AR035714A1 - Pirazoles sustituidos y composiciones farmaceuticas que los contienen - Google Patents

Pirazoles sustituidos y composiciones farmaceuticas que los contienen

Info

Publication number
AR035714A1
AR035714A1 ARP010103883A ARP010103883A AR035714A1 AR 035714 A1 AR035714 A1 AR 035714A1 AR P010103883 A ARP010103883 A AR P010103883A AR P010103883 A ARP010103883 A AR P010103883A AR 035714 A1 AR035714 A1 AR 035714A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocyclyl
alkenyl
phenyl
hydrogen
Prior art date
Application number
ARP010103883A
Other languages
English (en)
Spanish (es)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of AR035714A1 publication Critical patent/AR035714A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
ARP010103883A 2000-08-14 2001-08-14 Pirazoles sustituidos y composiciones farmaceuticas que los contienen AR035714A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22513800P 2000-08-14 2000-08-14
US09/928,122 US7309703B2 (en) 2000-08-14 2001-08-10 Substituted pyrazoles

Publications (1)

Publication Number Publication Date
AR035714A1 true AR035714A1 (es) 2004-07-07

Family

ID=26919335

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103883A AR035714A1 (es) 2000-08-14 2001-08-14 Pirazoles sustituidos y composiciones farmaceuticas que los contienen

Country Status (17)

