JP2001354570A - Immunoactivating agent and cosmetic using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an effective component and cosmetics capable of keeping humectant effect for a long time, excellent in protection effect and inflammation- suppressing effect, superiorly improving reduction of skin immunological competence caused by living environment, physiological aging and the like and bringing skin and hair to be healthy. SOLUTION: This immunoactivating agent comprises a water soluble β-1, 3-glucan derivative and/or a yeast extract as effective ingredients. A bleaching cosmetic material and a hair cosmetic material are provided by using the immunoactivating agent together with a bleaching ingredient, a hair-growing agent and/or a blood flow accelerating agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a water-soluble β-1,3
The present invention relates to an immunostimulant containing a glucan derivative and / or a yeast extract as an active ingredient and a cosmetic containing them.
In more detail, we used an immunostimulant to protect the skin and hair, improve the skin immunity due to living environment and physiological aging, and improve the soundness of the skin and hair. Cosmetics, whitening ingredients, hair growth ingredients and / or
Also, the present invention relates to a whitening cosmetic and a hair cosmetic using a blood flow promoting component in combination.

[0002]

2. Description of the Related Art Human skin and hair have a moderate moisturizing property when they are in a healthy state and usually do not require special care. However, various environmental factors (for example, stress, ultraviolet rays, Inhalation contamination by gas or tobacco, change in temperature and humidity by an air conditioner, contact with chemicals, etc.) and physiological aging often cause problems.

[0003] That is, skin and hair that have lost their healthy state
It is dry and hard, loses its luster and elasticity, and exhibits symptoms such as slapstick and gowatsuki. In recent years, dry skin has been pointed out to be associated with atopic dermatitis, which has been rapidly increasing, and may cause various skin troubles. It is feared that such troubles as well as serious conditions such as hair loss may be caused.

[0004] Conventionally, in external preparations such as cosmetics to prevent drying and damage of skin and hair, ultraviolet protection agents such as ultraviolet absorbers or screening agents have been used, and glycerin, propylene glycol, 1,3-butylene glycol have been used. In addition to other polyhydric alcohols, moisturizing components such as oils and fats, amino acids, proteins, polysaccharides, and mucopolysaccharides are widely used.

[0005] These objects are to reduce the damage from ultraviolet rays, to form a film to prevent the evaporation of moisture, and to bring the skin and hair into close contact with the natural moisturizing factor (NMF), a stratum corneum component called NMF (Natural Moisturizing Factor). It was devised to improve the soundness of the building.

[0006]

However, ultraviolet absorbers and screening agents are only preventive measures, and safety problems have been pointed out. On the other hand, conventional moisturizing components are not yet satisfactory in terms of feel, durability, safety, and physicochemical stability. In particular, the moisturizing effect of the conventional component is temporary, and cannot be said to be a sufficient external preparation component in terms of maintaining and regenerating healthy skin or hair such as prevention or improvement of rough skin and split ends.

[0007] The present invention solves the above-mentioned problems and has a long-lasting moisturizing effect, is excellent in a protective effect and an inflammation-inhibiting effect, and further reduces the skin immunity caused by the living environment and physiological aging. It is an object of the present invention to provide an active ingredient and cosmetics which are superior to improve the skin and the hair and make the hair healthy.

That is, the skin is dry, rough,
Prevention of cracks, redtails, dandruff, Kayumi, inflammatory diseases,
It is effective for reducing or improving hair, preventing or improving dryness, pastsuki, split ends, and breakage of hair, imparting luster, improving hair styling properties, and reducing skin immunity caused by stress, ultraviolet rays, and the like. Active ingredients for improving skin and maintaining healthy condition of skin and hair and cosmetics using this,
Cosmetics such as toiletry products and detergents, as well as whitening ingredients,
By using a hair growth component and / or a blood flow promoting component together, a more effective whitening cosmetic and hair cosmetic are provided.

[0009]

According to the present invention, there is provided a water-soluble β-
The 1,3-glucan derivative is a low-molecular-weight oligomer obtained by hydrolyzing β-1,3-glucan to make it water-soluble,
Hydroxyethylation, hydroxypropylation, carboxymethylation, with respect to the hydroxy group (-OH) released on the molecule of 1,3-glucan or a low molecular oligomer thereof,
At least one of sulfate esterification and phosphate esterification
It is a compound in which a water-soluble functional group is introduced by employing more than one kind of chemical modification means.

The β-1,3-glucan contains β-1,3-linked glucopyranose as a main chain.
Β-1,6 or β-1,4 linked glucopyranose may be included as a side chain. For example, the cell wall of yeast (genus Saccharomyces), Alcaligenes faecalis v
Curdlan produced by microorganisms such as ar.myxogenes and Agrobacterium, and Euglena protozoa (Euglena gracili
s, Euglena gracilis var.bacillaris, Euglena viridi
β-1,3-glucan such as paramylon produced by s) can be used.

The low molecular oligomer of β-1,3-glucan has a glucose unit of 30 or less, preferably 20 or less. The average degree of substitution of the functional group in the compound derived from the water-soluble functional group is preferably about 0.1 to 5.0 (per glucose unit sugar). Considering this, about 0.2 to 3 are particularly suitable for use in external preparations such as cosmetics.

A compound having a water-soluble functional group introduced into β-1,3-glucan has an average degree of substitution of the functional group of 0.1 to 5.0 by analysis and a molecular weight of about 200,000 to 400,000. It is estimated that the compound has a molecular weight of about 3,000 to 5,000,000, but a compound having a molecular weight of 5,000 or more is particularly preferable in view of the functions of moisturizing, thickening effect, and film properties.

On the other hand, the yeast extract according to the present invention includes an extract obtained by simply using an aqueous solvent from yeast of the genus Saccharomyces, and an aqueous solvent from a digest obtained by autolyzing yeast. Extract obtained by using an aqueous solvent from the digest obtained by digesting yeast with a protease, using an aqueous solvent than the digest obtained by hydrolyzing yeast with an acid. The extract obtained by using can be used. The aqueous solvent used for extraction is water,
Ethanol, 1,3-butylene glycol, propylene glycol, glycerin, or any mixture thereof. The yeast extract can be used in any form of paste or powder from which the solvent has been removed, even if the extract contains a solvent. Components include various enzymes, proteins, RN
A, nucleosides, nucleic acid-related substances such as nucleotides,
Coenzymes, vitamin B1, vitamin B2, vitamin B6,
It contains components such as vitamins such as nicotinic acid and inositol, various amino acids, glutathione, lipids, and minerals.

The immunostimulant according to the present invention comprises powder, granules,
Any form such as gel, liquid, and emulsion can be provided. In that case, for example, excipients, binders, solvents, surfactants, preservatives, pH adjusters, stabilizers, discoloration inhibitors, oils and fats, and other additives required according to each form may be used. No problem.

The compound in which a water-soluble substituent has been introduced into β-1,3-glucan has a high gel-forming ability in an aqueous system and has poor fluidity in a concentration range exceeding 2% by weight. Therefore, when a liquid or emulsion formulation is prepared, it is desirable to adjust the concentration to a lower level.

As the solvent in the form of a liquid or emulsion, water or any mixture of water, ethanol, 1,3-butylene glycol and propylene glycol can be used. Preservatives such as alkyl esters can also be added.

The immunostimulant, cosmetic, whitening cosmetic or hair cosmetic according to the present invention contains a water-soluble β-1,3-glucan derivative and / or yeast extract as an essential component. Is preferably not less than 0.0001% by weight as a solid content. If the concentration is lower than this, the effect of the present invention may not be sufficiently exhibited. As for the upper limit, in the case of a liquid or emulsion form, usually up to 2% by weight is appropriate. In addition, when formulating in the form of a gel, a powder, a solid, or the like, a higher blending ratio is possible.

A whitening component (whitening agent or tyrosinase activity inhibitor) used in the whitening cosmetic or hair cosmetic according to the present invention.
In addition, the hair growth component and the blood flow promoting component refer to many active substances whose effects are already known in cosmetic applications, components extracted from plants or animals, active components utilizing microorganisms and biotechnology, and the like. . Among them, as an extractable component from a plant or animal, water, ethanol, propylene glycol, 1,3-butylene glycol, or any mixture thereof is used as a solvent with respect to the raw material, and the solvent is used at room temperature or in a solvent. An extract extracted at the boiling point temperature or a concentrate or dried product thereof can be suitably used. These are all commercially available as industrial products. For example, when the raw material is a plant, it can be easily extracted and manufactured. In addition, available parts are flowers, seeds, leaves,
In addition to using medicinal sites such as stems, roots, fruits, bark, or above-ground parts, whole plants may be used.

