JP2001097842A - Acne medicine originated from natural product - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe cosmetic composition which is effective for preventing or treating skin diseases such as acne or inflammatory chapped skin caused by the acne. SOLUTION: This acne medicine, comedon production inhibitor or cosmetic composition contains one or more ingredients selected from whey and a Phellodendron amurense Ruprecht extract, and further one or more plant extracts selected from Scutellaria baicalensis Geoegi, Symphytum officinale Linne, and Glycine max (L.)Merrill (G. hirsta Maxim.). Thereby, the acne medicine or comedon production inhibitor is effective for preventing or treating skin diseases such as the acne or inflammatory chapped skin caused by the acne. In addition, the composition can be used for general drinks, general foods, and so on.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a remedy for acne containing at least one of whey and oat extract, a suppressant for face formation, and a cosmetic composition containing these.
In addition, 1 which is chosen from ogong, comfrey, soybean
By using more than one plant extract in combination, it exerts a synergistic effect on the various effects of the title, and is effective in preventing and treating skin diseases such as acne or skin inflammation caused by acne and rough skin, and is effective and safe The present invention relates to an application to a highly cosmetic composition.

[0002] The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) of liquid, gel or air bubbles
Quasi-drugs, 3) topical or systemic skin cosmetics (e.g., basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents) , Cleansing agent, depilatory, depilatory, shaving treatment, after-shave lotion, pre-show lotion, shaving cream, etc.),
4) Pharmaceutical or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent liquids, hair dyes, hair styling, hair tonics, hair growth / hair restoration, etc.), 5 ) Bath agent used by throwing it into bath water, 6) Other, axillary deodorant and deodorant, deodorant, sanitary goods, sanitary cotton, wet tissue, mouth freshener (for example,
Brushing, mouthwash, etc.).

[0003]

2. Description of the Related Art Acne is a chronic inflammatory disease that mainly occurs in sebaceous glands at seborrheic sites such as the face from puberty, and its name is acne vulgaris. Acne is more common among adolescents and high school students, but in recent years the number of working women has increased and the number of people suffering from acne has grown rapidly even after adulthood.

The process of acne generation can be divided into two stages. The first basic lesion that occurs is acne, followed by acne, an inflammatory disease that is difficult to treat, such as papules and pustules.

[0005] In the first stage, the onset of coma is caused by excessive secretion of sebum dependent on male hormones from sebaceous glands in the hair follicles, and keratinization is enhanced at the outlet of the pore, which is the secretion port, and secretions are secreted. Get up by blocking. That is, it is considered that the face is filled with sebum and keratin. However, at the onset stage, inflammation has not yet developed.

[0006] If the non-inflammatory skin is left untreated, acne bacteria (Propionibacterium acnes) proliferate, inflammation occurs, and the papules and pustules move. The mechanism of inflammation is not only acne infection, but also leukocytes destroy the hair follicle itself with active oxygen or the like in order to eliminate the acne, resulting in inflammation that leaves scars.

[0007] As described above, various factors are complicatedly intertwined with each other, and various test methods have been proposed for hypersecretion of sebum, hyperkeratosis, and acne bacteria. Or effective approaches for improvement are being actively pursued.

[0008]

At present, topical agents for treating acne include keratolytic agents, antibiotics for acne bacteria, antibacterial agents and anti-inflammatory agents, but most of them are synthetic pharmaceuticals and are safe. There was a problem in the point. In addition, it is hard to say that the effect is sufficient, and at present, there is no substance that can exhibit a satisfactory effect in terms of treatment.

