JP5545984B2 - Fundus imaging device with wavefront compensation - Google Patents

Description

  The present invention relates to a fundus imaging apparatus with wavefront compensation that captures a fundus image of a subject's eye while correcting the wavefront aberration of the subject's eye.

  An apparatus that detects wavefront aberration of an eye using a wavefront sensor, controls a wavefront compensation device based on the detection result, and photographs a fundus image after wavefront compensation at a cellular level is disclosed (for example, Patent Document 1). reference).

JP-T-2001-507258

  By the way, the examiner needs to finely adjust the alignment between the eye to be examined and the apparatus until the result of compensation by the wavefront compensation device shows a satisfactory result. This adjustment was a burden on the examiner and the subject.

  In view of the above problems, an object of the present invention is to provide a fundus photographing apparatus with wavefront compensation that can smoothly photograph a fundus image in a state where wavefront aberration is corrected.

  In order to solve the above problems, the present invention is characterized by having the following configuration.

(1) A fundus imaging apparatus with wavefront compensation according to a first aspect of the present invention includes a fundus imaging optical system that receives reflected light from the fundus of a subject's eye and images a fundus image, and an optical path of the fundus imaging optical system. is arranged, and the wavefront compensation device for compensating the wavefront aberration of the eye to control the wavefront of the incident light, you received as target pattern image by the wavefront sensor light reflected light projecting basil measurement light toward the fundus a test Idemitsu Gakukei, based on the displacement information of the outer periphery of the light receiving area of the front Symbol index pattern image by the wavefront sensor and the outer circumference of the compensating region of the wavefront compensation device, wherein as the displacement information is within the allowable range And a position adjusting means for relatively adjusting the positional relationship between the detection optical system and the eye to be examined.
(2) A fundus imaging apparatus with wavefront compensation according to a second aspect of the present invention includes a fundus imaging optical system that receives reflected light from the fundus of the subject's eye and images a fundus image, and an optical path of the fundus imaging optical system. A wavefront compensation device that is arranged and controls the wavefront of the incident light to compensate for the wavefront aberration of the subject's eye, and a detection that projects measurement light toward the fundus of the subject's eye and receives the reflected light as an index pattern image by the wavefront sensor The detection optical system and the eye to be examined so that the deviation information falls within an allowable range based on deviation information between the optical system and the compensation area of the wavefront compensation device and the light receiving area of the index pattern image by the wavefront sensor. A position adjustment unit that relatively adjusts the positional relationship of the image and a fundus image captured by the fundus imaging optical system on the screen of the display unit, along with the correction degree of the aberration correction by the wavefront compensation device, along with the fundus image. Characterized in that it comprises a display control unit for displaying on the basis of the detection result.

  In view of the above problems, the present invention can smoothly shoot a fundus image in a state where wavefront aberration is corrected.

  An embodiment of the present invention will be described. FIG. 1 is an external view of a fundus imaging apparatus according to the present embodiment. The apparatus includes a face support unit 20 and an imaging unit 400 on a base 21. In the present embodiment, the depth direction of the eye to be examined is described as the Z direction (the optical axis L1 direction), the horizontal direction is the X direction, and the vertical direction is the Y direction. The face support unit 20 is provided with a chin rest 22 on which the chin rest 22 is supported so as to be movable in each direction of the XYZ axes, and a forehead support.

  The apparatus is also provided with an electric movement mechanism (Y-axis movement mechanism 34 / X-axis movement mechanism 36 / Z-axis movement mechanism 39) that moves the chin rest 22 in the three-dimensional directions of XYZ with respect to the eye to be examined. ing.

  2A is an external view when the face support unit 20 is viewed from the examiner side, and FIG. 2B is a schematic cross-sectional view showing the Y-axis moving mechanism 34 of the chin rest 22.