Representative whitening components include kojic acid, arbutin, ascorbic acid or a salt thereof, ascorbic acid phosphate or a magnesium salt thereof, ascorbic acid glucoside, ellagic acid, lucinol, human or bovine placenta extract, sodium lactate , Achillea millefol extract, Kawataya extract, Fujibama extract, Mulberry extract, Artemisia extract, Ogon extract, water-soluble silk protein decomposed product, Aloe extract, Bompi extract, Yukinoshita extract, Kumazasa extract, Licorice Extract components, N-acetyltyrosine or a salt thereof, glutathione, tannic acid, quercetin, fermented metabolites of lactic acid bacteria, and the like can be used.

The hair growth component and blood flow promoting component include capronium chloride, cepharanthin, nicotinamide,
Benzyl nicotinate, Vitamin E acetate, Pantothenyl alcohol, Biotin, Glyceride pentadecanoate, Hematin, Hypericum extract component, l-menthol, Minoxidil, Canthari tincture, Pepper tincture, Clara extract component, Assembly extract, Korean ginseng extract component Chicset ginseng extract component, buttonpig extract component, Japanese radish extract component, Calendula extract component,
Arnica extract components, hop extract components and the like can be used.

The whitening component, hair growth component or blood flow promoting component used in the present invention is desirably contained in the range of known or recommended effective concentrations of each component. 0.1 as single or mixed solids
It is desirable to contain it in a concentration range of 0001 to 10% by weight.

The cosmetics, whitening cosmetics, and hair cosmetics according to the present invention include 1) topical or systemic skin cleansing or skin cosmetics, and 2) medicinal and / or cosmetics applied to the scalp and hair. Formulations, 3) Bath agent to be thrown into bath water, 4) Deodorant / deodorant for human body, 5) Skin sticking sheet, cosmetic sheet, cosmetic cotton, sanitary goods, sanitary cotton, wet tissue 6) Household detergent, 7) Oral cleaner, etc., including ampules, capsules, powders (powder), granules, solids, solutions, gels (gels), air bubbles, emulsions, sheets, mist, sprays, etc. It can be in a form suitable for use.

Specifically, basic cosmetics such as lotions, emulsions, creams, ointments, gels, lotions, oils, packs, mist, etc., shaving agents, facial cleansing agents such as cleansing, skin cleansing agents, shampoos, Rinsing, hair treatment, hair styling, perm, hair tonic, hair dye,
Hair cosmetics such as hair growth and hair restoration, foundation, makeup cosmetics such as lipstick, blusher, eyeshadow, eyeliner, mascara, perfume, skin deodorant, antiperspirant, bath salt, tableware or kitchen Examples include mouthwashes such as detergents, dentifrices and mouthwashes.

In the immunostimulant, cosmetics, whitening cosmetics and hair cosmetics of the present invention, in addition to the above-mentioned essential components, if necessary, the following components and additives are optionally selected and blended. Can be.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )etc.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid And synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactants:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenyl alcohol, pantothenic acids, biotins, choline, inositols, vitamin C
Group: Vitamin C acid or derivative thereof, Vitamin D group: Ergocalciferol (Vitamin D2), Cholecalciferol (Vitamin D3), Dihydrotaxerol, Vitamin E group: Vitamin E or a derivative thereof, ubiquinones, Vitamin K group: Phytonadione (vitamin K1),
Menaquinone (vitamin K2), menadione (vitamin K
3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, compression, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

[0038] The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol) is used. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application,
Only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in any mixed solution with water, or may be extracted and extracted.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by aroma, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
Antiseptic and buffering effects can also be expected.

