PL2844647T3 - Nowy sposób wytwarzania czystych optycznie i opcjonalnie podstawionych pochodnych 2-(1-hydroksyalkilo)-chromen-4-onu i ich zastosowanie do wytwarzania środków farmaceutycznych - Google Patents
Nowy sposób wytwarzania czystych optycznie i opcjonalnie podstawionych pochodnych 2-(1-hydroksyalkilo)-chromen-4-onu i ich zastosowanie do wytwarzania środków farmaceutycznychInfo
- Publication number
- PL2844647T3 PL2844647T3 PL13729095T PL13729095T PL2844647T3 PL 2844647 T3 PL2844647 T3 PL 2844647T3 PL 13729095 T PL13729095 T PL 13729095T PL 13729095 T PL13729095 T PL 13729095T PL 2844647 T3 PL2844647 T3 PL 2844647T3
- Authority
- PL
- Poland
- Prior art keywords
- chromen
- hydroxy
- derivatives
- alkyl
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1737CH2012 | 2012-05-04 | ||
| US201261671956P | 2012-07-16 | 2012-07-16 | |
| EP13729095.3A EP2844647B1 (en) | 2012-05-04 | 2013-05-03 | Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals |
| PCT/IB2013/053544 WO2013164801A1 (en) | 2012-05-04 | 2013-05-03 | Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2844647T3 true PL2844647T3 (pl) | 2021-01-25 |
Family
ID=54193684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13729095T PL2844647T3 (pl) | 2012-05-04 | 2013-05-03 | Nowy sposób wytwarzania czystych optycznie i opcjonalnie podstawionych pochodnych 2-(1-hydroksyalkilo)-chromen-4-onu i ich zastosowanie do wytwarzania środków farmaceutycznych |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9309216B2 (pl) |
| EP (1) | EP2844647B1 (pl) |
| JP (2) | JP6290186B2 (pl) |
| KR (1) | KR102073181B1 (pl) |
| CN (2) | CN104507922B (pl) |
| AP (1) | AP3547A (pl) |
| AU (1) | AU2013255469B2 (pl) |
| BR (1) | BR112014027470A2 (pl) |
| CA (1) | CA2871000C (pl) |
| CL (1) | CL2014002986A1 (pl) |
| CO (1) | CO7141413A2 (pl) |
| CY (1) | CY1123456T1 (pl) |
| EA (1) | EA032812B1 (pl) |
| IL (1) | IL235181A (pl) |
| MX (1) | MX365250B (pl) |
| MY (1) | MY171207A (pl) |
| NZ (1) | NZ701198A (pl) |
| PH (1) | PH12014502453B1 (pl) |
| PL (1) | PL2844647T3 (pl) |
| RS (1) | RS61035B1 (pl) |
| SG (1) | SG11201407184PA (pl) |
| SI (1) | SI2844647T1 (pl) |
| WO (1) | WO2013164801A1 (pl) |
| ZA (1) | ZA201407769B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3444242A3 (en) | 2009-11-05 | 2019-03-20 | Rhizen Pharmaceuticals S.A. | Novel benzopyran kinase modulators |
| US10130635B2 (en) | 2012-05-04 | 2018-11-20 | Rhizen Pharmaceuticals Sa | Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals |
| PL2844647T3 (pl) * | 2012-05-04 | 2021-01-25 | Rhizen Pharmaceuticals S.A. | Nowy sposób wytwarzania czystych optycznie i opcjonalnie podstawionych pochodnych 2-(1-hydroksyalkilo)-chromen-4-onu i ich zastosowanie do wytwarzania środków farmaceutycznych |
| EP3004106B1 (en) | 2013-06-07 | 2017-08-30 | Rhizen Pharmaceuticals S.A. | Dual selective pi3 delta and gamma kinase inhibitors |
| EP3160968B1 (en) | 2014-06-27 | 2018-10-31 | Rhizen Pharmaceuticals S.A. | Substituted chromene derivatives as selective dual inhibitors of pi3 delta and gamma protein kinases |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US20180215727A1 (en) * | 2015-07-23 | 2018-08-02 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