  A feed screw 21 is erected on the support base 26, and a support 23 having a female screw screwed to the feed screw 21 is guided by the support base 26 and attached to be movable in the Y direction. A chin rest 22 is fixed on the support post 23. A gear 29 is provided below the feed screw 21 and meshes with the gear 29 on the Y drive unit 35 (for example, motor) side. Further, the support column 26 has a groove 25, and the support column 26 is prevented from rotating by the groove 25 and the screw 24 for rotation prevention. The feed screw 21 is rotated by the rotation of the Y driving unit 35, and thereby the chin base 22 is moved in the Y-axis direction together with the column 26. A light shielding plate 27 is attached below the column 23, and photosensors 28a, 28b, and 28c for detecting the light shielding plate 27 are provided on the support base 20 side. The photo sensor 28a detects that the chin rest 22 has been lowered to the lower limit by detecting the light shielding plate 27. Further, the photo sensor 28b detects that the chin rest 22 has returned to the initial position by detecting the light shielding plate 27. The photo sensor 28c detects that the chin rest 22 has been raised to the upper limit by detecting the light shielding plate 27.

  The X-axis moving mechanism 36 includes a feed screw 37 extending in the X-axis direction and an X drive unit (for example, a motor) 38 connected to the feed screw 37, and is attached to the housing. The feed screw 37 is fitted with a female screw formed at the lower end of the support base 26. When the feed screw 37 is rotated by driving the X drive unit 38, the support 26 is moved in the X-axis direction. . Thereby, the chin rest 22 is moved in the X-axis direction. The Z-axis moving mechanism 39 is disposed below the X-axis moving mechanism 36, and moves the support base 26 and the X-axis moving mechanism 36 integrally in the Z direction by a mechanism similar to the X-axis moving mechanism 36. .

  FIG. 3 is a schematic diagram showing an optical system of the fundus imaging apparatus of the present embodiment. The fundus imaging apparatus of the present embodiment is broadly divided into a fundus imaging optical system 100 that images the fundus of the subject's eye based on the reflected light from the fundus of the subject's eye, and a wavefront sensor 73 for detecting the wavefront aberration of the subject's eye. A wavefront aberration detection optical system (hereinafter referred to as an aberration detection optical system) 110 that projects measurement light onto the fundus of the eye to be examined and receives the reflected light as an index pattern image by the wavefront sensor 73; Aberration correction units 10 and 72 arranged in the fundus imaging optical system 100 to correct the aberration of the eye to be examined, and a photographing position of a fundus image obtained by the fundus imaging optical system 100 (hereinafter referred to as a first fundus image) are shown. A second imaging unit 200 for obtaining an observation image of the fundus for designating (hereinafter referred to as a second fundus image), detecting a time-dependent change in position shift due to fixation eye movement of the eye E to be imaged, and moving To obtain location information Kkingu for unit (position detection unit) 300 comprises a. Here, the fundus imaging optical system 100 captures the fundus of the eye E with high resolution (high resolution) and high magnification. The aberration correction unit includes a diopter correction unit 10 for correcting low-order aberrations (diopter: for example, spherical power) of the eye to be examined, and a high-order aberration correction unit for correcting high-order aberrations of the eye to be examined. (Wavefront compensation device) 72.

  The fundus imaging optical system 100 includes a first illumination optical system 100a that irradiates the eye E with illumination light (illumination light beam) to illuminate the fundus two-dimensionally, and reflected light (reflected light beam) of the illumination light irradiated on the fundus. And a first correction optical system 100b for obtaining a first fundus image and an aberration correction unit 72. The fundus imaging optical system 100 has, for example, a scanning laser ophthalmoscope configuration using a confocal optical system.

  The first illumination optical system 100a includes a light source 1 (first light source) that emits illumination light for illuminating the fundus and a scanning unit 15 that two-dimensionally scans the illumination light (spot light) on the fundus. The light source 1 emits near-infrared illumination light that is hardly visible to the eye to be examined. In the present embodiment, the light source 1 is an SLD (Super Luminescent Diode) light source having a wavelength of 840 nm. The light source may be any light source that emits spot light having a high convergence property, and may be, for example, a semiconductor laser.

  First, the first illumination optical system 100a will be described. In the optical path from the light source 1 to the fundus, a lens 2, a beam splitter 3, a polarizing plate 4, a lens 5, a beam splitter 71, a lens 6, a wavefront compensation device 72, a lens 7, and a beam splitter 75 are arranged. Further, the lens 8, the scanning unit 15, the lens 9, the deflection unit 400 for correcting the scanning position of the illumination light scanned two-dimensionally, the diopter correction unit 10 composed of two prisms, the lens 11, 2 A beam splitter 90 is disposed so that the optical path of the photographing unit 200 or the like is substantially coaxial with the first illumination optical system. The beam splitter 3 is a half mirror in this embodiment.

  Illumination light emitted from the light source 1 is converted into parallel light by the lens 2 and then converted into a light beam of only the S-polarized component by the polarizing plate 4 in this embodiment via the beam splitter 3. The illumination light that has passed through the polarizing plate 4 is once condensed by the lens 5, converted into a parallel light beam by the lens 6 through the beam splitter 71, and enters the wavefront compensation device 72. The illumination light reflected by the wavefront compensation device 72 is relayed by the lens 7 and the lens 8 and travels toward the scanning unit 15.

  The scanning unit 15 is configured to scan illumination light two-dimensionally on the fundus, and here, as illustrated, scans illumination light in the XY direction on the fundus. In the present embodiment, a resonant mirror serving as a deflecting member for deflecting and scanning illumination light in the horizontal direction (X direction) on the fundus, and scanning by deflecting the illumination light in a direction perpendicular to the horizontal scanning direction (Y direction). A galvanometer mirror serving as a deflection member and a drive unit for driving each mirror. The illumination light that has passed through the scanning unit 15 is condensed again by the lens 9. The deflecting unit 400 has a function of further deflecting the illumination light having passed through the scanning unit 15 by a predetermined amount with respect to the horizontal direction and the vertical direction, and is configured by two galvanometer mirrors in the present embodiment. The illumination light that has passed through the deflection unit 400 is condensed on the fundus of the eye E through the diopter correction unit 10, the lens 11, and the beam splitter 90, and is scanned two-dimensionally on the fundus by the scanning unit 15. The diopter correction unit 10 includes a drive unit 10a, and one prism moves in the direction of the arrow shown in the figure, so that the optical path length can be changed and plays a role in diopter correction. The diopter correction unit 10 may be configured by a driving unit and a lens that can move in the optical axis direction by driving the driving unit. In addition, the beam splitter 90 is a dichroic mirror in the present embodiment, and reflects the light beam from the second imaging unit 200 and tracking unit 300 described later, and transmits the light beam from the light source 1 and the light source 76 described later. have. Note that the emission ends of the light source 1 and the light source 76 and the eye E to be examined are conjugate. In this way, the first illumination optical system that irradiates the fundus with illumination light two-dimensionally is formed.

  Next, the first photographing optical system 100b will be described. The first photographing optical system 100 has a common optical path from the beam splitter 90 to the beam splitter 3 described in the first illumination optical system 100a, and further includes a lens 51, a pinhole plate 52 placed at a position conjugate with the fundus, and a light collecting unit. An optical lens 53 and a light receiving element 54 are included. In this embodiment, the light receiving element 54 is an APD (avalanche photodiode).

  The reflected light from the fundus of the illumination light emitted from the light source 1 traces the first illumination optical system 100a in the reverse direction and is transmitted by the polarizing plate 4 only for S-polarized light, and then partially reflected by the beam splitter 3. Is reflected. This reflected light is focused on the pinhole of the pinhole plate 52 through the lens 51. The reflected light focused at the pinhole is received by the light receiving element 54 through the lens 53. Although a part of the illumination light is reflected on the cornea, most of the illumination light is removed by the pinhole plate 52, and the adverse effect of the corneal reflection on the image is reduced. For this reason, the light receiving element 54 can receive reflected light from the fundus while suppressing the influence of corneal reflection. The beam splitter 3 may be a hall mirror. In this case, the hole of the Hall mirror suppresses the incident corneal reflection light from entering the first imaging optical system 100.

  In this way, the first photographing optical system 100b is formed. The processed image received by the first imaging optical system 100b becomes the first fundus image. Note that the mirror swing angle (swing angle) in the scanning unit 15 is determined so that the angle of view of the fundus image (fundus image) acquired by the first photographing unit 100 is a predetermined angle. Here, in order to observe and photograph a predetermined range of the fundus at a high magnification (here, observation at a cell level or the like), the angle of view is set to about 1 to 5 degrees. In this embodiment, the angle is 1.5 degrees. Although depending on the diopter of the eye to be examined, the imaging range of the first fundus image is about 500 μm square.

