AP3104A - New association between 4-{3-[CIS-hexahydrocyclopenta[c]pyrrol-2(1H)-YL]propoxy}benzamide and an Acetylcholinesterase inhibitor, and pharmaceutical compositions containing it - Google Patents
New association between 4-{3-[CIS-hexahydrocyclopenta[c]pyrrol-2(1H)-YL]propoxy}benzamide and an Acetylcholinesterase inhibitor, and pharmaceutical compositions containing itInfo
- Publication number
- AP3104A AP3104A AP2012006232A AP2012006232A AP3104A AP 3104 A AP3104 A AP 3104A AP 2012006232 A AP2012006232 A AP 2012006232A AP 2012006232 A AP2012006232 A AP 2012006232A AP 3104 A AP3104 A AP 3104A
- Authority
- AP
- ARIPO
- Prior art keywords
- hexahydrocyclopenta
- pyrrol
- benzamide
- propoxy
- cis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1101347A FR2974729B1 (fr) | 2011-05-02 | 2011-05-02 | Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
AP2012006232A0 AP2012006232A0 (en) | 2012-04-30 |
AP3104A true AP3104A (en) | 2015-01-31 |
Family
ID=44351420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2012006232A AP3104A (en) | 2011-05-02 | 2012-04-23 | New association between 4-{3-[CIS-hexahydrocyclopenta[c]pyrrol-2(1H)-YL]propoxy}benzamide and an Acetylcholinesterase inhibitor, and pharmaceutical compositions containing it |
Country Status (28)
Country | Link |
---|---|
US (3) | US8940785B2 (es) |
EP (1) | EP2520296A1 (es) |
JP (1) | JP2012232978A (es) |
KR (2) | KR101493757B1 (es) |
CN (1) | CN102764439A (es) |
AP (1) | AP3104A (es) |
AR (1) | AR086146A1 (es) |
BR (1) | BR102012010244A2 (es) |
CA (1) | CA2775624A1 (es) |
CL (1) | CL2012001102A1 (es) |
CR (1) | CR20120192A (es) |
CU (1) | CU20120064A7 (es) |
EA (1) | EA020987B1 (es) |
EC (1) | ECSP12011862A (es) |
FR (1) | FR2974729B1 (es) |
GE (1) | GEP20146076B (es) |
MA (1) | MA34776B1 (es) |
MX (1) | MX2012005103A (es) |
NI (1) | NI201200070A (es) |
PE (1) | PE20130016A1 (es) |
RU (1) | RU2013153140A (es) |
SG (2) | SG185240A1 (es) |
SV (1) | SV2012004203A (es) |
TN (1) | TN2012000177A1 (es) |
TW (1) | TW201247200A (es) |
UY (1) | UY34050A (es) |
WO (1) | WO2012150412A1 (es) |
ZA (1) | ZA201203163B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2976285B1 (fr) * | 2011-06-08 | 2013-05-24 | Servier Lab | Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent |
MX2019001698A (es) * | 2016-08-18 | 2019-07-04 | Suven Life Sciences Ltd | Combinacion triple de agonistas inversos del receptor de histamina 3, inhibidores de la acetilcolinestearasa y antagonistas del receptor nmda. |
CN109640975B (zh) * | 2016-08-18 | 2020-10-20 | 苏文生命科学有限公司 | 组胺-3受体反向激动剂与乙酰胆碱酯酶抑制剂的组合 |
CN108371660B (zh) * | 2017-12-14 | 2020-03-10 | 五邑大学 | 一种四氢环戊二烯并吡咯化合物及其衍生物的用途 |
US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
CA3139082A1 (en) * | 2019-05-21 | 2020-11-26 | LA PharmaTech Inc. | Novel pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005089747A1 (fr) * | 2004-02-20 | 2005-09-29 | Les Laboratoires Servier | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2565018A1 (en) * | 2004-04-28 | 2005-11-10 | Takeda Pharmaceutical Company Limited | Fused quinoline derivative and use thereof |
TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
TW200845977A (en) * | 2007-03-30 | 2008-12-01 | Targacept Inc | Sub-type selective azabicycloalkane derivatives |