[0009]

In view of these circumstances, the present inventors have studied various useful components from naturally occurring substances having excellent safety, and found that whey and oak extract were found to be useful. It is found to be useful for the prevention and treatment of acne, and is also selected from Japanese gourd, comfrey and soybean.
A synergistic effect on the efficacy of the title was found by using more than one plant extract in combination. Accordingly, the present invention has been completed by providing a highly safe cosmetic composition which is effective for prevention and treatment of skin diseases such as acne or skin inflammation caused by acne and rough skin.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION "Whey: whey" used in the present invention refers to (a) raw milk or an aqueous solution of skim milk powder containing lactic acid bacteria.
Fermented milk obtained by inoculating and culturing (Lactobacillus bulgaricus) into whey or powder obtained by removing solids.
(B) using an aqueous solution of milk protein or an aqueous solution of skim milk powder and glucose with Streptococcus thermophilus;
Alternatively, a solution obtained by filtering a liquid fermented with lactobacillus (Lactobacillus bulgaricus). (C) Proteolytic enzyme (Chymosi
nn) and lactic acid bacteria (Lactobacillus bulgaricus, Lactococcus
lactis, Laceptococcus thermophilus, Leuconostoc mes
enteroides), and dried by removing whey proteins from whey obtained by fermentation.

"Otaku: Hakubashi" means Rutaceae (Ruta)
ceae), a plant of the genus Phellodendron, "Phe
llodendron amurense Ruprecht ”or other bark of the same genus plant, excluding the bark.

"Ogon: Yellow Gon" is a Labiatae (Labi
atae), a root of the plant Scutellaria baicalensis Geoegi of the genus Scutellaria excluding the pericytes.

The term "comfrey: fin-bare grass" refers to the leaves of the plant comfrey (Symphytum officinale Linne), a plant belonging to the family Boraginaceae or the genus Symphytum.
Branches, stems.

"Soybean: soybean" is a legume (Legumino)
sae), a plant soybean of the genus Glycine (Glycine ma)
x (L.) Merrill (= G.hirsta Maxim.) "

The extract of oak, oak, comfrey, soybean used in the present invention is the extraction of various parts (bark, roots, leaves, branches, stems, seeds, etc.) of each plant as it is or after crushing. What you did. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent for the plant extract include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), acetone and the like. Ketones, ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform can be used alone or in any combination of two or more kinds. It can also be used in a state where the extracts are combined.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or use of an ion-exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

Further, various plant extracts of oak, ogon, comfrey, soybean, or whey may be dried, concentrated, or concentrated depending on the type and form of the acne treatment agent, face formation inhibitor or cosmetic composition to be applied. Dilution or the like may be arbitrarily performed and adjusted.

The whey and oak extract of the present invention can be used as they are as a treatment for acne and as a suppressant for the formation of acne, and can be contained in a cosmetic composition. However, the content is not particularly limited. It may vary slightly depending on the type, quality and expected degree of action of the acne remedy, acne formation inhibitor and cosmetic composition, and is usually 0.001% by weight or more (hereinafter, expressed in%), preferably 0.2 to 20%. % Is good.
If the content is less than 0.001%, the effect cannot be expected sufficiently.

Similarly, the plant extracts of the plant of the present invention, eg, gogon, comfrey and soybean, are also used for treating acne,
It can be contained in a cosmetic composition inhibitor and a cosmetic composition, and the content thereof is not particularly limited. However, the type, quality, and expectation of the acne therapeutic agent, the cosmetic composition inhibitor, and the form of the cosmetic composition Varies slightly depending on the degree of action taken,
0.01% or more, preferably 3 to 30% is good. In addition, the content
If it is less than 0.01%, the effect cannot be expected sufficiently.