  Next, the second photographing unit 200 will be described. The second imaging unit is a unit for acquiring a fundus image (second fundus image) having a wider angle of view than the angle of view of the first imaging unit, and the acquired second fundus image has the narrow angle of view described above. Used for position designation and position confirmation for obtaining the first fundus image. The second imaging unit 200 for acquiring such a second fundus image only needs to be able to acquire the fundus image of the eye E to be examined in real time with a wide angle of view (for example, about 20 to 60 degrees). Therefore, the second imaging unit 200 can use an observation / imaging optical system of an existing fundus camera, an optical system of a scanning laser ophthalmoscope (SLO), and a control system.

  Next, the aberration detection optical system 110 will be described. As described above, the aberration detection optical system 110 has some optical elements on the optical path of the first illumination optical system 100a, and shares a part of the optical path with the first illumination optical system 100a. The aberration detection optical system 110 includes a wavefront sensor 73, a polarizing plate 74, a light source 76, a lens 77, a polarizing plate 78, and a lens 79. From the beam splitter 71 to the beam splitter 90 placed on the optical path of the first illumination optical system. These optical members are shared. The wavefront sensor 73 includes, for example, a microlens array composed of a number of microlenses and a two-dimensional imaging element 73a (two-dimensional light receiving element) for receiving a light beam that has passed through the microlens array. A light source 76 that is an aberration detection light source (third light source) is a light source that emits light in an infrared region different from that of the light source 1. In the present embodiment, the light source 76 uses a laser diode that emits laser light having a wavelength of 780 nm. The laser light emitted from the light source 76 is converted into a parallel light beam by the lens 77, and the polarization direction (P-polarized light) is orthogonal to the illumination light from the light source 1 by the polarizing plate 78, and the optical path of the first illumination optical system by the beam splitter 75. Led to. Note that there is a fundus conjugate position between the lenses 7 and 8, and the emission end of the light source 76 has a conjugate relationship with this fundus conjugate position. The beam splitter 75 is a half mirror in this embodiment. The polarizing plate 78 has a role of making the light of the third light source irradiated to the fundus a predetermined polarization direction, and has a role of a first polarizing means provided in the wavefront compensation unit.

  The laser beam reflected by the beam splitter 75 is condensed on the fundus of the eye E through the optical path of the first illumination optical system 100a. The laser beam reflected from the fundus is reflected by the wavefront compensation device 72 through each optical member of the first illumination optical system 100a, deviated from the optical path of the first illumination optical system 100a by the beam splitter 71, the lens 79, and S-polarized light. The light is guided to the wavefront sensor 73 through the polarizing plate 74 through which only the component passes. The polarizing plate 74 is a second polarization unit provided in the wavefront compensation unit, and blocks the polarization direction (P-polarized light) of the light of the third light source irradiated to the fundus and is polarized perpendicular to the polarization direction. It plays the role of transmitting the direction (S-polarized light) and guiding it to the wavefront sensor 73. Note that the beam splitter 71 transmits light (840 nm) having the wavelength of the light source 1 and reflects light (780 nm) having the wavelength of the light source 76 for detecting aberration. Accordingly, the wavefront sensor 73 detects light having an S-polarized component from the scattered light on the fundus of the irradiated laser light. In this way, light reflected by the cornea and the optical element is suppressed from being detected by the wavefront sensor 73. The scanning unit 15, the reflection surface of the wavefront compensation device 72, and the microlens array of the wavefront sensor 73 are substantially conjugate with the pupil of the eye to be examined. The light receiving surface of the wavefront sensor 73 is substantially conjugate with the fundus of the eye E. As the wavefront sensor 73, an element capable of detecting wavefront aberration including low-order aberration and high-order aberration, for example, a Hartmann Shack detector, a wavefront curvature sensor that detects a change in light intensity, or the like is used.

  The wavefront compensation device 72 is, for example, a liquid crystal spatial light modulator and uses a reflective LCOS (Liquid Crystal On Silicon) or the like. The wavefront compensation device 72 is disposed in the optical path of the fundus imaging optical system 100 and controls the wavefront of incident light to compensate for the wavefront aberration of the eye to be examined. The wavefront compensation device 72 is a predetermined unit such as illumination light from the light source 1 (S-polarized light), reflected light from the fundus of the illumination light (S-polarized light), reflected light from wavefront aberration detection light (S-polarized light component), or the like. Are arranged in a direction capable of compensating the aberration with respect to the linearly polarized light (S-polarized light). As a result, the wavefront compensation device 72 can modulate the S-polarized component of the incident light. Further, the wavefront compensation device 72 has a liquid crystal molecule arrangement direction in the liquid crystal layer substantially parallel to the polarization plane of the incident reflected light, and the liquid crystal molecules rotate in accordance with a change in voltage applied to the liquid crystal layer. The predetermined surface is substantially parallel to a plane including the incident optical axis and the reflected optical axis of the reflected light from the fundus to the wavefront compensation device 72, and the normal of the mirror layer of the wavefront compensation device 72. Have been placed.

  In this embodiment, the wavefront compensation device 72 is a liquid crystal modulation element and uses a reflective LCOS (Liquid Crystal On Silicon) or the like, but is not limited thereto. Any reflective wavefront compensation device may be used. For example, a deformable mirror that is a form of MEMS (Micro Electro Mechanical Systems) may be used. Further, instead of a reflection type wavefront compensation device, a transmission type wavefront compensation device that transmits reflected light from the fundus and compensates for wavefront aberration can also be used.

  In the above description, a light source that emits illumination light having a wavelength different from that of the first light source is used as the aberration detection light source. However, the first light source may be used as the aberration detection light source.

  In the present embodiment described above, the wavefront sensor and the wavefront compensation device are the pupil conjugate of the eye to be examined. However, the position may be a position that is substantially conjugate with a predetermined part of the anterior eye portion of the eye to be examined. There may be.

  Next, a control system of the fundus imaging apparatus will be described. FIG. 4 is a block diagram showing a control system of the fundus imaging apparatus of the present embodiment. The control unit 80 that controls the entire apparatus includes a light source 1, a scanning unit 15, a light receiving element 51, a wavefront compensation device 72, a wavefront sensor 73, a light source 76, a second imaging unit 200, a light receiving element 251, a tracking unit 300, The deflection unit 400, the deflection unit 410, the diopter correction unit 10, the Y drive unit 35, the X drive unit 38, and the drive unit of the Z-axis moving mechanism 39 are connected. A storage unit 81, a control unit 82, an image processing unit 83, and a monitor 85 are connected. The image processing unit 83 forms, on the monitor 85, images of the fundus oculi having different angles of view, that is, a first fundus image and a second fundus image, based on signals received by the light receiving element 51 and the second imaging unit 200. Various setting information and captured images are stored in the storage unit 81. As the monitor 85, for example, a monitor of an external personal computer or a monitor provided in an apparatus can be considered. The fundus images (first fundus image and second fundus image) updated at a predetermined frame rate are displayed on the monitor 85. The frame rate is, for example, 10 to 100 Hz. In this way, the fundus image is displayed as a moving image. In the present embodiment, the control unit 80 also functions as the display control unit 80 of the monitor 85, the drive control unit 80 of the deflection units 400 and 410, and the emission control unit 80 such as the light sources 1 and 76.

  When the wavefront compensation device 72 is controlled, the wavefront compensation device 72 is controlled based on the wavefront aberration detected by the wavefront sensor 73, and the illumination emitted from the light source 1 together with the S-polarized component of the reflected light of the light source 76. Higher order aberrations of the light and its reflected light are removed. In this way, the aberration of the illumination light emitted from the light source 1 and the reflected light is removed. In other words, a high-resolution first fundus image from which the high-order aberration of the eye E is removed (wavefront compensated) is obtained. In this case, the low-order aberration is corrected by the diopter correction unit 10.

  In addition, an X-direction chin rest operation switch 47a, a Y-direction chin rest operation switch 47b, and a Z-direction chin rest operation switch 47c that are used when the examiner moves the chin rest 22 in the three-dimensional directions of XYZ by electric drive are provided. ing.

  The operation of the fundus imaging apparatus having the above configuration will be described with reference to the flowchart shown in FIG.