As specific plants (crude) as raw materials,
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akasho (Akasho), Akasuri `` Fruit '', Red clover, Red grape, Akaminoki (Logwood), Red acacia (Red bud), Akane (Akane grass root), Red acacia or Jio ( Ground yellow), Agi (Awei), Aki Larch, Akinire (Latinaceae),
Aguay Guacu, Aguahe (Omitengu palm),
Akebi (Kidori), Asa (John Asako), Malva Asagao or Asagao (Toshibushi), Hydrangea (hydrangea), Ashitaba (Ashitaba),
Azuki (red azuki), acerola, asenyaku (Asenyaku), acira (shokuyoukanna), anise, abiu, abiurana, rape, avemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), Amana (Kikomiko), Amaranthus (Amaranthus), Amaranthus hippochondriacus, Haribiyu, Amaranthus hippochondriax, Amigasa lily or Bimo (shellfish),
Aristolomeria (Yurizisen), Arcana (Alcanna), Algarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Souduq), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azusa), Yellow sapote , Ikakozorina (ground bile head), Epimedium or Epimedium
(Inyokaku), Igusa (Wicked grass), Knotweed (Tiger root),
Strawberry (first place), strawberry, fig (Fig.
Leaf)), Ichihatsu (first time), Ichibi (Fuyu aoi), Ichiyakuso (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimemegi (Enshi), Locust bean, Inu-zuna (Telelexi), Inubeyu (Sorainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwatsuchi-chi), iwahiba or iwamatsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (miyoko) ), Uguisukagura "fruit",
Himeuikyo, turmeric (Utsukin), duckweed (buoying), Usubasaishin or Keirinsaishin or Shousaisaishin (spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer dry grass), Udo or Shishiudo (Qangji, Independent, Tang Independent) ), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Urajirogashi, Uwaurushi (Kusakokomomo), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezogoka), Echinashi (Hosobamurasakikirengiku) , Enishida, Enokitake (Enokitake), Ebisugusa or Cassia Tora (Keiko), Elcampre, Elderberry `` fruit '', Elemi, Elingy or Prelotus elinge, Endu (Gossip, Sophoraceae rice), Ogi or Kibananagi (yellow) Hoki), Ousei (Naruko lily, Kagi Kurumabanarukoyuri), OuHisasa Yuki or Sasanoyuki, Coptis (Coptis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil engineering incense), giant Tsudzurafuji
(Self defense), psyllium (vegetative child, vegetative grass), toucan hazel (haruko), toucan cactus, pygmy plant or okera
(White jujube), giant leaf sedge (banaba), giant leaf beetle "fruit", giant squirrel (grain sperm), giant caterpillar, giant hawthorn or hawthorn (yamashiko), barley
(Barley), oka, okazeri (snake bed), okra `` fruit '', ogulma (turnover), panax ginseng or ginseng (carrot), hypericum or hypericum perforatum or perforated periwinkle (brother cut grass), dragonfly (continuous cut), onamimi (blue) Ears), Onigurimi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasayuri or Hakatayuri (Yuri), Ononis, Halibut
(Hihayu), Ominaeshi (defeated), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp", silkworm (ripened yellow) , Cocoa "fruit, peel,
Seeds '', oysters (persimmons `` leaves ''), kagi kazura (crop hooks), oysters or kantosou (rensensou), gaku hydrangea, cassia, casino ki (crocodile fruit `` fruits ''), gajutsu (shadotsutsu), Kashiwa
(Sakura tree, Sakhalin), Kascarilla, Kascara sagrada, Gypsophila, Kasensou, Kanixa (Kinosato), Kaniwa, Carnation, Kanokoso (Yoshikone), Birch or Shidare kamba (White birch), Gerbera, Pumpkin, Capoknoki `` Seeds '', Kahoku Sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Camellia japonica (weed), Camu cam (camouflage), color, Karaku Sakeman, Ragwort or Chinese Ragwort (Our melon), Ragwishak (midsummer), Ragwort, Guarana `` Seeds '', Karaho (thick), Karaya, Galu, Karin (Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Seiryuna, Hakubaku), Kawazusha, Kawatake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko ), Japanese carrot (Aoko), Japanese sagebrush (Inchinko), Kansui (Kansu), Licorice Kantarasa, Candelilla, Kanto, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Maple strawberry, European strawberry), Kiwi `` Fruits, leaves '', Kiwiasuuri (Uroro root), Kikyo (Kikyo, Kikyo root), Kiku (Kikyo) Chrysanthemum flower, oak daisies, daffodils, kikutani daisies, catalpa (Azumizumi), daisies (sheep-of-ears), pheasants (kokomi), kizuta, kidachi aloe, lucky mint, quina, linden (cincona, red linden), quinoa (quinoa), cinnamon (yellow) ), Gymnema Sylvester,
Kimimaku, cabbage, cabbage `` immature fruit '', cucumber, gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja saponaria, Kiraya, Kyransou (gold acne grass), Kumquat `` fruit '', Ginkai, Kimbusen, Kinma, Kinmizukiki
(Sengaku grass), guapeba vermelilla, guava `` fruit '', guayule, quelux infectria (gallicate), kukui nuts, wolfberry (glygi, gugiko, gugi leaf, skeletal bark), kusagi-kazura (tenmon winter), kuzu (kuzukane) ), Camphor tree, gooseberry `` fruit '', ginseng, yellowtail, gardenia, gardenia, blackberry,
Kupuas, Kumazasa, Kumatsuzura (horse whipweed), Clara (bitter butter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit / leaf", buckthorn, black stalk
(Rescue rescue), Kurobana Hikikoshi or Hikikoshi (extended life grass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), kaigai (infested, infested ears), celosia
(Cow flower, rooster), geccavidin, bay (laurel), kenashi sardine rose (Tsubukuryo, Yamakiko), gentiana, gennoshoko (Older's grass), kenponashi (Kigushi),
Koukisekoku, Kishumitsukan (Koji, Tachibana,
Olivenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana skin)), Koushinbara (Monthly flower), Kosuui mint, Kozo `` fruit '', Kocha (tea), Kohone
(River bone), kouhon (straw and kara straw), kouriang, kourikyo (takara kang), cilantro `` fruit '', koren
(Hou Lian), Scutellaria (Yellow Gon), Cowberry (Koshibachi), Coco Palm `` Fruit '', Goshuyu (Goshuyu), Goshostrawberry (Uboniko), Pepper (Hot Pepper), Cosmos, Copaiba Balsam,
Coffee `` seed, leaf '', kobushi or magnolia (hot spring), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame hahagusa (gensen), goji (gomiko), Sanekazura or binankazura or Matsubusa, wheat (wheat) , Rice or rice bran “red bran, white bran”, rice oil, cola acuminata “seed”, cola vera “seed”, colony llah, fenugreek “fruit”,
Colombo, Konzulango, Kombu, Konjac, Comfrey (Shinbari grass), Sisal (Sisal Asa), Sakisima button or Sinata button or Sinensensou (Eisensen), Sakura (Oshimashima cherry, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamazakura, Somei Yoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''),
Cherries, pomegranate, sasa, sasanqua, sagemodaka
(Sawashatsu), sweet potato, sugar cane, sugar beet, sapling jujube (acid jujube), saffron (safflower, west safflower), sapodilla, sapotea marillo, pomelo `` fruit '', savonso, salmon berry `` fruit '', sarasinachoma (masuma), Salvia (sage), Sawagyoukyo (Yamakosai), Sawagumi (Yamawomo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin carrot
(37 ginseng), sanshuyu (sanshuyu), sansho (sansho),
Sandscon (Yamazone), Shea (Karite), Cyanoki `` fruit '', Shiitake (Shiitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenjiso or Kamenjiso (Shiso leaf, Shiso), Rosewood, linden,
Chinese pine, Chinese forsythia (forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiiroshimeji,
Bunashimeji, honjimeshi, shirotamogitake), shimokuren (hot spring), shimotsukeisou, potato, peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat gate winter), shukukonemisou, shukushamitsu (sunin, Shredded sand), jujudama, palm `` fruit '', ginger (ginger), giant hydrangea (Tsuneyama), shobu (iris, iris root), shojiku `` fruit '', shirakashi `` seed '',
White butterfly (seed), white clover (clover), white adzuki (chicken bone grass), white iris (small iris), white natto (flower), white nanten (minamitenmi),
Cinchona Sacrifura, Jinjuge (Mizuka, Mizuka,
Cinnamon), cinnamon, cinnamomum cassia (cinnamon bark), watermelon (watermelon), honeysuckle (gold and silver flowers, shinto winter), sorrel (acid model), swimberry "fruit", star apple, stevia, strawberry "fruit", tin shiko ,
Horsetail (Thorn), Purslane (Horse Tongue, Horse Tongue), Plum (Fruit), Pinus sylvestris (Cones), Larix sylvestris, European Lentils, European Walnut, European Hawthorn, European Dandelion, European Chestnut (Marronnier), Pear "fruit", snow pear,
Sambucus elder (Elder), Atlantic shrew (Juniper, Juniper), Achillea millefolium (Mirfoil), Atlantic rose, Aurora magnolia, Atlantic mistletoe, Western mackerel or Western mackerel, Western horseradish, Sekisho (stone irises) Cedron (Bowshukuboku), Zeniaoi, Hirohasenega, Senega, Seri, Celery, Senkyu (River Kyu), Senshinren (Shingenren), Sendan, Sennin Cactus, Senna `` Fruits, Leaves '', Senninsou (Otatate), Senbri ), Souka (grass), elephant, rosacea, buckwheat `` seed seed '', soybean potato, rhubarb (daisou), radish, soybean, daidai (orange skin, kikomi), takasaburo (dry lotus grass), takatodai (daigo), takawarabi (Inu), Dark Sweet Cherry "Fruit", Tachioi, Tachiji High-rise (time,
(Marika), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', onion, tamshiba (spicy), Taranoki `` fruit, leaf, root bark '', dahlia (tenjikubotan), tarwi,
Tanshiniwa, Tanjin (Dan ginseng), Dandelion (Gankoei) or Shirobana dandelion or Moko dandelion, Danmar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', Chixet carrot (Bamboo ginseng), Chicory, Chancapiedra (Kidachiko Mikansou) , Datura (Rhuanghuang), Datura elm (Wuyi), Datura mugwort (Aiba), Choreimaitake (Irei), Chorogi, Tsukimisou, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer primrose), Camellia Ducklings), Tsuruazuki (red azuki bean), Tsurukudami
(Hanshu crow), Tsuruna (Ban apricot), Crucian carrot (Four leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tulip, Chocolate stay, Tengusa, Tencha (Tencha), Tendaiyaku (Wood medicine), Touga (Winter ginger) ), Squash, capsicum (pepper), squid (return), calendula (marigold), tonabena (river cut), corn or corn hair (southern hair), horned beetle (female child), torindo or kosen Gentian,
Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), sashimi or mamedaoshi or scutellaria, eucommia (mushroom `` bark, leaves, roots ''), ash (qin bark), tomato, tragacanth, triacanthos `` seed '', Turkey Kikyo, Tormentilla, Dronoki, Troloa oy, Niseria berry "fruit", Chinese yam or Yamanoimo (Yamayaku),
(Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsume Bean or Hatehaki (Sword Bean), Natsumikan, Jujube (Daijutsu), Naniwaibara (Kanakurako), Navena (intermittent), Nameko, Narco Lily (Yoshimi), Peanut (Peanut) ), Nanten (Minami Tenmi), Namban Karamushi (ramie), Niois violet,
Nigaki (bitter tree), bitter mugwort (bitter mite), nutmeg, kei or nikkei or ceylon nikkei or yabnikkei (cinnamon bark)
Or Keishi (Keishi), Chinese chive (Nirako), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (fivefold child), leek, nemoki or neb or nebi or nemlinoki or zigokubana ( Healing), thistle (daiji), noibara (real fruit), nozuka quail (ryohana), nogateto, yarrow, nodoke (maehu), nobara, peach, pineapple `` fruit '', hibiscus (bussouge, hurinbussouge, roselle), hayindow, Hauchiwa, Pau Doce, Hakamauraboshi (bone crushing), Hakusen (ringworm skin), Huckleberry `` Fruit '', Hakobe (proliferation), Hashibami (Haruko),
Hasiridokoro (rotor root), basil, lotus (lotus, lotus, lotus root), parsley (Netherland jelly), naked mussels, batata, bees, or Madake (bamboo-boiled), patchouli, mint (light-weight, light-weight leaves), adlay (yokunin) , Hanasuge (Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Scotch (Rice koji), Pahalobobo, Hub `` Whole grass, stem, leaf '', Paprika, Hamago or Hitsuba Hamago Child), Hamasuge (Kazuke), Hamabishi
(Ritsuko Riko), Hamanas (maikai flower), Hamabofu (beach storm), Hamamelis, palm, rose (rose), valata,
Balata rubber tree, agaric mushroom (aratake mushroom) Bamboo tree, breadfruit, giant gourd (radish), lycopodium carrot (party), pecan nut, giganbana (garland, vinegar), higuru madaria, haishi (hishomi), pistachio, beet, hitoshiba (stone reed), Aedes aegypti, daisies (daisy), hinata nokozuchi (cow knees), hinoki, hiba, castor, sunflower,
Bell pepper, Himeuzu (Tamaoi), Himegama (Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Biancucuum, Hyacinth `` Fruit '', Belowudo Oi, Hiroha Okinagusa (Hakuto Okina), Loquat `` Fruit,
Leaves, stems ”, betel nut (large clothing skin, betel nut), puer tea (
? Tea), spruce buds (southern rattan), butterflies, coltsfoot dandelions (winter flowers, winter leaves), fujibakama (orchid grass), wisteria beans (flat beans),
Fujimodoki (choujizakura, shikahana), grapes `` fruit, peel, seeds, leaves '', beech, fuyumushinatsukutake (Cordyceps sinensis), Brazilian liquorice, Brazilian carrots, black currant `` fruits '', blackberries, blanin,
Plum `` fruit '', flucellaria, blueberry (Acacia catechu), prune, floral blanka, blond psyllium, bundou (green bean), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '', Percea, Perbianberg, Pereskia
Grandifolia, Bensui beetle or duckweed (Keiten), Boysenberry `` fruit '', Broomweed or Elderweed or Nendow or Hawakigi kokia (dermis), Baldwink (Hosen, acute child, osteophyte), Potteria sapota, potteria Lucuma, spinach, boufu (windbreak), spinach, physalis (Torone), honoki (Japanese magnolia, park), bokeh
(Gourd melon), Hosoba aburagiku (bitter gourd), Hosoba oguruma,
Hosovanaokera (Aojutsu), Hosobanokirinsou (Kageten 37), Hosobabarengiku, Bodaiju (Bodaiju), Button
(Peony `` flowers, leaves, stems, bark ''), buttonpies (peony bark), hops, jojoba, borage (ruriichisha), bordeaux, white berries `` fruits '', hon-onik (meat porcelain, daigei), hon-sekko (iron Peeling stones, sparrow mountain stones), myzuruten nansha (Tennan star), maitake (maitake), ephedra (mao), maca, macadamia nuts, margaret (mokushungiku), macri (seaman grass), maguwa (mulberry white bark) `` Bark, leaves ''), Magnolia splengeri, Masaranpouba, Masaranzuba do Ceara, Masheira de Boi, Masahua (Tamanouzenhallen, Cucumber kinrenka), Matatabi (Kiten Tate), Matsukasa, pine `` leaves, bark, Root, Matta Oryo, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanojazine (Bittersweet), Mulberry "Fruit", Quince, Murray (Below mou watermelon), mango, mangosteen, mansagna (andesukamitsure), mansugurumi, mandarin `` fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mizunyanagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobalan, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, Purple (purple root), Purple or purple
(Purple pearl), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, mehajiki (mother grass), mebougi, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), mock berry (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherry `` fruits '', Moroheiya (Burlap), yakawamurasaki potato, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabushi `` fruit,
`` Peel, ears '', willows, yatsude (octagonal gilded), mistletoe (parasitic willow), willows (kawayanagi, tachiyanagi, weeping willow, red willow, pussy willow, dogwood willow,
(Sweet willow, koreanagi, unryuyanagi, yamayamayanagi, palm, yamayanagi, giant psyllium, tyrichkinuyanagi, foxwillow, bonsai), willow `` leaf,
Stalk '', scabbard, savannah koji (purple beef), savory tobacco
(Tsurusu, Tenmei), pokeweed (commercial land), yamanoki (yamaharu), yamamomo (yangbai skin), sagebrush, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, yorigusa , Mugwort (Aiba), reigan (Rainuma), lime "fruit", rye, lakanka "fruit",
Raspberry `` leaves, fruits '', latania (Clameria), Rakkyo or shallots (Shiroi), lavender, longan (longan meat), agave (Aono agave,
Fukurin agave), Ryokucha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', Red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, wax bye, wax palm,
Lokon (reeds and radishes), Loganberry "fruit", rosemary (mannan wax), rose hips (nobara), wasabi, cottonweed cypress (mitsumenbana), waremoko (jimyu) and the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaa nori, Susiaonori, Hiraaonori, Bowa nori, Hosoedao aonori), Anaausa algae [Aosa algae] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Junyashinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas spp .: Chlamydomonas spp., Akayukimo, Dunaliella spp .: Dunaliella spp. Spirogyra: Hizaori, Spirogyra, Tsurugimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Blue-green algae (Genus Lynchium: L., L., L., L .;
(Hassay, genus genus, genus racenmo (spirulina): spirulina, genus trichodesmium (aiakacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike, Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabo kintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Scutellariae, Osmanthus Nagaobabane: Nagaobabane,
Genus Funori: Hanafunori, Fukurofunori, Makunori, Kalexigusa: Kalexigusa, Sasamodoki: Hosobanotosakamaki, Hirohanokasakamuki, Yatsudegatatasakamoki, Kurosakamaki, Nezashinosakamukado, Yukasakanookado Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenija, honooo genus: honoo, genus genus: lyca genus, genus genus, genus nikonobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Asterina: Acacia serrata, Fushikrenori genus: Fushikrenori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Simi genus: Itanisa, Simi, Harigane, Lotus japonicus
Lotus spiders, genus genus: Ikanoashi, Hosoibonori,
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishbukuro, Madaragusa: Togemadara, Echimadara, Taoyagousou: Genus Ottawa, Scrophularia , Hirata goat: Hirata goat, Dulce: Dars, Masagoshibari, Anadalus, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushinagi: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragons: Snapdragons, Snapdragons, Species: igis, keiigis, crickets, nigiri, amixa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usbeni: Usveni, Hasuginu: Hasuginu, Nagakonohanori: Nagakosugino, Genus: suginanu Yareusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia genus: Enashidazia, Simadadia genus: Isohagi, Shimadada, Dazimodoki genus: Daziomomodoki, Itogusa genus: Moletogusa, Futoigusa, Macri genus: Macri, Yanaginori genus: Hanayanagi, Yuna, Sanaginori, Mosanyugina, Sasa, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshig, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawwort: Genus Hakezakinokawa, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

