AR006942A1 - Manufactura de un medicamento para inhibir una respuesta antigeno- especifica, composiciones farmaceuticas y celulas t anergicas antigeno-especificas - Google Patents
Manufactura de un medicamento para inhibir una respuesta antigeno- especifica, composiciones farmaceuticas y celulas t anergicas antigeno-especificasInfo
- Publication number
- AR006942A1 AR006942A1 ARP970101817A ARP970101817A AR006942A1 AR 006942 A1 AR006942 A1 AR 006942A1 AR P970101817 A ARP970101817 A AR P970101817A AR P970101817 A ARP970101817 A AR P970101817A AR 006942 A1 AR006942 A1 AR 006942A1
- Authority
- AR
- Argentina
- Prior art keywords
- specific
- cells
- antigen
- inhibit
- manufacture
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 102000003814 Interleukin-10 Human genes 0.000 abstract 3
- 108090000174 Interleukin-10 Proteins 0.000 abstract 3
- 230000000961 alloantigen Effects 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229940076144 interleukin-10 Drugs 0.000 abstract 2
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000024908 graft versus host disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se describe la Interleucina-10 para producir una población de células que son capaces de inhibir o suprimir las reacciones a los aloantígenos, porejempo, en la enfermedad injerto-versus-huésped o el rechazo de tejido. La Interleucina-10 parar educir las respuestas en la respuesta de linfocitomixta (RLM) también se describe. Puede utilizarse la IL-10 inducida exógena o endógena para la inhibición o supresión de las reacciones a los aloantígenos.Además se describe un método parafabricar un medicamento que la contiene, una composición farmacéutica y células T anérgicas antígeno-específicas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/643,810 US6277635B1 (en) | 1992-03-04 | 1996-05-06 | Use of interleukin-10 to produce a population of suppressor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
AR006942A1 true AR006942A1 (es) | 1999-09-29 |
Family
ID=24582315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970101817A AR006942A1 (es) | 1996-05-06 | 1997-05-02 | Manufactura de un medicamento para inhibir una respuesta antigeno- especifica, composiciones farmaceuticas y celulas t anergicas antigeno-especificas |
Country Status (16)
Country | Link |
---|---|
US (1) | US6277635B1 (es) |
EP (1) | EP0906428A1 (es) |
JP (1) | JP2000509604A (es) |
KR (1) | KR20000010799A (es) |
AR (1) | AR006942A1 (es) |
AU (1) | AU2927597A (es) |
BR (1) | BR9709307A (es) |
CA (1) | CA2253803A1 (es) |
CZ (1) | CZ347798A3 (es) |
IL (1) | IL126658A0 (es) |
NO (1) | NO985160L (es) |
NZ (1) | NZ332413A (es) |
PL (1) | PL329732A1 (es) |
SK (1) | SK151898A3 (es) |
WO (1) | WO1997042324A1 (es) |
ZA (1) | ZA973815B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6358506B1 (en) | 1997-11-05 | 2002-03-19 | University Of Southern California | Use of cytokines and mitogens to inhibit pathological immune responses |
WO1999030730A1 (en) * | 1997-12-15 | 1999-06-24 | Universite Laval | Methods and compositions for improving the success of cell transplantation in a host |
US6803036B1 (en) | 1998-03-03 | 2004-10-12 | University Of Southern California | Use of cytokines, cells and mitogens to inhibit graft versus host disease |
EP1061949B1 (en) | 1998-03-03 | 2009-07-15 | University of Southern California | Cytokines and mitogens to inhibit graft-versus-host disease |
WO2001016296A2 (en) * | 1999-09-01 | 2001-03-08 | University Of Southern California | Use of cytokines, cells, and mitogens to inhibit graft versus host disease |
GB9928193D0 (en) * | 1999-11-29 | 2000-01-26 | Univ Bristol | Cell treatment method |
WO2001077299A2 (en) | 2000-04-11 | 2001-10-18 | University Of Southern California | A METHOD TO PREVENT GRAFT REJECTION USING TGF-β TO INDUCE T SUPPRESSOR CELLS |
AU2001296962A1 (en) | 2000-09-29 | 2002-04-08 | Schering Corporation | Pegylated interleukin-10 |
FR2824567B1 (fr) * | 2001-05-11 | 2003-08-08 | Inst Nat Sante Rech Med | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene |
WO2003074685A2 (en) * | 2002-03-07 | 2003-09-12 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Il-10 gene transfer to peripheral blood mononuclear cells |
GB0214528D0 (en) * | 2002-06-24 | 2002-08-07 | Univ Aberdeen | Materials and methods for induction of immune tolerance |
DK1565183T3 (da) | 2002-11-29 | 2008-12-01 | Maria Grazia Roncarolo | Rapamycin og IL-10 til behandling af autoimmune sygdomme |
FR2852967B1 (fr) * | 2003-03-26 | 2007-12-07 | Txcell | Procede d'obtention de cellules dendritiques et de cellules t |
FR2856700B1 (fr) * | 2003-06-24 | 2007-06-08 | Txcell | Procede d'identification de lymphocytes tr1 regulateurs par la presence et la surexpression de molecules specifiques et ses applications |
EP2591786B1 (en) | 2003-10-16 | 2017-04-12 | Cancure Limited | Immunomodulating compositions and uses therefor |
CA2545841A1 (en) * | 2003-11-12 | 2005-05-26 | Txcell | Use of lipopeptides for activating t lymphocytes through the skin |
JP4863452B2 (ja) * | 2006-03-30 | 2012-01-25 | 国立大学法人 千葉大学 | ヒトTh1/Th2分化誘導系及びその用途 |
CA2652148C (en) | 2006-05-12 | 2016-10-04 | Fondazione Centro San Raffaele Del Monte Tabor | Tolerogenic dendritic cells, method for their production and uses thereof |
US20120058096A1 (en) | 2009-03-03 | 2012-03-08 | St. Jude Children's Research Hospital | Compositions and methods for generating interleukin-35-induced regulatory t cells |
US10143778B2 (en) * | 2010-12-21 | 2018-12-04 | Cormatrix Cardiovascular, Inc | Cardiovascular prostheses |
EP3882337A1 (en) | 2012-06-18 | 2021-09-22 | Ospedale San Raffaele S.r.l. | Compositions and methods for diminishing an immune response |
CA2782942C (en) * | 2012-07-12 | 2019-08-27 | Canadian Blood Services | Method for inducing immune tolerance using polymer-modified antigenic leukocytes |
US11007221B2 (en) | 2013-07-12 | 2021-05-18 | Canadian Blood Services | Acellular pro-inflammatory compositions, process for making same and methods of using same |
KR101868950B1 (ko) | 2017-05-18 | 2018-06-19 | 연세대학교 산학협력단 | Il-10을 발현하는 신경줄기세포를 포함하는 중추 신경계 질환 또는 손상의 치료용 약학적 조성물 및 이를 이용한 방법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4483920A (en) | 1982-05-17 | 1984-11-20 | Hahnemann University | Immobilization of message RNA directly from cells onto filter material |
US4559310A (en) | 1983-05-20 | 1985-12-17 | Dana Farber Cancer Institute | Assay methods and systems utilizing mast cell clones |
IL94878A (en) | 1989-06-28 | 2003-01-12 | Schering Corp | Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same |
-
1996
- 1996-05-06 US US08/643,810 patent/US6277635B1/en not_active Expired - Fee Related
-
1997
- 1997-05-02 ZA ZA9703815A patent/ZA973815B/xx unknown
- 1997-05-02 CA CA002253803A patent/CA2253803A1/en not_active Abandoned
- 1997-05-02 WO PCT/US1997/007120 patent/WO1997042324A1/en not_active Application Discontinuation
- 1997-05-02 JP JP9539982A patent/JP2000509604A/ja active Pending
- 1997-05-02 EP EP97923483A patent/EP0906428A1/en not_active Withdrawn
- 1997-05-02 IL IL12665897A patent/IL126658A0/xx unknown
- 1997-05-02 AU AU29275/97A patent/AU2927597A/en not_active Abandoned
- 1997-05-02 NZ NZ332413A patent/NZ332413A/xx unknown
- 1997-05-02 KR KR1019980708933A patent/KR20000010799A/ko not_active Application Discontinuation
- 1997-05-02 PL PL97329732A patent/PL329732A1/xx unknown
- 1997-05-02 SK SK1518-98A patent/SK151898A3/sk unknown
- 1997-05-02 AR ARP970101817A patent/AR006942A1/es unknown
- 1997-05-02 CZ CZ983477A patent/CZ347798A3/cs unknown
- 1997-05-02 BR BR9709307A patent/BR9709307A/pt not_active IP Right Cessation
-
1998
- 1998-11-05 NO NO985160A patent/NO985160L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL126658A0 (en) | 1999-08-17 |
EP0906428A1 (en) | 1999-04-07 |
WO1997042324A1 (en) | 1997-11-13 |
ZA973815B (en) | 1997-11-03 |
NO985160L (no) | 1999-01-06 |
SK151898A3 (en) | 2000-04-10 |
AU2927597A (en) | 1997-11-26 |
BR9709307A (pt) | 1999-08-10 |
CZ347798A3 (cs) | 1999-03-17 |
NZ332413A (en) | 2000-10-27 |
PL329732A1 (en) | 1999-04-12 |
CA2253803A1 (en) | 1997-11-13 |
KR20000010799A (ko) | 2000-02-25 |
NO985160D0 (no) | 1998-11-05 |
US6277635B1 (en) | 2001-08-21 |
JP2000509604A (ja) | 2000-08-02 |
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