JPH10328129A - Fluorescent observing device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To observe plural internal organs by a single device with small, light weight and inexpensive constitution by freely attaching and detaching a fluorescent detecting filter transmitting a specific wavelength band from fluorescence to exchange with an adapter with a filter with a wavelength characteristic optimum to the internal organs to be observed. SOLUTION: Two filters, etc., for switching illuminating lamp generated from a lamp 11 to observing light for observing in fluorescence or for observing in white light are arranged at a turret 12 and a filter switch control part 14 switches observing light guiding observing light to guide to a light guide 22 within a universal cord 21 extended form an endoscope to a filter for observing in white light or for observing in fluorescence. A motor 15 receives a signal from the part 14 to rotate-drive the turret 12 to arrange a prescribed filter on the optical axis of the lamp 11 to exchange the filter for an exciting light on the turret 12 with the filter for generating observing light of a wavelength characteristic optimum to the internal organs through the use of operable and closable door for attaching and detaching 17 corresponding to the arranging position of the turret 12.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fluorescence observation apparatus for irradiating a site to be observed of a living tissue with excitation light and white light as observation light.

[0002]

2. Description of the Related Art In recent years, excitation light is applied to an object to be observed in a living tissue, and autofluorescence generated directly from the living tissue by the excitation light or fluorescence of a drug injected into the living body is detected as a two-dimensional image. Then, from the fluorescent image, the disease state of the living tissue such as degenerative cancer (eg, the type of disease and the invasion range)
The technique of diagnosing the fluorescence is being used, and a fluorescence observation apparatus for performing this fluorescence observation has been developed.

In autofluorescence, when a living tissue is irradiated with excitation light, fluorescence having a longer wavelength than the irradiated excitation light is generated. Examples of the fluorescent substance in the living body include collagen, NADH (nicotinamide adenine nucleotide), FMN (flavin mononucleotide),
There are pyridine nucleotides and the like, and recently, it becomes possible to diagnose cancer and the like by clarifying the correlation between such a fluorescent endogenous substance and a disease.

On the other hand, in the fluorescence of drugs, HpD (hematoporphyrin), Photofrin, and ALA (δ-amino levulinic acid) are used as fluorescent substances to be injected into a living body.
d) and the like are used. These drugs have accumulation properties in cancer and the like, and a disease site can be diagnosed by injecting these drugs into a living body and observing fluorescence. There is also a method of adding a fluorescent substance to a monoclonal antibody and accumulating the fluorescent substance in a lesion by an antigen-antibody reaction.

As the excitation light, for example, a laser, a mercury lamp, a metal halide lamp or the like is used as a light source. By irradiating the excitation light from these light sources to the observation target site of the living tissue, weak fluorescence is generated from the observation target site, and the weak fluorescence is detected and generated in a two-dimensional fluorescence image for observation. , Make a diagnosis.

[0006] In a fluorescence observation apparatus for irradiating a living tissue with excitation light and observing fluorescence emitted from the living tissue, an optimal excitation light wavelength and an optimum excitation light for exciting the fluorescence are detected due to different types of organs. Are considered to be different from each other.

For example, Japanese Patent Application Laid-Open No. Hei 8-224209 discloses a fluorescence observation apparatus provided with a plurality of filters having different wavelength characteristics and an exchange means for switching and exchanging these filters.

[0008]

However, the fluorescence observation apparatus disclosed in Japanese Patent Application Laid-Open No. 8-224209 has a problem that the apparatus becomes large and the mechanism becomes complicated. For this reason, a compact and lightweight fluorescence observation device capable of observing a plurality of organs in an optimal state has been desired.

The present invention has been made in view of the above circumstances. By replacing an adapter with a filter having a filter having an optimum wavelength characteristic for an organ to be observed, a plurality of organs can be reduced in size by one apparatus. It is an object of the present invention to provide a fluorescence observation device that can be observed with a lightweight and inexpensive configuration.

[0010]

According to the present invention, there is provided a fluorescence observation apparatus comprising: a light source that emits light in a specific wavelength band that excites tissue in a body cavity; and imaging means that images specific fluorescence generated from the tissue in the body cavity. And a fluorescence detection filter that transmits a specific wavelength band from the fluorescence, and the fluorescence detection filter is detachable.