The axle algae (Charus spider, Shiratamamo,
Hossiturimo: Hossiturimo, Lichnotumnus, Flassula: Himegrass, Chaboflas, Tripella, etc., Yellow algae (Hikarimo: Hikarimo, etc.) and the like.

Materials derived from animal-based raw materials include cockscomb extracts, bovine or human placenta extracts, swine or bovine stomachs, duodenum or intestinal extracts or their degradation products, and swine or bovine spleen extracts. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products and trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigment: anhydrous silicic acid, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonic acid salt, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid Derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate,
Methyl salicylate), anthranilic acid derivatives (methyl anthranilate), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin Guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative (alkylsalicylic acid, alkylsalicylic acid ester, alkoxysalicylic acid, etc.), anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative,
Tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin C or a derivative thereof (vitamin C phosphate ester magnesium salt, vitamin C glucoside, etc.) , Vitamin E or a derivative thereof, kojic acid or a derivative thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol and the like.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Its derivatives, N-acetyl tyrosine or its derivatives, glutathione, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, water-soluble hydrolyzed silk, quercetin, tannin, plant extracts (chamomile, mulberry, corn,
Waremokou, Clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay, hydrangea, hops,
Hawthorn, Eucalyptus, Achillea millefolium, Altea, Cahi, Mankeishi, Hamamerisu, Yamaguwa, Life-extended grass, Bellflower, Toshishi, Zizuko, Sun-dried, Mao, Senkyu,
Dokkatsu, Psycho, Bofu, Hamabofu, Ogon, Peony, Peony, Gennoshoko, Kakkon, Licorice, Gotobiko, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku), etc.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(21) Promoting action of turnover / cell activator hydroquinone, lactic acid bacteria extract, placenta extract of human or cow, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk Extracts, plant extracts (aloe, ogon, horsetail, gentian, burdock, sicon, carrot, hamamelis, hops,
(Yokinin, edulis, assemblage, touki, balsam pear, amacha, hypericum, cucumber, tadpole, rosemary, parsley) and the like.

(22) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) etc.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis extract, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emisoso, Birch, Salvia, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea) and the like.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, sicon extract, age extract, propolis and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.),
Cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine,
Brilliant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis, etc. .

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Bacillus natto extract, Loofah water, Birch (birch) or Akamatsu sap

(29) Inhibitors of elastase activity diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, salvia, elderberry, bollige, buttonpi), seaweed extracts and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Stimulants Pepper tincture, vanillamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placental extract, biotin, glyceride pentadecanoate, and the like.

(35) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(38) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like;

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonic acid sodium salt, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

(43) Marine components Seawater, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) ), Such as Italian Fango, German Fango,
Sea mud or mud from various places such as Eifelfango, Freiburgfango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium , Magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Shotoku stone etc.

(44) Others Moisturizing agents, hormones, sequestering agents, pH adjusters,
Chelating agents, preservatives / antibiotics, cooling agents, stabilizers, emulsifiers, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products, animal / vegetable glycoproteins and their degradation products, Blood flow enhancers, anti-inflammatory agents / anti-allergic agents, cell activators, keratolytic agents, wound treatment agents, foam enhancers, thickeners, deodorants
Deodorizers, bittering agents, enzymes and the like are raised, and when used in combination therewith, various additive and synergistic effects can be expected.

[0079]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these.

[0080]

EXAMPLES [Production Example 1] 15 g of β-1,3-glucan derived from yeast cell wall was prepared as 10 M
Disperse in phosphate buffer solution (pH = 7) and add enzyme (β
-1,3 glucanase) at 37 ° C. and 48 mg.
After performing the hydrolysis reaction for a period of time, the temperature was raised to 80 ° C. and maintained for 20 minutes to inactivate the enzyme, filtered, and dried under reduced pressure to obtain β-1,
3-glucan low molecular oligomer (average molecular weight of about 3,50
0) 12 g were obtained.

[0081]

[Production Example 2] Hydroxyalkylated β-1,
3-glucan Paramylon 15g in 40% sodium hydroxide aqueous solution 20
0 mL and 40 mL of t-butyl alcohol were added, and 500 g of crushed ice was gradually added thereto with stirring to obtain a solution. While keeping this at 0-5 ° C in an ice bath,
2-3 alkylene oxides (about 35-55 g for ethylene oxide, about 4 g for propylene oxide)
(Equivalent to 5 to 70 g) was added gradually, and the mixture was reacted for 3 to 5 hours. After stirring at room temperature to 50 ° C. for about 5 to 15 hours, the mixture was filtered, and the filtrate was transferred to a dialysis membrane and dialyzed for about 1 to 3 days. Then, it was freeze-dried to obtain about 14 g of a water-soluble hydroxyalkylated β-1,3-glucan (substitution degree: about 0.52 / unit sugar).

[0082]

Example Production Example 3 Carboxymethylated β-1,3
-Glucan Paramylon 15g in 40% sodium hydroxide aqueous solution 20
0 mL and 40 mL of isopropyl alcohol were added, and 500 g of crushed ice was gradually added thereto with stirring to obtain a solution. While maintaining this at 0 to 5 ° C. in an ice bath, a sodium monochloroacetate (equivalent to 120 to 150 g) solution was gradually added, and the mixture was reacted for 3 to 5 hours. Further room temperature ~
After stirring at 50 ° C. for about 5 to 15 hours, the mixture was filtered, and the filtrate was transferred to a dialysis membrane and dialyzed for 2 days. This was then lyophilized to give a water-soluble hydroxyalkylated β-1,3-
Glucan about 15g (degree of substitution about 0.44 / unit sugar)
I got

[0083]

[Production Example 4] 10 g of sulfated β-1,3-glucan curdlan was added to N, N-dimethylformamide 80
of sulfur trioxide-N, N-dimethylformamide complex 80-1.
After gradually adding 00 g, the mixture was stirred for about 3 to 5 hours while naturally warming to room temperature. Next, this was neutralized with a dilute aqueous sodium hydroxide solution, filtered, and the filtrate was dialyzed with a dialysis membrane for 2 to 3 days, and this was freeze-dried to obtain a water-soluble sulfated β-1,3-glucan. About 9 g (degree of substitution about 0.3
8 / unit sugar).

[0084]

[Production Example 5] Phosphorylated β-1,3-glucan 10 g of β-1,3-glucan derived from yeast cell wall was added to 70 mL of methanesulfonic acid, and phosphorus pentoxide 20 to 3 was added thereto.
Add 0 g slowly and stir at 0-5 ° C for about 3 hours. Next, the mixture is allowed to stand at -15 to -20 ° C for about 10 hours, and ether is added thereto to cause precipitation. The product is thoroughly washed with ether, dissolved in deionized water and dialyzed. Then, this is freeze-dried to give a water-soluble phosphorylated β-
About 9 g of 1,3-glucan (degree of substitution: about 1.2 / unit sugar) was obtained.

[0085]

[Production Example 6] Yeast extract-1 500 g of yeast cells were suspended in 10 L of a 20% ethanol solution and thoroughly homogenized with a homomixer.
Centrifugation and filtration yielded a solution containing the yeast extract.

[0086]

[Production Example 7] Yeast extract-2 500 g of yeast cells were suspended in 10 L of purified water.
Allow to digest for 8 hours. Then, this is freeze-dried or concentrated under reduced pressure, 10 L of a 30% 1,3-butylene glycol solution is added thereto, and the mixture is sufficiently stirred and extracted. Filtration yielded a solution containing the yeast extract.

[0087]

[Example] [Production Example 8] Extract component of Achillea millefolium Achillea millefolium Linne (C
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof, or ethanol solution containing 1% urea, 1,3-butylene containing 1% urea A glycol solution was added, immersed and extracted at room temperature to 60 ° C., and filtered to obtain an extract component of Achillea millefolium containing tannin.

[0088]

[Example] [Production Example 9] Extract component of Artemisia capillaris Thunb. (Composite)
ae)) water, ethanol, propylene glycol, 1,3-butylene glycol or an arbitrary mixture thereof is added to the head flower or the above-ground part or the whole plant, extracted at normal temperature to 60 ° C., and filtered to remove flavonoids. An extract component of the Japanese sagebrush was obtained.

[0089]

[Example] [Production Example 10] Extract of Fujibakama (Eupatorium fortunei Turcz. (Composita
e)) Water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the foliage, above-ground part or whole plant of e)), extracted at room temperature to 60 ° C., filtered, and filtered to extract Fujibakama I got

[0090]

[Production Example 11] Mulberry extract component Mulberry (Morus alba Linne) or other congener plant (Morac)
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the root bark or leaves of eae), extracted at room temperature to 60 ° C., filtered, and contains triterpenoids and flavonoids A mulberry extract was obtained.

[0091]

[Production Example 12] Artemisia princeps Pampanini (Composita
e)), Artemisia mongolia Fischer (Com
positae)) or Artemisia montanaPampa
nini (Compositae)) leaves or whole plants with water, ethanol,
Propylene glycol, 1,3-butylene glycol or any mixture thereof is added, and extracted at room temperature to 60 ° C.,
Filtration yielded a mugwort extract containing a coumarin derivative and a flavonoid.

[0092]

[Example 13] [Production Example 13] Japanese gourd extract component Scutellaria baicalensis Georgi (Labiata
e)) Water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the roots or roots excluding the pericytes, and the mixture is extracted at room temperature to 60 ° C., filtered, and baicalin or A gougin extract component containing baicalein, gougonin and tannin was obtained.

[0093]

[Production Example 14] Aloe extract component Aloe ferox Miller or Aloe africana Miller
Or hybrid with Aloe spicata Baker (Liliaceae), or Al
oe barbadensis Miller (Aloe vera Linne), or Aloe arborescens Miller and its variants (Lilia
ceae) Leaf or leaf sap is added with water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof, extracted at room temperature to 60 ° C., and filtered to obtain an aloe extract. .

[0094]

[Example] [Production Example 15] Extract of buttoned peas (Paeonia suffruticosa Andrews (Paeonia mouta)
n Sims) (Paeoniaceae)), add water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof, extract at room temperature to 60 ° C, and filter to remove paeonol and paeoniflorin. A contained peanut extract component was obtained.

[0095]

[Example] [Preparation Example 16] Saxifrage stolonifera Meerburg (Saxifra)
gaceae)), water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the foliage or whole plant, extracted at room temperature to 60 ° C., and filtered to extract Saxifrage containing tannin. The components were obtained.

[0096]

[Production Example 17] Extract of Kumazasa Extract from water, ethanol, propylene glycol, 1,3-butylene glycol, or an arbitrary mixture thereof is added to leaves of Kumazasa (Sasa veitchii (Carr.) Rehd. (Gramineae)). Then, the mixture was extracted at room temperature to 60 ° C. and filtered to obtain a Kumazasa extract component containing a terpenoid.

[0097]

[Production Example 18] Licorice extract component Licorice (Glycyrrhiza glabra Linne or Glycyrrhiza ur)
alensis Fisher (Leguminosae)) or other congeneric plants (Le
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the roots or rhizomes of guminosae), extracted at room temperature to 60 ° C, filtered, and glycyrrhizic acid or a salt thereof, flavonoid. A contained licorice extract component was obtained.

[0098]

Example Production Example 19 Hypericum extract component Hypericum perforatum (Hypericum perforatum Linne (G
uttiferae)) or Hypericum (Hypericum erectum Th)
unberg (Guttiferae)) or water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the above-ground part or whole plant, extracted at normal temperature to 60 ° C., filtered, and flavonoid, tannin The extract component of Hypericum perforated was obtained.

[0099]

[Production Example 20] Clara extract component Clara (Sophora flavescens Aiton (Leguminosae)) without root or its perimeter, or whole plant with water, ethanol, propylene glycol, 1,3-butylene glycol or An arbitrary mixture of these was added, extracted at room temperature to 60 ° C., and filtered to obtain a flavonoid-containing Clara extract.

[0100]

[Example] [Production Example 21] Assembly extract component Assembly (Swertia japonica Makino (Gentianaceae))
Water, ethanol, propylene glycol, 1,3-butylene glycol or an arbitrary mixture thereof is added to the foliage or whole plant of the plant, extracted at room temperature to 60 ° C., filtered, and filtered to obtain a component extract of swertiamarin. I got

[0101]

[Example] [Production Example 22] Korean carrot extract component Korean carrot (Panax ginseng CAMeyer (Panax schins)
eng Nees) (Araliaceae)), add water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof, extract at room temperature to 60 ° C, filter, and saponin-containing Korean A carrot extract was obtained.

[0102]

[Example] [Production Example 23] Extract of ginseng carrot ginseng (Panax japonicus CAMeyer (Aralia)
water, ethanol, propylene glycol, 1,3-butylene glycol or an arbitrary mixture thereof is added to the rhizome of ceae), extracted at room temperature to 60 ° C., filtered, and filtered to obtain a saponin-containing extract of ginseng. I got

[0103]

[Example] [Production Example 24] Ingredients extracted from the Japanese radish, Isodon japonicus Hara (Amethystamtus ja
ponicus Nakai, Plectranthus japonicus (Burm.) Koidz
(Labiatae)) or black clover (Isodon trich)
ocarpus Kudo (Plectranthus trichocarpus Maxim.) (Lab
iatae)), water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the foliage or aerial part of iatae), extracted at room temperature to 60 ° C, filtered, and contains emmain and tannin An extract of the extract of radish was obtained.

[0104]

[Production Example 25] Calendula officinalis Linne (Compos
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the head flower or foliage or whole plant of itae), extracted at room temperature to 60 ° C., and filtered to remove saponins and flavonoids. A contained calendula extract component was obtained.

[0105]

[Production Example 26] Extract of Arnica Water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to Arnica (Arnica montana Linne (Compositae)) flowers, foliage or whole plant. Then, the mixture was extracted at room temperature to 60 ° C., and filtered to obtain an extract of Arnica containing flavonoid and saponin.

[0106]

[Production Example 27] Hop Extraction Components Water, ethanol, propylene glycol,
Add 1,3-butylene glycol or any mixture thereof, extract at room temperature to 60 ° C., filter and filter flavonoids,
A hop extract component containing tannin was obtained.

[0107]

[Examples] Safety test (1) Skin primary irritation test For the water-soluble β-1,3-glucan derivative obtained in Production Examples 1 to 5, its aqueous solution (solid content concentration: 2.0%) was adjusted, The yeast extract-containing solution obtained in Production Examples 6 and 7 was used as a sample as it was, and attached to the skin of a Hartley-type guinea pig (female, 5 per group, weighing about 320 g) whose hair was removed from the back. The determination was made 24 hours after application using the primary irritancy scoring method with erythema and edema as indices. As a result, in all animals, erythema and edema were not recognized, and the determination was negative.

[0108]

[Examples] Safety test (2) Skin cumulative irritation test Using the same sample as in the skin primary irritation test, the skin of a Hartley-type guinea pig (female, 5 per group, body weight of about 320 g) with hair removed from the flank was used. Once a day, five times a week,
0.5 mL / animal was applied. Application was performed over 4 weeks and hair removal was performed on the last application day of each week. The judgment is
Erythema and edema were used as indices by the primary irritation scoring the day after the last day of each week. As a result, in all animals, no erythema and edema were observed for 1 to 4 weeks after application, and the animals were determined to be negative.

[0109]

[Examples] Effect on skin immunity decline by ultraviolet rays (Test method) Dehaired mice (10-week-old CH3 / HeN, 8 mice per group)
Irradiate UV (UV-B lamp) on back (50mJ / c)
m ² ), and immediately thereafter, the sample ointment was applied to the irradiated site.
The sample ointment was applied to the same site the next day and the next two days (total of three times), and 6 hours after the final sample application, the sample was applied to the back of the mouse at 0.
25% 2% dinitrofluorobenzene (DNFB) solution
L was applied and sensitized. The challenge was carried out 7 days after sensitization by applying 20 μL of a 0.2% DNFB solution to one ear of the mouse. 24 hours after the induction, the left and right auricles were cut out with a punch (about 5 mm in diameter), the weight was measured, and the difference was defined as the auricular edema value.

(Sample Ointment) The following sample obtained according to the production example was adjusted to an aqueous solution having a solid content of 0.01%, and mixed with a hydrophilic ointment (Japanese Pharmacopoeia) in an amount of 10%. β-1,3-glucan low molecular oligomer (Production Example 1) hydroxypropylated β-1,3-glucan (Production Example 2) carboxymethylated β-1,3-glucan (Production Example 3) sulfated β-1 , 3-Glucan (Production Example 4) Phosphorylated β-1,3-glucan (Production Example 5) Yeast extract-1 (Production Example 6) Yeast extract-2 (Production Example 7)

(Results) As shown in FIG. The non-irradiated value is regarded as the immune response of a normal mouse, and the immune response is reduced to a control value by irradiating ultraviolet rays. It was confirmed that the application of the sample significantly strengthened the immune function and improved the homeostatic balance.

[0112]

Example: Effect on skin immunity decline due to overcrowding stress (Test method) Ten mice (10-week-old CH3 / HeN) in one cage (relative ratio W: D: H = 1.0: 1.0: 1) .
Rearing for 3 weeks at 0). After a lapse of 3 weeks, the cages (relative ratio W: D: H = 0.5: 0.5: 1.0) are replaced and the mice are placed in overcrowded conditions and stress is applied. A sample ointment was applied to the irradiated site. The sample ointment was applied to the same site the next day and the next two days (a total of three times). Six hours after the application of the final sample, 0.2% dinitrofluorobenzene (DNF) was applied to the back of the mouse.
B) 25 μL of the solution was applied and sensitized. In addition, sensitization 7
One day later, 20 μL of a 0.2% DNFB solution
L was applied. 24 hours after the induction, the left and right pinna were cut out with a punch (about 5 mm in diameter), the weight was measured, and the difference was defined as the pinna edema value. The sample ointment used was the same as that used in the previous test.

(Results) As shown in FIG. The untreated value is usually taken as the immune response of the mouse, and the immune response is reduced to a control value by applying stress due to the overcrowded environment. It was confirmed that the application of the sample significantly strengthened the immune function and improved the homeostatic balance.

[0114]

Example: Skin protection (alleviation of irritation, prevention of rough skin) An equal amount of sodium lauryl sulfate (SDS) adjusted to 1% (w / v) with purified water and a sample solution are mixed, and a bandage for patch test (trade name) : Patch tester, made by Torii)
0 μL is dropped, and an obstruction patch is applied to the inside of the left upper arm of the volunteer. After 8 hours, remove the bandage and after another hour,
The index of erythema was evaluated by the primary irritation evaluation method.

(Sample Solution) The following sample obtained according to the production example was adjusted to a 0.05% aqueous solution and used. β-1,3-glucan low molecular oligomer (Production Example 1) hydroxypropylated β-1,3-glucan (Production Example 2) carboxymethylated β-1,3-glucan (Production Example 3) sulfated β-1 , 3-Glucan (Production Example 4) Phosphorylated β-1,3-glucan (Production Example 5) Yeast extract-1 (Production Example 6) Yeast extract-2 (Production Example 7) Purified water only (control)

(Results) As shown in Table 1. Each of the volunteers showed lower irritation than the control (purified water).
From this, it was considered that the immunostimulant according to the present invention has an effect of reducing irritation caused by lauryl sulfate, protecting the skin, and preventing skin roughness.

[0117]

[Table 1]

[0118]

EXAMPLES Moisturizing Effect In order to evaluate the moisturizing effect of the immunostimulant according to the present invention, the change over time in the transepidermal water loss by volunteers (7) was measured.

(Sample Solution) The following sample obtained according to the production example was adjusted to a 0.001% solid content aqueous solution and used. β-1,3-glucan low molecular oligomer (Production Example 1) hydroxypropylated β-1,3-glucan (Production Example 2) carboxymethylated β-1,3-glucan (Production Example 3) sulfated β-1 , 3-Glucan (Production Example 4) Phosphorylated β-1,3-glucan (Production Example 5) Yeast extract-1 (Production Example 6) Yeast extract-2 (Production Example 7) Purified water only (control)

(Measurement device) TEWAMETER TM210; COURAGE + KHA
Made by ZAKA Electronic Gmbh

(Method) A sample solution (1 mL) is applied to the left and right forearms flexion side of volunteers three times a day. After the third application, after stabilizing for 1 hour in a thermo-hygrostat (24 ° C., 50% RH), measurement of transepidermal water loss is started. Measurement is 2
Measure at 3 minute intervals for 2 minutes, and calculate the average of all values as T
Let it be an EWL value. The blank was measured under the same conditions before sample application.

(Results) As shown in Table 2. It has been found that the immunopotentiator according to the present invention suppresses transepidermal water evaporation and has a good moisturizing action. According to the volunteers, it was reported that the skin had a good feeling when applied to the skin, had an uncomfortable feeling of film, and maintained a moisturizing effect.

[0123]

[Table 2]

[0124]

EXAMPLES Effect of Combination with Whitening Component Samples shown in Tables 3 and 4 were used to examine whether the immunostimulant of the present invention, when used in combination with a whitening cosmetic containing a known whitening component, would affect the cosmetic effect. The cream was prepared and a volunteer use test was attempted.

20 healthy male and female volunteers were set as subjects, and the inner diameter of the left and right forearms was 1.2c.
After attaching a path with 8 circular holes (4 holes-2 rows), a UV lamp (Toshiba UV FL manufactured by Toshiba)
20-SE) 15.2 mJ / cm ² once a day, 2 times
Irradiated for days. After applying the creams 1 to 7 and the comparatives 1 to 7 to the respective circular irradiation portions of the volunteers in an appropriate amount twice a day, which satisfies the sunburn marks, twice a day for 4 weeks, the whitening effect was visually determined. In addition, as a control treatment, one of the sunburn marks was only the base cream (containing no immunostimulating agent and whitening component), and the other was untreated (leave).

[0126]

[Table 3]

[0127]

[Table 4]

Table 5 shows the results. By combining the cream containing a known whitening component with the immunostimulant according to the present invention, the result that the whitening effect was improved was obtained.

[0129]

[Table 5]

[0130]

EXAMPLES Effect of Combination with Hair Restorative Ingredients In order to examine whether the immunostimulant of the present invention, when used in combination with a hair cosmetic containing a known hair restoring ingredient, would affect the hair restoring effect, the sample hairs in Tables 6 and 7 were used. The tonic was adjusted, and a hair growth test using mice was attempted.

[0131]

[Table 6]

[0132]

[Table 7]

Approximately 8 cm ^{2 of} C3H mouse back (length 2 cm,
(4 cm in width) was depilated with an electric clipper and an electric shaver. Next, a sample hair tonic is placed on the back with hair removed once a day.
Approximately 0.2 mL was applied 5 times a week for 20 days (the test animals were 8 per group, the back was divided into the left side and the right side, and the sample hair tonic and its control hair tonic were applied, respectively). On the 12th and 20th days after application, the area ratio (%) at which hair regeneration was observed with respect to the depilated area was measured using an image analyzer on the 12th and 20th days, and compared with the control group. The results are shown in FIG. "Test method by Ogawa et al. (Fragrance Journal,
Vol.17, No.5, pp.20-29 (1989))

As experimental animals, 8-week-old male C3H mice were used. These animals are at room temperature 20-24 ° C, humidity 35-65%,
All freshly ventilated 15 times / hour, lighted for 9 hours / day. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

As shown in FIG. 3, the immunostimulator according to the present invention comprises:
It has been found that a more remarkable hair-growth effect appears when used in combination with a hair-growth component.

[0136]

EXAMPLES Production of Various Formulations Various cosmetic compositions according to the present invention were produced. The formulation examples are shown below, but the invention is not limited thereto.

1) Production Example of Lotion A lotion was produced according to the following formulation. % By weight Sorbitol 2 2.1,3-butylene glycol 2 3. Polyethylene glycol 1000 1 4. Polyoxyethylene oleyl ether (25E.O.) 25 Ethanol 10 6. 6. Compound of Production Example 2 0.01 Saxifrage extract component of Production Example 2.0 2.08. Sodium lactate 0.2 9. pH adjuster qs. Preservative appropriate amount 11. Purified water 100 residue

2) Production Example of Emulsion An emulsion was produced according to the following formulation. % By weight Squalane 3 2. Vaseline 1 3. Stearyl alcohol 0.3 4. Sorbitan monostearate 1.55. Polyoxyethylene (20) sorbitan monooleate 3 6.1,3-butylene glycol 5 7. 7. Yeast extract of Production Example 6 1.0 N-acetyltyrosine 0.19. Bovine placenta extract (CP-12: manufactured by Ichimaru Falcos) 1.0 10. Quercetin 0.005 11. Glycolic acid 0.1 Preservative appropriate amount 13. Purified water 100 residue

3) Production Example of Cream A cream was produced according to the following formulation. % By weight Squalane 20 2. Beeswax 5 3. Refined jojoba oil 5 4. Glycerin monostearate 2 5. Sorbitan monostearate 2 6 Polyoxyethylene (20) sorbitan monostearate 2 7. Glycerin 5 8. 8. Compound of Production Example 1 0.2 9. Kumazasa extract component of Production Example 17 2.0 N-acetyltyrosine sodium 1 11. Tannic acid (Japanese Pharmacopoeia) 0.01 12. 12. Glutathione-rich yeast extract 2.0 Sodium citrate 0.2 14. Preservative appropriate amount 15. Purified water 100 residue

