AR006521A1 - Compuesto intermediario util, en la sintesis de inhibidores de la elastasa [s-(r'', s'')n-1-(1,3-benzodioxol-5-il)butil]-3,3-dietil-2-[4-[(4-metil-1-piperazinil)carbonil]fenoxil]-4-oxo-1-azetidin-carboxamida, procesos de sintesis de -r-alfa-propil-peperonil, amina - Google Patents

Compuesto intermediario util, en la sintesis de inhibidores de la elastasa [s-(r'', s'')n-1-(1,3-benzodioxol-5-il)butil]-3,3-dietil-2-[4-[(4-metil-1-piperazinil)carbonil]fenoxil]-4-oxo-1-azetidin-carboxamida, procesos de sintesis de -r-alfa-propil-peperonil, amina

Info

Publication number
AR006521A1
AR006521A1 ARP970101148A ARP970101148A AR006521A1 AR 006521 A1 AR006521 A1 AR 006521A1 AR P970101148 A ARP970101148 A AR P970101148A AR P970101148 A ARP970101148 A AR P970101148A AR 006521 A1 AR006521 A1 AR 006521A1
Authority
AR
Argentina
Prior art keywords
synthesis
amine
alpha
benzodioxol
piperazinyl
Prior art date
Application number
ARP970101148A
Other languages
English (en)
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of AR006521A1 publication Critical patent/AR006521A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Compuesto intermediario útil en la síntesis de inhibidores de la elastasa [S-(R*,S*) N-1-(1,3-benzodioxol-5-il)butil] 3,3-dietil-2-[1-[(4-metil-1-piperazinil)carbonil]fenoxi]-4-oxo-1 azetinincarboxamida y proseco para la preparación de una R)-(alfa-propil-piperonil-amina de la fórmula I o unestereoisómero o sal del mismo. Con respecto al campo de aplicación, se han descrito vías de sintéticas para varios compuestos similares a la elastinaarriba mencionada, del tipo de la azetidinocarboxamida. Pero la R-alfa-propil- -piperonil-amina es una amina quiral que podría por tanto ser un intermediariosignificativo en el proceso de inhibición de la elastasa si se contara con una vía sintética a escala industrial.
ARP970101148A 1996-03-22 1997-03-21 Compuesto intermediario util, en la sintesis de inhibidores de la elastasa [s-(r'', s'')n-1-(1,3-benzodioxol-5-il)butil]-3,3-dietil-2-[4-[(4-metil-1-piperazinil)carbonil]fenoxil]-4-oxo-1-azetidin-carboxamida, procesos de sintesis de -r-alfa-propil-peperonil, amina AR006521A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1395596P 1996-03-22 1996-03-22

Publications (1)

Publication Number Publication Date
AR006521A1 true AR006521A1 (es) 1999-09-08

Family

ID=21762727

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101148A AR006521A1 (es) 1996-03-22 1997-03-21 Compuesto intermediario util, en la sintesis de inhibidores de la elastasa [s-(r'', s'')n-1-(1,3-benzodioxol-5-il)butil]-3,3-dietil-2-[4-[(4-metil-1-piperazinil)carbonil]fenoxil]-4-oxo-1-azetidin-carboxamida, procesos de sintesis de -r-alfa-propil-peperonil, amina

Country Status (23)

