AR012598A1 - Un analogo de vitamina d3 con dos cadenas laterales sobre el c-20, utilizaciones del mismo, un metodo para obtenerlo , un medicamento que contiene a dicho analogo y un compuesto util como intermedio para obtener dicho analogo - Google Patents
Un analogo de vitamina d3 con dos cadenas laterales sobre el c-20, utilizaciones del mismo, un metodo para obtenerlo , un medicamento que contiene a dicho analogo y un compuesto util como intermedio para obtener dicho analogoInfo
- Publication number
- AR012598A1 AR012598A1 ARP980101897A ARP980101897A AR012598A1 AR 012598 A1 AR012598 A1 AR 012598A1 AR P980101897 A ARP980101897 A AR P980101897A AR P980101897 A ARP980101897 A AR P980101897A AR 012598 A1 AR012598 A1 AR 012598A1
- Authority
- AR
- Argentina
- Prior art keywords
- analog
- analogues
- bond
- double bond
- vitamin
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010020707 Hyperparathyroidism primary Diseases 0.000 abstract 1
- 201000000981 Primary Hyperparathyroidism Diseases 0.000 abstract 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000005348 fluorocycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 201000006409 renal osteodystrophy Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/21—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Análogos de vitamina D3, con dos cadenas laterales sobre el C-20 de la formula (I), en la que: X es H2 o CH2; Y es hidrogeno, hidroxi o fluor; Z eshidroxi; R1 y R2 son alquilo o fluoralquilo (C1-4), o bien R1 y R2 junto con el C25 forman unc icloalquilo o fluorcicloalquilo C3-6; R3 y R4 son alquiloo fluoralquilo C1-4, o bien R3 y R4 junto con el C25 forman un cicloalquilo o fluorcicloalquilo C3-6; A es un enlace simple o un doble enlace; B1 es unenlace simple, un doble enlacetrans, un doble enlace cis o un tripe enlace; y B2 es un enlace simple, un doble enlace trans, un doble enlace cis o un tripleenlace; y los profármacos (= precursores de fármaco) de los mismos, los compuestos intermedios y métodos para laobtencion de estos análogos, losmedicamentos que contienen tales análogos, la utilizacion de tales análogos para la preparacion de medicamentos para el tratamiento de hiperparatiroidismoprimario y secundario, de la osteodistrofia renal, deenfermedades autoinmunes, de la esclerosis multiple o del lupus, y la utilizacion de talesanálogos para preparar un medicamento para prevenir y tratar enfermedades neoplásicas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4466197P | 1997-04-28 | 1997-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012598A1 true AR012598A1 (es) | 2000-11-08 |
Family
ID=21933610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101897A AR012598A1 (es) | 1997-04-28 | 1998-04-24 | Un analogo de vitamina d3 con dos cadenas laterales sobre el c-20, utilizaciones del mismo, un metodo para obtenerlo , un medicamento que contiene a dicho analogo y un compuesto util como intermedio para obtener dicho analogo |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6030962A (es) |
| AR (1) | AR012598A1 (es) |
| CO (1) | CO4940443A1 (es) |
| HR (1) | HRP980224A2 (es) |
| PE (1) | PE68499A1 (es) |
| ZA (1) | ZA983350B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673782B2 (en) * | 1999-04-29 | 2004-01-06 | Wisconsin Alumni Research Foundation | Treatment of systemic lupus erythematosis |
| CA2524026A1 (en) * | 2003-04-30 | 2004-11-18 | Bioxell S.P.A. | Gemini vitamin d3 compounds and methods of use thereof |
| US20050113348A1 (en) * | 2003-06-12 | 2005-05-26 | Yanchun Li | Vitamin D and vitamin D analogs or derivatives as new anti-hypertensive agents |
| US20060171983A1 (en) * | 2003-07-30 | 2006-08-03 | Jin Tian | Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| US9221753B2 (en) * | 2004-02-03 | 2015-12-29 | Chugai Seiyaku Kabushiki Kaisha | Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds |
| WO2005082375A2 (en) | 2004-03-01 | 2005-09-09 | Bioxell Spa | Treatment of interstitial cystitis with vitamin d compounds |
| AU2005303773A1 (en) | 2004-11-12 | 2006-05-18 | Bioxell Spa | Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer |
| US20090298799A1 (en) * | 2005-03-23 | 2009-12-03 | Bioxell S.P.A. | Methods of Treating Osteoporosis and Secondary Hyperparathyroidism Using 20-Methyl, Gemini Vitamin D3 Compounds |
| US20090099140A1 (en) * | 2005-03-23 | 2009-04-16 | Bioxell S.P.A. | 20-Alkyl, Gemini Vitamin D3 Compounds and Methods of Use Thereof |
| US20090298800A1 (en) * | 2005-09-23 | 2009-12-03 | Bioxell S.P.A. | 1,25-dihydroxy, 20-cyclopropyl,26-27-deuteroalkyl vitamin d3 compounds and methods of use thereof |
| US20080280859A1 (en) * | 2005-10-19 | 2008-11-13 | Bioxell S.P.A. | Gemini vitamin d3 compounds and methods of use thereof |
| US20100009949A1 (en) * | 2006-03-24 | 2010-01-14 | Bioxell S.P.A. | Novel method |
| US20120184514A1 (en) * | 2009-07-01 | 2012-07-19 | Vitamin Derivatives Inc. | Vitamin d compounds and methods for preparing same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2096105A1 (en) * | 1992-10-07 | 1994-04-08 | Enrico Giuseppe Baggiolini (Deceased) | Vitamin d3 fluorinated analogs |
-
1998
- 1998-04-16 US US09/061,664 patent/US6030962A/en not_active Expired - Fee Related
- 1998-04-21 ZA ZA983350A patent/ZA983350B/xx unknown
- 1998-04-24 CO CO98022703A patent/CO4940443A1/es unknown
- 1998-04-24 AR ARP980101897A patent/AR012598A1/es active IP Right Grant
- 1998-04-27 HR HR60/044,661A patent/HRP980224A2/hr not_active Application Discontinuation
- 1998-04-27 PE PE1998000322A patent/PE68499A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO4940443A1 (es) | 2000-07-24 |
| HRP980224A2 (en) | 1999-04-30 |
| US6030962A (en) | 2000-02-29 |
| PE68499A1 (es) | 1999-07-10 |
| ZA983350B (en) | 1998-10-28 |
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |