AR006717A1 - Una proteina, su uso y un metodo parar prepararla - Google Patents
Una proteina, su uso y un metodo parar prepararlaInfo
- Publication number
- AR006717A1 AR006717A1 ARP970101595A ARP970101595A AR006717A1 AR 006717 A1 AR006717 A1 AR 006717A1 AR P970101595 A ARP970101595 A AR P970101595A AR P970101595 A ARP970101595 A AR P970101595A AR 006717 A1 AR006717 A1 AR 006717A1
- Authority
- AR
- Argentina
- Prior art keywords
- intimin
- administration
- describes
- combination
- immune response
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0283—Shigella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Describe la aislación y purificación de porciones funcionales de intimina marcadas con histidina (intimina marcada con his o his-intimina), unaproteína asociada con la capacidad de ciertas cepas de bacterias patógenas de adherise a lascélulas epiteliales. Describe además el uso de intiminacomo un antígeno para promover una respuesta inmune protectora. Además, describe la combinación de intimina con uno o más antígenos y laadministración de la combinación para promover unarespues ta inmune protectora contra intimina y uno o más antígenos. Un aspecto es la administraciónde intimina para llegar a células epiteliales específicas para promover una respuesta inmune con respecto a las proteínas de intimina. Aspectosadicionale sincluyen el uso de intimina o intimina combinada con uno o más antígenos y la administración de la combinación para llegar a la mucosa gastrointestinal yestimular una respuesta inmune. Adicionalmente, describe la administración dela combinac ión de intimina combinada con drogas, para proveer un medio parala liberación orientada de drogas a células epiteliales específicas. Otros aspectos incluyen la producción de anticuerpos dirigidos contra his-intiminay métodos parausar tales anti cuerpos para proveer protección inmune pasiva, y en un sistema de ensayo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1565796P | 1996-04-19 | 1996-04-19 | |
US1593696P | 1996-04-22 | 1996-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR006717A1 true AR006717A1 (es) | 1999-09-08 |
Family
ID=26687660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970101595A AR006717A1 (es) | 1996-04-19 | 1997-04-21 | Una proteina, su uso y un metodo parar prepararla |
Country Status (7)
Country | Link |
---|---|
US (2) | US6942861B2 (es) |
EP (1) | EP0937148A1 (es) |
JP (2) | JP2000509270A (es) |
AR (1) | AR006717A1 (es) |
AU (1) | AU734532B2 (es) |
CA (1) | CA2252438C (es) |
WO (1) | WO1997040161A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2252438C (en) * | 1996-04-19 | 2011-03-29 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability |
GB9803322D0 (en) * | 1998-02-16 | 1998-04-15 | Imperial College | Methods |
AU3138999A (en) * | 1998-04-30 | 1999-11-23 | Gyre Ltd. | Multifunctional adhesin proteins and their display in microbial cells |
CA2339436A1 (fr) * | 2001-03-15 | 2002-09-15 | Josee Harel | Production d'anticorps contre les facteurs de virulence associes aux souches d'escherichia coli aeec, et leur utilisation |
AU2002251202A1 (en) * | 2001-03-29 | 2002-10-15 | Imperial College Innovations Limited | Intimins for the prevention or treatment of infections: i |
BR0316271A (pt) * | 2002-11-14 | 2005-10-11 | Inst Finlay Ct De Investigacio | Método para a obtenção de preparados vacinais conjugados multivalentes, composição vacinal multivalente e uso da mesma |
WO2008154603A1 (en) * | 2007-06-11 | 2008-12-18 | Richard Spedden | Biomimetic particles and films for pathogen capture and other uses |
US8101274B2 (en) * | 2007-06-11 | 2012-01-24 | Spedden Richard H | Solid state membranes with surface-embedded glycosylated amphiphilic molecules and micelles formed therefrom |
WO2010017459A1 (en) | 2008-08-07 | 2010-02-11 | Bioactive Surgical, Inc> | Stem cell capture and immobilization coatings for medical devices and implants |
AU2010234849B2 (en) | 2009-03-30 | 2017-06-22 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
WO2011123495A1 (en) | 2010-03-30 | 2011-10-06 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
EP4241785A3 (en) | 2011-09-20 | 2023-09-27 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
ES2929942T3 (es) | 2012-12-18 | 2022-12-05 | Icahn School Med Mount Sinai | Vacunas contra el virus de la gripe y sus usos |
US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
EP3247389A4 (en) | 2015-01-23 | 2019-10-30 | Icahn School of Medicine at Mount Sinai | INFLUENZAVIRUSSCHUTZIMPFPLÄNE |
MX2018015755A (es) | 2016-06-15 | 2019-08-29 | Icahn School Med Mount Sinai | Proteinas de hemaglutinina de virus de influenza y usos de las mismas. |
US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4141970A (en) * | 1975-05-07 | 1979-02-27 | Internationale Octrooimaatschappij "Octropa" B.V. | Method for enhancing the resistance of new born mammalian young to gastro-intestinal infections |
US4136167A (en) * | 1975-06-12 | 1979-01-23 | Internationale Octrooi Maatschappij "Octropa" B.V. | Process for reducing the incidence of neonatal diarrhoea in pigs |
US4652448A (en) * | 1982-10-07 | 1987-03-24 | Molecular Genetics, Inc. | Use of monoclonal antibodies against bacterial adhesins |
US5417986A (en) * | 1984-03-16 | 1995-05-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
US6309669B1 (en) * | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
US4736017A (en) | 1984-04-30 | 1988-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Chemically defined vaccine against urinary infections |
US4740585A (en) | 1984-07-30 | 1988-04-26 | The Board Of Trustees Of The Leland Stanford Junior University | Synthetic vaccine against urinary infections |
IL78775A (en) | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
US5310654A (en) * | 1985-07-31 | 1994-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining virulence of Yersinia |
US5338842A (en) * | 1985-07-31 | 1994-08-16 | The Board Of Trustees Of Leland Stanford Jr. University | Yersinia INV nucleic acids |
US5378824A (en) | 1986-08-26 | 1995-01-03 | E. I. Du Pont De Nemours And Company | Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase |
US5049500A (en) | 1987-01-13 | 1991-09-17 | E. I. Du Pont De Nemours | Pollen-mediated gene transformation in plants |
CA1340522C (en) * | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
IL91525A0 (en) | 1988-09-06 | 1990-04-29 | Univ Washington | Transgenic plants,pharmaceutical compositions containing the same and methods for the preparation thereof |
US5168063A (en) * | 1990-07-27 | 1992-12-01 | Wisconsin Alumni Research Foundation | Monoclonal antibody to enterohemorrhagic escherichia coli 0157:h7 and 026:h11 |
US5612487A (en) | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
CA2078716A1 (en) * | 1992-09-21 | 1994-03-22 | Joyce De Azavedo | Attaching and effacing protein of enterohemorrhagic e. coli |
WO1994018955A1 (en) * | 1993-02-22 | 1994-09-01 | Alza Corporation | Compositions for oral delivery of active agents |
US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
JPH09508786A (ja) | 1993-12-09 | 1997-09-09 | ザ、テクサス、エイアンドエム、ユーニヴァーサティ、システィム | バショウ種のアグロバクテリウム・ツメファシエンス(agrobacterium tumefaciens)形質転換 |
WO1996000233A1 (en) | 1994-06-24 | 1996-01-04 | Children's Hospital And Medical Center | Escherichia coli o157:h7 epithelial adhesin |
US5679564A (en) * | 1994-10-05 | 1997-10-21 | Antex Biologics, Inc. | Methods for producing enhanced antigenic campylobacter bacteria and vaccines |
AU691707B2 (en) | 1994-10-24 | 1998-05-21 | The Administrators Of The Tulane Eductional Fund | Oral immunization with transgenic plants |
US5800821A (en) * | 1995-03-10 | 1998-09-01 | New England Medical Center Hospitals, Inc. | Bacterial spores as a heat stable vaccine delivery system |
US5747293A (en) * | 1995-03-23 | 1998-05-05 | Imperial College Of Science, Technology & Medicine | Intimin-like proteins of E. coli |
US6682729B1 (en) * | 1995-05-03 | 2004-01-27 | University Of Maryland, Baltimore | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same |
US5914114A (en) * | 1995-06-02 | 1999-06-22 | The United States Of America As Represented By The Secretary Of The Army | Method of raising antibodies against E. coli of the family CS4-CFA/I |
ATE312934T1 (de) * | 1995-06-07 | 2005-12-15 | Univ Washington | Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit |
US20030219752A1 (en) * | 1995-12-07 | 2003-11-27 | Diversa Corporation | Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof |
CA2252438C (en) * | 1996-04-19 | 2011-03-29 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability |
JP2000510332A (ja) * | 1996-04-19 | 2000-08-15 | ヘンリー エム.ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン | インチミンを単独で、または1以上の他の抗原との融合タンパク質として発現する宿主生物の投与による、免疫応答を刺激する方法 |
DK0904288T3 (da) * | 1996-04-23 | 2012-09-24 | Univ British Columbia | Patogent Escherichia coli-associeret protein |
US5840322A (en) * | 1996-12-19 | 1998-11-24 | Ramot-University Authority For Applied Research & Industrial Devel. Ltd. | Anti-oral-microbial adhesion fraction derived from vaccinium |
EP1198245B1 (en) * | 1998-09-30 | 2004-08-25 | Walter Reed Army Institute of Research | Use of purified invaplex from gram negative bacteria as a vaccine |
CA2339436A1 (fr) * | 2001-03-15 | 2002-09-15 | Josee Harel | Production d'anticorps contre les facteurs de virulence associes aux souches d'escherichia coli aeec, et leur utilisation |
-
1997
- 1997-04-18 CA CA2252438A patent/CA2252438C/en not_active Expired - Fee Related
- 1997-04-18 JP JP9538106A patent/JP2000509270A/ja active Pending
- 1997-04-18 AU AU24479/97A patent/AU734532B2/en not_active Ceased
- 1997-04-18 EP EP97920236A patent/EP0937148A1/en not_active Ceased
- 1997-04-18 WO PCT/US1997/005832 patent/WO1997040161A1/en active Application Filing
- 1997-04-18 US US08/837,459 patent/US6942861B2/en not_active Expired - Fee Related
- 1997-04-21 AR ARP970101595A patent/AR006717A1/es not_active Application Discontinuation
-
2005
- 2005-04-19 US US11/108,864 patent/US20050244425A1/en not_active Abandoned
-
2008
- 2008-04-09 JP JP2008101613A patent/JP2008249712A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2008249712A (ja) | 2008-10-16 |
CA2252438C (en) | 2011-03-29 |
AU734532B2 (en) | 2001-06-14 |
US20020006407A1 (en) | 2002-01-17 |
US20050244425A1 (en) | 2005-11-03 |
AU2447997A (en) | 1997-11-12 |
WO1997040161A1 (en) | 1997-10-30 |
JP2000509270A (ja) | 2000-07-25 |
EP0937148A1 (en) | 1999-08-25 |
US6942861B2 (en) | 2005-09-13 |
CA2252438A1 (en) | 1997-10-30 |
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Legal Events
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FC | Refusal |