According to this configuration, the fluorescence detection filters respectively corresponding to the different organs are replaced with the optimum filters for the target organs to be observed, so that the different organs can be observed in an optimum state by one fluorescence observation apparatus. I can do it.

[0012]

Embodiments of the present invention will be described below with reference to the drawings. 1 to 3 relate to an embodiment of a fluorescence observation apparatus, FIG. 1 is a configuration diagram showing a schematic configuration of the entire fluorescence observation apparatus, and FIG. 2 is a schematic view of a detection adapter having a filter for determining a fluorescence detection wavelength range. FIG. 3 is a schematic view of a light source adapter for determining the excitation light wavelength range.

The fluorescence observation device 50 of this embodiment has a device configuration capable of obtaining a white light image and a fluorescence image. As shown in FIG. 1, excitation light for fluorescence observation and illumination for white light observation are used as observation light. Light source device 10 capable of generating light
Then, the excitation light or the illumination light from the light source device 10 is guided to the observation site in the living body via the light guide 22, and the fluorescence image by the excitation light or the white light image by the illumination light is transmitted through the image guide 26. An endoscope 20; a camera 30 that captures a fluorescent image or a white light image captured by the endoscope 20 with a fluorescent image observation system or a white light image observation system and converts the captured image into an electric signal; A fluorescence image processing unit 41 that processes the obtained fluorescence image signal to generate a fluorescence image; a white light image processing unit 42 that processes a white light image signal converted by the camera 30 to generate a white light image; A display unit 43 such as a CRT monitor for displaying at least one of the fluorescent light image and the white light image generated by the fluorescent light image processing unit 41 or the white light image processing unit 42 is provided.

Further, as shown in FIG.
A turret 1 provided with a lamp 11 serving as a light source and two filters described later for switching illumination light generated from the lamp 11 to observation light for fluorescence observation or white light observation.
2 and a universal cord 21 extending from the endoscope 20
A filter switching control unit 14, which is a filter switching unit for switching observation light guided to a light guide 22 in the inside to a filter for white light observation or fluorescence observation, and receives a signal from the filter switching control unit 14 to control the turret 12 A motor 15 for rotating and placing a predetermined filter on the optical axis of the lamp 11 and a detachable door 17 that can be opened and closed corresponding to the position of the turret 12 are provided. The detachable door 17 is used to replace the excitation light filter provided on the turret 12 with an observation light generation filter having an optimal wavelength characteristic for each organ.

As shown in FIG. 2, the turret 12 is provided with a transmission filter 12b for transmitting the white light from the lamp 11 as it is, and a plurality of excitation light having a wavelength characteristic optimal for each organ. A filter installation groove 12c in which an observation light generation filter 18 as a filter is detachably provided is formed.

Thus, the filter 18 having the optimum wavelength characteristic for the organ to be examined is selected and the light source device 10 is selected.
By disposing the filter 18 in the filter disposing groove 12c of the turret 12 from the detachable door 17 provided on the turret 12, excitation light having an optimal wavelength characteristic with respect to the organ to be examined enters the base end face 22a of the light guide 22. Then, the body cavity is irradiated.

The camera 30 shown in FIG.
Is removably connected to the eyepiece section 24. This camera 30
A movable reflection mirror 31 for selectively guiding a fluorescent image or a white light image transmitted and transmitted through the image guide 26 of the endoscope 20 to an imaging unit of a fluorescent image observation system or a white light image observation system, A dichroic mirror 32 that divides the fluorescent image passed without being reflected by the movable reflecting mirror 31 into two optical paths, a fixed reflective mirror 33 that changes the optical path of the fluorescent image reflected by the dichroic mirror 32,
A detection adapter 34 having a fluorescence detection filter, which will be described later, that transmits the two fluorescent images divided by the dichroic mirror 32, and a first amplifying each fluorescent image transmitted through the filter of the detection adapter 34 Image intensifier 35a and second image intensifier 35b, and a first fluorescent image capturing CCD 36a and a second fluorescent image capturing CCD 36b for capturing output images from the respective image intensifiers 35a and 35b. And a white light image capturing CCD 37 that captures a white light image reflected by the movable reflection mirror 31.