The therapeutic agent for acne, the suppressant for acne formation or the cosmetic composition of the present invention may further comprise, if necessary, the components exemplified below as long as the effects of the present invention are not impaired. And additives can be arbitrarily selected and used in combination.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. However, usually, water and a water-soluble organic solvent (for example, ethanol) are used. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsumuraji (Kibo), Acacia, Akashoma (Akashoma), Akasuguri "fruit", Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Aki larch, Akinire (Royu skin), Aguahe (Omiten palm), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Towushi) ), Hydrangea (hydrangea), ashitaba (morning leaf), adzuki (red azuki bean), acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abemaki `` fruit '', avocado, ama, amacha (sweet tea), Amachaworu, Amadokoro (Jade bamboo), Amana (Hikarigi), Amaranthus (Amaranthus), Amaranthus (Hymoptera), Senninkoku, Sugimorigeitou, Hosoaoigaito, Aogetoudo, Haribiyu, Amaranthus hippochondriacus, Amigasayuri or Birnamo Alcanna), Argarrobo (cabbage), Altea, Arnica,
Alpinia or red sea bream (Sou-zuku), aloe (lux),
Aloe vera, angelica, apricot or hon apricot (almond jelly), ansokkou (benzoic), Ikakozolina (bile head), epimedium or potato valerian (inyokaku), rush (light heart grass), knotweed (tiger stick root), yew (first place), Strawberry, fig (fructose `` fruit, leaf ''), strawberry (first time), strawberry (winter aoiko), ichiyakuso (one medicinal herb), ginkgo (ginko `` seed, leaf ''), Itohimehagi (enshi), carob, carob bean ( (Telelexi), Inubiyu (Honagainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwa-hi-chi-chi), iwahiba or iwa-matsu (makikashiwa), oolong tea, fennel-wheat, wheat (Chibusanoki), Ukiyagara (Mitsuryo), Uguisukagura `` fruit '', Himeuikyo, turmeric (Utsukin), duckweed (buoying), Usubasaishi Or Keirin Herba Asari or Scots. Recently (Hosokarashi), malva sylvestris, marshmallow, Prunella vulgaris (summer hay), Udo or Angelica (羌活, Udo, Tang Udo), Unyadegato (Uncaria, cat's claw), Uva tea, plum
(Umebashi `` seed, pulp ''), Vulgaris ogre, Uwaurushi (Kusaco peach), Unshu mandarin (Chin skin), Estragon, Ezocogi (Ezo Goka), Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (Enotake mushroom), Ebisugusa or Cassia tora (Keiko), Elcampre, Elderberry `` fruit '', Elemi, Eryngii or Pre-Lotus Erinji, Enju (Gossip, Sophoraceae rice), Ougi or Kibana-ohagi (Ohgi), Ouren (Yoren), Ookarasuuri
(Karokon), giant grove (civil engineering incense), giant clam (self-defense), giant psyllium (forehead child, forehead grass), toucan hazel (haruko), Obanana okera or okera (white jitsu), Obananasasurube (banaba), Obanayashabushi "fruit", Hawthorn or hawthorn (Yamakoko), Ousei (Naruko lily, Kagikurumabanarukoyuri), Oohisasanoyuki or Sasanoyuki, Barley (barley), Greater grass (Grass grass),
Oka, Okazeri (snake bed), Oguruma (turnover), Okra `` fruit '', Panax ginseng or carrot (carrot), Hypericum or Kogomebai perforated or Periwinkle (Brother's cut grass), Odorikosou (intermittent), Onamimomi (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Ononis, Halibut (Hibaha Yu), Ominaeshi (Loose), Oyuko, Dutch mustard (Crasson), Dutch jelly , Dutch honeybee, olives "fruits, seeds, leaves", oregano, orange "fruits, pericarp", calyxio (ripe yellow), cacao "fruits, pericarp,
Seeds '', oysters (persimmon `` leaves ''), kagi kazura (hootshoo), oysters or kantosou (rensensou), cassia, casino
(Kozoumi `` fruits ''), gajutsu (shajutsu), kasiwa (shaki), cascarilla, cascara sagrada, gypsophila, kanikusa (kinsato), kaniwa, kanokoso (valerian grass root), birch or shidare kamba (shirakaba) , Pumpkin, capoknoki "seed", kahoku sansho (shopper), tama (bamboo yellow), chamomile or roman chamomile, chamiyadee (tsukusa), camu cam