  First, the examiner operates the chin rest operation switches 47a to 47c while observing the anterior eye part image (not shown) displayed on the screen of the monitor 85, adjusts the position of the chin rest 22, and performs rough alignment. I do. Further, the examiner instructs the subject to fixate a fixation target (not shown).

  When rough alignment by the chin rest 22 is completed and a measurement switch (not shown) is selected by the examiner, diopter correction is performed by the control unit 80 using the diopter correction unit 10, and then necessary for aberration correction. Perform wavefront detection.

  FIG. 6 is a diagram for explaining a specific example of the index pattern image on the wavefront sensor and the compensable region. FIG. 7 is a diagram showing the aberration correction screen 40 displayed on the screen of the monitor 85. On the aberration correction screen 40, the index pattern image received by the two-dimensional imaging device 73a of the wavefront sensor 73 (in this embodiment, a Hartmann image, hereinafter referred to as a Hartmann image) and the correction degree of the aberration correction are displayed. An aberration correction graphic 41 displayed graphically and a cell image image 42 of the fundus that is actually photographed are displayed.

  A Hartmann image (dot pattern image) 31 represents a group of a plurality of point images 31 a received on the wavefront sensor 73. The fundus reflection light that has passed through the lens array is received by the two-dimensional imaging device 73a of the wavefront sensor 73 and captured as a Hartmann image. The Hartmann image 31 is displayed on the monitor 85. In the region where the point image 31a is detected by the wavefront sensor 73, aberration detection is possible.

  A circle 32 virtually indicates an area in which aberration correction can be performed by the wavefront compensation device 72 on the two-dimensional image sensor 73a. The graphic corresponding to the circle 32 is superimposed on the Hartmann image on the monitor 85 and displayed. The mark located at the center of the circle 32 is a graphic indicating the center position of the compensable region on the wavefront sensor 73.

  Then, the outer circumference, area, and position information of the circle 32 on the wavefront sensor 73 are set in the storage unit 81 in advance. These may be obtained in advance by calibration or simulation. In the wavefront compensation device 72, the compensable region is limited to a light beam in a certain region (for example, a 4 mm diameter region on the pupil) of the entire incident light. For this reason, other incident light is reflected toward the light receiving element 54, but the wavefront is not compensated.

  Here, the aberration correction is performed based on the aberration detection result by the wavefront sensor 73. That is, in the region where the Hartmann image 31 is formed in the region of the circle 32, the wavefront state can be detected (see FIG. 6B). On the other hand, in the region of the circle 32, in the region S where the Hartmann image 31 is not formed, the wavefront state is not detected. Here, when a part of the wavefront data is missing, information on the entire wavefront cannot be obtained, so that the wavefront aberration in the wavefront correction region is not properly measured (see FIG. 6A). Therefore, as shown in FIG. 7A, even when the aberration correction is performed, the aberration is not properly removed as shown in the aberration correction graphic 41. In addition, as shown in the cell image 42, photographing becomes difficult.

  A treatment method for filling the area of the circle 32 with the Hartmann image 31 will be described below. The control unit 80 obtains deviation information between the compensation area (for example, the circle 32) of the wavefront compensation device 72 set on the wavefront sensor 73 and the light receiving area of the index pattern image (for example, the Hartmann image 31) by the wavefront sensor 73. To detect. Then, the control unit 80 controls the Y-axis moving mechanism 34 / X-axis moving mechanism 36 based on the detection result, and moves the jaw table 22 so that the deviation information is within the allowable range.

  Specifically, first, the control unit 80 sequentially detects the position of the point image received at the outermost side among the Hartmann images 31 received by the wavefront sensor 73, and obtains positional information of the Hartmann image outer periphery 31b. To detect. Thereby, the detection area of the Hartmann image 31 is obtained.

  Next, the control unit 80 compares the position information of the Hartmann image outer periphery 31b with the position information of the circle 32 (aberration correctable region), and based on the comparison result, the wavefront measurement region satisfies the aberration correctable region beyond the allowable range. Judge whether it is. Thereby, it is determined whether or not the aberration of the eye E can be corrected.