Country Link
US (9) US7589202B2 (US07772236-20100810-C00036.png)
EP (1) EP1309591B1 (US07772236-20100810-C00036.png)
JP (1) JP5140225B2 (US07772236-20100810-C00036.png)
CN (1) CN1329392C (US07772236-20100810-C00036.png)
AR (1) AR035714A1 (US07772236-20100810-C00036.png)
AT (1) ATE352552T1 (US07772236-20100810-C00036.png)
AU (2) AU8125501A (US07772236-20100810-C00036.png)
CA (1) CA2419540A1 (US07772236-20100810-C00036.png)
CY (1) CY1106032T1 (US07772236-20100810-C00036.png)
DE (1) DE60126286T2 (US07772236-20100810-C00036.png)
DK (1) DK1309591T3 (US07772236-20100810-C00036.png)
ES (1) ES2281434T3 (US07772236-20100810-C00036.png)
HK (1) HK1052509B (US07772236-20100810-C00036.png)
MX (1) MXPA03001421A (US07772236-20100810-C00036.png)
NZ (1) NZ524193A (US07772236-20100810-C00036.png)
PT (1) PT1309591E (US07772236-20100810-C00036.png)
WO (1) WO2002014314A2 (US07772236-20100810-C00036.png)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
DK1309591T3 (da) * 2000-08-14 2007-03-26 Ortho Mcneil Pharm Inc Substituerede pyrazoler
US7332494B2 (en) * 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
US20070105841A1 (en) * 2000-08-14 2007-05-10 Breitenbucher J G Method for treating allergies using substituted pyrazoles
CA2433520A1 (en) * 2000-12-22 2002-07-04 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
US20040147503A1 (en) * 2002-06-04 2004-07-29 Sheila Zipfeil Novel compounds and compositions as cathepsin inhibitors
US20030073672A1 (en) * 2001-09-05 2003-04-17 Breitenbucher J. Guy Method for treating allergies using substituted pyrazoles
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
WO2003105853A1 (en) * 2002-06-12 2003-12-24 Chemocentryx, Inc. 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
GB0220214D0 (en) * 2002-08-30 2002-10-09 Novo Pharmaceuticals De Ltd Compounds and their use
JP4509028B2 (ja) 2002-09-24 2010-07-21 ノバルティス アーゲー 有機化合物
US7109243B2 (en) 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
US7384970B2 (en) 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7173051B2 (en) 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
BRPI0414541B8 (pt) 2003-09-17 2021-05-25 Janssen Pharmaceutica Nv compostos heterocíclicos fundidos tendo atividade de modulação de receptor de serotonina, método de preparação de compostos intermediários
EP1715921B1 (en) * 2003-09-25 2013-04-24 Abraxis BioScience, Inc. Tetrahydroindolone derivatives for treatment of neurological conditions
EP1720545B1 (en) * 2004-03-03 2014-10-29 ChemoCentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
CA2576407A1 (en) * 2004-08-12 2006-02-16 Prosidion Limited Substituted phenylacetamides and their use as glucokinase activators
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
US7598255B2 (en) 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
US20090118274A1 (en) * 2007-02-15 2009-05-07 Darin Allen Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090099157A1 (en) * 2007-02-15 2009-04-16 Ameriks Michael K Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s
US20080269241A1 (en) * 2007-02-15 2008-10-30 Darin Allen Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080207683A1 (en) * 2007-02-15 2008-08-28 Darin Allen Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080200454A1 (en) * 2007-02-15 2008-08-21 Ameriks Michael K Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s
JP5196685B2 (ja) * 2007-06-26 2013-05-15 メディア パテンツ エセ．エレ． マルチキャストグループを管理する方法と装置
US20100046516A1 (en) * 2007-06-26 2010-02-25 Media Patents, S.L. Methods and Devices for Managing Multicast Traffic
WO2009062134A1 (en) * 2007-11-09 2009-05-14 Cenomed Biosciences, Llc Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds
WO2009102937A1 (en) * 2008-02-14 2009-08-20 Sunesis Pharmaceuticals, Inc. Processes for the preparation of carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
SG10201406263SA (en) 2008-06-20 2015-02-27 Novartis Ag Paediatric compositions for treating multiple sclerosis
WO2010053825A1 (en) 2008-10-29 2010-05-14 Janssen Pharmaceutica Nv 2-aminopyrimidine compounds as serotonin receptor modulators
CN102264737A (zh) 2008-12-23 2011-11-30 雅培制药有限公司 抗病毒化合物
CA2740195A1 (en) 2008-12-23 2010-07-01 Abbott Laboratories Anti-viral compounds
RU2541571C2 (ru) 2009-04-15 2015-02-20 Эббви Инк. Противовирусные соединения
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
DK2455376T3 (en) 2009-06-11 2015-03-02 Abbvie Bahamas Ltd Heterocyclic compounds as inhibitors of hepatitis C virus (HCV)
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
US9527845B2 (en) * 2014-12-30 2016-12-27 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis B infections
ES2822979T3 (es) 2015-11-20 2021-05-05 Lundbeck La Jolla Research Center Inc Derivados de pirazol, procesos para su preparación, y sus usos
US10323038B2 (en) 2015-11-20 2019-06-18 Abide Therapeutics, Inc. Pyrazole compounds and methods of making and using same
US10385057B2 (en) 2015-11-20 2019-08-20 Lundbeck La Jolla Research Center, Inc. Pyrazole compounds and methods of making and using same
WO2017096315A1 (en) 2015-12-02 2017-06-08 The Scripps Research Institute TRIAZOLE DAGL(α) INHIBITORS
JP6935434B2 (ja) 2016-06-29 2021-09-15 ノヴィラ・セラピューティクス・インコーポレイテッド オキサジアゼピノン誘導体及びｂ型肝炎感染症の治療におけるその使用
JP6935433B2 (ja) 2016-06-29 2021-09-15 ノヴィラ・セラピューティクス・インコーポレイテッド ジアゼピノン誘導体及びｂ型肝炎感染症の治療におけるその使用
JOP20190267A1 (ar) 2017-05-23 2019-11-18 Lundbeck La Jolla Research Center Inc مثبطات بيرازول magl
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
UA124990C2 (uk) * 2017-05-23 2021-12-22 Луннбек Ла-Холья Рісьоч Сенте, Інк. Інгібітори magl на основі піразолу
EP3884948A1 (en) * 2020-03-26 2021-09-29 Ecole Polytechnique Fédérale de Lausanne (EPFL) Cathepsin inhibitors and uses thereof