The fluorescent image capturing CCDs 36a, 36a
6b and the fluorescent light image signal or white light image signal photoelectrically changed by the white light image photographing CCD 37 are transmitted to the fluorescent light image processing unit 41 or the white light image processing unit 42, respectively, and are generated as a fluorescent light image or a white light image. .

As shown in FIG.
Is a fluorescence detection filter 34a that transmits light having a wavelength band of wavelength λ1 from the fluorescence image divided into two by the dichroic mirror 32, and a fluorescence detection filter that transmits light having a wavelength band of wavelength λ2. With the filter 34b,
It is configured to be detachable from the camera 30.

The operation of the fluorescence observation device 50 configured as described above will be described. First, referring to the optimum excitation light wavelength and detection fluorescence wavelength for each organ recorded so far, the filter 18 that transmits the optimum wavelength band for the organ to be observed and the detection adapter 34 are formed. Prepare each.

Next, the filter 18 is mounted on the turret 12 through the removable door 17, while the detection adapter 34 is mounted on the camera 30. Then, in order to observe the white light image, the movable reflection mirror 31 in the camera 30 is used.
Is moved to a position indicated by a solid line where the image transmitted through the image guide 26 of the endoscope 20 is guided to the white light photographing CCD 37. Then, a sensor (not shown) detects that the movable reflection mirror 31 has moved to the white light photographing state, and the transmission filter 1 provided on the turret 12 is detected.
2b is arranged on the optical axis of the lamp 11.

The illumination light transmitted through the transmission filter 12b is incident on the base end face 22a of the light guide 22, is transmitted through the light guide 22, and is irradiated inside the living body. Then, the reflected light image of the illumination light irradiated into the living body is transmitted through the image guide 26 as a white light image, and enters the camera 30. The white light image that has entered the camera 30 is reflected by the movable reflection mirror 31 and the white light image capturing CCD 3
7 and photoelectrically converted. This CC for white light imaging
The electric signal photoelectrically changed in D37 is generated as a white light observation image by the white light image processing unit 42, output to the display unit 43, and displayed as a white light observation image.

Next, in order to perform fluorescence observation with the endoscope 20 inserted to a desired observation site, the movable reflection mirror 31 of the camera 30 is switched to the fluorescence observation side indicated by a broken line. Then, the turret 12 having the transmission filter 12b disposed on the optical axis of the lamp 11 is driven to rotate, and the filter 18 is disposed on the optical path of the lamp 11 instead of the transmission filter 12b.

As a result, the excitation light transmitted through the filter 18 is incident on the base end face 22a of the light guide 22, is transmitted through the light guide 22, and is irradiated inside the living body. Then, the fluorescent image generated by the fluorescent light generated by the excitation light irradiated into the living body is transmitted through the image guide 26 and enters the camera 30. The fluorescence image incident on the camera 30 is split into two optical paths by a dichroic mirror 32 and then incident on fluorescence detection filters 34 a and 34 b provided on a detection adapter 34.

The filter 34 of the detection adapter 34
a and 34b are transmitted by the fluorescent images, so that each fluorescent image has components in the wavelength bands of λ1 and λ2,
After being amplified by the image intensifier 35a and the second image intensifier 35b, it is imaged by the first fluorescent image capturing CCD 36a and the second fluorescent image capturing CCD 36b and converted into an electric signal.

The electrical signals of the fluorescent images in the two wavelength bands of λ1 and λ2, which have been photoelectrically converted by the fluorescent image capturing CCDs 36a and 36b, are input to a fluorescent image processing unit 41, where they are generated as fluorescent observation images and displayed. The image is output to the unit 43 and displayed as a fluorescence observation image.

When continuously observing different organs,
Filter 18 that transmits the optimal wavelength band for the observed organ
The inspection is performed by replacing the detection adapter 34 with the detection adapter 34.

