MXPA03011158A - Estructura de solucion de il - 13 y sus usos. - Google Patents

Estructura de solucion de il - 13 y sus usos.

Info

Publication number
MXPA03011158A
MXPA03011158A MXPA03011158A MXPA03011158A MXPA03011158A MX PA03011158 A MXPA03011158 A MX PA03011158A MX PA03011158 A MXPA03011158 A MX PA03011158A MX PA03011158 A MXPA03011158 A MX PA03011158A MX PA03011158 A MXPA03011158 A MX PA03011158A
Authority
MX
Mexico
Prior art keywords
solution structure
present
dimensional
interleukin
potent
Prior art date
Application number
MXPA03011158A
Other languages
English (en)
Inventor
Powers Robert
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA03011158A publication Critical patent/MXPA03011158A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5437—IL-13
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invencion se refiere a la estructura de solucion tridimensional de interleucina-13 (IL-13), asi como a la Identificacion y caracterizacion de varios sitios activos de Enlace de IL-13. la presente invencion proporciona tambien metodos para utilizar la estructura tridimensional para el diseno y la seleccion de agentes potentes y selectivos que interactuan con IL-13.
MXPA03011158A 2001-06-07 2002-05-16 Estructura de solucion de il - 13 y sus usos. MXPA03011158A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29660701P 2001-06-07 2001-06-07
PCT/US2002/015561 WO2002101629A1 (en) 2001-06-07 2002-05-16 Solution structure of il-13 and uses thereof

Publications (1)

Publication Number Publication Date
MXPA03011158A true MXPA03011158A (es) 2004-02-27

Family

ID=23142750

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011158A MXPA03011158A (es) 2001-06-07 2002-05-16 Estructura de solucion de il - 13 y sus usos.

Country Status (9)

Country Link
US (1) US20030013851A1 (es)
EP (1) EP1402451A4 (es)
JP (1) JP2005506960A (es)
AR (1) AR036333A1 (es)
CA (1) CA2450147A1 (es)
IL (1) IL159215A0 (es)
MX (1) MXPA03011158A (es)
WO (1) WO2002101629A1 (es)
ZA (1) ZA200309894B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501121B2 (en) * 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
US20090098142A1 (en) * 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
US7774811B2 (en) * 2004-08-26 2010-08-10 Sony Corporation Method and system for use in displaying multimedia content and status
EP1824886B1 (en) 2004-11-17 2010-12-22 Amgen Inc. Fully human monoclonal antibodies to il-13
MX349810B (es) 2006-09-08 2017-08-14 Abbvie Bahamas Ltd Proteinas de enlace de interleucina-13.
CN101977935A (zh) * 2007-04-23 2011-02-16 惠氏公司 用于治疗和监测il-13相关病症的方法和组合物
NZ591098A (en) 2008-08-20 2012-08-31 Centocor Ortho Biotech Inc Engineered anti-il-13 antibodies, compositions, methods and uses
EP2850093B1 (en) 2012-01-27 2019-01-09 The Board of Trustees of the Leland Stanford Junior University Therapeutic il-13 polypeptides
CN113563478A (zh) 2013-09-24 2021-10-29 梅迪塞纳医疗股份有限公司 白介素-4受体结合融合蛋白及其应用
CN108277226A (zh) * 2018-02-01 2018-07-13 北京市华信行生物科技有限公司 白细胞介素-6的编码基因及其制备方法和应用
CN112739713A (zh) 2018-06-25 2021-04-30 华盛顿大学 有力的且选择性的白介素模拟物的从头设计
AU2019384523A1 (en) * 2018-11-20 2021-04-22 University Of Washington Split interleukin mimetics and their use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
WO1994004680A1 (en) * 1992-08-21 1994-03-03 Schering Corporation Human interleukin-13
US5856116A (en) * 1994-06-17 1999-01-05 Vertex Pharmaceuticals, Incorporated Crystal structure and mutants of interleukin-1 beta converting enzyme
US5614191A (en) * 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
US5710023A (en) * 1996-03-01 1998-01-20 Genetics Institute, Inc. IL-13 cytokine receptor chain
JP2000319298A (ja) * 1999-03-04 2000-11-21 Seibutsu Bunshi Kogaku Kenkyusho:Kk 蛋白質複合体の結晶、構造座標、及び構造座標の使用
JP2001069995A (ja) * 1999-07-02 2001-03-21 Japan Tobacco Inc 結晶構造解析に適したｈｃｖポリメラーゼ及びその利用方法
WO2001027622A1 (en) * 1999-10-14 2001-04-19 Bristol-Myers Squibb Company Crystallographic structure of the androgen receptor ligand binding domain
CA2389569A1 (en) * 1999-11-16 2001-05-25 Vertex Pharmaceuticals Incorporated Crystallizable compositions comprising a caspase-7
US20040137518A1 (en) * 2002-01-31 2004-07-15 Lambert Millard Hurst CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME

Also Published As

Publication number Publication date
ZA200309894B (en) 2004-09-29
JP2005506960A (ja) 2005-03-10
EP1402451A4 (en) 2005-01-05
AR036333A1 (es) 2004-09-01
US20030013851A1 (en) 2003-01-16
CA2450147A1 (en) 2002-12-19
EP1402451A1 (en) 2004-03-31
WO2002101629A1 (en) 2002-12-19
IL159215A0 (en) 2004-06-01

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