AR036333A1 - Estructura en solucion de il-13, sitios activos de il-13, agentes de union para il-13 y metodos para disenar agentes de union para il-13 - Google Patents
Estructura en solucion de il-13, sitios activos de il-13, agentes de union para il-13 y metodos para disenar agentes de union para il-13Info
- Publication number
- AR036333A1 AR036333A1 ARP020102167A ARP020102167A AR036333A1 AR 036333 A1 AR036333 A1 AR 036333A1 AR P020102167 A ARP020102167 A AR P020102167A AR P020102167 A ARP020102167 A AR P020102167A AR 036333 A1 AR036333 A1 AR 036333A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino acid
- acid residues
- include amino
- solution
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5437—IL-13
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describe una estructura en solución tridimensional de la IL-13 humana. La estructura tridimensional de IL-13 puede ser útil en el diseno y selección de agentes de unión para IL-13. En algunas realizaciones se describe una solución que contiene IL-13, en donde la IL-13 incluye los residuos de aminoácidos 1-113. La IL-13 puede ser no marcada, enriquecida en 15N o enriquecida en 15N, 13C. La IL-13 puede incluir cuatro hélices alfa: alfaA, alfaB, alfaC y alfaD, y dos cadenas beta, beta1, y beta2. La alfaA puede incluir los residuos de aminoácidos P6-Q22 de la IL-13, la beta1 puede incluir M33-W35 de la IL-13, la alfaB puede incluir los residuos de aminoácidos M43-I52 de la IL-13, la alfaC puede incluir los residuos de aminoácidos A59-F70 de la IL-13, la beta2 puede incluir los residuos de aminoácidos K89-E91 de la IL-13 y la alfaD puede incluir los residuos de aminoácidos V92-R108 de la IL-13. En ciertas realizaciones se describe un sitio activo de IL-13, donde el sitio activo está caracterizado por una estructura tridimensional que incluye las coordenadas estructurales relativas de los residuos de aminoácidos I52, Q64, R65 y M66 de la IL-13, +/- una desviación cuadrática media de los átomos conservados de la cadena principal de dichos aminoácidos no mayor que 1,5 Amstrong. También se describen métodos de uso de la estructura tridimensional de IL-13 para disenar y seleccionar agentes de unión para IL-13. Adicionalmente se describen agentes de unión para IL-13.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29660701P | 2001-06-07 | 2001-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036333A1 true AR036333A1 (es) | 2004-09-01 |
Family
ID=23142750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102167A AR036333A1 (es) | 2001-06-07 | 2002-06-07 | Estructura en solucion de il-13, sitios activos de il-13, agentes de union para il-13 y metodos para disenar agentes de union para il-13 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20030013851A1 (es) |
EP (1) | EP1402451A4 (es) |
JP (1) | JP2005506960A (es) |
AR (1) | AR036333A1 (es) |
CA (1) | CA2450147A1 (es) |
IL (1) | IL159215A0 (es) |
MX (1) | MXPA03011158A (es) |
WO (1) | WO2002101629A1 (es) |
ZA (1) | ZA200309894B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7501121B2 (en) * | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
US20090098142A1 (en) * | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
US7774811B2 (en) * | 2004-08-26 | 2010-08-10 | Sony Corporation | Method and system for use in displaying multimedia content and status |
CA2587903A1 (en) * | 2004-11-17 | 2006-05-26 | Amgen Fremont Inc. | Fully human monoclonal antibodies to il-13 |
ES2902063T3 (es) | 2006-09-08 | 2022-03-24 | Abbvie Bahamas Ltd | Proteínas de unión a interleucina-13 |
TW200848429A (en) * | 2007-04-23 | 2008-12-16 | Wyeth Corp | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
WO2010021874A2 (en) | 2008-08-20 | 2010-02-25 | Centocor Ortho Biotech Inc. | Engineered anti-il-13 antibodies, compositions, methods and uses |
US9512194B2 (en) | 2012-01-27 | 2016-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Modified IL-13 polypeptides |
JP6936934B2 (ja) | 2013-09-24 | 2021-09-22 | メディシナ セラピューティクス インコーポレイテッド | インターロイキン−4受容体結合融合タンパク質及びその使用 |
CN108277226A (zh) * | 2018-02-01 | 2018-07-13 | 北京市华信行生物科技有限公司 | 白细胞介素-6的编码基因及其制备方法和应用 |
MX2020014027A (es) | 2018-06-25 | 2021-03-09 | Univ Washington | Dise?o de novo de mimeticos de interleucina potentes y selectivos. |
WO2020106708A1 (en) * | 2018-11-20 | 2020-05-28 | University Of Washington | Split interleukin mimetics and their use |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5331573A (en) * | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
CA2142860A1 (en) * | 1992-08-21 | 1994-03-03 | Gregorio Aversa | Human interleukin-13 |
US5856116A (en) * | 1994-06-17 | 1999-01-05 | Vertex Pharmaceuticals, Incorporated | Crystal structure and mutants of interleukin-1 beta converting enzyme |
US5614191A (en) * | 1995-03-15 | 1997-03-25 | The United States Of America As Represented By The Department Of Health And Human Services | IL-13 receptor specific chimeric proteins and uses thereof |