  More specifically, the control unit 80 compares the region surrounded by the Hartmann image outer periphery 31b (see the dotted line) with the region surrounded by the circle 32. Here, the control unit 80 determines that it is sufficient (OK) when the region formed by the circle 32 is within the region formed by the Hartmann image outer periphery 31b (see FIG. 6B). Moreover, the control part 80 determines with it being inadequate (NG), when the area | region which the circle | round | yen 32 comprises is not settled in the area | region which the outer periphery 31b comprises (refer Fig.6 (a)).

  If the control unit 80 determines that NG, the X drive unit 35 and the Y drive unit 38 are driven so that the region formed by the circle 32 enters the region formed by the outer periphery 31b of the Hartmann image 31, and the jaw table 22 is moved in the XY direction. Move to. As a result, as shown in FIG. 6B, the circle 32 is contained in the Hartmann image outer periphery 31a, and the aberration can be corrected. Further, as shown in FIG. 7B, the aberration is removed as shown in the aberration correction graphic 41, and an image from which the aberration is removed is also displayed in the cell image 42.

  After the position of the chin rest 22 is adjusted as described above, the control unit 80 detects the wavefront aberration of the eye E based on the detection result of the wavefront sensor 73 and controls the wavefront compensation device 72 based on the detection result. To do. When wavefront aberration is compensated as described above and a predetermined trigger signal is output, a cell image of the fundus is captured as a moving image or a still image.

  During imaging, the fixation direction of the eye E is greatly changed, and the position of the eye to be inspected is displaced, so that the circle 32 may come off from the outer periphery 31a of the Hartmann image 31. Therefore, the control unit 80 moves the jaw table 22 so that the circle 32 is again accommodated in the Hartmann image 31. That is, the control unit 80 performs tracking using the chin rest 22.

  According to the above configuration, even if the aberration information of the eye E in the wavefront compensation region cannot be acquired due to the change in the fixation direction of the eye to be examined, the shift of the measurement position is corrected by the movement of the jaw table 22, A small area of the fundus is photographed smoothly.

  In the above determination, the control unit 80 determines that all point image position coordinates of the Hartmann image outer periphery 31b are outside or the same position as the position coordinates of the circle 32, and the area formed by the outer periphery of the Hartmann image 31 is the outer periphery of the circle 32. If it is within the area to be formed, it may be determined as OK. Further, the control unit 80 may determine that the position coordinates of the point image on the outer periphery of the Hartmann image 31 are inside the position coordinates on the outer periphery of the circle 32 as NG.

  The control unit 80 may calculate the center coordinates of the Hartmann image 31 and move the jaw table 22 so as to coincide with the center coordinates of the circle 32.

  Further, an anterior ocular segment imaging optical system may be used as a configuration for detecting a shift between the compensable region and the light receiving region of the index pattern image by the wavefront sensor. For example, a compensable area is set on the anterior segment imaging camera, a pupil part is extracted from the anterior segment image by image processing, and the position information of the compensable area is compared with the position information of the outer periphery of the pupil, thereby A shift between regions may be detected.

  In the present embodiment, the configuration in which the face support unit is moved with respect to the imaging unit 400 enables the eye E to be moved even when the imaging unit 3 is difficult to move due to the increase in size and weight of the imaging unit 3. Can be aligned. In this case, for example, a drive mechanism that moves the forehead and cheek pads may be provided.

  In the above determination, the index pattern image may not satisfy 100% of the compensable region, and the wavefront aberration may be measured with a certain accuracy (for example, 95% region). When a deviation is detected in the determination result, the control unit 80 drives the X drive unit 35 and the Y drive unit 38 to exceed a certain allowable range (for example, a certain ratio or more) within the compensation range. The jaw table 22 is moved so that the index pattern image is received.

  In the above description, any configuration may be used as long as the positional relationship between the detection optical system 110 and the eye to be examined is relatively adjusted. For example, the configuration may be such that the photographing unit 400 is moved with respect to the eye E so that the shift information is within an allowable range. In addition, a light deflection unit that changes the traveling direction of the measurement light beam may be provided in the optical path of the detection optical system 110, and the positional relationship may be adjusted by driving the light deflection unit.

