AR038549A1 - Derivados de aminociclohexano heteroarilsustituidos - Google Patents
Derivados de aminociclohexano heteroarilsustituidosInfo
- Publication number
- AR038549A1 AR038549A1 ARP020104958A ARP020104958A AR038549A1 AR 038549 A1 AR038549 A1 AR 038549A1 AR P020104958 A ARP020104958 A AR P020104958A AR P020104958 A ARP020104958 A AR P020104958A AR 038549 A1 AR038549 A1 AR 038549A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- alkoxy
- cycloalkyl
- hydrogen
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a compuestos de la fórmula (1), y su manufactura y uso como medicamentos, en los cuales A1, A2, A3, A4, A5, A6, U, V, m, n y o son tal como se han definido en la descripción y reivindicaciones, y las sales farmacéuticamente aceptables de los mismos. Los compuestos son útiles para el tratamiento y/o profilaxis de enfermedades que están asociadas con 2,3-oxidoescualeno-lanoesterol ciclasa tal como hipercolesterolemia, hiperlipemia, arterioesclerosis, enfermedades vasculares, micosis, infecciones parasitarias, cálculos vesicales, tumores y/o desordenes hiperproliferativos y para el tratamiento y/o la alteración de la tolerancia a la glucosa y diabetes. Reivindicación 1: Un compuesto de la fórmula (1), en la cual: U es O ó un par aislado; V es un enlace simple, O, S, -CH=CH-CH2-O-, -CH=CH-, o -CsC-, m y n independientemente uno del otro son 0 a 7 y m+n es 0 a 7, con la condición de que m no es 0 si V es O ó S, o es 0 a 2; A1 es hidrógeno, alquilo inferior, hidroxi-alquilo inferior, o alquenilo inferior, A2 es alquilo inferior, cicloalquilo, cicloalquilo-alquilo inferior, o alquenilo inferior opcionalmente sustituido con R1, o A1 y A2 están unidos entre sí para formar un anillo y -A1-A2- es alquileno inferior o alquenileno inferior opcionalmente sustituido con R1 en el cual un grupo -CH2- de -A1-A2- puede estar opcionalmente reemplazado con NR2, S u O; A3 y A4 independientemente uno del otro son hidrógeno o alquilo inferior, o A3 y A4 están unidos entre sí para formar un anillo conjuntamente con el átomo de carbono al cual están unidos y -A3-A4- es -(CH2)2-5-; A5 es hidrógeno, alquilo inferior, o alquenilo inferior, A6 es piridinilo, piridazinilo, pirimidinilo o pirazinilo, opcionalmente sustituido con 1 ó 2 sustituyentes independientemente seleccionados del grupo que consiste en alquilo inferior, alquilo inferior-cicloalquilo, tio-alcoxi inferior, cicloalquilo, carbamoilo, carboxi, carboxi-alquilo inferior, ciano, amino, mono- y dialquilamino, alcoxi inferior, alcoxi inferior-alquilo inferior, alcoxi inferior-carbonilo, alcoxi inferior-carbonilo-alquilo inferior, alquenilo inferior, alquinilo inferior, arilo, arilo-alquilo inferior, ariloxi, halógeno, heteroarilo, heterocíclico, heterociclil-alquilo inferior y trifluormetilo; R1 es hidroxi, hidroxi-alquilo inferior, alcoxi inferior, alcoxi carbonilo inferior, halógeno, CN, N(R3, R4) o tio-alcoxi-inferior, R2, R3 y R4 independientemente uno del otro son hidrógeno o alquilo inferior, y sus sales farmacéuticamente aceptables con la condición de que el compuesto de fórmula (1) no sea trans-[4-(2-Dipropilamino-etil)-ciclohexil]-pirimidin-2-il-amina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01130284 | 2001-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR038549A1 true AR038549A1 (es) | 2005-01-19 |
Family
ID=8179606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020104958A AR038549A1 (es) | 2001-12-20 | 2002-12-18 | Derivados de aminociclohexano heteroarilsustituidos |
Country Status (16)
Country | Link |
---|---|
US (1) | US7012077B2 (es) |
EP (1) | EP1458683B1 (es) |
JP (1) | JP4316384B2 (es) |
KR (1) | KR20040075905A (es) |
CN (1) | CN1296357C (es) |
AR (1) | AR038549A1 (es) |
AT (1) | ATE346045T1 (es) |
AU (1) | AU2002366732B2 (es) |
BR (1) | BR0215257A (es) |
CA (1) | CA2469380C (es) |
DE (1) | DE60216319T2 (es) |
ES (1) | ES2275939T3 (es) |
MX (1) | MXPA04005907A (es) |
PL (1) | PL370713A1 (es) |
RU (1) | RU2286987C2 (es) |