Country Link
US (1) US5932749A (es)
EP (1) EP0888329A1 (es)
JP (1) JP2000506891A (es)
KR (1) KR20000064735A (es)
CN (1) CN1218463A (es)
AR (1) AR006521A1 (es)
AU (1) AU719633B2 (es)
BR (1) BR9708233A (es)
CA (1) CA2249401A1 (es)
CZ (1) CZ295098A3 (es)
EA (1) EA001207B1 (es)
EE (1) EE9800299A (es)
HR (1) HRP970165A2 (es)
IL (1) IL126223A0 (es)
LT (1) LT4540B (es)
LV (1) LV12259B (es)
NO (1) NO984344L (es)
NZ (1) NZ331875A (es)
PL (1) PL329070A1 (es)
SI (1) SI9720023A (es)
SK (1) SK127398A3 (es)
WO (1) WO1997034887A1 (es)
ZA (1) ZA972342B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5587299A (en) 1998-08-31 2000-03-21 Du Pont Pharmaceuticals Company An efficient process for the preparation of a human leukocyte elastase inhibitor
KR20040044909A (ko) * 2001-09-12 2004-05-31 아노르메드 인코포레이티드 거울상이성체적으로 순수한 아미노-치환된 융합비사이클릭 환의 합성
AU2009333391B2 (en) * 2008-12-15 2013-05-02 Taigen Biotechnology Co., Ltd. Stereoselective synthesis of piperidine derivatives
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US9126906B2 (en) 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds
EP3389652B1 (en) 2015-12-14 2022-09-28 X4 Pharmaceuticals, Inc. Methods for treating cancer
EP3389634B1 (en) 2015-12-14 2021-10-06 X4 Pharmaceuticals, Inc. Methods for treating cancer
SI3393468T1 (sl) 2015-12-22 2023-01-31 X4 Pharmaceuticals, Inc. Postopki za zdravljenje bolezni imunske pomanjkljivosti
CN109153722A (zh) 2016-04-08 2019-01-04 X4 制药有限公司 用于治疗癌症的方法
CN109640988A (zh) 2016-06-21 2019-04-16 X4 制药有限公司 Cxcr4抑制剂及其用途
CN109641838A (zh) 2016-06-21 2019-04-16 X4 制药有限公司 Cxcr4抑制剂及其用途
CN116554168A (zh) 2016-06-21 2023-08-08 X4 制药有限公司 Cxcr4抑制剂及其用途
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
US20230109467A1 (en) * 2021-09-17 2023-04-06 ATAI Life Sciences AG Preparation of optically active enantiomers of piperonyl amines by resolution of the diastereomeric salts
US11845736B2 (en) 2021-10-01 2023-12-19 Empathbio, Inc. Prodrugs of MDMA, MDA, and derivatives thereof
US11912680B2 (en) 2021-12-28 2024-02-27 Empathbio, Inc. Nitric oxide releasing prodrugs of MDA and MDMA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819438A1 (de) * 1987-06-30 1989-01-19 Basf Ag Verfahren zur herstellung von optisch aktiven 1-arylethylaminen
IL99658A0 (en) * 1990-10-15 1992-08-18 Merck & Co Inc Substituted azetidinones and pharmaceutical compositions containing them
US5149838A (en) * 1991-09-20 1992-09-22 Merck & Co., Inc. Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents

Also Published As

Publication number Publication date
ZA972342B (en) 1998-09-18
EP0888329A1 (en) 1999-01-07
KR20000064735A (ko) 2000-11-06
EA199800844A1 (ru) 1999-02-25
US5932749A (en) 1999-08-03
HRP970165A2 (en) 1998-04-30
SI9720023A (sl) 1999-04-30
WO1997034887A1 (en) 1997-09-25
IL126223A0 (en) 1999-05-09
SK127398A3 (en) 1999-04-13
NO984344D0 (no) 1998-09-18
CZ295098A3 (cs) 1999-03-17
AU719633B2 (en) 2000-05-11
CA2249401A1 (en) 1997-09-25
LT98132A (en) 1999-03-25
PL329070A1 (en) 1999-03-15
LV12259B (en) 1999-09-20
NZ331875A (en) 2000-01-28
AU2196897A (en) 1997-10-10
EE9800299A (et) 1999-06-15
NO984344L (no) 1998-09-18
BR9708233A (pt) 2000-01-04
LV12259A (lv) 1999-04-20
JP2000506891A (ja) 2000-06-06
EA001207B1 (ru) 2000-12-25
CN1218463A (zh) 1999-06-02
LT4540B (lt) 1999-08-25

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