  In the above description, the positional relationship may be relatively adjusted based on the deviation information. For example, the control unit 80 controls the monitor 40 to receive the index pattern image received by the wavefront sensor 73 (for example, the Hartmann image 31) and the graphic indicating the wavefront compensation area on the wavefront sensor 73 (for example, the circle 32, or The center mark of the circle 32) is displayed in a display area of the monitor 40, and is output as deviation information (see, for example, FIG. 7).

  In this way, the examiner can grasp to which position on the wavefront sensor 73 the area that can be compensated by the wavefront compensation device 72 corresponds. Then, the examiner operates the chin rest operation switch 47 while confirming the deviation information displayed on the monitor 40. It should be noted that the examiner can perform alignment more easily by the graphic indicating the outer periphery such as the circle 32.

  In the above description, the fundus imaging optical system 100 receives the light beam reflected from the fundus of the eye to be examined through the confocal aperture disposed at a position substantially conjugate to the fundus of the eye to be examined, and confocals the fundus of the eye to be examined. Although a confocal optical system (SLO optical system) that captures a front image is used, the present invention is not limited to this (see, for example, JP 2001-507258 A).

  For example, a fundus camera optical system that captures a frontal image of the fundus of the subject's eye by receiving a light beam reflected from the fundus of the subject's eye with a two-dimensional image sensor. Further, it may be an optical interference optical system (OCT optical system) that captures a tomographic image of the eye to be inspected by receiving the light beam reflected from the fundus of the eye to be examined and the interference light by the reference light.

It is an external view of the fundus imaging apparatus of the present embodiment. It is a figure which shows the moving mechanism of the face support unit of this embodiment. It is the schematic diagram which showed the optical system of the fundus imaging apparatus of this embodiment. It is the block diagram which showed the control system of the fundus imaging apparatus of this embodiment. It is a flowchart which shows the operation | movement in this apparatus. It is a figure which shows the aberration correction screen displayed on the screen of a monitor. It is a figure which shows the state which the aberration correction possible area | region has settled in the outer periphery of a Hartmann image, and an aberration correction is possible.

DESCRIPTION OF SYMBOLS 10 Diopter correction | amendment part 15 Scan part 20 Face support unit 22 Jaw stage 34 Y-axis direction movement mechanism 36 X-axis direction movement mechanism 39 Z-axis direction movement mechanism 40 Aberration correction screen 47 Jaw stage operation switch 72 Wavefront compensation device 73 Wavefront sensor 76 Light source 80 Control unit 85 Monitor 100 Fundus imaging optical system 200 Second imaging unit 300 Tracking unit 400, 410 Deflection unit 500 Anterior segment imaging optical system

Claims (2)

A fundus imaging optical system that receives reflected light from the fundus of the subject's eye and captures a fundus image;
A wavefront compensation device that is disposed in the optical path of the fundus imaging optical system and that controls the wavefront of incident light to compensate the wavefront aberration of the eye to be examined;
A test Idemitsu Gakukei you received as target pattern image by the wavefront sensor light reflected light projecting basil measurement light toward the fundus,
Based on the displacement information of the outer periphery of the light receiving area of the target pattern image by the wavefront sensor and the outer circumference of the compensable region before Symbol wavefront compensation device, said detection optical system and the eye to be examined so that the shift information is within the allowable range And a position adjusting means for relatively adjusting the positional relationship with the fundus imaging apparatus with wavefront compensation. A fundus imaging optical system that receives reflected light from the fundus of the subject's eye and captures a fundus image;
A wavefront compensation device that is disposed in the optical path of the fundus imaging optical system and that controls the wavefront of incident light to compensate the wavefront aberration of the eye to be examined;
A test Idemitsu Gakukei you received as target pattern image by the wavefront sensor light reflected light projecting basil measurement light toward the fundus,
Based on the displacement information of the previous SL wavefront compensation device compensating region and the light-receiving area of the target pattern image by the wavefront sensor, the positional relationship between the detection optical system and the eye to be examined so that the shift information is within the allowable range Position adjusting means for relatively adjusting
A display control unit for displaying, on the screen of the display means, a fundus image captured by the fundus imaging optical system and a correction degree of aberration correction by the wavefront compensation device based on a detection result of the wavefront sensor. A fundus imaging apparatus with wavefront compensation.

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