As described above, in the fluorescence observation apparatus of the present embodiment, the detection adapter provided with the fluorescence detection filters respectively corresponding to the different organs and the observation light generation filter are prepared in advance, and each of the target organs to be observed is prepared. By exchanging the detection adapter and the filter that are optimal for each other, different organs can be observed in an optimal state with one fluorescence observation apparatus. Thus, a compact, lightweight, and inexpensive fluorescent observation apparatus capable of observing white light and performing fluorescent observation of a plurality of organs under optimal conditions is provided.

In the present embodiment, both the detection adapter for determining the fluorescence detection wavelength and the filter for determining the wavelength of the excitation light are exchangeable, but only one of them is exchangeable. There may be. Further, instead of providing the transmission filter 12b, an opening may be simply formed in the turret 12.

When fluorescence is observed in the gastrointestinal tract of the stomach and large intestine, bacteria such as bacteria contained in a large amount in the residue emit fluorescence close to the fluorescent color from the lesion. For this reason, when observing a fluorescent image, it is difficult to determine whether the fluorescence is due to these bacteria or the fluorescence from a lesion, and there has been a problem that the diagnostic ability is reduced. In addition, there is a method of temporarily switching the fluorescence observation image to a white light observation image in order to confirm whether or not it is a residue. However, since a light color change is observed in the fluorescence observation, a bright white light observation is temporarily performed. When the observation is performed again after switching to the fluorescence observation image after observing the image, there is a problem that it takes a while for the operator's eyes to get used to the fluorescence observation image.

Therefore, in this embodiment, a fluorescence observation camera is configured as shown in FIG. As shown in the figure, the fluorescence observation camera 30 of the present embodiment includes a specific fluorescence cut filter 61 for cutting specific fluorescence from bacteria,
A residual fluorescence processing unit 60 composed of a motor 62 for inserting and removing the specific fluorescence cut filter 61 from the optical path and a filter control unit 63 for controlling the operation of the motor 62,
It is arranged between the eyepiece 24 of the endoscope 20 and the movable reflection mirror 31 in the camera 30. Other configurations are the same as those of the fluorescence observation device 50 described above, and the same members are denoted by the same reference numerals and description thereof will be omitted.

The operation of the camera 30 configured as described above will be described. In the initial fluorescence observation state, the fluorescence image transmitted through the image guide 26 of the endoscope 20 is amplified by the image intensifiers 35a and 35b without passing through the specific fluorescence cut filter 61, and the fluorescence image capturing CCD 3
Images are taken by 6a and 36b.

During the fluorescence observation, when it is difficult to determine whether the fluorescence is from a lesion such as a cancer or the specific fluorescence from bacteria, the operator operates a switch provided on the camera 30. By operating (not shown), the motor 62 is driven by a predetermined amount via the control unit 63, and the specific fluorescence cut filter 61 is arranged on the optical path between the eyepiece lens 24a and the movable reflection mirror 31. Then, by inserting the specific fluorescence cut filter 61 into the optical path of the fluorescence image, if the fluorescence was considered to be a lesion and the fluorescence became extremely dark, it was found that the observed fluorescence image was from bacteria. Unless the fluorescence becomes almost dark, the observed fluorescence image is confirmed to be a lesion.

As described above, in the camera according to the present embodiment, the specific fluorescence processing section provided with the specific fluorescence cut filter is detachably provided in the optical path between the eyepiece of the endoscope and the movable mirror of the camera. By doing so, without changing the observation illumination light during the fluorescence observation that hindered the discrimination of whether the observed fluorescent image was from bacteria or from a lesion,
A unique fluorescent cut filter is placed in the optical path between the endoscope eyepiece and the movable mirror to determine whether the observed fluorescent image is from bacteria or a lesion. Can be easily lowered. As a result, more accurate diagnosis can be made. In addition, there is no loss of time until the surgeon's eyes become accustomed to a bright image for white light observation and a light image for fluorescence observation.