US5710023A (en) * | 1996-03-01 | 1998-01-20 | Genetics Institute, Inc. | IL-13 cytokine receptor chain |
JP2000319298A (ja) * | 1999-03-04 | 2000-11-21 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | 蛋白質複合体の結晶、構造座標、及び構造座標の使用 |
JP2001069995A (ja) * | 1999-07-02 | 2001-03-21 | Japan Tobacco Inc | 結晶構造解析に適したhcvポリメラーゼ及びその利用方法 |
US6795776B1 (en) * | 1999-10-14 | 2004-09-21 | Bristol-Myers Squibb Company | Crystallographic structure of the androgen receptor ligand binding domain |
EP1232253A2 (en) * | 1999-11-16 | 2002-08-21 | Vertex Pharmaceuticals Incorporated | Crystallizable compositions comprising a caspase-7 |
US20040137518A1 (en) * | 2002-01-31 | 2004-07-15 | Lambert Millard Hurst | CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME |
-
2002
- 2002-05-16 JP JP2003504310A patent/JP2005506960A/ja active Pending
- 2002-05-16 EP EP02726880A patent/EP1402451A4/en not_active Withdrawn
- 2002-05-16 IL IL15921502A patent/IL159215A0/xx unknown
- 2002-05-16 MX MXPA03011158A patent/MXPA03011158A/es unknown
- 2002-05-16 CA CA002450147A patent/CA2450147A1/en not_active Abandoned
- 2002-05-16 WO PCT/US2002/015561 patent/WO2002101629A1/en not_active Application Discontinuation
- 2002-05-16 US US10/150,874 patent/US20030013851A1/en not_active Abandoned
- 2002-06-07 AR ARP020102167A patent/AR036333A1/es not_active Application Discontinuation
-
2003
- 2003-12-22 ZA ZA200309894A patent/ZA200309894B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2005506960A (ja) | 2005-03-10 |
WO2002101629A1 (en) | 2002-12-19 |
MXPA03011158A (es) | 2004-02-27 |
EP1402451A1 (en) | 2004-03-31 |
ZA200309894B (en) | 2004-09-29 |
CA2450147A1 (en) | 2002-12-19 |
IL159215A0 (en) | 2004-06-01 |
EP1402451A4 (en) | 2005-01-05 |
US20030013851A1 (en) | 2003-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR036333A1 (es) | Estructura en solucion de il-13, sitios activos de il-13, agentes de union para il-13 y metodos para disenar agentes de union para il-13 | |
EP0684982B1 (en) | Cleansing compositions | |
IT1288290B1 (it) | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie | |
BR9506452A (pt) | Composto heterocíclico processo de preparação do composto heterocíclico composição farmacêutica composição farmacêutica adequada para o tratamento de inflamação neurogênica processo de tratamento de inflamação neurogênica em um individuo necessitado de tal tratamento e uso de um composto heterocíclico | |
HK1062140A1 (en) | 4-fluoro-n-indan-2-yl benzamide and its use as pharmaceutical 4-n-(1,2-2-?) | |
BR9916790A (pt) | Uso de um composto, composto, processo para amanufatura do mesmo, composição farmacêtica, e,método para produzir um efeito de dano vascularem um animal de sangue quente | |
EA199801001A1 (ru) | Состав для очистки кожи, способы его приготовления и использования | |
ES2146784T3 (es) | Composiciones de peracido espesadas. | |
ES2108375T3 (es) | Derivados de oxazolidinadiona, su produccion y utilizacion para reducir los niveles de azucares y lipidos en sangre. | |
ES2026844T3 (es) | Una composicion detergente. | |
MXPA05008382A (es) | Acidos grasos, gliceridos y analogos con longitud de cadena media como estimuladores de eritropoyesis. | |
DE3586935D1 (de) | Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen. | |
BR0304298A (pt) | Composição contendo um ácido orgânico cosmeticamente ativo e um produto de legume | |
EA200101116A1 (ru) | Способ лечения фиброза с помощью альфа-4-субъединицы антагониста интегрина | |
AR043918A1 (es) | Reduccion del crecimiento del vello utilizando una composicion que contiene difluorometilornitina | |
AR001838A1 (es) | Derivados de azacicloal canos utiles para el tratamiento de la obesidad diabetes e hiperglucemia procedimiento para prepararlos composiciones farmacéuticas que los contienen y aplicación de dichos derivados en la preparación de dichas composiciones | |
PA8581701A1 (es) | Derivados de indolilo | |
ATE205489T1 (de) | N-substituierte azaheterocyclische carbonsäuren und ihre alkylester | |
ATE439846T1 (de) | Zusammensetzungen von cholesterolsulfat und aminozuckern zur verbesserung der stratum corneum funktion | |
AR007052A1 (es) | Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende | |
AR008371A1 (es) | Una sal de adicion con acido de una 10-aminoalifatil-dibenz[b,f],oxepina, su empleo; procedimiento para su elaboracion, una 10-aminoalifatil-dibenz[b,f]oxepina, una preparacion farmaceutica que contiene dicha sal o dicha oxepina y un procedimiento para el tratamiento de enfermedades neurodegenerativ | |
JPS5756420A (en) | Bath agent | |
RU2001126403A (ru) | Низкомолекулярные производные пептидов как ингибиторы взаимодействия ламинина/нидогена | |
ES2970630T3 (es) | Composiciones que comprenden unos compuestos organo-silanoles, y aplicaciones | |
BR0109343A (pt) | Processo para produzir camptotecina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |