AR016413A1 - Composicion de materia terapeuticamente activa, y uso de compuestos para la preparacion de una composicion de materia terapeuticamente activa - Google Patents
Composicion de materia terapeuticamente activa, y uso de compuestos para la preparacion de una composicion de materia terapeuticamente activaInfo
- Publication number
- AR016413A1 AR016413A1 ARP980105533A ARP980105533A AR016413A1 AR 016413 A1 AR016413 A1 AR 016413A1 AR P980105533 A ARP980105533 A AR P980105533A AR P980105533 A ARP980105533 A AR P980105533A AR 016413 A1 AR016413 A1 AR 016413A1
- Authority
- AR
- Argentina
- Prior art keywords
- diseases
- therapeutically active
- composition
- independently selected
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- -1 benzoimidazolyl Chemical group 0.000 abstract 6
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 2
- 206010040070 Septic Shock Diseases 0.000 abstract 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 abstract 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 abstract 1
- VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical compound C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 abstract 1
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
- IMLSAISZLJGWPP-UHFFFAOYSA-N 1,3-dithiolane Chemical compound C1CSCS1 IMLSAISZLJGWPP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005955 1H-indazolyl group Chemical group 0.000 abstract 1
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 206010014824 Endotoxic shock Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 108010044467 Isoenzymes Proteins 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 206010044248 Toxic shock syndrome Diseases 0.000 abstract 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 abstract 1
- 125000000641 acridinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002632 imidazolidinyl group Chemical group 0.000 abstract 1
- 125000002636 imidazolinyl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 230000009103 reabsorption Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 230000009897 systematic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen composiciones terapéuticamente activas de interés que son utiles para el tratamiento o prevencion de enfermedades, y afecciones que comprendenenfermedades inflamatorias, que incluyen inflamacion de las articulares, enfermedad de Crohn, enfermedad inflamatoria del intestino; enfermedades respiratoriastales como la enfermedad pulmonar obstructiva cronica (COPD) incluyendo el asma, la bronquitis cronica y el enfisema pulmonar; enfermedades infecciosas, queincluyen el choque endotoxicoy el síndrome del choque toxico; enfermedades inmunes, que incluyen el lupus sistemático eritematoso y la psoriasis; y otrasenfermedades que incluyen enfermedades de reabsorcion o sea y lesiones de reperfusion; donde dicha composicion de materia comprende un compuesto que esinhibidor de la isoenzima 4 de la fosfodiesterasa (PDE4) y donde un indazol es un componente esencial de la estructura química general de dicho compuesto, ydonde dicho indazol constituye un reemplazo bioisostérico de un componente de catecol o de un derivado funcional del mismo en un compuesto conocido que tienela misma dicha actividad terapéutica y los mismos dichos componentes restantes de su estructura química global. Se incluyen compuestos de formula (IA) o (IB)enlasque: R es un miembro seleccionado independientemente entre grupo compuesto esencialmente por hidrogeno, alquilo C1-9, -(CH2)ncicloalquilo C3-10, donde n esun numero entero seleccionado entre 0, 1 y 2; alcoxi C1-6-alquilo C1-6; alquenilo C2-6; -(CH2)nheterociclilo C3-9; donde n es un numero entero seleccionadoentre 0, 1 y 2; y -(Z1)b(Z2)c arilo(C6-10)son numeros enteros seleccionados independientemente entre 0 y 1, Z1 es alquileno C1-6 o alquenileno C2-6 y Z2 es O,S,SO2 o NR19; y además, donde dicho heterociclilo es un miembro seleccionado independientemente entre el grupo compuesto esencialmente por acridinilo, benzoimidazolilo,benzodioxolano, 1,3-benzodioxol-5-ilo; benzo[b]furanilo;benzo[b]tiofenilo;benzoxazolilo;benzotiazolilo;carbazolilo;cinnolinilo; 2,3-dihidrobenzofuranonilo,1,3 dioxano,1,3-dioxolano;1,3-ditiano;1,3-ditiolano;furanilo;imidazolidinilo;imidazolinilo;imidazolilo;1H-indazolilo;indolinilo;indolilo;3H-indolilo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6416097P | 1997-11-04 | 1997-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016413A1 true AR016413A1 (es) | 2001-07-04 |