Generally, specific fluorescence from bacteria is as follows:
It emits strong red fluorescence (especially a peak at 630 nm). Then, in the fluorescence observation, the intensity is strong especially in the vicinity of the green region (especially 490 nm to 560 nm) in the normal part, and weak in the affected part. Therefore, the vicinity of the green region and the vicinity of the red region having a longer wavelength (particularly 620 nm to 800 nm)
By performing the arithmetic processing of m), it is possible to determine a normal part and a lesion part from the fluorescence image. Thus, the specific fluorescence cut filter may be arranged at any position in the optical path between the image intensifier that captures fluorescence in the vicinity of the red region and the endoscope eyepiece.

Next, a modification of the above embodiment will be described with reference to FIG. As shown in the figure, the fluorescence observation camera 30 of the present embodiment includes a half mirror 81 for dividing a fluorescence image from the image guide 26 into two, and this half mirror 81.
A specific fluorescent light transmitting filter 82 that transmits only specific fluorescent light from bacteria from a fluorescent image reflected from the light source, a third image intensifier 83 that amplifies the fluorescent image transmitted through the specific fluorescent light transmitting filter 82, C for specific fluorescence capturing an output image from the image intensifier 83 of FIG.
The specific fluorescence imaging section 80 constituted by the CD 84 and the endoscope 2
0 and the movable reflection mirror 31 in the camera 30. A specific fluorescent image processing unit 85 that processes an image signal from the specific fluorescent CCD 84 to generate a specific fluorescent image, a fluorescent image from the fluorescent image processing unit 41, and a specific fluorescent image from the specific fluorescent image processing unit 85 And an image synthesizing unit 86 for synthesizing. Other configurations are the same as those of the fluorescence observation device 50 described above, and the same members are denoted by the same reference numerals and description thereof will be omitted.

The operation of the camera 30 configured as described above will be described. Image guide 2 of endoscope 20 during fluorescence observation
The fluorescent image transmitted through 6 is split into two optical paths by the half mirror 81. The fluorescent images transmitted through the half mirror 81 are image intensifiers 35a and 35b.
And is imaged by the fluorescent image photographing CCDs 36a and 36b.

The fluorescence image reflected by the half mirror 82 passes through the specific fluorescence transmission filter 82. Then, the fluorescence image transmitted through the specific fluorescence transmission filter 82 is amplified by the third image intensifier 83 and is captured by the specific fluorescence CCD 84. The specific fluorescent image captured by the specific fluorescent CCD 84 is processed by the specific fluorescent image processing unit 85 to generate a specific fluorescent image.
The specific fluorescent image is superimposed on the fluorescent image from the fluorescent image processing unit 41 by the image synthesizing unit 86, or is arranged in parallel and displayed on the display unit 43.

Since the specific fluorescent image displays almost only the specific fluorescent light from bacteria, it can be easily compared with the conventional fluorescent image.

As described above, in the camera of the present embodiment, the unique fluorescent image pickup unit for picking up a unique fluorescent image from bacteria is inserted into and removed from the optical path between the eyepiece of the endoscope and the movable reflecting mirror of the camera. Freely provided, by combining the conventional fluorescent image and the unique fluorescent image from the bacteria in the image synthesis unit and displaying it, by comparing both images, it is possible to confirm the part affected by the bacteria, An accurate diagnosis can be made.

Incidentally, instead of generating a specific fluorescent image,
CCD8 for specific fluorescent light with specific fluorescent light above a certain brightness
The same effect can be obtained by using a notifying means for notifying the operator of this by a warning sound, a warning light, or the like when the image is captured in step 4.

Referring to FIG. 6, a schematic configuration of another fluorescence observation apparatus will be described. When a single lamp including light of multiple wavelengths is used to obtain white observation light and excitation light that is fluorescence observation light having a narrow wavelength band of blue, a large amount of light is required to obtain sufficient excitation light intensity. It is necessary to use a lamp of this type.However, in the method of directly separating and selecting white light and excitation light by inserting and removing an interference filter, the strong light emitted from the lamp may cause the filter to be broken or the life of the filter to be longer. May be shorter.