(Duck), Karaku salmon, Calla uri or Sinara cucumber (Gourd melon), Callas bishaku (Midsummer), Raspberry, Guarana `` seed '', Karahoo (Popular), Karaya, Karin (Gourd), Garcinia, Kawamidori, Kawara psycho (Koryosai) ,
Japanese white grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaran Ginseng (Aokko), Kawamuragi (Inchinko), Kansui (Kansai), Licorice (Lucifera), Kantarasa, Candelilla, canto, canna, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry,
(European strawberry), Kiwi `` fruits, leaves '', Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum flower), Simakangiku, Daffodilium, Catalpa (Azumi), Rigid vine (Yotei) Pheasant (Kikomi), Kizuta, Kidachi Aloe, Kidney Mint, Kina, Kinoki (Shincona, Akinoki), Quinoa (Kinoa), Gymnema Sylvester, Cabbage, Cabbage "Immature Fruit", Cucumber, Goryu (Nishikawayanagi, Teriyaki), Kiraja Saponaria, Kiraya, Kylansou (gold pea), Kumquat `` fruit '', betel, quince (Senaku grass), guava `` fruit '', guayule, quelux infectria (gallicate), cucuinuts, wolfberry (cucumber, cucumber, cucumber) , Ground bone bark), cedar grass (Tenmen Fuyu), kudzu (kuzukon), camphor tree, gooseberry `` fruit '', xinseng (yellow flower), cutina (Gardenia),
Kunugi (Bokusou), Kupuasu, Kumazasa, Kumatsuzura (horse whip grass), Clara (Bitterfruit), Cranberry `` fruit '', Chestnut `` seed, fruit, astringent skin '', Curculigo Latifolia `` fruit '', Grapefruit `` fruit / leaf '', Buckthorn, black squirrel (rescue rescue), black crab sprouts or sprouts (extended life grass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), keigai (infestation, infestation ears), celosia (corolla, cockpit), bayberry (Laurel), Kenashi sardine rose (Tobukuryo, Yamakiko), gentian, gennoshoko (Oirou grass), Kemponashi (Kigushi),
Koukisekoku, Kishumitsukan (Koji, Tachibana,
Olivenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana skin)), Koushinbara (Monthly flower), Kosuui mint, Kozo `` fruit '', Kocha (tea), Kohone
(River bone), kouhon (straw and kara straw), kouriang, kourikyo (takara kang), cilantro `` fruit '', koren
(Huangren), lingonberry (Koshibachi), coconut `` fruit '', goshyu (goshuyu), goshoichigo (covered bonko), pepper (pepper),
Copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame scrophus (gensen), goji (gomiko), scallop or binankazura or matsubusa, wheat (Wheat), rice or rice bran `` red bran, white bran '', rice oil, cola acuminata `` seed '', cola vera `` seed '', fenugreek `` fruit '', colombo, conzulango, kelp, konjac, sisal (sisalasa), saxima Button-button or Chinese button-button or Chinese cinnamon
(Leaf, flower, fruit, bark (cherry bark)) , Sadomodaka (Sawaka), Sweet potato, Sugarcane, Sugar beet, Satsuma jujube (Satsumitsujin), Saffron (Bamboo safflower, West safflower), Pomelo `` Fruit '', Sabonsou, Salmonberry `` Fruit '', Sarasinoshima (Somasa), Salvia (Somabia) Sage), Sawagikyo (Yamakona), Sawagumi (Yamawomo), Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (Sanjin ginseng), Sanshuyu (sanshuyu), Sanshoyu (sansho), Sunzukon (Yamato) Root, Shea (Karite), Cyano (fruit), Shiitake (Shitake mushroom), Shion (Purple) ), Digitalis, gentleman (Acts gentleman), perilla or Perilla or Chirimenjiso or Katamenjiso (shiso leaf, Sissoko), rosewood, linden, Shinahoonoki, Sina forsythia (Forsythia), mushroom
(Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishimeji, Bunashimeji, Honjimeshi, Shirotamogitake),
Spiraea, potatoes, peonies (peony), shajin (sasan), jasmine (matsurika), scabbard (wheat gate winter), sycamore, sycamore (sandy sand, compact sand), jujudama, palm "fruit", ginger ( ginger),
Jouzan hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku "fruit", Shirakashi "seed", Shirogoshi butterfly "seed", White adzuki bean (chicken bone grass), Shirovanairisu
(Small iris), Shirobanatsuta `` flower '', Shirominanten
(Minami Tenmi), Shinkonasakushirubura, Jingkoge (Mizuka, Mizuka, Shencho), Cinnamon, Cinnammum cassia (cinnamon), watermelon (watermelon), honeysuckle (gold and silver flowers,