| JP2019508400A (ja) | 2016-02-09 | 2019-03-28 | ファーマケア，インク． | キノリノンリシルオキシダーゼ様２阻害剤とその使用 |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2023130334A1 (zh) * | 2022-01-07 | 2023-07-13 | 同润生物医药(上海)有限公司 | 一种色烯-4-酮化合物及其中间体的制备方法 |
| CN116444521A (zh) * | 2022-01-07 | 2023-07-18 | 同润生物医药(上海)有限公司 | 一种色烯-4-酮化合物及其中间体的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62201882A (ja) * | 1985-11-18 | 1987-09-05 | Yamanouchi Pharmaceut Co Ltd | イソフラボン誘導体 |
| PE20060426A1 (es) * | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| EP3444242A3 (en) * | 2009-11-05 | 2019-03-20 | Rhizen Pharmaceuticals S.A. | Novel benzopyran kinase modulators |
| PT2705029T (pt) * | 2011-05-04 | 2019-02-01 | Rhizen Pharmaceuticals S A | Novos compostos como moduladores de proteína quinases |
| PL2844647T3 (pl) * | 2012-05-04 | 2021-01-25 | Rhizen Pharmaceuticals S.A. | Nowy sposób wytwarzania czystych optycznie i opcjonalnie podstawionych pochodnych 2-(1-hydroksyalkilo)-chromen-4-onu i ich zastosowanie do wytwarzania środków farmaceutycznych |
| HRP20171610T1 (hr) * | 2012-07-04 | 2018-03-23 | Rhizen Pharmaceuticals S.A. | Selektivni inhibitori pi3k delta |
-
2013
- 2013-05-03 PL PL13729095T patent/PL2844647T3/pl unknown
- 2013-05-03 MX MX2014013426A patent/MX365250B/es active IP Right Grant
- 2013-05-03 CN CN201380023361.1A patent/CN104507922B/zh not_active Expired - Fee Related
- 2013-05-03 AU AU2013255469A patent/AU2013255469B2/en not_active Ceased
- 2013-05-03 US US14/398,902 patent/US9309216B2/en not_active Expired - Fee Related
- 2013-05-03 KR KR1020147034065A patent/KR102073181B1/ko not_active Expired - Fee Related
- 2013-05-03 CN CN201810028555.5A patent/CN108084138A/zh active Pending
- 2013-05-03 WO PCT/IB2013/053544 patent/WO2013164801A1/en not_active Ceased
- 2013-05-03 EP EP13729095.3A patent/EP2844647B1/en active Active
- 2013-05-03 SG SG11201407184PA patent/SG11201407184PA/en unknown
- 2013-05-03 MY MYPI2014003098A patent/MY171207A/en unknown
- 2013-05-03 RS RS20201267A patent/RS61035B1/sr unknown
- 2013-05-03 SI SI201331803T patent/SI2844647T1/sl unknown
- 2013-05-03 JP JP2015509560A patent/JP6290186B2/ja not_active Expired - Fee Related
- 2013-05-03 EA EA201491818A patent/EA032812B1/ru unknown
- 2013-05-03 CA CA2871000A patent/CA2871000C/en not_active Expired - Fee Related
- 2013-05-03 AP AP2014008087A patent/AP3547A/xx active
- 2013-05-03 NZ NZ701198A patent/NZ701198A/en not_active IP Right Cessation
- 2013-05-03 BR BR112014027470A patent/BR112014027470A2/pt not_active Application Discontinuation
-
2014
- 2014-10-19 IL IL235181A patent/IL235181A/en active IP Right Grant
- 2014-10-24 ZA ZA2014/07769A patent/ZA201407769B/en unknown
- 2014-11-03 PH PH12014502453A patent/PH12014502453B1/en unknown
- 2014-11-04 CL CL2014002986A patent/CL2014002986A1/es unknown
- 2014-12-03 CO CO14266920A patent/CO7141413A2/es unknown
-
2017
- 2017-12-14 JP JP2017239643A patent/JP2018039849A/ja active Pending
-
2020
- 2020-10-15 CY CY20201100974T patent/CY1123456T1/el unknown
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