AP2498A - Fumarate salt of (ALPHA S, BETA R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol - Google Patents

Fumarate salt of (ALPHA S, BETA R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol

Info

Publication number
AP2498A
AP2498A AP2009004870A AP2009004870A AP2498A AP 2498 A AP2498 A AP 2498A AP 2009004870 A AP2009004870 A AP 2009004870A AP 2009004870 A AP2009004870 A AP 2009004870A AP 2498 A AP2498 A AP 2498A
Authority
AP
ARIPO
Prior art keywords
alpha
beta
quinolineethanol
naphthalenyl
dimethylamino
Prior art date
Application number
AP2009004870A
Other languages
English (en)
Other versions
AP2009004870A0 (en
Inventor
Jean Francois Alexandre Lucas Hegyi
Wim Albert Alex Aelterman
Yolande Lydia Lang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37983588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2498(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP2009004870A0 publication Critical patent/AP2009004870A0/xx
Application granted granted Critical
Publication of AP2498A publication Critical patent/AP2498A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2009004870A 2006-12-05 2007-12-03 Fumarate salt of (ALPHA S, BETA R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol AP2498A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125443 2006-12-05
PCT/EP2007/063186 WO2008068231A1 (fr) 2006-12-05 2007-12-03 Sel de fumarate de (alpha s, bêta r)-6-bromo-alpha-[2-(diméthylamino)éthyl]-2-méthoxy-alpha-1-naphtalényl-bêta-phényl-3-quinoléineéthanol

Publications (2)

Publication Number Publication Date
AP2009004870A0 AP2009004870A0 (en) 2009-06-30
AP2498A true AP2498A (en) 2012-10-19

Family

ID=37983588

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2009004870A AP2498A (en) 2006-12-05 2007-12-03 Fumarate salt of (ALPHA S, BETA R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol

Country Status (34)

Country Link
US (1) US8546428B2 (fr)
EP (1) EP2086940B1 (fr)
JP (2) JP2010511663A (fr)
KR (1) KR101514700B1 (fr)
CN (2) CN101547904A (fr)
AP (1) AP2498A (fr)
AR (1) AR064149A1 (fr)
AU (1) AU2007328945B2 (fr)
BR (1) BRPI0719693A2 (fr)
CA (1) CA2668512C (fr)
CL (1) CL2007003472A1 (fr)
CY (1) CY1113594T1 (fr)
DK (1) DK2086940T3 (fr)
EA (1) EA017091B9 (fr)
ES (1) ES2387923T3 (fr)
HK (1) HK1214513A1 (fr)
HR (1) HRP20120639T1 (fr)
IL (1) IL199077A (fr)
JO (1) JO2973B1 (fr)
ME (1) ME01456B (fr)
MX (1) MX2009005909A (fr)
MY (1) MY148844A (fr)
NO (1) NO342773B1 (fr)
NZ (1) NZ576485A (fr)
PE (1) PE20081350A1 (fr)
PL (1) PL2086940T3 (fr)
PT (1) PT2086940E (fr)
RS (1) RS52408B (fr)
SI (1) SI2086940T1 (fr)
TW (1) TWI417098B (fr)
UA (1) UA97813C2 (fr)
UY (1) UY30762A1 (fr)
WO (1) WO2008068231A1 (fr)
ZA (1) ZA200903907B (fr)

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US20120010216A1 (en) * 2010-07-06 2012-01-12 Brown Arthur M Pharmaceutical compositions containing vanoxerine
CZ2014708A3 (cs) * 2014-10-16 2016-04-27 Zentiva, K.S. Soli Bedaquilinu
PL3250182T3 (pl) * 2015-01-27 2023-07-31 Janssen Pharmaceutica Nv Kompozycje dyspergowalne
CN106279017A (zh) * 2015-05-21 2017-01-04 重庆圣华曦药业股份有限公司 贝达喹啉晶型、组合物及其制备方法
CZ2015391A3 (cs) * 2015-06-09 2016-12-21 Zentiva, K.S. Sůl bedaquilinu s kyselinou citronovou
WO2017066926A1 (fr) * 2015-10-20 2017-04-27 浙江海正药业股份有限公司 Formes cristallines de fumarate de bédaquiline et leurs procédés de préparation
DK3487851T3 (da) * 2016-07-20 2021-12-20 Novartis Ag Aminopyridinderivater og deres anvendelse som selektive alk-2-inhibitorer
CN106316943A (zh) * 2016-07-27 2017-01-11 重庆华邦制药有限公司 富马酸贝达喹啉晶型化合物的精制方法
WO2020123336A1 (fr) * 2018-12-13 2020-06-18 Qrumpharma Inc. Compositions de bédaquiline, combinaisons les comprenant, leurs procédés de préparation, utilisations et procédés les comprenant
JP2022516671A (ja) 2019-01-09 2022-03-01 ヤンセン ファーマシューティカ エヌ．ベー． 非結核性抗酸菌症の処置における組合せ
WO2020161743A1 (fr) * 2019-02-08 2020-08-13 Mylan Laboratories Limited Procédé de préparation de fumarate de bédaquiline
KR102303635B1 (ko) * 2020-07-01 2021-09-17 동아에스티 주식회사 (1r,2s)-1-(6-브로모-2-메톡시퀴놀린-3-일)-4-디메틸아미노-2-(1-나프틸)-1-페닐-부탄-2-올 및 이의 약제학적으로 허용 가능한 염의 제조방법
CN111888477B (zh) * 2020-09-15 2023-03-07 北京福元医药股份有限公司 一种贝达喹啉药物制剂
KR20230107275A (ko) 2020-11-12 2023-07-14 얀센 파마슈티카 엔.브이. 비결핵성 마이코박테리아 질환의 치료에서 베다퀼린, 에탐부톨 및 마크롤라이드의 조합물
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
WO2023150747A1 (fr) 2022-02-07 2023-08-10 Insmed Incorporated Compositions de poudre sèche de bédaquiline et de sels et leurs méthodes d'utilisation
WO2023232838A1 (fr) 2022-05-31 2023-12-07 Janssen Pharmaceutica Nv Bédaquiline destinée à être utilisée dans le traitement de la lèpre