Therefore, in this embodiment, the light source device is configured as follows. That is, as shown in the figure, the light source device 10a of the present embodiment includes a lamp 11 for generating observation light.
A first dichroic mirror 71 that reflects the excitation light component from the illumination light of the lamp 11 and transmits other wavelength bands, and fixed reflection mirrors 72 and 73 that reflect the light transmitted through the dichroic mirror 71. An openable and closable shutter 74 disposed in the optical path between the fixed reflection mirrors 72 and 73, a wavelength correction filter 75 for correcting the wavelength of the excitation light component reflected by the dichroic mirror 71, and a wavelength correction filter 75. A dimming filter 76 for dimming light having a transmitted wavelength, and a dimming filter 76
And a second dichroic mirror 77 that transmits light having a wavelength that has passed through and reflects light in other wavelength bands. The neutral density filter 76 is removably disposed on an optical path including a wavelength correction filter 75 and a second dichroic mirror 77 in conjunction with the opening and closing operation of the shutter 74. Other configurations are the same as those of the light source device 10 shown in FIG. 1, and the same members are denoted by the same reference numerals and description thereof will be omitted.

The operation of the light source device 10a configured as described above will be described. At the time of fluorescence observation, the illumination light emitted from the lamp 11 is first emitted by the first dichroic mirror 71.
The light is separated into excitation light of the excitation light component and white light excluding the excitation light component. And the dichroic mirror 7
The white light from which the excitation light component transmitted through 1 has been removed is reflected by the fixed reflection mirror 72, and then is shielded by the shutter 74 in the closed state. The neutral density filter 76 is
When the shutter 74 is closed, it is removed from the optical path of the excitation light.

On the other hand, the first dichroic mirror 7
The excitation light of the excitation light component reflected by 1 transmits through the wavelength correction filter 75, adjusts the excitation light wavelength, transmits through the second dichroic mirror 77, enters the light guide 22, and enters the light of the endoscope. The light is transmitted through the guide 22 and irradiated inside the living body.

On the other hand, when the shutter 74 is opened when observing white light, the light reduction filter 76 is arranged on the optical path between the wavelength correction filter 75 and the dichroic mirror 77. As a result, the first dichroic mirror 7
The white light, which has passed through 1 and from which the excitation light component that has been shielded from light during fluorescence observation has been removed, is reflected by the fixed reflecting mirror 73 and the second dichroic mirror 77, respectively, due to the opening of the shutter 74. The light is separated by the first dichroic mirror 71 and combined with the excitation light of the excitation light component attenuated by the neutral density filter 76, enters the light guide 22, is transmitted through the light guide 22 of the endoscope, and enters the living body. Irradiated.

As described above, in the fluorescence observation apparatus of the present embodiment, the excitation light is generated by transmitting the white light of the illumination light emitted from the lamp by the dichroic mirror and reflecting only the excitation light component. In the case of (1), by combining the transmitted light with the excitation light, thermal damage to the filter can be suppressed and the life of the filter can be extended. Further, the white light reduces the wavelength component of the excitation light, so that the color temperature of the light changes, and the color becomes a color that makes it easier to observe the living tissue.

The present invention is not limited to only the above-described embodiments, but can be variously modified without departing from the gist of the invention.

[Appendix] According to the above-described embodiment of the present invention as described in detail above, the following configuration can be obtained.

(1) In a fluorescence observation apparatus having a light source for emitting light in a specific wavelength band for exciting tissue in a body cavity and an imaging means for imaging specific fluorescence generated from the tissue in the body cavity, A fluorescence observation device comprising a fluorescence detection filter that transmits the above wavelength band, and the fluorescence detection filter is detachable.

(2) The fluorescence observation apparatus according to appendix 1, wherein the fluorescence detection filter comprises an interference filter transmitting two different wavelength bands.

(3) The fluorescence observation apparatus according to appendix 1, wherein the light source includes an excitation filter that transmits light in a specific wavelength band that excites tissue in a body cavity.

(4) The fluorescence observation apparatus according to attachment 3, wherein the excitation filter is detachable from the optical axis of the light source.

(5) The fluorescence observation apparatus according to attachment 3, wherein the fluorescence detection filter and the excitation filter have a certain combination.

(6) The fluorescence observation apparatus according to appendix 1, wherein the light source is a laser light source capable of changing a wavelength.

(7) The fluorescence observation apparatus according to appendix 6, wherein the laser light source is a dye laser or an OPO laser.