WO (1) | WO2003053933A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001293744B2 (en) * | 2000-08-16 | 2007-05-10 | F. Hoffmann-La Roche Ag | Novel aminocyclohexane derivatives |
EP1464335A3 (en) * | 2003-03-31 | 2007-05-09 | Taisho Pharmaceutical Co. Ltd. | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist |
CN101475528A (zh) * | 2003-03-31 | 2009-07-08 | 大正制药株式会社 | 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法 |
CA2545048A1 (en) * | 2003-11-20 | 2005-06-02 | Warner-Lambert Company Llc | Androgen receptor modulators |
ITMI20110666A1 (it) * | 2011-04-19 | 2012-10-20 | Dipharma Francis Srl | Procedimento per la preparazione di (r) ed (s) pramipexolo e suoi intermedi |
CN104936953B (zh) | 2013-01-23 | 2017-03-08 | 阿斯利康(瑞典)有限公司 | 化合物 |
CA3026149A1 (en) | 2016-06-02 | 2017-12-07 | Cadent Therapeutics, Inc. | Potassium channel modulators |
TWI751271B (zh) | 2017-01-23 | 2022-01-01 | 美商凱登製藥公司 | 鉀離子通道調節子 |
US11993586B2 (en) | 2018-10-22 | 2024-05-28 | Novartis Ag | Crystalline forms of potassium channel modulators |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO122123B (es) | 1966-03-25 | 1971-05-24 | Miles Lab | |
US3592824A (en) | 1970-03-12 | 1971-07-13 | Miles Lab | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
DE4239151A1 (de) | 1992-11-20 | 1994-05-26 | Thomae Gmbh Dr K | N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
TW438774B (en) | 1993-07-14 | 2001-06-07 | Hoffmann La Roche | Pharmaceutical composition for lowering cholesterol containing phenalkylamines and certain novel phenalkylamines |
CA2190699A1 (en) | 1995-12-08 | 1997-06-09 | Johannes Aebi | Tertiary amines |
US6964974B2 (en) | 2000-09-08 | 2005-11-15 | Hoffmann-La Roche Inc. | 2,3-oxidosqualene-lanosterol cyclase inhibitors |
CN1261429C (zh) | 2000-11-02 | 2006-06-28 | 弗·哈夫曼-拉罗切有限公司 | 降胆固醇的苯并「b」噻吩和苯并「d」异噻唑 |
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2002
- 2002-12-05 US US10/310,559 patent/US7012077B2/en not_active Expired - Fee Related
- 2002-12-11 AU AU2002366732A patent/AU2002366732B2/en not_active Ceased
- 2002-12-11 AT AT02790481T patent/ATE346045T1/de not_active IP Right Cessation
- 2002-12-11 DE DE60216319T patent/DE60216319T2/de not_active Expired - Lifetime
- 2002-12-11 KR KR10-2004-7009921A patent/KR20040075905A/ko not_active Application Discontinuation
- 2002-12-11 ES ES02790481T patent/ES2275939T3/es not_active Expired - Lifetime
- 2002-12-11 PL PL02370713A patent/PL370713A1/xx not_active Application Discontinuation
- 2002-12-11 EP EP02790481A patent/EP1458683B1/en not_active Expired - Lifetime
- 2002-12-11 CA CA2469380A patent/CA2469380C/en not_active Expired - Fee Related
- 2002-12-11 JP JP2003554649A patent/JP4316384B2/ja not_active Expired - Fee Related
- 2002-12-11 RU RU2004122480/04A patent/RU2286987C2/ru not_active IP Right Cessation
- 2002-12-11 BR BR0215257-6A patent/BR0215257A/pt not_active IP Right Cessation
- 2002-12-11 MX MXPA04005907A patent/MXPA04005907A/es unknown
- 2002-12-11 CN CNB028256654A patent/CN1296357C/zh not_active Expired - Fee Related
- 2002-12-11 WO PCT/EP2002/014037 patent/WO2003053933A1/en active IP Right Grant
- 2002-12-18 AR ARP020104958A patent/AR038549A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2004122480A (ru) | 2005-08-10 |
JP4316384B2 (ja) | 2009-08-19 |
EP1458683B1 (en) | 2006-11-22 |
EP1458683A1 (en) | 2004-09-22 |
AU2002366732A1 (en) | 2003-07-09 |
AU2002366732B2 (en) | 2006-11-02 |
US7012077B2 (en) | 2006-03-14 |
RU2286987C2 (ru) | 2006-11-10 |
CA2469380A1 (en) | 2003-07-03 |
ES2275939T3 (es) | 2007-06-16 |
US20030186984A1 (en) | 2003-10-02 |
WO2003053933A1 (en) | 2003-07-03 |
DE60216319T2 (de) | 2007-05-31 |
JP2005517667A (ja) | 2005-06-16 |
ATE346045T1 (de) | 2006-12-15 |
CA2469380C (en) | 2010-01-26 |
BR0215257A (pt) | 2004-12-07 |
MXPA04005907A (es) | 2004-09-13 |
KR20040075905A (ko) | 2004-08-30 |
CN1610669A (zh) | 2005-04-27 |
PL370713A1 (en) | 2005-05-30 |
DE60216319D1 (en) | 2007-01-04 |
CN1296357C (zh) | 2007-01-24 |
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