AR036508A1 - Antagonistas v del receptor de ccr-3 - Google Patents

Antagonistas v del receptor de ccr-3

Info

Publication number
AR036508A1
AR036508A1 ARP020103435A ARP020103435A AR036508A1 AR 036508 A1 AR036508 A1 AR 036508A1 AR P020103435 A ARP020103435 A AR P020103435A AR P020103435 A ARP020103435 A AR P020103435A AR 036508 A1 AR036508 A1 AR 036508A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
cycloalkyl
acyl
radical
Prior art date
Application number
ARP020103435A
Other languages
English (en)
Inventor
Bois Daisy Joe Du
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR036508A1 publication Critical patent/AR036508A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos derivados de 1,2-diaminociclopentano de Fórmula (1), en la cual: R1 es hidrógeno o alquilo C1-6; R2 es arilalquilo C1-6; R3 es hidrógeno, alquilo C1-6, acilo, arilo o arilalquilo C1-6; R4 es -W-X-Y-Z; W está ausente o es alquileno C1-6; X está ausente, o es un carbonilo, oxi, -S(O)n-, o -N(Ra)-; Y es arileno o heteroarileno; y Z es hidrógeno, arilo, heteroarilo, ariloxi, heteroariloxi, arilalquilo C1-6 o heteroarilalquilo C1-6; Ra es hidrógeno, alquilo C1-6, acilo, arilo, arilalquilo C1-6, alcoxicarbonilo C1-6 o benciloxicarbonilo; y cada n es 0, 1 ó 2; o una sal farmacéuticamente aceptable de los mismos; en donde: "Acilo" se refiere a un radical -C(O)R, en donde R es hidrógeno, alquilo C1-6, cicloalquilo C3-7, cicloalquilo C3-7-alquilo C1-6, fenilo o fenilalquilo C1-6; "Arilo" se refiere a un radical hidrocarburo aromático monocíclico o bicíclico que es opcionalmente sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en alquilo C1-6, haloalquilo C1-6, hidroxialquilo C1-6, heteroalquilo, acilo, acilamino, amino, alquilamino C1-6, di-alquilamino C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, -SO2NR'R'' (en donde R' y R'' son independientemente hidrógeno o alquilo C1-6), alcoxi C1-6, haloalcoxi C1-6, alcoxicarbonilo C1-6, carbamoilo, hidroxi, halo, nitro, ciano, mercapto, metilenodioxi o etilenodioxi; "Arileno" se refiere a un grupo arilo divalente; "Heteroarilo" se refiere a un radical monocíclico o bicíclico de 5 a 12 átomos del anillo que tiene por lo menos un anillo aromático que contiene uno, dos o tres heteroátomos del anillo seleccionados entre N, O ó S, siendo los átomos del anillo restantes C, entendiéndose que el punto de unión del radical heteroarilo será en un anillo aromático y el anillo heteroarilo es opcionalmente independientemente sustituido con uno o más sustituyentes seleccionados entre alquilo C1-6, haloalquilo C1-6, hidroxialquilo C1-6, heteroalquilo, acilo, acilamino, amino, alquilamino C1-6, di-alquilamino C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, -SO2NR'R'' (en donde R' y R'' son independientemente hidrógeno o alquilo C1-6), alcoxi C1-6, haloalcoxi C1-6, alcoxicarbonilo C1-6, carbamoilo, hidroxi, halo, nitro, ciano, mercapto, metilendioxi o etilenodioxi; "Heteroarileno" se refiere a un grupo heteroarilo divalente; "Heteroalquilo" se refiere a un radical alquilo C1-6 con uno, dos o tres sustituyentes seleccionados independientemente entre -ORa; -NRbRc, y -S(O)nRd, en donde Ra es hidrógeno, acilo, alquilo C1-6, cicloalquilo C3-7 o cicloalquilo C3-7-alquilo C1-6; Rb y Rc son independientemente uno de otro hidrógeno, acilo, alquilo C1-6, cicloalquilo C3-7 o cicloalquilo C3-7-alquilo C1-6; Rd es hidrógeno (siempre que n sea 0), alquilo C1-6, cicloalquilo C3-7, cicloalquilo C3-7-alquilo C1-6, amino, acilamino, mono-alquilamino C1-6 o di-alquilamino C1-6; y n es un número entero de 0 a 2, entendiéndose que el punto de unión del radical heteroalquilo es a través de un átomo de carbono del radical heteroalquilo. Uso de los compuestos de fórmula (1), métodos para prepararlos, medicamentos que los contienen y un método para preparar un compuesto intermediario. Los compuestos de fórmula (1) son antagonistas de los receptores CCR-3 e inhiben el reclutamiento de eosinófilos por las quimioquinas CCR-3 tales como RANTES, eotaxina, MCP-2, MCP-3 y MCP-4. Los compuestos de fórmula (1) y composiciones que los contienen son útiles en el tratamiento de enfermedades inducidas por eosinófilos tales como las enfermedades inflamatorias o alérgicas e incluyendo enfermedades alérgicas respiratorias tales como asma, rinitis alérgica, hipersensibilidad a las enfermedades pulmonares, hipersensibilidad a la neumonitis, neumonías eosinofílicas (por ej. Neumonía eosinofílica crónica); enfermedades inflamatorias del intestino (por ej., enfermedad de Crohn y colitis ulcerosa); y psoriasis y dermatosis inflamatorias tales como dermatitis y eczema.
ARP020103435A 2001-09-13 2002-09-11 Antagonistas v del receptor de ccr-3 AR036508A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31899201P 2001-09-13 2001-09-13