Family
ID=22053970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980105533A AR016413A1 (es) | 1997-11-04 | 1998-11-03 | Composicion de materia terapeuticamente activa, y uso de compuestos para la preparacion de una composicion de materia terapeuticamente activa |
Country Status (34)
Country | Link |
---|---|
US (2) | US6716978B2 (es) |
EP (1) | EP1040100A1 (es) |
JP (1) | JP2001521925A (es) |
KR (1) | KR20010031783A (es) |
CN (1) | CN1281441A (es) |
AP (1) | AP1122A (es) |
AR (1) | AR016413A1 (es) |
AU (1) | AU754184B2 (es) |
BG (1) | BG104391A (es) |
BR (1) | BR9813938A (es) |
CA (1) | CA2309175A1 (es) |
CZ (1) | CZ20001623A3 (es) |
DZ (1) | DZ2639A1 (es) |
EA (1) | EA200000385A1 (es) |
HN (1) | HN1998000172A (es) |
HR (1) | HRP20000262A2 (es) |
HU (1) | HUP0100330A3 (es) |
ID (1) | ID24942A (es) |
IL (1) | IL135714A0 (es) |
IS (1) | IS5452A (es) |
MA (1) | MA26562A1 (es) |
NO (1) | NO20002127L (es) |
NZ (1) | NZ503995A (es) |
OA (1) | OA11353A (es) |
PA (1) | PA8462601A1 (es) |
PE (1) | PE131099A1 (es) |
PL (1) | PL340799A1 (es) |
SK (1) | SK6262000A3 (es) |
TN (1) | TNSN98199A1 (es) |
TR (1) | TR200001256T2 (es) |
UY (1) | UY25232A1 (es) |
WO (1) | WO1999023076A1 (es) |
YU (1) | YU25400A (es) |
ZA (1) | ZA9810042B (es) |
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JP4510383B2 (ja) * | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 軟骨疾患修復治療用組成物 |
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UA94733C2 (ru) | 2006-01-31 | 2011-06-10 | Эррей Биофарма Инк. | Ингибиторы киназы и способы их использования |
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CN102803248B (zh) * | 2009-12-23 | 2015-09-16 | 梅迪奇制药有限公司 | 作为组胺h4受体拮抗剂的氨烷基嘧啶 |
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DE2064304A1 (de) * | 1970-12-29 | 1972-07-20 | Agfa-Gevaert Ag, 5090 Leverkusen | Lichtempfindliches farbfotografisches Material |
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CA2264798A1 (en) * | 1996-09-04 | 1998-03-12 | Pfizer Inc. | Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf) |
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1998
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- 1998-10-09 CZ CZ20001623A patent/CZ20001623A3/cs unknown
- 1998-10-09 IL IL13571498A patent/IL135714A0/xx unknown
- 1998-10-09 PL PL98340799A patent/PL340799A1/xx not_active Application Discontinuation
- 1998-10-09 CN CN98811981A patent/CN1281441A/zh active Pending
- 1998-10-09 ID IDW20000820A patent/ID24942A/id unknown
- 1998-10-09 HU HU0100330A patent/HUP0100330A3/hu unknown
- 1998-10-09 KR KR1020007004849A patent/KR20010031783A/ko active IP Right Grant
- 1998-10-09 US US09/381,446 patent/US6716978B2/en not_active Expired - Fee Related
- 1998-10-09 AU AU92777/98A patent/AU754184B2/en not_active Ceased
- 1998-10-09 JP JP2000518951A patent/JP2001521925A/ja not_active Ceased
- 1998-10-09 EA EA200000385A patent/EA200000385A1/ru unknown
- 1998-10-09 BR BR9813938-0A patent/BR9813938A/pt not_active Application Discontinuation
- 1998-10-09 WO PCT/IB1998/001579 patent/WO1999023076A1/en not_active Application Discontinuation
- 1998-10-09 NZ NZ503995A patent/NZ503995A/xx unknown
- 1998-10-09 TR TR2000/01256T patent/TR200001256T2/xx unknown
- 1998-10-09 EP EP98945473A patent/EP1040100A1/en not_active Withdrawn
- 1998-10-09 CA CA002309175A patent/CA2309175A1/en not_active Abandoned
- 1998-10-30 PA PA19988462601A patent/PA8462601A1/es unknown
- 1998-11-02 AP APAP/P/1998/001376A patent/AP1122A/en active
- 1998-11-03 MA MA25331A patent/MA26562A1/fr unknown
- 1998-11-03 TN TNTNSN98199A patent/TNSN98199A1/fr unknown
- 1998-11-03 DZ DZ980249A patent/DZ2639A1/xx active
- 1998-11-03 ZA ZA9810042A patent/ZA9810042B/xx unknown
- 1998-11-03 AR ARP980105533A patent/AR016413A1/es not_active Application Discontinuation
- 1998-11-03 PE PE1998001040A patent/PE131099A1/es not_active Application Discontinuation
- 1998-11-04 UY UY25232A patent/UY25232A1/es not_active Application Discontinuation
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2000
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- 2000-04-26 NO NO20002127A patent/NO20002127L/no unknown
- 2000-04-28 BG BG104391A patent/BG104391A/xx unknown
- 2000-04-28 OA OA1200000126A patent/OA11353A/en unknown
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2002
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