AP3529A - Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors - Google Patents

Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors

Info

Publication number
AP3529A
AP3529A AP2014007378A AP2014007378A AP3529A AP 3529 A AP3529 A AP 3529A AP 2014007378 A AP2014007378 A AP 2014007378A AP 2014007378 A AP2014007378 A AP 2014007378A AP 3529 A AP3529 A AP 3529A
Authority
AP
ARIPO
Prior art keywords
hydroxymethylaryl
pyrrolotriazines
substituted
alk1 inhibitors
alk1
Prior art date
Application number
AP2014007378A
Other languages
English (en)
Other versions
AP2014007378A0 (en
Inventor
Juergen Klar
Verena Voehringer
Joachim Telser
Mario Lobell
Frank Suesmeier
Volkhart Min-Jian Li
Michael Boettger
Stefan Golz
Dieter Lang
Karl-Heinz Schlemmer
Thomas Schlange
Andreas Schall
Wenlang Fu
Original Assignee
Bayer Ip Gmbh
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47436537&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3529(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh
Publication of AP2014007378A0 publication Critical patent/AP2014007378A0/xx
Application granted granted Critical
Publication of AP3529A publication Critical patent/AP3529A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AP2014007378A 2011-07-01 2012-06-26 Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors AP3529A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161503840P 2011-07-01 2011-07-01
EP12161547 2012-03-27
PCT/EP2012/062366 WO2013004551A1 (fr) 2011-07-01 2012-06-26 Pyrrolotriazines substituées par hydroxyméthylaryle utilisées comme inhibiteurs d'alk1

Publications (2)

Publication Number Publication Date
AP2014007378A0 AP2014007378A0 (en) 2014-01-31
AP3529A true AP3529A (en) 2016-01-11

Family

ID=47436537

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014007378A AP3529A (en) 2011-07-01 2012-06-26 Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors

Country Status (24)

Country Link
US (1) US9040691B2 (fr)
EP (1) EP2726482B1 (fr)
JP (1) JP5955953B2 (fr)
KR (1) KR20140036269A (fr)
CN (1) CN103764657B (fr)
AP (1) AP3529A (fr)
AR (1) AR087017A1 (fr)
AU (1) AU2012280508A1 (fr)
BR (1) BR112014000049A2 (fr)
CA (1) CA2840518A1 (fr)
CO (1) CO6870031A2 (fr)
CU (1) CU20130170A7 (fr)
DO (1) DOP2013000300A (fr)
EA (1) EA023775B1 (fr)
EC (1) ECSP13013120A (fr)
ES (1) ES2598027T3 (fr)
GT (1) GT201300313A (fr)
IL (1) IL229533A0 (fr)
MA (1) MA35601B1 (fr)
MX (1) MX2013014315A (fr)
PE (1) PE20140570A1 (fr)
SG (1) SG195100A1 (fr)
UY (1) UY34167A (fr)
WO (1) WO2013004551A1 (fr)

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NZ617987A (en) 2011-05-10 2016-02-26 Gilead Sciences Inc Fused heterocyclic compounds as sodium channel modulators
TWI478908B (zh) 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (fr) 2011-07-01 2018-04-28
WO2013113097A1 (fr) 2012-01-31 2013-08-08 Beta Pharma Canada Inc. Molécules cycliques en tant qu'inhibiteurs de tyrosine kinase de bruton
AU2015243261B2 (en) 2014-04-10 2020-06-25 Lankenau Institute For Medical Research Methods and compositions for the treatment of ocular diseases and disorders
MX2016015624A (es) 2014-05-28 2017-02-27 Bayer Cropscience Ag Proceso para la preparacion de derivados de tiazol.
US10214537B2 (en) 2014-10-22 2019-02-26 Bristol-Myers Squibb Company Bicyclic heteroaryl amine compounds
EP3209665B1 (fr) 2014-10-22 2019-08-14 Bristol-Myers Squibb Company Composés pyrrolotriaziniques aminés substitués en tant qu'inhibiteurs de pi3k
WO2016083276A1 (fr) 2014-11-25 2016-06-02 Bayer Pharma Aktiengesellschaft Dérivés de pyridobenzodiazepinone substitués et leur utilisation
ES2766835T3 (es) 2015-04-16 2020-06-15 Merck Patent Gmbh Derivados de 3-(1H-bencimidazol-2-il)-1H-piridin-2-ona
US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
SI3436461T1 (sl) 2016-03-28 2024-03-29 Incyte Corporation Pirolotriazinske spojine kot tam-inhibitorji
CN109111447A (zh) * 2017-06-23 2019-01-01 中国科学院上海药物研究所 7-位取代吡咯并三嗪类化合物或其药学上可用的盐，及其制备方法和用途
RS62872B1 (sr) 2017-09-27 2022-02-28 Incyte Corp Soli derivata pirrolotriazina korisne kao tam inhibitori
CN117771250A (zh) 2018-06-29 2024-03-29 因赛特公司 Axl/mer抑制剂的制剂
WO2024097980A1 (fr) 2022-11-04 2024-05-10 Bristol-Myers Squibb Company Inhibiteurs de protéines ret-ldd

