en) * 2012-11-28 2014-06-04 Commissariat A L'energie Atomique Et Aux Energies Alternatives Heterocyclic compounds as inhibitors of the sodium iodide symporter
CN103864803A (zh) * 2012-12-07 2014-06-18 天津科技大学 一种1-(苯基)-1,3,4,9-四氢吡喃并[3,4-b]吲哚衍生物的制备及其抗肿瘤药物中的应用
MX2017008417A (es) 2014-12-23 2017-09-28 Gilead Sciences Inc Procedimientos para preparar inhibidores de cinasa 1 reguladora de señal de apoptosis (ask1).
JP2019001715A (ja) * 2015-10-30 2019-01-10 協和発酵キリン株式会社 三環性化合物

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Also Published As

Publication number Publication date
BR0311223A (pt) 2005-03-15
WO2003099275A1 (en) 2003-12-04
EP1509225A1 (en) 2005-03-02
JP2005531572A (ja) 2005-10-20
US7217730B2 (en) 2007-05-15
US20040082643A1 (en) 2004-04-29
CN1655778A (zh) 2005-08-17
MXPA04011162A (es) 2005-02-17
CA2485972A1 (en) 2003-12-04
TW200400818A (en) 2004-01-16
AU2003239593A1 (en) 2003-12-12

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