AR010904A1 - Benzotiadiazoles sustituidos comoantagonista del receptor endotelial, procedimiento para prepararlos, medicamentos y composiciones farmaceuticas quelas contienen. - Google Patents
Benzotiadiazoles sustituidos comoantagonista del receptor endotelial, procedimiento para prepararlos, medicamentos y composiciones farmaceuticas quelas contienen.Info
- Publication number
- AR010904A1 AR010904A1 ARP980101123A ARP980101123A AR010904A1 AR 010904 A1 AR010904 A1 AR 010904A1 AR P980101123 A ARP980101123 A AR P980101123A AR P980101123 A ARP980101123 A AR P980101123A AR 010904 A1 AR010904 A1 AR 010904A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- atoms
- nha
- naa
- independently represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Benzotiadiazoles sustituidos de formula I, en donde X representa O o S, R1 representa H, Hal, OH, OA, A, NO2, NH2, NHA, NAA, NHCOR4, NHCOR6, NHSO2R4,NHSO2R6, S(O)mR6, SO3H, SO3H, SO2NR4R4 o formilo, R2, R2 representan independientemente A,(CH2)nHet, CH2COAr, CH2COHet o OAr, R2 también representaH, R3 representa COOR4, CN, 1H-tetrazol-5-ilo o CONHSO2R5, R4, R4 representan independientemente H o A, R5 representa A o Ar, R6 representa fenilo o naftilono sustituido o mono, di o trisustituido con A, NH2, NHA, NAA, NO2, CN o Hal, R7, R7 representan independientemente H o alquilo de 1 a 6 átomos de C, A, Arepresentan independientemente alquilo de 1 a 6 átomos de C, en donde uno o dos grupos de CH2 pueden estar remplazados por átomos deO o S o por prupos-CR7=CR7 y/o 1 a 7 átomos de H pueden estar reemplazados por F, o bencilo , Ar representa fenilo o naftilo no sustituido o mono, di o trisustituido con A, OR4,NH2, NHA, NAA, NO2, CN, Hal, NHCOR4, NHCOR6, NHSO2R4, NHSO2R6, COOR4,OPh,CONH2,CONHA,CONAA,COR4,CONHSO2R4,CONHSO2R6,O(CH2)nCOOR4,O(CH2)nOR4,SO3H,SO2NR4R4,S(O)mR6 o S(O)mR4, Het representa un heterociclo saturado, insaturado o aromatio de uno o dos nucleos, que contienen de 1 a 4 átomos de N, O y/o S, quese encuentra unido a traves del N o C y que puede no estar sustituido o estar mono, di o trisustituido con Hal,A,R3,NHA,NAA,NO2 y/o =O,Hal representa fluor,cloro, bromo o yodo, m es 0, 1 o 2 y n es 1 o 2, siendo R3 distinto de COOA cuando R2 representaCH2COAr y R2 representa H, y sus sales. Procedimiento parapreparar dichos compuestos y composiciones farmaceuticas que los contienen, que son utiles para combatir la hipertonia, la insuficiencia cardíaca, lainsuficiencia renal, el infarto cerebral,la enfermedad coronaria,la isquemia renal, cerebral y de miocardio, la hemorragia subaracnoidal, las inflamaciones,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19710831A DE19710831A1 (de) | 1997-03-15 | 1997-03-15 | Endothelin-Rezeptor-Antagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010904A1 true AR010904A1 (es) | 2000-07-12 |
Family
ID=7823513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101123A AR010904A1 (es) | 1997-03-15 | 1998-03-13 | Benzotiadiazoles sustituidos comoantagonista del receptor endotelial, procedimiento para prepararlos, medicamentos y composiciones farmaceuticas quelas contienen. |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR010904A1 (es) |
| AU (1) | AU6826498A (es) |
| DE (1) | DE19710831A1 (es) |
| WO (1) | WO1998041515A1 (es) |
| ZA (1) | ZA982111B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432432B1 (en) | 1999-03-05 | 2002-08-13 | Arch Chemicals, Inc. | Chemical method of making a suspension, emulsion or dispersion of pyrithione particles |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| DE10155076A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen |
| DE102005047647A1 (de) | 2005-10-05 | 2007-04-12 | Merck Patent Gmbh | a,a'-Dihydroxyketonderivate und deren Verwendung als UV-Filter |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4659862A (en) * | 1984-05-03 | 1987-04-21 | E. I. Du Pont De Nemours And Company | Process of preparing nitrodihydroaryl carbonyl compounds |
| DK0617001T3 (da) * | 1993-03-19 | 2000-04-17 | Merck & Co Inc | Phenoxyphenyleddikesyrederivater |
| US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
| DE19509950A1 (de) * | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| DE19530032A1 (de) * | 1995-08-16 | 1997-02-20 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| DE19607096A1 (de) * | 1996-02-24 | 1997-08-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
-
1997
- 1997-03-15 DE DE19710831A patent/DE19710831A1/de not_active Withdrawn
-
1998
- 1998-03-04 AU AU68264/98A patent/AU6826498A/en not_active Abandoned
- 1998-03-04 WO PCT/EP1998/001205 patent/WO1998041515A1/de active Application Filing
- 1998-03-12 ZA ZA982111A patent/ZA982111B/xx unknown
- 1998-03-13 AR ARP980101123A patent/AR010904A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE19710831A1 (de) | 1998-09-17 |
| AU6826498A (en) | 1998-10-12 |
| ZA982111B (en) | 1998-09-14 |
| WO1998041515A1 (de) | 1998-09-24 |
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