AP3547A - Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals - Google Patents

Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals

Info

Publication number
AP3547A
AP3547A AP2014008087A AP2014008087A AP3547A AP 3547 A AP3547 A AP 3547A AP 2014008087 A AP2014008087 A AP 2014008087A AP 2014008087 A AP2014008087 A AP 2014008087A AP 3547 A AP3547 A AP 3547A
Authority
AP
ARIPO
Prior art keywords
chromen
hydroxy
derivatives
alkyl
preparation
Prior art date
Application number
AP2014008087A
Other languages
English (en)
Other versions
AP2014008087A0 (en
Inventor
Jayaraman Venkat Raman
Swaroop Kumar Venkata Satya Vakkalanka
Original Assignee
Rhizen Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54193684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3547(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhizen Pharmaceuticals Sa filed Critical Rhizen Pharmaceuticals Sa
Publication of AP2014008087A0 publication Critical patent/AP2014008087A0/xx
Application granted granted Critical
Publication of AP3547A publication Critical patent/AP3547A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AP2014008087A 2012-05-04 2013-05-03 Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals AP3547A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1737CH2012 2012-05-04
US201261671956P 2012-07-16 2012-07-16
PCT/IB2013/053544 WO2013164801A1 (en) 2012-05-04 2013-05-03 Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals

Publications (2)

Publication Number Publication Date
AP2014008087A0 AP2014008087A0 (en) 2014-11-30
AP3547A true AP3547A (en) 2016-01-14

Family

ID=54193684

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014008087A AP3547A (en) 2012-05-04 2013-05-03 Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals

Country Status (24)

Country Link
US (1) US9309216B2 (es)
EP (1) EP2844647B1 (es)
JP (2) JP6290186B2 (es)
KR (1) KR102073181B1 (es)
CN (2) CN108084138A (es)
AP (1) AP3547A (es)
AU (1) AU2013255469B2 (es)
BR (1) BR112014027470A2 (es)
CA (1) CA2871000C (es)
CL (1) CL2014002986A1 (es)
CO (1) CO7141413A2 (es)
CY (1) CY1123456T1 (es)
EA (1) EA032812B1 (es)
IL (1) IL235181A (es)
MX (1) MX365250B (es)
MY (1) MY171207A (es)
NZ (1) NZ701198A (es)
PH (1) PH12014502453B1 (es)
PL (1) PL2844647T3 (es)
RS (1) RS61035B1 (es)
SG (1) SG11201407184PA (es)
SI (1) SI2844647T1 (es)
WO (1) WO2013164801A1 (es)
ZA (1) ZA201407769B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201500895XA (en) 2009-11-05 2015-04-29 Rhizen Pharmaceuticals Sa Chromen-4-one Derivatives As Kinase Modulators
US9309216B2 (en) * 2012-05-04 2016-04-12 Rhizen Pharmaceuticals Sa Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
US10130635B2 (en) 2012-05-04 2018-11-20 Rhizen Pharmaceuticals Sa Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
EP3004106B1 (en) 2013-06-07 2017-08-30 Rhizen Pharmaceuticals S.A. Dual selective pi3 delta and gamma kinase inhibitors
EP3160968B1 (en) 2014-06-27 2018-10-31 Rhizen Pharmaceuticals S.A. Substituted chromene derivatives as selective dual inhibitors of pi3 delta and gamma protein kinases
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
JP2018521044A (ja) * 2015-07-23 2018-08-02 ファーマケア，インク． リシルオキシダーゼ様２阻害剤とその使用
CN108884049A (zh) 2016-02-09 2018-11-23 法玛克亚公司 喹啉酮赖氨酰氧化酶样2抑制剂及其用途
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2018344739B2 (en) * 2017-10-06 2023-04-13 Shionogi & Co., Ltd. Stereoselective process for preparing substituted polycyclic pyridone derivatives
WO2023130334A1 (zh) * 2022-01-07 2023-07-13 同润生物医药(上海)有限公司 一种色烯-4-酮化合物及其中间体的制备方法
CN116444521A (zh) * 2022-01-07 2023-07-18 同润生物医药(上海)有限公司 一种色烯-4-酮化合物及其中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011055215A2 (en) * 2009-11-05 2011-05-12 Incozen Therapeutics Pvt. Ltd. Novel kinase modulators
WO2012151525A1 (en) * 2011-05-04 2012-11-08 Rhizen Pharmaceuticals Sa Novel compounds as modulators of protein kinases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62201882A (ja) * 1985-11-18 1987-09-05 Yamanouchi Pharmaceut Co Ltd イソフラボン誘導体
PE20060426A1 (es) * 2004-06-02 2006-06-28 Schering Corp DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa
US9309216B2 (en) * 2012-05-04 2016-04-12 Rhizen Pharmaceuticals Sa Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
CN109970742A (zh) * 2012-07-04 2019-07-05 理森制药股份公司 选择性PI3Kδ抑制剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011055215A2 (en) * 2009-11-05 2011-05-12 Incozen Therapeutics Pvt. Ltd. Novel kinase modulators
WO2012151525A1 (en) * 2011-05-04 2012-11-08 Rhizen Pharmaceuticals Sa Novel compounds as modulators of protein kinases

Also Published As

Publication number Publication date
SG11201407184PA (en) 2014-12-30
US20150087699A1 (en) 2015-03-26
CN108084138A (zh) 2018-05-29
EP2844647A1 (en) 2015-03-11
ZA201407769B (en) 2016-05-25
WO2013164801A1 (en) 2013-11-07
KR102073181B1 (ko) 2020-02-04
PL2844647T3 (pl) 2021-01-25
MX365250B (es) 2019-05-28
AU2013255469A1 (en) 2014-11-13
US9309216B2 (en) 2016-04-12
CO7141413A2 (es) 2014-12-12
CA2871000A1 (en) 2013-11-07
CA2871000C (en) 2021-10-19
JP2018039849A (ja) 2018-03-15
CY1123456T1 (el) 2022-03-24
PH12014502453A1 (en) 2015-03-16
CN104507922B (zh) 2018-02-09
IL235181A (en) 2017-12-31
NZ701198A (en) 2016-09-30
MX2014013426A (es) 2015-05-11
CN104507922A (zh) 2015-04-08
BR112014027470A2 (pt) 2017-06-27
RS61035B1 (sr) 2020-12-31
JP6290186B2 (ja) 2018-03-07
JP2015515975A (ja) 2015-06-04
EP2844647B1 (en) 2020-07-22
AP2014008087A0 (en) 2014-11-30
HK1203964A1 (en) 2015-11-06
EA032812B1 (ru) 2019-07-31
KR20150006876A (ko) 2015-01-19
CL2014002986A1 (es) 2015-01-09
EA201491818A1 (ru) 2015-04-30
SI2844647T1 (sl) 2020-12-31
PH12014502453B1 (en) 2019-07-03
MY171207A (en) 2019-10-02
AU2013255469B2 (en) 2017-10-12

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