AP2773A - NANO-PCR: Methods and devices for nucleic acid amplification and detection - Google Patents

NANO-PCR: Methods and devices for nucleic acid amplification and detection

Info

Publication number
AP2773A
AP2773A AP2006003813A AP2006003813A AP2773A AP 2773 A AP2773 A AP 2773A AP 2006003813 A AP2006003813 A AP 2006003813A AP 2006003813 A AP2006003813 A AP 2006003813A AP 2773 A AP2773 A AP 2773A
Authority
AP
ARIPO
Prior art keywords
pcr
nano
detection
methods
devices
Prior art date
Application number
AP2006003813A
Other languages
English (en)
Other versions
AP2006003813A0 (en
Inventor
Anita Goel
Original Assignee
Nanobiosym Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanobiosym Inc filed Critical Nanobiosym Inc
Publication of AP2006003813A0 publication Critical patent/AP2006003813A0/xx
Application granted granted Critical
Publication of AP2773A publication Critical patent/AP2773A/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/30—Characterised by physical treatment
    • C12Q2523/303—Applying a physical force on a nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/30—Characterised by physical treatment
    • C12Q2523/307—Denaturation or renaturation by electric current/voltage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/101—Sanger sequencing method, i.e. oligonucleotide sequencing using primer elongation and dideoxynucleotides as chain terminators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Immunology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Fluid Mechanics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AP2006003813A 2004-05-13 2005-05-13 NANO-PCR: Methods and devices for nucleic acid amplification and detection AP2773A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57090704P 2004-05-13 2004-05-13
US61679304P 2004-10-06 2004-10-06
PCT/US2005/016638 WO2006076022A2 (fr) 2004-05-13 2005-05-13 Amplification par la polymerase a l'echelle nanometrique: procedes et dispositifs pour l'amplification et la detection d'acides nucleiques

Publications (2)

Publication Number Publication Date
AP2006003813A0 AP2006003813A0 (en) 2006-12-31
AP2773A true AP2773A (en) 2013-09-30

Family

ID=36678035

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003813A AP2773A (en) 2004-05-13 2005-05-13 NANO-PCR: Methods and devices for nucleic acid amplification and detection

Country Status (11)