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914340A (en) * 1970-06-02 1975-10-21 Gen Tire & Rubber Co Block copolymerization with azoamidino compounds as initiator
JPS5720663B2 (US07772236-20100810-C00036.png) * 1973-06-11 1982-04-30
US3994890A (en) * 1974-01-31 1976-11-30 Chugai Seiyaku Kabushiki Kaisha 1-Aminoalkyl, 3-phenyl indazoles
JPS5640714B2 (US07772236-20100810-C00036.png) * 1974-03-04 1981-09-22
JPS5944312B2 (ja) * 1974-11-22 1984-10-29 中外製薬株式会社 インダゾ−ル誘導体の製法
JPS5936627B2 (ja) * 1975-07-25 1984-09-05 中外製薬株式会社 インダゾ−ル誘導体の製法
US4523928A (en) * 1980-04-28 1985-06-18 Battelle Development Corporation Gasohol production from thermochemical conversion of biomass to ethanol
US4401823A (en) * 1981-05-18 1983-08-30 Uop Inc. Hydrogenolysis of polyhydroxylated compounds
US4364745A (en) * 1981-06-26 1982-12-21 Standard Oil Company (Indiana) Plant hydrocarbon recovery process
DE3132915A1 (de) * 1981-08-20 1983-03-03 Kali-Chemie Pharma Gmbh, 3000 Hannover 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK27383A (da) * 1982-02-17 1983-08-18 Lepetit Spa Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
JPH0615542B2 (ja) * 1986-07-22 1994-03-02 吉富製薬株式会社 ピラゾロピリジン化合物
US4925540A (en) * 1988-10-04 1990-05-15 Delphi Research Inc. Method for treating organic waste material and an oxidation catalyst/cocatalyst composition useful therefor
FR2642759B1 (fr) 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
US5177169A (en) * 1989-04-03 1993-01-05 Colorado State University Research Foundation Method for recovering and using lignin in adhesive resins
FR2673628B1 (fr) 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
US5186722A (en) * 1991-06-25 1993-02-16 Cantrell Research, Incorporated Hydrocarbon-based fuels from biomass
JP2818061B2 (ja) * 1991-12-10 1998-10-30 三菱電機株式会社 放電加工装置
US5264576A (en) 1992-10-22 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Pyrazolo[4,3-c]pyridines which are intermediates
CN1050604C (zh) 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
FR2712808B1 (fr) 1993-11-25 1996-02-16 Esteve Labor Dr Utilisation des dérivés de 1-{4-[4-aryl(ou hétéroaryl)-1-pipérazinyl]-butyl}-1-H-azole pour la préparation de médicaments destinés au traitement des troubles de la sécrétion gastrique .
IL112759A0 (en) 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
US5516960A (en) * 1994-08-02 1996-05-14 Board Of Regents, The University Of Texas System Process for producing hydrocarbon fuels
AU713492B2 (en) 1995-03-24 1999-12-02 Axys Pharmaceuticals, Inc. Reversible protease inhibitors
US5776718A (en) 1995-03-24 1998-07-07 Arris Pharmaceutical Corporation Reversible protease inhibitors
TW438591B (en) 1995-06-07 2001-06-07 Arris Pharm Corp Reversible cysteine protease inhibitors
AU5966196A (en) 1995-06-08 1997-01-09 Eli Lilly And Company Methods of treating cold and allergic rhinitis
FR2742052B1 (fr) 1995-12-12 1998-04-10 Esteve Labor Dr Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports
DE19602505A1 (de) 1996-01-25 1997-07-31 Merck Patent Gmbh 1-(Pyrazol-4-Indol-3-yl)-Piperidine
DK0912601T4 (da) 1996-04-22 2009-03-09 Massachusetts Inst Technology Suppression af immunrespons ved inhibering af cathepsin S
IL120561A0 (en) 1996-04-24 1997-07-13 Akzo Nobel Nv Peptides suitable for use in immunosuppressive therapy
US5830850A (en) 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
GB9626643D0 (en) * 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
AU7553198A (en) 1997-06-12 1998-12-30 Sumitomo Pharmaceuticals Company, Limited Pyrazole derivatives
FR2767827A1 (fr) 1997-09-03 1999-02-26 Adir Nouveaux derives de l'indole et de l'indazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HUP0004400A3 (en) 1997-11-05 2002-10-28 Novartis Ag Dipeptide nitriles, process for their preparation, pharmaceutical compositions comprising thereof and their use
GB9806287D0 (en) 1998-03-24 1998-05-20 Synphar Lab Inc Monobactam enzyme inhibitors
WO1999058153A1 (en) 1998-05-08 1999-11-18 Brigham & Women's Hospital Methods of diagnosing and modulating autoimmunity
JP2002537294A (ja) 1999-02-20 2002-11-05 アストラゼネカ アクチボラグ カテプシンｌ及びカテプシンｓの阻害剤としてのジ−及びトリペプチドニトリル誘導体
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
DE60028045T2 (de) 1999-07-30 2007-02-15 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Neue bernsteinsäure derivative als cysteine-protease-inhibitoren
AU777472B2 (en) 1999-09-16 2004-10-21 Axys Pharmaceuticals, Inc. Compounds and pharmaceutical compositions as cathepsin S inhibitors
KR20020062312A (ko) 1999-12-03 2002-07-25 오노 야꾸힝 고교 가부시키가이샤 １,３,４-옥사디아졸린 유도체 및 이들을 유효 성분으로하는 약제
US6214813B1 (en) 2000-04-07 2001-04-10 Kinetek Pharmaceuticals, Inc. Pyrazole compounds
DK1309591T3 (da) * 2000-08-14 2007-03-26 Ortho Mcneil Pharm Inc Substituerede pyrazoler
US7332494B2 (en) * 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
BRPI0113286B8 (pt) * 2000-08-14 2021-05-25 Johnson & Johnson pirazóis substituídos e composição farmacêutica compreendendo os mesmos.
US20070105841A1 (en) * 2000-08-14 2007-05-10 Breitenbucher J G Method for treating allergies using substituted pyrazoles
EP1184443A1 (en) * 2000-09-04 2002-03-06 Biofuel B.V. Process for the production of liquid fuels from biomass
WO2002020012A2 (en) * 2000-09-06 2002-03-14 Ortho Mcneil Pharmaceutical, Inc. Method for treating allergies using substituted pyrazoles

