AR030868A1 - Compuestos de 14-[n-oxicarbonilcarbamato] de mutilina; procedimiento para prepararlos; composiciones farmaceuticas formuladas con dichos compuestos; el uso terapéutico de los mismos y procedimiento de tratamiento de infecciones microbianas administrando dichos compuestos - Google Patents

Compuestos de 14-[n-oxicarbonilcarbamato] de mutilina; procedimiento para prepararlos; composiciones farmaceuticas formuladas con dichos compuestos; el uso terapéutico de los mismos y procedimiento de tratamiento de infecciones microbianas administrando dichos compuestos

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Publication number
AR030868A1
AR030868A1 ARP010104734A ARP010104734A AR030868A1 AR 030868 A1 AR030868 A1 AR 030868A1 AR P010104734 A ARP010104734 A AR P010104734A AR P010104734 A ARP010104734 A AR P010104734A AR 030868 A1 AR030868 A1 AR 030868A1
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AR
Argentina
Prior art keywords
compounds
procedure
prepare
therapeutic use
oxicarbonyl
Prior art date
Application number
ARP010104734A
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English (en)
Original Assignee
Smithkline Beecham Plc
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Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR030868A1 publication Critical patent/AR030868A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D331/00—Heterocyclic compounds containing rings of less than five members, having one sulfur atom as the only ring hetero atom
    • C07D331/04—Four-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/66—Y being a hetero atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

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Abstract

Se trata de un compuesto de 14-[N-oxicarbonilcarbamato] de mutilina; procedimiento para prepararlos; composiciones formuladas con dichos compuestos; el uso terapéutico de los mismos y procedimiento de tratamiento de infecciones microbianas administrando dichos compuestos de formula 1, donde R1 es alquilo C1-6 o cicloalquilo C3-6 opcionalmente sustituido o heterociclilo opcionalmente sustituido; R2 es vinilo o etilo; R3 es H, OH o F, R4 es H o R3 es H y R4 es F, y R5 y R6 forman conjuntamente un grupo oxo; o R3 y R4 es cada uno H, R5 es OH o H y R6 es H o R5 es H y R6 es OH o H. También se proponen los objetos restantes mencionados en el título.
ARP010104734A 2000-10-10 2001-10-09 Compuestos de 14-[n-oxicarbonilcarbamato] de mutilina; procedimiento para prepararlos; composiciones farmaceuticas formuladas con dichos compuestos; el uso terapéutico de los mismos y procedimiento de tratamiento de infecciones microbianas administrando dichos compuestos AR030868A1 (es)

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GB0209262D0 (en) * 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
CA2591898A1 (en) * 2004-12-27 2006-07-06 Kyorin Pharmaceutical Co., Ltd. Mutilin-derivative substituted at position 12
PE20070825A1 (es) * 2005-11-18 2007-08-05 Glaxo Group Ltd Nuevo derivado de pleuromutilina y su uso
US20080275251A1 (en) * 2005-11-18 2008-11-06 Glaxo Group Limited Novel Intermediates and Their Use
TW200736203A (en) * 2005-11-18 2007-10-01 Glaxo Group Ltd New pleuromutilin derivative and its use
WO2008117796A1 (ja) * 2007-03-28 2008-10-02 Dainippon Sumitomo Pharma Co., Ltd. 新規ムチリン誘導体
US8222407B2 (en) * 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
WO2018152408A1 (en) * 2017-02-17 2018-08-23 University Of Tennessee Research Foundation Pleuromutilin derivatives and uses thereof
CN115197169B (zh) * 2018-11-02 2023-07-11 华南农业大学 一种以2-氨基苯巯醇为连接基团截短侧耳素衍生物制备方法和用途
CN110437157B (zh) * 2019-07-05 2022-05-17 西华大学 一种芳基嘧啶类截短侧耳素衍生物及其制备方法和用途

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TR199801282T2 (xx) * 1996-01-03 1998-12-21 Smithkline Beecham P.L.C. Mutilin'in karbamoiloksi t�revleri ve antibakteriyel olarak kullan�m�.
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB9919839D0 (en) * 1999-08-20 1999-10-27 Smithkline Beecham Plc Novel compounds
HUP0300370A3 (en) * 2000-04-04 2005-07-28 Smithkline Beecham Plc 2-hydroxy-mutilin carbamate derivatives of antibacterial effect process for preparation and pharmaceutical compositions containing them

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US6900345B2 (en) 2005-05-31
EP1538150A1 (en) 2005-06-08
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EP1351959B1 (en) 2005-06-01
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US20040024059A1 (en) 2004-02-05
GB0024811D0 (en) 2000-11-22
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PT1538150E (pt) 2007-09-04
ATE296824T1 (de) 2005-06-15
EP1889845A1 (en) 2008-02-20
JP2004511482A (ja) 2004-04-15
PT1351959E (pt) 2005-09-30
DE60111268T2 (de) 2006-03-23
WO2002030929A1 (en) 2002-04-18
US7160907B2 (en) 2007-01-09
US20050096357A1 (en) 2005-05-05
ES2288284T3 (es) 2008-01-01
DE60129174T2 (de) 2008-03-06
CY1105411T1 (el) 2010-04-28

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