Country Link
US (3) US7494791B2 (fr)
EP (2) EP1751314B1 (fr)
JP (1) JP5007440B2 (fr)
KR (1) KR101506727B1 (fr)
AP (1) AP2773A (fr)
AU (2) AU2005324505B2 (fr)
BR (2) BRPI0510811B1 (fr)
CA (2) CA3152535C (fr)
IL (2) IL179006A (fr)
NZ (2) NZ551996A (fr)
WO (1) WO2006076022A2 (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1751314B1 (fr) * 2004-05-13 2019-09-18 Nanobiosym, Inc. Amplification par la polymerase a l'echelle nanometrique: procedes et dispositifs pour l'amplification et la detection d'acides nucleiques
US20060105433A1 (en) * 2004-11-18 2006-05-18 Bickmore William D Jr Rapid thermocycler
US7315376B2 (en) * 2005-01-07 2008-01-01 Advanced Molecular Systems, Llc Fluorescence detection system
US20060188891A1 (en) * 2005-02-23 2006-08-24 Bickmore William D Jr Methods and apparatus for controlling DNA amplification
US9360526B2 (en) * 2005-10-24 2016-06-07 The Johns Hopkins University Methods for beaming
CN101479605A (zh) * 2006-04-21 2009-07-08 纳诺拜希姆公司 用于药物发现的单分子平台：用于包括抗癌和抗病毒剂的发现的药物发现的方法和装置
US7833716B2 (en) 2006-06-06 2010-11-16 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
US7312029B1 (en) 2006-06-30 2007-12-25 Searete Llc Method of combing an elongated molecule
US7745129B1 (en) * 2006-07-12 2010-06-29 Kenneth David Schatz Methods for sequencing of a necleic acid
US9328378B2 (en) * 2006-07-31 2016-05-03 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
CA3138078C (fr) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Dispositifs modulaires a utiliser sur place et leurs utilisations
GB2469424B (en) * 2008-02-19 2013-04-17 Intelligent Bio Systems Inc Non-emulsion methods and masked biomolecules
US8741815B2 (en) 2008-02-19 2014-06-03 Intelligent Bio Systems, Inc. Methods and devices for amplification of nucleic acid
JP2010207133A (ja) * 2009-03-10 2010-09-24 Sony Corp 細胞分離方法
DE112010002222B4 (de) * 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
WO2011032040A1 (fr) 2009-09-10 2011-03-17 Centrillion Technology Holding Corporation Procédés de séquençage ciblé
US9579402B2 (en) * 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
EP2601286A4 (fr) 2010-08-02 2016-10-05 Brent L Weight Cartouche pouvant être mise sous pression pour réactions de polymérisation en chaîne
WO2012051529A1 (fr) 2010-10-15 2012-04-19 Lockheed Martin Corporation Conception optique microfluidique
CN106290160A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
EP2744916A4 (fr) 2011-07-13 2015-06-17 Primeradx Inc Méthodes multimodales de détection et de quantification simultanées de plusieurs acides nucléiques dans un échantillon
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US9044729B2 (en) * 2012-07-27 2015-06-02 International Park Of Creativity Methods and devices for electromagnetic amplification of nucleic acids
JP6063693B2 (ja) * 2012-10-03 2017-01-18 株式会社日立ハイテクノロジーズ 分析装置及び分析方法
KR101437261B1 (ko) * 2013-01-17 2014-11-03 한국과학기술원 회전 ｐｃｒ 공정용 시료 처리 칩, 이를 구비하는 회전 ｐｃｒ 장치 및 이를 이용한 회전 ｐｃｒ 방법
US10401373B1 (en) 2013-02-18 2019-09-03 Theranos Ip Company, Llc Systems and methods for analyte testing and laboratory oversight
US11008628B1 (en) 2013-02-18 2021-05-18 Labrador Diagnostics Llc Systems and methods for analyte testing and laboratory oversight
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US20160016171A1 (en) * 2013-03-15 2016-01-21 Nanobiosym, Inc. Systems and Methods for Mobile Device Analysis of Nucleic Acids and Proteins
US10422806B1 (en) 2013-07-25 2019-09-24 Theranos Ip Company, Llc Methods for improving assays of biological samples
WO2015017604A1 (fr) * 2013-08-02 2015-02-05 International Park Of Creativity Procédés et dispositifs pour la ligature électromagnétique d'acides nucléiques et la transformation électromagnétique de cellules
MX2016002797A (es) 2013-09-06 2016-05-26 Theranos Inc Dispositivos, sistemas, metodos y equipos para recibir un hisopo.
KR20160053979A (ko) 2013-09-06 2016-05-13 테라노스, 인코포레이티드 전염성 질환의 검출을 위한 시스템 및 방법
EP3077430A4 (fr) 2013-12-05 2017-08-16 Centrillion Technology Holdings Corporation Surfaces modifiées
EP3628747B1 (fr) 2013-12-05 2022-10-05 Centrillion Technology Holdings Corporation Fabrication de réseaux à motifs
CN107002117B (zh) 2013-12-05 2021-12-10 生捷科技控股公司 核酸测序方法
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
US11360107B1 (en) 2014-02-25 2022-06-14 Labrador Diagnostics Llc Systems and methods for sample handling
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
CN106460232B (zh) 2014-05-23 2019-12-24 生捷科技控股公司 用于原位合成的探针阵列的寡核苷酸探针倒转方法
WO2016004171A1 (fr) 2014-07-03 2016-01-07 Centrillion Technology Holdings Corporation Dispositif de stockage et de distribution de réactifs
EP3276359A4 (fr) * 2015-03-24 2018-08-29 The University of Tokyo Dispositif, système ainsi que procédé fluidique