Also Published As

Publication number Publication date
US7417046B2 (en) 2008-08-26
US7393850B2 (en) 2008-07-01
US20070004754A1 (en) 2007-01-04
US20080293732A1 (en) 2008-11-27
DK1309591T3 (da) 2007-03-26
WO2002014314A2 (en) 2002-02-21
CN1329392C (zh) 2007-08-01
EP1309591B1 (en) 2007-01-24
CY1106032T1 (el) 2011-04-06
JP2004512272A (ja) 2004-04-22
ES2281434T3 (es) 2007-10-01
US7309703B2 (en) 2007-12-18
WO2002014314A3 (en) 2002-06-06
AU8125501A (en) 2002-02-25
EP1309591A2 (en) 2003-05-14
DE60126286T2 (de) 2007-11-15
HK1052509B (zh) 2007-09-07
PT1309591E (pt) 2007-04-30
US20070021437A1 (en) 2007-01-25
US7772236B2 (en) 2010-08-10
US7429591B2 (en) 2008-09-30
CN1468239A (zh) 2004-01-14
US7589202B2 (en) 2009-09-15
US20080300255A1 (en) 2008-12-04
US20070004755A1 (en) 2007-01-04
NZ524193A (en) 2004-12-24
DE60126286D1 (de) 2007-03-15
JP5140225B2 (ja) 2013-02-06
CA2419540A1 (en) 2002-02-21
US20070004738A1 (en) 2007-01-04
MXPA03001421A (es) 2004-01-26
US20070004747A1 (en) 2007-01-04
US20070010530A1 (en) 2007-01-11
US20020040020A1 (en) 2002-04-04
HK1052509A1 (en) 2003-09-19
ATE352552T1 (de) 2007-02-15
AU2001281255B2 (en) 2006-07-20
US7388011B2 (en) 2008-06-17
US7452890B2 (en) 2008-11-18

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