AP3511A - NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES - Google Patents

NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES

Info

Publication number
AP3511A
AP3511A AP2013007177A AP2013007177A AP3511A AP 3511 A AP3511 A AP 3511A AP 2013007177 A AP2013007177 A AP 2013007177A AP 2013007177 A AP2013007177 A AP 2013007177A AP 3511 A AP3511 A AP 3511A
Authority
AP
ARIPO
Prior art keywords
pyrrolo
diazepines
benzo
dihydro
heterocyclic derivatives
Prior art date
Application number
AP2013007177A
Other languages
English (en)
Other versions
AP2013007177A0 (en
Inventor
Lieven Meerpoel
Louis Jules Roger Marie Maes
Wit Kelly De
Koen Jan Ludovicus Augustyns
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP2013007177A0 publication Critical patent/AP2013007177A0/xx
Application granted granted Critical
Publication of AP3511A publication Critical patent/AP3511A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AP2013007177A 2011-05-05 2012-05-03 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES AP3511A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11164960 2011-05-05
PCT/EP2012/058142 WO2012150305A1 (en) 2011-05-05 2012-05-03 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO- DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES

Publications (2)

Publication Number Publication Date
AP2013007177A0 AP2013007177A0 (en) 2013-10-31
AP3511A true AP3511A (en) 2016-01-04

Family

ID=46022282

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013007177A AP3511A (en) 2011-05-05 2012-05-03 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES

Country Status (18)

Country Link
US (2) US9493468B2 (ru)
EP (1) EP2707370B1 (ru)
JP (1) JP6018179B2 (ru)
KR (1) KR20140021630A (ru)
CN (2) CN106674226B (ru)
AP (1) AP3511A (ru)
AU (1) AU2012251661C1 (ru)
BR (1) BR112013028415A8 (ru)
CA (1) CA2833509C (ru)
EA (1) EA022852B1 (ru)
ES (1) ES2542900T3 (ru)
IL (1) IL229181A (ru)
MX (1) MX359749B (ru)
MY (1) MY170601A (ru)
SG (1) SG194781A1 (ru)
UA (1) UA110640C2 (ru)
WO (1) WO2012150305A1 (ru)
ZA (1) ZA201308261B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101858630B1 (ko) * 2010-11-24 2018-05-16 얀센 파마슈티카 엔.브이. 페닐 유도체로 치환된, 항진균성 5,6-디하이드로-4H-피롤로-[1,2-α][1,4]벤조디아제핀 및 6H-피롤로-[1,2-α][1,4]벤조디아제핀

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (en) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA85362B (en) * 1984-01-19 1985-09-25 Hoffmann La Roche Imidazodiazepine derivatives
IL74070A (en) 1984-01-19 1988-12-30 Hoffmann La Roche Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
US4959361A (en) 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
CA2184802C (en) 1995-10-10 2007-07-31 Karl-Heinz Bender Process for manufacture of imidazo benzodiazepine derivatives
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
US7135480B2 (en) * 2002-12-12 2006-11-14 Cytovia, Inc. Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis
US8178545B2 (en) * 2004-06-01 2012-05-15 University Of Virginia Patent Foundation Dual small molecule inhibitors of cancer and angiogenesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (en) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]benzodiazepines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MEERPOEL L ET AL: "Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 14, 15 July 2005 (2005-07-15) , pages 3453-3458 *
RAINES S ET AL: "MANNICH REACTIONS. SYNTHESIS OF 4,5-DIHYDROPYRROLO not 1,2-A 3/4 QUINOXALINES, 2,3,4,5-TETRAHYDRO-1H-PYRROLO not 1,2-A 3/4 not 1,4 3/4 DIAZEPINES AND 5,6-DIHYDRO-4H-PYRROLO not 1,2-A 3/4 not 1,4 3/4 BENZODIAZEPINES", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 13, no. 4, 1 August 1976 (1976-08-01) , pages 711-716 *

Also Published As

Publication number Publication date
JP6018179B2 (ja) 2016-11-02
MX2013012884A (es) 2014-02-20
BR112013028415A2 (pt) 2017-01-24
ZA201308261B (en) 2018-05-30
CN106674226B (zh) 2020-05-26
US9493468B2 (en) 2016-11-15
AU2012251661A1 (en) 2013-10-24
UA110640C2 (uk) 2016-01-25
CN103502250A (zh) 2014-01-08
CA2833509A1 (en) 2012-11-08
ES2542900T3 (es) 2015-08-13
SG194781A1 (en) 2013-12-30
EA201391630A1 (ru) 2014-04-30
EP2707370B1 (en) 2015-04-29
CA2833509C (en) 2019-11-26
KR20140021630A (ko) 2014-02-20
IL229181A0 (en) 2013-12-31
AU2012251661B2 (en) 2016-08-11
IL229181A (en) 2015-09-24
AU2012251661C1 (en) 2016-11-03
CN106674226A (zh) 2017-05-17
JP2014513114A (ja) 2014-05-29
EA022852B1 (ru) 2016-03-31
WO2012150305A1 (en) 2012-11-08
US20140045827A1 (en) 2014-02-13
NZ618456A (en) 2015-05-29
CN103502250B (zh) 2016-10-26
US9975899B2 (en) 2018-05-22
MX359749B (es) 2018-10-08
AP2013007177A0 (en) 2013-10-31
MY170601A (en) 2019-08-20
BR112013028415A8 (pt) 2017-12-19
US20170073348A1 (en) 2017-03-16
EP2707370A1 (en) 2014-03-19

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