EP3280424B1 (fr) 2015-04-06 2020-10-14 Centrillion Technology Holdings Corporation Procédés permettant de phraser les modifications épigénétiques de génomes
EP3091026B1 (fr) * 2015-05-08 2019-02-20 Centrillion Technology Holdings Corporation Terminateurs réversibles à liaison disulfure
WO2017004502A1 (fr) 2015-07-02 2017-01-05 Centrillion Technology Holdings Corporation Systèmes et procédés de distribution et de mélange de réactifs
WO2017027779A1 (fr) 2015-08-13 2017-02-16 Centrillion Technology Holdings Corporation Construction de bibliothèque à l'aide d'adaptateurs y et élimination des sites de restriction
EP3130681B1 (fr) 2015-08-13 2019-11-13 Centrillion Technology Holdings Corporation Procédés de synchronisation de molécules d'acide nucléique
US10695735B2 (en) 2015-08-18 2020-06-30 Centrillion Technology Holdings Corporation Probe inversion process for in situ synthesized probe arrays
CN105139824B (zh) * 2015-10-16 2018-02-06 重庆京东方光电科技有限公司 栅极驱动器及其配置系统和调节配置方法
CN107841575B (zh) * 2017-11-06 2021-04-23 青岛农业大学 一种区分四种血清型禽腺病毒i群的纳米多重pcr方法
EP3789117A1 (fr) * 2019-09-09 2021-03-10 F. Hoffmann-La Roche AG Smartphone dispositif pour pcr
TR202008937A2 (tr) * 2020-06-09 2020-07-21 Gigabiomol Biyoteknoloji Sanayi Ve Ticaret Ltd Sirketi Elastik Polimer ile Mikroorganizma Konsantrasyon Yöntemi
CN111763718A (zh) * 2020-07-09 2020-10-13 广东省农业科学院动物卫生研究所 一种检测猪链球菌感染的纳米pcr方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4962020A (en) * 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
DE4027616A1 (de) 1990-08-31 1992-03-05 Boehringer Mannheim Gmbh Verfahren zur bestimmung von polymerase-aktivitaet
US5824477A (en) * 1990-09-12 1998-10-20 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
US5527670A (en) 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
EP0702728B1 (fr) * 1993-06-09 1998-04-15 Gamera Bioscience Corporation Reaction de cycle magnetique
ATE175723T1 (de) * 1994-03-15 1999-01-15 Scient Generics Ltd Elektrochemische denatusierung von doppelsträngiger nukleinsäure
CA2185239C (fr) 1994-03-16 2002-12-17 Nanibhushan Dattagupta Amplification d'acide nucleique par deplacement de la souche isotherme
US6613560B1 (en) 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
US5683875A (en) * 1995-05-04 1997-11-04 Hewlett-Packard Company Method for detecting a target nucleic acid analyte in a sample
CA2257109C (fr) * 1996-06-04 2009-10-06 University Of Utah Research Foundation Controle de l'hybridation pendant la pcr
US5939291A (en) * 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
GB9614544D0 (en) 1996-07-11 1996-09-04 Scient Generics Ltd Denaturation of double-stranded nucleic acid
GB9706654D0 (en) * 1997-04-02 1997-05-21 Scient Generics Ltd Disassociation of interacting molecules
US6391622B1 (en) * 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
CA2256563A1 (fr) * 1997-04-04 1998-10-15 Innogenetics N.V. Amplification isothermique en chaine par polymerase par oscillation controlee de la concentration d'ions metalliques divalents
US6055106A (en) 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
GB9903906D0 (en) 1999-02-19 1999-04-14 Microbiological Res Authority Method and apparatus for nucleic acid strand separation
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
KR100865105B1 (ko) * 1999-06-28 2008-10-24 캘리포니아 인스티튜트 오브 테크놀로지 마이크로 가공된 탄성중합체 밸브 및 펌프 시스템
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
WO2001013088A1 (fr) * 1999-08-13 2001-02-22 U.S. Genomics, Inc. Procede et appareil d'etirage de polymeres
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6699713B2 (en) * 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US6960437B2 (en) * 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6793752B2 (en) * 2001-09-21 2004-09-21 The Goodyear Tire & Rubber Company Precision longitudinal registration of tire building drum to automated tire building system work station
JPWO2003071271A1 (ja) 2002-02-21 2005-06-16 東京瓦斯株式会社 医薬品の薬理作用を評価するための検査薬、並びに酵素、酵素阻害剤若しくは受容体リガンドからなる薬物および／またはそのプロドラッグの中から投与効果が高いものおよび／または副作用が小さいものをスクリーニングする方法および試薬
US20040022764A1 (en) * 2002-07-31 2004-02-05 Hanan Polansky Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease
EP1751314B1 (fr) 2004-05-13 2019-09-18 Nanobiosym, Inc. Amplification par la polymerase a l'echelle nanometrique: procedes et dispositifs pour l'amplification et la detection d'acides nucleiques
CN101479605A (zh) 2006-04-21 2009-07-08 纳诺拜希姆公司 用于药物发现的单分子平台：用于包括抗癌和抗病毒剂的发现的药物发现的方法和装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAIER B ET AL: "Replication by a single DNA polymerase of a stretched single-stranded DNA" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 97, no. 22, 24 October 2000 (2000-10-24), pages 12002-12007, XP003019099 ISSN: 0027-8424 *

