AP189A - 5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids. - Google Patents

5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids. Download PDF

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Publication number
AP189A
AP189A APAP/P/1990/000188A AP9000188A AP189A AP 189 A AP189 A AP 189A AP 9000188 A AP9000188 A AP 9000188A AP 189 A AP189 A AP 189A
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AP
ARIPO
Prior art keywords
formula
hydrogen
compound
carbon atoms
carbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
APAP/P/1990/000188A
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English (en)
Other versions
AP9000188A0 (en
Inventor
Schmidt Gunther Dr
Engel Wolfhard Dr
Trummlitz Gunter Dr
Eberlein Wolfgang Dr
Hargrave Karl D Dr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomae Dr Karl GmbH
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Thomae Dr Karl GmbH
Boehringer Ingelheim Pharma GmbH Co KG
Boehringer Ingelheim Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Thomae Dr Karl GmbH, Boehringer Ingelheim Pharma GmbH Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Thomae Dr Karl GmbH
Publication of AP9000188A0 publication Critical patent/AP9000188A0/xx
Application granted granted Critical
Publication of AP189A publication Critical patent/AP189A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1990/000188A 1989-06-28 1990-06-28 5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids. Expired - Lifetime AP189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37297489A 1989-06-28 1989-06-28

Publications (2)

Publication Number Publication Date
AP9000188A0 AP9000188A0 (en) 1990-07-31
AP189A true AP189A (en) 1992-05-04

Family

ID=23470402

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1990/000188A Expired - Lifetime AP189A (en) 1989-06-28 1990-06-28 5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids.

Country Status (21)

Country Link
EP (1) EP0410148B1 (ja)
JP (1) JP2911967B2 (ja)
KR (1) KR0160285B1 (ja)
AP (1) AP189A (ja)
AT (1) ATE103918T1 (ja)
AU (1) AU620724B2 (ja)
CA (1) CA2019812C (ja)
DD (1) DD295849A5 (ja)
DE (1) DE69007891T2 (ja)
DK (1) DK0410148T3 (ja)
ES (1) ES2063202T3 (ja)
FI (1) FI92828C (ja)
HU (1) HU206504B (ja)
IE (1) IE65247B1 (ja)
IL (1) IL94883A (ja)
NO (1) NO174468B (ja)
NZ (1) NZ234261A (ja)
OA (1) OA09741A (ja)
PT (1) PT94521B (ja)
RU (1) RU2024522C1 (ja)
ZA (1) ZA904991B (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3802334A1 (de) * 1988-01-27 1989-08-10 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
JP2912007B2 (ja) * 1989-11-17 1999-06-28 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレーテッド ５，１１―ジヒドロ―６Ｈ―ジピリド〔３，２―ｂ：２′，３′―ｅ〕〔１，４〕ジアゼピンおよび該化合物を含有するＨＩＶ感染の予防又は治療用組成物
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
ATE143018T1 (de) * 1991-02-07 1996-10-15 Boehringer Ingelheim Pharma Pyridobenzodiazepine, dipyrido-(3,2-b:2',3'-3> (1,4>-diazepine und deren verwendung in der vorbeugung und behandlung von aids
DE4403311C1 (de) * 1994-02-03 1995-04-20 Boehringer Ingelheim Kg Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on)
ES2118575T3 (es) * 1994-02-18 1998-09-16 Boehringer Ingelheim Pharma 2-heteroaril-5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de la infeccion con hiv.
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
DE10023492A1 (de) * 2000-05-09 2001-11-22 Schering Ag Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
KR101194036B1 (ko) 2010-08-18 2012-10-24 한국에너지기술연구원 태양에너지를 활용한 유체가열장치
WO2016083276A1 (de) 2014-11-25 2016-06-02 Bayer Pharma Aktiengesellschaft Substituierte pyridobenzodiazepinon-derivate und ihre verwendung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines
CA835391A (en) * 1970-02-24 Schmidt Gunther 5,6-dihydro-5-oxo-11h-pyrido (2,3-6) (1,5) benzodiazepine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL131929C (ja) * 1966-10-31
GB1262864A (en) * 1968-03-29 1972-02-09 Glaxo Lab Ltd Diazacarbazoles
DE3122670A1 (de) * 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
DE3726908A1 (de) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820345A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820346A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines
CA835391A (en) * 1970-02-24 Schmidt Gunther 5,6-dihydro-5-oxo-11h-pyrido (2,3-6) (1,5) benzodiazepine compounds

Also Published As

Publication number Publication date
JPH03115283A (ja) 1991-05-16
HUT55017A (en) 1991-04-29
HU206504B (en) 1992-11-30
KR910000727A (ko) 1991-01-30
OA09741A (en) 1993-11-30
ZA904991B (en) 1992-03-25
CA2019812A1 (en) 1990-12-28
NO902851L (no) 1991-01-02
ES2063202T3 (es) 1995-01-01
IE65247B1 (en) 1995-10-18
IL94883A (en) 1994-10-07
DE69007891D1 (de) 1994-05-11
IE902322L (en) 1990-12-28
EP0410148A1 (en) 1991-01-30
CA2019812C (en) 2000-11-21
FI92828B (fi) 1994-09-30
HU904021D0 (en) 1990-12-28
AU620724B2 (en) 1992-02-20
JP2911967B2 (ja) 1999-06-28
ATE103918T1 (de) 1994-04-15
DK0410148T3 (da) 1994-08-08
NO902851D0 (no) 1990-06-27
PT94521B (pt) 1997-02-28
NO174468C (ja) 1994-05-18
KR0160285B1 (ko) 1998-12-01
RU2024522C1 (ru) 1994-12-15
PT94521A (pt) 1991-02-08
IE902322A1 (en) 1991-01-16
FI92828C (fi) 1995-01-10
DE69007891T2 (de) 1994-08-25
EP0410148B1 (en) 1994-04-06
AU5792190A (en) 1991-01-03
AP9000188A0 (en) 1990-07-31
DD295849A5 (de) 1991-11-14
NO174468B (no) 1994-01-31
FI903225A0 (fi) 1990-06-27
IL94883A0 (en) 1991-04-15
NZ234261A (en) 1992-11-25

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