AP2008004656A0 - Substituted biphenyl carboxylic acids and derivatives thereof - Google Patents

Substituted biphenyl carboxylic acids and derivatives thereof

Info

Publication number
AP2008004656A0
AP2008004656A0 AP2008004656A AP2008004656A AP2008004656A0 AP 2008004656 A0 AP2008004656 A0 AP 2008004656A0 AP 2008004656 A AP2008004656 A AP 2008004656A AP 2008004656 A AP2008004656 A AP 2008004656A AP 2008004656 A0 AP2008004656 A0 AP 2008004656A0
Authority
AP
ARIPO
Prior art keywords
derivatives
carboxylic acids
substituted biphenyl
biphenyl carboxylic
substituted
Prior art date
Application number
AP2008004656A
Other languages
English (en)
Inventor
Jess Taylor
Francis Wilson
Yan Zhang
Original Assignee
Cellzome Ltd
Orthomcneil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd, Orthomcneil Pharmaceutical Inc filed Critical Cellzome Ltd
Publication of AP2008004656A0 publication Critical patent/AP2008004656A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AP2008004656A 2006-04-21 2007-04-20 Substituted biphenyl carboxylic acids and derivatives thereof AP2008004656A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof
PCT/US2007/067039 WO2007124394A1 (en) 2006-04-21 2007-04-20 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
AP2008004656A0 true AP2008004656A0 (en) 2008-10-31

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004656A AP2008004656A0 (en) 2006-04-21 2007-04-20 Substituted biphenyl carboxylic acids and derivatives thereof

Country Status (35)

Country Link
US (1) US7557244B2 (pl)
EP (2) EP1849762B1 (pl)
JP (1) JP5479088B2 (pl)
KR (1) KR101542255B1 (pl)
CN (1) CN101687758B (pl)
AP (1) AP2008004656A0 (pl)
AR (1) AR060568A1 (pl)
AU (1) AU2007240335B2 (pl)
BR (1) BRPI0710656A2 (pl)
CA (1) CA2650006C (pl)
CR (2) CR10375A (pl)
CY (1) CY1109399T1 (pl)
DE (1) DE602006007810D1 (pl)
DK (1) DK1849762T3 (pl)
EA (1) EA016129B9 (pl)
ES (2) ES2328616T3 (pl)
GE (1) GEP20115269B (pl)
GT (1) GT200900120A (pl)
IL (2) IL194852A0 (pl)
MA (1) MA30475B1 (pl)
MX (1) MX2008013445A (pl)
MY (1) MY148953A (pl)
NO (1) NO20084517L (pl)
NZ (1) NZ573000A (pl)
PE (1) PE20080364A1 (pl)
PL (1) PL1849762T3 (pl)
PT (1) PT1849762E (pl)
SI (1) SI1849762T1 (pl)
SM (1) SMP200800061B (pl)
TN (1) TNSN08413A1 (pl)
TW (1) TWI399362B (pl)
UA (1) UA95952C2 (pl)
UY (1) UY30301A1 (pl)
WO (1) WO2007124394A1 (pl)
ZA (1) ZA200809856B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100082351A (ko) * 2007-10-19 2010-07-16 얀센 파마슈티카 엔.브이. γ-세크레타아제의 아민 결합된 조절제
KR20100081350A (ko) * 2007-10-19 2010-07-14 얀센 파마슈티카 엔.브이. Gsm 중간체
MX2010004309A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de piperidinil y piperazinil de gamma-secretasa.
KR101618068B1 (ko) 2007-10-19 2016-05-04 얀센 파마슈티카 엔.브이. γ-세크레타아제의 탄소 결합된 조절제
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
KR20100135711A (ko) 2007-12-20 2010-12-27 엔비보 파마슈티칼즈, 인코퍼레이티드 사중치환된 벤젠
US8871796B2 (en) 2009-10-16 2014-10-28 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
US20140187556A1 (en) * 2011-03-03 2014-07-03 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
EP1284729A4 (en) * 2000-04-13 2007-12-19 Mayo Foundation REDUCTION AGENTS OF A (BETA) 42
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
BR0311788A (pt) * 2002-06-27 2005-03-15 Fujisawa Pharmaceutical Co Composto derivado aminoalcoólico, processo para sua preparação, composição farmacêutica, compreendendo o mesmo, seu uso e método de tratamento
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
WO2006022237A1 (ja) * 2004-08-24 2006-03-02 Kissei Pharmaceutical Co., Ltd. 脂肪肝の予防または治療剤
EP1937632A1 (en) * 2005-10-06 2008-07-02 Astra Zeneca AB Novel compounds

Also Published As

Publication number Publication date
DK1849762T3 (da) 2009-10-12
CA2650006A1 (en) 2007-11-01
GT200900120A (es) 2009-11-16
EP2021314A1 (en) 2009-02-11
CA2650006C (en) 2016-08-23
KR101542255B1 (ko) 2015-08-06
MA30475B1 (fr) 2009-06-01
BRPI0710656A2 (pt) 2011-08-16
ES2328616T3 (es) 2009-11-16
AR060568A1 (es) 2008-06-25
MX2008013445A (es) 2009-03-10
CR10375A (es) 2009-02-26
US20070293567A1 (en) 2007-12-20
GEP20115269B (en) 2011-08-25
JP5479088B2 (ja) 2014-04-23
IL194852A0 (en) 2009-08-03
EP1849762A1 (en) 2007-10-31
PT1849762E (pt) 2009-09-16
EA200802172A1 (ru) 2009-06-30
EA016129B9 (ru) 2012-06-29
MY148953A (en) 2013-06-14
ZA200809856B (en) 2009-06-24
EA016129B1 (ru) 2012-02-28
SMAP200800061A (it) 2008-11-19
EP2021314B1 (en) 2013-01-23
EP1849762B1 (en) 2009-07-15
IL194790A0 (en) 2009-08-03
UY30301A1 (es) 2007-08-31
NZ573000A (en) 2011-11-25
WO2007124394A1 (en) 2007-11-01
CN101687758B (zh) 2014-05-14
AU2007240335B2 (en) 2013-05-02
KR20090024679A (ko) 2009-03-09
TWI399362B (zh) 2013-06-21
ES2400530T3 (es) 2013-04-10
SMP200800061B (it) 2009-07-14
CN101687758A (zh) 2010-03-31
TNSN08413A1 (en) 2010-04-14
IL194790A (en) 2012-12-31
PE20080364A1 (es) 2008-05-16
CR10451A (es) 2009-03-31
UA95952C2 (ru) 2011-09-26
JP2009544573A (ja) 2009-12-17
PL1849762T3 (pl) 2009-12-31
CY1109399T1 (el) 2014-07-02
TW200815320A (en) 2008-04-01
AU2007240335A1 (en) 2007-11-01
DE602006007810D1 (de) 2009-08-27
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
SI1849762T1 (sl) 2009-12-31

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