AP2011005697A0 - The 1-butyl-2-hydroxyaralkyl piperazine derivatives and the uses as anti-depression medicine thereof. - Google Patents

The 1-butyl-2-hydroxyaralkyl piperazine derivatives and the uses as anti-depression medicine thereof.

Info

Publication number
AP2011005697A0
AP2011005697A0 AP2011005697A AP2011005697A AP2011005697A0 AP 2011005697 A0 AP2011005697 A0 AP 2011005697A0 AP 2011005697 A AP2011005697 A AP 2011005697A AP 2011005697 A AP2011005697 A AP 2011005697A AP 2011005697 A0 AP2011005697 A0 AP 2011005697A0
Authority
AP
ARIPO
Prior art keywords
hydroxyaralkyl
butyl
piperazine derivatives
depression medicine
depression
Prior art date
Application number
AP2011005697A
Other languages
English (en)
Inventor
Jianqi Li
Na Lv
Hua Jin
Original Assignee
Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
Shanghai Inst Pharm Industry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd, Shanghai Inst Pharm Industry filed Critical Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
Publication of AP2011005697A0 publication Critical patent/AP2011005697A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AP2011005697A 2008-10-07 2009-09-29 The 1-butyl-2-hydroxyaralkyl piperazine derivatives and the uses as anti-depression medicine thereof. AP2011005697A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2008100438218A CN101712658B (zh) 2008-10-07 2008-10-07 1-丁基-2-羟基芳烷哌嗪衍生物及作为抗抑郁剂应用
PCT/CN2009/074314 WO2010040315A1 (zh) 2008-10-07 2009-09-29 1-丁基-2-羟基芳烷哌嗪衍生物及作为抗抑郁剂的应用

Publications (1)

Publication Number Publication Date
AP2011005697A0 true AP2011005697A0 (en) 2011-06-30

Family

ID=42100220

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2011005697A AP2011005697A0 (en) 2008-10-07 2009-09-29 The 1-butyl-2-hydroxyaralkyl piperazine derivatives and the uses as anti-depression medicine thereof.

Country Status (14)

Country Link
US (1) US8252796B2 (de)
EP (1) EP2351746B1 (de)
JP (1) JP5486008B2 (de)
KR (1) KR20110074574A (de)
CN (1) CN101712658B (de)
AP (1) AP2011005697A0 (de)
AU (1) AU2009301530A1 (de)
BR (1) BRPI0920885A2 (de)
CA (1) CA2739877A1 (de)
CO (1) CO6731066A2 (de)
EA (1) EA020716B1 (de)
IL (1) IL212164A0 (de)
MX (1) MX2011003660A (de)
WO (1) WO2010040315A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102050800B (zh) * 2009-11-03 2013-05-29 石药集团中奇制药技术（石家庄）有限公司 一种1-丁基-2-羟基芳烷醇哌嗪衍生物光学异构体的制备方法
CN102050801B (zh) * 2009-11-03 2013-05-29 石药集团中奇制药技术（石家庄）有限公司 一种芳烷哌嗪衍生物光学异构体的制备方法
KR101380181B1 (ko) 2012-02-01 2014-03-31 한국과학기술연구원 단가아민 재흡수 억제 활성을 보이는 (1Ｓ,3ａＲ,9ｂＳ)-1-페닐-2,3,3ａ,4,5,9ｂ-헥사하이드로-1Ｈ-벤조［ｅ］인돌 유도체와 3,4-다이아릴피롤리딘-2-온 유도체
CN107586281A (zh) * 2016-07-06 2018-01-16 上海医药工业研究院 芳烷杂环类衍生物及其在多靶点抗抑郁症中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3626837A1 (de) 1986-08-08 1988-02-11 Weinmann & Co Kg Drehverschluss fuer einen sportschuh, insbesondere skischuh
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
CN100415728C (zh) * 2005-10-10 2008-09-03 上海医药工业研究院 烷醇哌嗪衍生物光学异构体或其盐及其制备药物的应用

Also Published As

Publication number Publication date
MX2011003660A (es) 2011-05-25
EP2351746A1 (de) 2011-08-03
JP5486008B2 (ja) 2014-05-07
EP2351746B1 (de) 2014-11-12
EA201170528A1 (ru) 2012-03-30
KR20110074574A (ko) 2011-06-30
CO6731066A2 (es) 2013-08-15
IL212164A0 (en) 2011-06-30
EP2351746A4 (de) 2012-04-04
AU2009301530A1 (en) 2010-04-15
EA020716B1 (ru) 2015-01-30
CN101712658B (zh) 2012-03-14
US20110183996A1 (en) 2011-07-28
WO2010040315A1 (zh) 2010-04-15
JP2012505166A (ja) 2012-03-01
BRPI0920885A2 (pt) 2015-12-22
US8252796B2 (en) 2012-08-28
CN101712658A (zh) 2010-05-26
CA2739877A1 (en) 2010-04-15

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