AR027586A1 - Metodo y producto de programa de computacion para disenar grupos combinatorios - Google Patents

Metodo y producto de programa de computacion para disenar grupos combinatorios

Info

Publication number
AR027586A1
AR027586A1 ARP010100966A ARP010100966A AR027586A1 AR 027586 A1 AR027586 A1 AR 027586A1 AR P010100966 A ARP010100966 A AR P010100966A AR P010100966 A ARP010100966 A AR P010100966A AR 027586 A1 AR027586 A1 AR 027586A1
Authority
AR
Argentina
Prior art keywords
reagents
groups
combinatorial
design
adaptability
Prior art date
Application number
ARP010100966A
Other languages
English (en)
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of AR027586A1 publication Critical patent/AR027586A1/es

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G16C20/62—Design of libraries

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computing Systems (AREA)
  • Medicinal Chemistry (AREA)
  • Library & Information Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un método exhaustivo para disenar grupos combinatorios. Un grupo de reactivos son seleccionados inicialmente de una lista de reactivos candidatos en unabiblioteca combinatoria. Los reactivos en el grupo que maximiza un objetivo de diseno son determin ados en una manera reiterativa, examinando cada sitio devariacion en la biblioteca combinatoria en una secuencia estrictamente alternante. Durante cada capa, cada reactivo candidato en un sitio de variacion dado esevaluado construyendo y evaluando el sub-grupo que resulta de la combinacion sistemática de ese reactivo con los reactivos seleccionados en todos los otrossitios de variacion en la biblioteca. Los candidatos reactivos en ese sitio de variacion son clasificados de acuerdo a la adaptabil idad de sus respectivos sub-grupos, y los reactivos con la más alta adaptabilidad son seleccionados. El proceso es repetido para cada sitio de variacion en la biblioteca combinatoria,hasta que la adaptabilidad del grupo combinatorio completo ya no pu eda ser más mejorada.
ARP010100966A 2000-02-29 2001-03-01 Metodo y producto de programa de computacion para disenar grupos combinatorios AR027586A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18570000P 2000-02-29 2000-02-29

Publications (1)

Publication Number Publication Date
AR027586A1 true AR027586A1 (es) 2003-04-02

Family

ID=22682096

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100966A AR027586A1 (es) 2000-02-29 2001-03-01 Metodo y producto de programa de computacion para disenar grupos combinatorios

Country Status (5)

Country Link
US (1) US6671627B2 (es)
AR (1) AR027586A1 (es)
AU (1) AU2001241800A1 (es)
TW (1) TW523699B (es)
WO (1) WO2001065462A2 (es)

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US20080155235A1 (en) * 2006-10-02 2008-06-26 Dewey Douglas W Instructions Capable of Preventing Incorrect Usage of UContext Functions in a Multi-Process Environment

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Also Published As

Publication number Publication date
TW523699B (en) 2003-03-11
AU2001241800A1 (en) 2001-09-12
WO2001065462A3 (en) 2002-03-07
US6671627B2 (en) 2003-12-30
US20010029026A1 (en) 2001-10-11
WO2001065462A2 (en) 2001-09-07

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