4) Production Example of Shampoo A shampoo was produced according to the following formulation. % By weight Triethanolamine lauryl sulfate 5 2. 3. Polyoxyethylene lauryl ether sulfate Na 12 3.1,3-butylene glycol 4 Lauric acid diethanolamide 2 5. Disodium edetate 0.16. Compound of Production Example 3 0.57. 7. Hop extract component of Production Example 27 2.0 8. An extract of Glycyrrhiza L. in Production Example 24 2.0 9. Calendula extract component of Production Example 25 2.0 Sodium tartrate 0.2 11. Preservative appropriate amount 12. Purified water 100 residue

5) Production Example of Body Soap A body soap was produced according to the following formulation. % By weight Potassium laurate 15 2. Potassium myristate 5 3. Propylene glycol 5 4. Compound of Production Example 4 0.015. 5. Yeast extract of Production Example 2.0 2.0 N-acetyltyrosine 0.2 7. 7. Arnica extracted component of Production Example 26 2.0 Sodium citrate 0.19. Sodium lactate 0.1 10. Appropriate amount of pH adjuster 11. Preservative appropriate amount 12. Purified water 100 residue

6) Production Example of Bath Agent (Type A) A bath agent was produced according to the following formulation. % By weight Sodium bicarbonate 50 2. Anhydrous sodium sulfate 25 3. Borax 2 4. Compound of Production Example 5 10 5. N-acetyltyrosine ethyl ester 10 6. Sodium lactate 2 7 Sodium glycolate 1

7) Production Example of Bath Agent (Type B) A bath agent was manufactured according to the following formulation. % By weight Refined jojoba oil 5 2. 2. Polyoxyethylene sorbitan monolaurate 20 Glycerin monostearate 5 4. Liquid paraffin 2 5. Lauric acid diethanolamide 3 6. Compound of Production Example 1 10 7. 7. Artemisia extract component of Production Example 12 8. Kumazasa extract component of Production Example 17 Licorice extract component of Production Example 18 310. Sodium lactate 1 11. Purified water 100 residue

8) Production example of facial cleanser A facial cleanser was produced according to the following formulation. % By weight Triethanolamine myristate 15 2. Lauryl dimethylamine oxide 3 3. Propylene glycol 5 4. Glycerin 5 5. Compound of Production Example 2 0.16. 6. Red bean extract component of Production Example 15 2.0 7. Mulberry extract component of Production Example 2.0 8. Ethylene glycol distearyl 3.0 Purified water 100 residue

9) Production Example of Mouthwash A mouthwash was produced according to the following formulation. % By weight Ethanol 20 2. Glycerin 15 3. Polyoxyethylene hydrogenated castor oil 1.04. Saccharin 0.15. Chlorohexidine 0.003 6. 6. Compound of Production Example 1 0.01 Purified water 100 residue

10) Production example of dishwashing detergent A dishwashing detergent was produced according to the following formulation. 1. wt% 1.1,3-butylene glycol 2.0 Glycerin 3.0 3. 3. Polyoxyethylene (3) dodecyl ether sulfate Na 10 Ethanol 5 5. 5. Aloe extractable component of Production Example 14 2.0 Compound of Production Example 4 0.17. Purified water 100 residue

[0147]

The immunostimulant according to the present invention has functions such as a physiologically healthy effect on the skin by the essential components water-soluble β-1,3-glucan and / or yeast extract and a skin conditioning effect by moisturizing. The condition of the skin is improved, and the permeability of another essential component, a whitening component and a hair-growth component, is enhanced, and they have an excellent effect that they act more effectively on the skin. Cosmetics that have better functions and effects than conventional products by using anti-inflammatory, anti-allergic, anti-acne, anti-skin roughening, and anti-wrinkle ingredients in addition to whitening and hair growth ingredients It is also possible to get

[Brief description of the drawings]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 shows the effect of improving the immune function of mice, performed according to the example (effect of ultraviolet rays on skin immunity decline).

FIG. 2 shows the effect of improving the immune function of mice, performed in accordance with the example (effect on skin immunity decline due to overcrowding stress).

FIG. 3 shows the hair growth effect on C3H mice, which was performed according to the example (effect of combination with hair growth component).

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] December 21, 2000 (200.12.
21)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claim 6

[Correction method] Change

[Correction contents]

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0020

[Correction method] Change

[Correction contents]

The hair growth component and blood flow promoting component include carpronium chloride, cepharanthin, nicotinamide, benzyl nicotinate, vitamin E acetate, pantothenyl alcohol, biotin, glyceride pentadecanoate, hematin, hypericum extract component, l-menthol , Minoxidil, cantaris tincture, capsicum tincture, Clara extract component, assembly extract component, Korean ginseng extract component, thixet ginseng extract component, buttonpig extract component, emperor extract extract component, calendula extract component,
Arnica extract components, hop extract components and the like can be used.

[Procedure amendment 3]

[Document name to be amended] Statement

[Correction target item name]

[Correction method] Change

[Correction contents]

[0131]

[Table 6]

[Procedure amendment 4]

[Document name to be amended] Statement

[Correction target item name]

[Correction method] Change

[Correction contents]

[0132]

[Table 7] ────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0024

[Correction method] Change

[Correction contents]

The immunostimulant, cosmetics, whitening cosmetics, and hair cosmetics of the present invention may further include the following essential components, if necessary, as long as the effects of the present invention are not impaired. And additives can be arbitrarily selected and used in combination, and the content in the preparation is not particularly defined, but usually,
0.0001 to 50% is preferred.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification Symbol FI Theme Court ゛ (Reference) A61K 7/16 A61K 7/16 7/48 7/48 7/50 7/50 35/72 35/72 A61P 37/04 A61P 37/04 C11D 3/382 C11D 3/382 3/48 3/48 F term (reference) 4C083 AA071 AA072 AA082 AA111 AA112 AA122 AB272 AB312 AB352 AC022 AC072 AC102 AC132 AC182 AC242 AC302 AC311 AC421 AC422 AC442 AC471 AC472 AC532 AC641 AC642 AC662 AC691 AC692 AC782 AC841 AC842 AC851 AC852 AC861 AC862 AD112 AD211 AD212 AD332 AD391 AD451 AD531 AD532 AD611 AD612 AD641 AD642 AD661 AD662 BB51 BB53 CC01 CC04 CC05 CC23 CC25 CC31 CC33 CC38 CC41 DD31 EE12 EE10 A31 EE12 EE14 A31 EE12 EE10 EA20 EA25 EA26 MA01 MA04 NA14 ZA89 ZA92 ZB09 4C087 AA01 AA02 BC11 MA01 NA14 ZA89 ZA92 ZB09 4H003 AB27 AB31 AB46 AC13 BA12 DA02 EB04 EB08 EB16 EB41 EB45 ED02 ED28 FA33

Claims (6)

[Claims] 1. An immunostimulant comprising, as an active ingredient, at least one selected from a water-soluble β-1,3-glucan derivative and a yeast extract. 2. A water-soluble β-1,3-glucan derivative and / or
Or a cosmetic containing the immunostimulant according to claim 1, which comprises a yeast extract as an active ingredient. 3. A whitening cosmetic comprising essentially one or more selected from a water-soluble β-1,3-glucan derivative and a yeast extract, and a whitening component. 4. A whitening component comprising kojic acid, arbutin, ascorbic acid or a salt thereof, ascorbic acid phosphate or a magnesium salt thereof, ascorbic acid glucoside,
At least one selected from ellagic acid, rucinol, Yarrow extract, Achillea millefolium extract, Fujikawakama extract, Mulberry extract, Ogon extract, water-soluble silk protein hydrolyzate, Aloe extract, tannic acid, fermented metabolite of lactic acid bacteria The whitening cosmetic according to claim 3, which is: 5. A hair cosmetic which essentially contains at least one selected from a water-soluble β-1,3-glucan derivative and a yeast extract, and a hair growth component and / or a blood flow promoting component. 6. A hair growth component and / or a blood flow promoting component, wherein capronium chloride, cepharanthin, nicotinamide, benzyl nicotinate, vitamin E acetate, pantothenyl alcohol, biotin, glyceride pentadecanoate,
Hypericum extract component, l-menthol, minoxidil, cantaris tincture, capsicum tincture, Clara extract component, assembly extract component, Korean ginseng extract component, thixet ginseng extract component, buttonpig extract component, at least one selected from the extract of Glycyrrhiza The hair cosmetic according to claim 5, wherein