Ninwinter), sorrel (acid pattern), swimberry `` fruit '', stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (question thorn), purslane (horse dent, horse tooth kenko), plum `` fruit '', pear Japanese red pine `` cone '', larch, larch, walnuts, hawthorn, dandelion, horse chestnut (malonie),
Pear `` fruits '', snowy pear, elderflower, elderflower, juniper (juniper, juniper), yarrow (milfoil), rose, foliage, mistletoe, mint, or swordfish (Ishishone), Sekkoku (Ishimo), Cedron
(Bowshuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Senkyu (River Kyu), Senshinren (Shingenren), Sendan, Senburi (Drug), Senna `` Fruits, Leaves '', Senninsou (Ootate), Soka ( (Grass), buckwheat `` seed nuts '', soybean potato, rhubarb (daisou), radish, daidai (orange, kikomi), takasaburo (dry lotus grass), takatodai (daiseki), takawarabi (gull), dark sweet cherry `` fruits '' , Tachiaoi, Tachijakoso (thyme, Hyoka), Tachidokoro (Hikari), Tachiyanagi, Tamarind `` seed '', onion, tamshiba (spicy), taro tree `` fruit, leaf, root bark '', talwi, tanjin (dansan), dandelion
(Gakukoei) or white dandelion or moko dandelion, dammar, cherry `` fruit '', tigaya `` fruit, root, bud '',
Chicset carrot (bamboo ginseng), chicory, chancapiedra (Kidachikomikansou), Korean ginseng (Orange),
Korean elm (Wuyi), Korean artemisia (Aiba), Choreimaitake (Irei), Japanese cricket, Tsukimiso, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer lacustrine), Tsuyukusa (Duckweed grass), Tsuruazuki ( (Red azuki bean), tsuldokudami (what crow), tsuruna (ban-an), tsujin carrot (four-leaf ginseng), tsuwabuki, daico, teuchigurumi, duberry `` fruit '', tengusa, tencha, tendaiyaku
(Crowd drug), Pepper (Furry gourd), Pepper sparrow, Pepper
(Pan pepper), Touki (Toki), Tokinsenka (Marigold), Tonabena (River cut), Maize or Maize hair (Nanbaru hair), Tomozumomochi (Female Sadako), Toudodo or Korean gooseberry (dragon bile), Tokusa (Wood pirates), dokudami (jujutsu), radish (root spit), red sea bream or mamedaoshi or scutellaria, eucommia (mushroom `` bark, leaves, roots ''), ash (skin), tomato, tragacanth, triacanthos `` seed '', tolmentilla, Dronoki, Trolloa mallow, Niseria berry `` fruit '', potato or yam (yakuyaku),
Naginika (butcher bloom), Naginata Kouju,
Nazuna, oilseed rape, oil bean or sword bean (sword bean), jujube, jujube (daijutsu), nanawaibara (gold cherry blossom), navena
(Intermittent), nameko, narco lily (yellow), peanut (peanut), nanten (minamitenmi), nambangarashi (ramie),
Nigaki (bitter tree), bitter mugwort (bitter), nutmeg, kei or nikkei or ceylon nikkei or yabnikkei (cinnamon bark)
Or Keishi (Keishi), Chinese chive (Nirako), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (fivefold child), leek, nemoki or neb or nebi or nemlinoki or zigokubana ( Healing), Nozami (Ohi), Noibara (Fruit), Yarrow, Nodake (Maehu), Nobara, Nomomo,
Palm, pineapple `` fruit '', hibiscus (Bussouge, Furinbussouge, Roselle), Hi-Gindo, Hakamauraboshi (bone crushing supplement), Hakusen (ringworm skin), Huckleberry `` Fruits '', Hakobe (frequent breeding), Hashibami (Haruko), Hashiridoro ( Roth root), basil, lotus (lotus, lotus, lotus root), parsley (holland jelly), naked mussels, batata, bees or medakes (bamboo-boiled), patchouli, mint (light-weight, light-weight leaves), pearl barley (yokunin), hanasuge (Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Scotch grass (Rat malt), Pahalobobo, Hub `` whole grass, stem, leaf '', Paprika, Hamago or Hitsuba Hamago , Hamasuge (Kazuke), Hamabishi
(Ritsuko Riko), Hamanas (maikai flower), Hamabofu (beach storm), Hamamelis, rose (rose), agaric (aratake,
White agaricus, Usukimori no kasa), Haran, Pariurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigauri), Harunire (Yellow, Yuzhi bark, Yuba), Harlindou, Handaikai (Giantai), Breadfruit, Hiougi Ginseng carrot (party),