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007061882A2 (fr) * 2005-11-18 2007-05-31 Bristol-Myers Squibb Company Pyrrolotriazine en tant qu’inhibiteurs de kinase
EP1873157A1 (fr) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines et sels de ceux-ci, compositions pharmaceutiques contenant ces composes, procedes de preparation associes, et leur utilisation

Family Cites Families (16)

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DE60026297T2 (de) * 1999-05-21 2006-11-02 Bristol-Myers Squibb Co. Pyrrolotriazin kinasehemmer
MXPA05001549A (es) 2002-08-08 2005-05-05 Kissei Pharmaceutical Derivado de pirazol, composicion medicinal que lo contiene, su uso medicinal, e intermediario para su produccion.
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
UY28931A1 (es) 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
DE102005042742A1 (de) * 2005-09-02 2007-03-08 Schering Ag Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
WO2007056170A2 (fr) 2005-11-02 2007-05-18 Bayer Healthcare Ag Derives pyrrolo-[2,1-f]-[1,2,4]-triazin-4-ylamines inhibiteurs de la igf-1r kinase pour le traitement des cancers et autres maladies hyperproliferatives
WO2007064931A2 (fr) * 2005-12-02 2007-06-07 Bayer Healthcare Llc Derives substitues de 4-amino-pyrrolotriazine utiles dans le traitement de troubles hyperproliferatifs et de maladies associees a l'angiogenese
PE20070855A1 (es) 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
CN101389630A (zh) 2005-12-29 2009-03-18 艾博特公司 蛋白激酶抑制剂
WO2008052734A1 (fr) * 2006-10-30 2008-05-08 Novartis Ag Composés hétérocycliques en tant qu'agents anti-inflammatoires
ES2390188T3 (es) 2007-01-12 2012-11-07 Biocryst Pharmaceuticals, Inc. Análogos de nucleósidos antivirales
US8124759B2 (en) 2007-05-09 2012-02-28 Abbott Laboratories Inhibitors of protein kinases
US8143253B2 (en) * 2007-07-26 2012-03-27 Novartis Ag Organic compounds
PE20091383A1 (es) * 2007-10-17 2009-10-17 Novartis Ag DERIVADOS DE IMIDAZO-[1,2-a]PIRIDINA COMO INHIBIDORES DE ALK-5 Y ALK-4
WO2009140128A2 (fr) * 2008-05-13 2009-11-19 Irm Llc Composés et compositions servant d'inhibiteurs de kinases
WO2010126960A1 (fr) 2009-04-29 2010-11-04 Locus Pharmaceuticals, Inc. Composés de pyrrolotriazine

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2007061882A2 (fr) * 2005-11-18 2007-05-31 Bristol-Myers Squibb Company Pyrrolotriazine en tant qu’inhibiteurs de kinase
EP1873157A1 (fr) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines et sels de ceux-ci, compositions pharmaceutiques contenant ces composes, procedes de preparation associes, et leur utilisation

Also Published As

Publication number Publication date
PE20140570A1 (es) 2014-04-28
BR112014000049A2 (pt) 2017-02-07
US9040691B2 (en) 2015-05-26
ES2598027T3 (es) 2017-01-24
GT201300313A (es) 2014-11-13
SG195100A1 (en) 2013-12-30
JP5955953B2 (ja) 2016-07-20
WO2013004551A1 (fr) 2013-01-10
KR20140036269A (ko) 2014-03-25
IL229533A0 (en) 2014-01-30
CN103764657B (zh) 2016-05-25
CU20130170A7 (es) 2014-04-24
DOP2013000300A (es) 2014-02-28
CA2840518A1 (fr) 2013-01-10
EA023775B1 (ru) 2016-07-29
AR087017A1 (es) 2014-02-05
NZ619453A (en) 2016-01-29
EP2726482B1 (fr) 2016-07-20
CN103764657A (zh) 2014-04-30
EA201490103A1 (ru) 2014-06-30
JP2014525902A (ja) 2014-10-02
US20140256718A1 (en) 2014-09-11
ECSP13013120A (es) 2014-02-28
AP2014007378A0 (en) 2014-01-31
CO6870031A2 (es) 2014-02-20
MA35601B1 (fr) 2014-11-01
UY34167A (es) 2013-01-31
AU2012280508A1 (en) 2013-12-12
EP2726482A1 (fr) 2014-05-07
CU24146B1 (fr) 2016-02-29
MX2013014315A (es) 2014-01-31

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