(8) In a fluorescence observation camera having an imaging means for imaging fluorescence generated from a tissue in a body cavity and a fluorescence detection filter for transmitting a specific wavelength band from the fluorescence, a wavelength transmitted by the fluorescence detection filter. A fluorescence observation camera, comprising: a light-blocking filter that blocks a part of a band, wherein the light-blocking filter is detachably disposed on an optical path of the fluorescence detection filter.

(9) The fluorescence observation camera according to appendix 8, wherein the light shielding filter shields a narrow band including a wavelength of 630 nm.

(10) In a fluorescence observation camera having an imaging means for imaging fluorescence generated from a tissue in a body cavity and a fluorescence detection filter for transmitting a specific wavelength band from the fluorescence, a wavelength transmitted by the fluorescence detection filter. A fluorescence observation camera comprising: a light-blocking filter that blocks a part of a band; a second imaging unit that captures fluorescence transmitted through the light-blocking filter; and a notification unit that notifies information from the second imaging unit. .

(11) A fluorescence observation light source having a light source that emits light in a plurality of wavelength bands for illuminating a body cavity tissue, and an excitation filter that transmits a specific wavelength that excites the body cavity tissue from the light of the light source. Separating means for splitting light of a first wavelength band including a wavelength band transmitted by the excitation filter and light of a second wavelength band not including the first wavelength band; A light source for fluorescence observation, comprising: a light-shielding means for selectively shielding light; and an optical means for combining the light of the first wavelength and the light of the second wavelength.

(12) The fluorescent observation light source according to appendix 11, wherein the separation means is a dichroic mirror.

(13) A fluorescence observation light source having a light source for emitting light in a plurality of wavelength bands for illuminating a tissue in a body cavity, and an excitation filter for transmitting a specific wavelength for exciting the tissue in the body cavity from the light of the light source. Separating means for splitting light of a first wavelength band including a wavelength band transmitted by the excitation filter and light of a second wavelength band not including the first wavelength band; and light of the first wavelength band. Filter, which diminishes light, light blocking means for selectively blocking light of the second wavelength band, and optical means for combining the light of the first wavelength and the light of the second wavelength. And a light source for fluorescence observation.

[0063]

As described above, according to the present invention, it is possible to provide a fluorescent observation apparatus capable of observing a plurality of organs with fluorescence at a small size, light weight and at low cost.

[Brief description of the drawings]

FIG. 1 to FIG. 3 relate to an embodiment of a fluorescence observation device, and FIG. 1 is a configuration diagram showing a schematic configuration of the entire fluorescence observation device.

FIG. 2 is a schematic diagram of a detection adapter having a filter for determining a fluorescence detection wavelength range.

FIG. 3 is a schematic diagram of a light source adapter for determining an excitation light wavelength range.

FIG. 4 is an explanatory view showing another configuration of the fluorescence observation camera.

FIG. 5 is an explanatory diagram showing another configuration of the fluorescence observation camera.

FIG. 6 is an explanatory diagram showing another configuration of the light source device.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 10 ... Light source device 11a ... Lamp 12 ... Turret 12b ... Transmission filter 14 ... Control part 15 ... Motor 18 ... Observation light generation filter 34 ... Detection adapter 50 ... Fluorescence observation device

Continued on the front page (72) Inventor Masaya Yoshihara 2-43-2 Hatagaya, Shibuya-ku, Tokyo Inside Olympus Optical Co., Ltd. (72) Inventor Mamoru Kaneko 2-43-2 Hatagaya, Shibuya-ku, Tokyo Olympus Optics (72) Inventor Nobuyuki Michiguchi 2-43-2 Hatagaya, Shibuya-ku, Tokyo Inside Olympus Optical Co., Ltd.

Claims (1)

[Claims] 1. A fluorescence observation apparatus comprising: a light source that emits light in a specific wavelength band that excites tissue in a body cavity; and an imaging unit that captures specific fluorescence generated from the tissue in the body cavity. A fluorescence observation device comprising a fluorescence detection filter that transmits a wavelength band, wherein the fluorescence detection filter is detachable.