Pu'er tea (peo tea), pecan nuts, giganbana (stone and vines), Hishi (hishomi), pistachio, beet, hitsuba (stone reed), hitsuba enishida, hinota nokozuchi
(Cow knee), cypress, hiba, castor, sunflower, pepper,
Himeuzu (Aoi), Himegama (incense crab), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Bjackyu, Hiyu `` Fruit '', Bilobaoi,
Hiro-Okinagusa (Hakuto Okina), Loquat `` Fruits, Leaves, Stems '', Betel Nuts (Large Cloth, Betel Loaf), Butterbur Kazura (Southern Rattan), Butterbur, Butterfly Poppy (Foliage Flower, Winter Leaves), Fuji Bacama (Rancho), Fuji Bean (Tan Bean) ), Grape "fruit, peel, seeds,
Leaf '', beech, sycamore (caterpillar), licorice brazilian, carrot, black currant `` fruit '', blackberry, plum `` fruit '', flucellaria, blueberry (Prunus avium), prunes,
Blond psyllium, bundou (mung bean), hazelnut, loofah, safflower (safflower), henneken, belladonna,
Berry `` fruit '', Peruvian bergh, beetwort or duckweed (Keiten), Boysenberry `` fruit '', duckweed or elderweed or nendowe or hawkigi kokia (terrestrial), balsam (horizon), acute child, ostrich ,
Bofu (windbreak), spinach, physalis (Torone), honoki (Japanese thick, magnolia), bokeh (wood melon), bonsai (green apricot), bonsai linsou (Sanju Jingtian), bonsai valengus, bodaiju (bodice tree), Button (peony `` flower, leaf, stem,
Bark), buttonpi (peony bark), hops, jojoba, bordeaux, white berries `` fruits '', hon-oniku (meat porcelain, big art), honsekkoku (iron bark stones, sparrow mountain stones), mezul tennanshaw (tennan star) ), Maitake (Maitake), Ephedra
(Mao), maca, macadamia nuts, macri (sea grass), maguwa (mulberry white bark `` bark, leaves ''), magnolia splengeri, masure (tamanousenharen, kukonkinrenka), matatabi (kiten tate), matsukasa , Pine "leaves, bark,
Roots '', Matsuhod (Bukuryo), Matico (Cordon Sillo),
Mayorum (Hanaminka), Malvanojazine (Difficult), Mulberry `` fruit '', Quince, Mango, Mangosteen,
Mansagna (Andesukamitsure), Mansugurumi,
Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikomi `` Fruit ''), Mishima Psycho (Saiko), Mizuobako or Mizuasagao (Ryungoshi), Mizokaku (Hanbe Lotus), Misohagi
(Chikuna), beet willow or elder willow (enrichment), honeywort, honeywort, green peppermint, mimosa, mioga, miracle fruit `` fruit '', myrrh, mirobaran, wheat waragiku, mukuge (wooden), mukunoki, mukuroji (extended life skin), munya , Murasaki (purple root), Murasakisikibu or Omurasakikibu (purple beads), Murasaki maize, Murasaki natsufuji (Kunming chicken blood wisteria), Mehajiki (meadow grass), Mebokugi, Melaleuca, Melissa, melilot, melon `` fruit '', mokoyomigi, mushroom Moje (Keikoboku), Mokko (Kinka), Maple Butterfly, Peach (peach `` leaf, seed,
`` Flowers, fruits ''), sprouts, morello cherries `` fruits '', moroheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflower (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabashi Fruits, peels, and ears "
(Octagonal gold plate), mistletoe (parasitic willow), willow (river willow,
Twill willow, weeping willow, red eye willow, pussy willow, dog koreanagi, kinuyanagi, kolyanagi, unryuyanagi, yamayanagi, coconut palm, yamayanagi, obanyanagi, tyrikkinyanagi, foxeye willow, foxwort, bonsai
(Purple gold beef), yabu tobacco (crane squirrel, Tenna sei), pokeweed (land), yamahanoki (yamaharu), yamamomo (yangmei skin), sagebrush, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu Fruits, Lilies, Yogurusa, Artemisia (Aiba), Lygan (Rainuma), Lime `` Fruit '', Rye, Lacanca `` Fruit '', Raspberry `` Leaf, Fruit '', Latania (Clameria), Rakkyo or Shallot (Scallop), Lavender , Longan (longan meat), agave (Aono agave, fukurin agave),
Ryokucha (green tea), apple "fruits, seeds, leaves, roots", gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant "fruit", lemon "fruit" , Lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, wax palm, lokon
(Yoshi, Azune), Loganberry "fruit", Rosemary
(Mannenrou), Rosehip (Nobara), Wasabi, Waremokou (Jiyu) and the like.

In addition, other seawater, for example, seawater salt, seawater dried product, inorganic salt (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic or Pacific Ocean, sea mud or mud (fango) Species, for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaonori, Sugiaoonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombubu , Resiliconibu, hosomekombu, mitsuishikomubu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Sujiusbanori, haiusbanori, akaminominori] and the like.

Also, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Blue-green algae (Genus Lynch: L., L., L., L .;
(Hassay, Yuremo genus, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio) genus, etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp .: Namiami sp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cyno (Kayamonoli etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike, Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

Axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lychnotanus genus, Hessian moss: Himejirasamo, Chaboshiramo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Examples of the material derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow extract from the stomach, duodenum or intestine or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran ferment extract, euglena extract, trehalose or a derivative thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (eg, magnesium phosphate magnesium phosphate, vitamin C glucoside), hydroquinone or a derivative thereof (eg, hydroquinone benzyl ether), kojic acid or a derivative thereof, vitamin E or a derivative thereof Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extracts (chamomile, mulberry, mulberry, waremokou, clara, mugwort, Honeysuckle, yellowfin, yellowtail, matsuhodo, pearl barley, scotch, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, enmeisou, bellflower, toshishi, seizome, sun dried, mao, senkyu Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Amami,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, etc.

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, sage, seaweed, bollige, botanpi), seaweed extract and the like.

(30) Agent for hair Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Topical stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate, and the like.

(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral preparations, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

Further, the dosage form of the acne treatment agent, acne formation inhibitor or cosmetic composition of the present invention is optional, and capsules,
Powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets and the like can be blended and used.