Publications (1)

Publication Number Publication Date
AR036508A1 true AR036508A1 (es) 2004-09-15

Family

ID=23240431

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103435A AR036508A1 (es) 2001-09-13 2002-09-11 Antagonistas v del receptor de ccr-3

Country Status (12)

Country Link
US (2) US7049317B2 (es)
EP (1) EP1427696A1 (es)
JP (1) JP2005502700A (es)
KR (1) KR100652451B1 (es)
CN (1) CN1267412C (es)
AR (1) AR036508A1 (es)
BR (1) BR0212451A (es)
CA (1) CA2459364A1 (es)
MX (1) MXPA04001977A (es)
PL (1) PL370367A1 (es)
RU (1) RU2286339C2 (es)
WO (1) WO2003022799A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
IN2006CH00378A (en) * 2003-06-30 2007-05-11 Sumitomo Chemical Co Asymmetric urea compound and process for producing asymmetric compound by asymmetric conjugate addition reaction with the same as catalyst
US7378409B2 (en) * 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
WO2007034252A1 (en) * 2005-09-22 2007-03-29 Sanofi-Aventis Amino-alkyl-amide derivatives as ccr3 receptor liquids
HUP0500879A2 (en) 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098904A (en) * 1976-11-12 1978-07-04 The Upjohn Company Analgesic n-(2-aminocycloaliphatic)benzamides
US4204003A (en) * 1976-11-30 1980-05-20 The Upjohn Company N-(2-Aminocyclopentyl)-N-alkanoylanilides as CNS anti-depressants
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
CA2157412A1 (en) 1993-03-03 1994-09-15 Julia Marie Heerding Balanoids
DE4326344A1 (de) 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
FR2729140A1 (fr) 1995-01-06 1996-07-12 Smithkline Beecham Lab Nouveaux derives d'amine, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques
EP1086078B1 (en) 1998-06-08 2003-02-05 Schering Corporation Neuropeptide y5 receptor antagonists
KR20010086045A (ko) * 1998-11-20 2001-09-07 프리돌린 클라우스너, 롤란드 비. 보레르 피롤리딘 유도체-씨씨알-3 수용체 길항제
US6462076B2 (en) * 2000-06-14 2002-10-08 Hoffmann-La Roche Inc. Beta-amino acid nitrile derivatives as cathepsin K inhibitors
EP1343751A2 (en) * 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US6576792B2 (en) * 2001-05-04 2003-06-10 Eastman Kodak Company 2-halo-1-cycloalkenecarboxamides and their preparation
US7291744B2 (en) * 2003-11-13 2007-11-06 Bristol-Myers Squibb Company N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
CA2459364A1 (en) 2003-03-20
MXPA04001977A (es) 2004-06-07
RU2286339C2 (ru) 2006-10-27
US20060167105A1 (en) 2006-07-27
CN1267412C (zh) 2006-08-02
PL370367A1 (en) 2005-05-16
BR0212451A (pt) 2004-10-19
RU2004111535A (ru) 2005-10-20
EP1427696A1 (en) 2004-06-16
US7049317B2 (en) 2006-05-23
US20030119885A1 (en) 2003-06-26
WO2003022799A1 (en) 2003-03-20
KR100652451B1 (ko) 2006-12-01
JP2005502700A (ja) 2005-01-27
KR20040044915A (ko) 2004-05-31
CN1555358A (zh) 2004-12-15

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