Also Published As

Publication number Publication date
BRPI0510811A (pt) 2007-11-06
JP5007440B2 (ja) 2012-08-22
EP1751314A4 (fr) 2008-06-25
EP1751314A2 (fr) 2007-02-14
IL179006A0 (en) 2007-03-08
KR20070048651A (ko) 2007-05-09
US8632973B2 (en) 2014-01-21
AU2009208132A1 (en) 2009-09-24
AU2005324505A1 (en) 2006-07-20
KR101506727B1 (ko) 2015-04-03
CA2566538C (fr) 2023-03-14
AP2006003813A0 (en) 2006-12-31
IL213850A0 (en) 2011-07-31
IL179006A (en) 2011-07-31
CA2566538A1 (fr) 2006-07-20
WO2006076022A2 (fr) 2006-07-20
BRPI0510811B1 (pt) 2018-12-26
US20140186940A1 (en) 2014-07-03
JP2008500029A (ja) 2008-01-10
NZ582558A (en) 2012-06-29
US20090246834A1 (en) 2009-10-01
NZ551996A (en) 2010-07-30
BR122016013290B1 (pt) 2021-04-20
WO2006076022A3 (fr) 2007-12-06
CA3152535A1 (fr) 2006-07-20
IL213850A (en) 2015-04-30
EP1751314B1 (fr) 2019-09-18
EP3640342A1 (fr) 2020-04-22
US7494791B2 (en) 2009-02-24
US20060019274A1 (en) 2006-01-26
CA3152535C (fr) 2023-08-29
AU2005324505B2 (en) 2009-09-10

Similar Documents

Publication Publication Date Title
AP2773A (en) NANO-PCR: Methods and devices for nucleic acid amplification and detection
EP1745120A4 (fr) Systeme pour l'amplification rapide et la detection d'acides nucleiques
EP1737985A4 (fr) Systeme de detection d'acides nucleiques
GB2413796B (en) Methods and means for nucleic acid sequencing
IL187130A0 (en) Turnover probes and use thereof for nucleic acid detection
GB0701253D0 (en) Nucleic acid amplification and testing
IL212000A0 (en) Multi-threat detection system and method
EP1997888A4 (fr) Cassette et appareil de détection d'acide nucléique
PL1937834T3 (pl) Sposoby wzmacniania, kwantyfikacji i identyfikacji kwasów nukleinowych
HK1105850A1 (en) System and method for detecting swallowing activity
EP2121956A4 (fr) Procédés et compositions pour l'amplification d'acide nucléique
GB0514909D0 (en) Methods of nucleic acid amplification and sequencing
EP1856282A4 (fr) Procédés d'isolation d'acide nucléique et matériaux et dispositifs associés
EP1962514A4 (fr) Procede de binarisation et dispositif associe
EP1932473A4 (fr) Dispositif et procédé de détection de toux
EP2058396A4 (fr) Procédé d'amplification d'acide nucléique
HK1146086A1 (en) Nucleic acid amplification method, and reagent and reagent kit for use in the method
EP1922418A4 (fr) Procédé et/ou dispositif de conception d'oligonucléotides et/ou de détection d'acides nucléiques
HK1110629A1 (en) Nucleic acid analysis method
EP2208795A4 (fr) Procédé de détection d'acide nucléique, et coffret de détection d'acide nucléique
HK1101414A1 (en) Method of detecting nucleic acid and utilization thereof
GB0524746D0 (en) Assay device and method
GB0505777D0 (en) Enzyme detection method and reagent
EP1620556A4 (fr) Detection d'acide nucleique
ZA200609413B (en) Nano-PCR: Methods and devices for nucleic acid amplification and detection