JPWO2009048101A1 (ja) * | 2007-10-10 | 2011-02-24 | 武田薬品工業株式会社 | アミド化合物 |
US20090221554A1 (en) * | 2008-02-28 | 2009-09-03 | Zenyaku Kogyo Kabushiki Kaisha | Method of treating cognitive impairment |
FR2937251B1 (fr) * | 2008-10-16 | 2011-03-18 | Servier Lab | Utilisation du 4-{3-°hexahydrocyclopenta°c!pyrrol-2(1h)-yl! propoxy}benzamide pour l'obtention de medicaments destines au traitement des troubles du sommeil |
FR2953515B1 (fr) * | 2009-12-09 | 2011-12-23 | Servier Lab | Nouveaux derives du type hexahydrocyclopenta[b]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2011
- 2011-05-02 FR FR1101347A patent/FR2974729B1/fr not_active Expired - Fee Related
-
2012
- 2012-04-18 TN TNP2012000177A patent/TN2012000177A1/fr unknown
- 2012-04-19 CR CR20120192A patent/CR20120192A/es unknown
- 2012-04-23 CU CU2012000064A patent/CU20120064A7/es unknown
- 2012-04-23 AP AP2012006232A patent/AP3104A/xx active
- 2012-04-23 PE PE2012000533A patent/PE20130016A1/es not_active Application Discontinuation
- 2012-04-23 EA EA201200527A patent/EA020987B1/ru not_active IP Right Cessation
- 2012-04-25 CA CA2775624A patent/CA2775624A1/fr not_active Abandoned
- 2012-04-27 NI NI201200070A patent/NI201200070A/es unknown
- 2012-04-27 CL CL2012001102A patent/CL2012001102A1/es unknown
- 2012-04-27 SG SG2012031282A patent/SG185240A1/en unknown
- 2012-04-27 SG SG2014010904A patent/SG2014010904A/en unknown
- 2012-04-27 AR ARP120101487A patent/AR086146A1/es unknown
- 2012-04-30 MX MX2012005103A patent/MX2012005103A/es not_active Application Discontinuation
- 2012-04-30 BR BRBR102012010244-7A patent/BR102012010244A2/pt not_active IP Right Cessation
- 2012-04-30 TW TW101115413A patent/TW201247200A/zh unknown
- 2012-04-30 MA MA34823A patent/MA34776B1/fr unknown
- 2012-04-30 GE GEAP201212686A patent/GEP20146076B/en unknown
- 2012-05-01 JP JP2012104353A patent/JP2012232978A/ja active Pending
- 2012-05-01 US US13/461,063 patent/US8940785B2/en not_active Expired - Fee Related
- 2012-05-02 WO PCT/FR2012/050971 patent/WO2012150412A1/fr active Application Filing
- 2012-05-02 ZA ZA2012/03163A patent/ZA201203163B/en unknown
- 2012-05-02 KR KR20120046521A patent/KR101493757B1/ko not_active IP Right Cessation
- 2012-05-02 UY UY0001034050A patent/UY34050A/es unknown
- 2012-05-02 SV SV2012004203A patent/SV2012004203A/es unknown
- 2012-05-02 EC ECSP12011862 patent/ECSP12011862A/es unknown
- 2012-05-02 EP EP12166348A patent/EP2520296A1/fr not_active Withdrawn
- 2012-05-02 RU RU2013153140/04A patent/RU2013153140A/ru not_active Application Discontinuation
- 2012-05-02 CN CN2012101341396A patent/CN102764439A/zh active Pending
-
2014
- 2014-03-31 KR KR1020140037996A patent/KR20140051200A/ko not_active Application Discontinuation
- 2014-11-25 US US14/553,167 patent/US20150080378A1/en not_active Abandoned
- 2014-11-26 US US14/554,778 patent/US20150080379A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005089747A1 (fr) * | 2004-02-20 | 2005-09-29 | Les Laboratoires Servier | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Non-Patent Citations (1)
Title |
---|
BEMBENEK ET AL: "Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 6, 25 décembre 2007 (2007-12-25), pages 2968-2973, XP022558531 * |
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