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (fr) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Derives de quinoleine et leur utilisation en tant qu'inhibiteurs mycobacteriens
WO2005117875A1 (fr) * 2004-05-28 2005-12-15 Janssen Pharmaceutica N.V. Utilisation de derives quinoline substitues destines aux traitements de maladies mycobacteriennes resistant aux medicaments

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DE3237575A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale mopidamolformen
GB8824392D0 (en) * 1988-10-18 1988-11-23 Ciba Geigy Ag Dispersible formulation
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
US5965572A (en) 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
CZ300261B6 (cs) * 1996-10-30 2009-04-01 Eli Lilly And Company Použití hydrochloridové soli raloxifenu pro prípravu léciva pro prevenci rakoviny prsu
US6819464B2 (en) * 2002-06-19 2004-11-16 Seiko Epson Corporation Optical modulator, optical device and projector
AU2002350719A1 (en) * 2002-11-29 2004-06-23 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
KR101276571B1 (ko) * 2004-09-02 2013-06-18 얀센 파마슈티카 엔.브이. 4-((4-((4-(2-시아노에텐일)-2,6-디메틸페닐)아미노-2-피리미딘일)아미노)벤조니트릴의 푸마레이트
EA009779B1 (ru) * 2004-12-24 2008-04-28 Янссен Фармацевтика Н.В. Лечение латентного туберкулёза

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (fr) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Derives de quinoleine et leur utilisation en tant qu'inhibiteurs mycobacteriens
WO2005117875A1 (fr) * 2004-05-28 2005-12-15 Janssen Pharmaceutica N.V. Utilisation de derives quinoline substitues destines aux traitements de maladies mycobacteriennes resistant aux medicaments

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE REGISTRY, 14 May 2005 (2005-05-14), XP002433954, accession no. 845533-86-0, abstract *

Also Published As

Publication number Publication date
KR101514700B1 (ko) 2015-04-24
KR20090087020A (ko) 2009-08-14
SI2086940T1 (sl) 2012-09-28
MX2009005909A (es) 2009-06-16
JO2973B1 (en) 2016-03-15
WO2008068231A1 (fr) 2008-06-12
HRP20120639T1 (hr) 2012-08-31
DK2086940T3 (da) 2012-08-20
MY148844A (en) 2013-06-14
JP2015028049A (ja) 2015-02-12
UY30762A1 (es) 2008-07-03
US8546428B2 (en) 2013-10-01
EA017091B9 (ru) 2014-10-30
AR064149A1 (es) 2009-03-18
EA200970532A1 (ru) 2009-10-30
AU2007328945B2 (en) 2014-04-03
PT2086940E (pt) 2012-08-09
EA017091B1 (ru) 2012-09-28
CL2007003472A1 (es) 2008-08-22
UA97813C2 (uk) 2012-03-26
ES2387923T3 (es) 2012-10-04
JP2010511663A (ja) 2010-04-15
AP2009004870A0 (en) 2009-06-30
US20100028428A1 (en) 2010-02-04
CN101547904A (zh) 2009-09-30
RS52408B (en) 2013-02-28
NO342773B1 (no) 2018-08-06
EP2086940B1 (fr) 2012-05-16
IL199077A (en) 2016-09-29
TWI417098B (zh) 2013-12-01
NZ576485A (en) 2012-01-12
CN105012303A (zh) 2015-11-04
PL2086940T3 (pl) 2012-10-31
CA2668512A1 (fr) 2008-06-12
HK1214513A1 (zh) 2016-07-29
NO20092535L (no) 2009-08-06
CA2668512C (fr) 2015-03-24
JP5894239B2 (ja) 2016-03-23
ZA200903907B (en) 2013-08-28
CY1113594T1 (el) 2016-06-22
BRPI0719693A2 (pt) 2013-12-24
AU2007328945A1 (en) 2008-06-12
ME01456B (me) 2014-04-20
TW200838527A (en) 2008-10-01
PE20081350A1 (es) 2008-09-18
EP2086940A1 (fr) 2009-08-12

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