Specifically, for example, topical pharmaceutical preparations, lotions, emulsions, creams, ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, hair removers, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth and hair growth products, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
It can be applied to various products such as deodorant, sanitary cotton, wet tissue, and can be used for general food and drink.

The method of adding to the acne treating agent, the acne formation inhibitor or the cosmetic composition of the present invention may be added in advance or during the production, and the workability is considered. May be selected appropriately.

[0079]

The present invention will be described below with reference to Test Examples and Formulation Examples, but the present invention is not limited to these.

(Production Example 1) Lactic acid bacterium was inoculated to 30 L of a raw material (aqueous solution of milk protein or skim milk powder and glucose) at a concentration of 1%.
C. for 3 days to prepare fermented milk, sterilize and filter to obtain about 24 L of whey.

(Production Example 2) 100 g of dried plant material of oak, ogon, comfrey, and soybean was heated and extracted with purified water (about 80 ° C.) for about 5 hours, and filtered to obtain an extract (dry solid). Minutes: 0.5% to 2.0% of Obak, 0.8% to 2.6% of Ogon
%, Comfrey 1.5-3.0%, soybean 1.5-3.0%)
Get 0-3.0kg.

(Production Example 3) 100 g of dried plant material of oak, ogun, comfrey and soybean were immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid). Minutes: 0.5% to 2.0% of Obak, 0.8% to 2.6% of Ogon, 1.5% to 3.0% of comfrey, 1.5% to 3.0% of soybean
%) Of about 1.0-3.0 kg.

(Production Example 4) 100 g of dried plant material of oak, ogon, comfrey, and soybean are mixed with 1 L of an equal volume of a 30% propylene glycol solution and a 30% 1,3-butylene glycol solution at 50 ° C. for 6 hours. Slowly heat-extract, extract by suction filtration, and extract (dry solids: Oubak 0.5-2.0%, Ougon 0.8-2.6%, Comfrey 1.5-3.0%, Soybean 1.5-
3.0%) of about 1.0-3.0 kg.

(Test 1) Test for Inhibiting the Formation of Face Wash The present inventors evaluated the action of suppressing the face formation using rabbit auricles.

[Test Method and Evaluation Method] The central part of the inner skin of the pinna of a Japanese white rabbit (male, about 3.0 kg in weight) was wiped with acetone, and oleic acid adjusted to 50% with liquid paraffin was added. 0.3 mL was applied to the site. Perform this operation 1 day
Application (5 days a week) was continued for 2 weeks, and application of the test drug was started at the same site after the final application. As the test drug, a sample was applied to the left ear and purified water was applied to the right ear once a day at 0.3 mL for one week (a total of six times).
The judgment was made by measuring the diameter (maximum diameter) of the five test pieces generated with a video microscope (Higher Microscope VH-6110, manufactured by KEYENCE CORPORATION) at the test site before and after application of the test drug. Then, the suppression rate for the face of the sample was calculated based on the diameter from the face of the left ear to the face of the right ear. In addition, three Japanese white rabbits were used for the test, and the results are shown in Tables 1 and 2. "Sample" The sample of the test for inhibiting the formation of a face was prepared by dissolving the whey of Production Example 1 of the present invention in purified water (solid content: 0.1%), and the extract obtained in Production Example 2 (solid content). Concentration 0.1
%). (However, when two or more essential components of the present invention are used in combination, the same concentration of each component is added to obtain a solid content of 0.1%.)
1%) and subjected to the test.

[0086]

[0087]

(Test Results) As shown in Tables 1 and 2, the whey and oak extracts of the present invention were found to have a high inhibitory effect on the formation of squamous milk. It was also confirmed that the combined use of plant extracts of more than one species significantly suppressed the formation of conges and had a high inhibitory effect on concretion. Therefore, it was confirmed that the composition was effective as a therapeutic agent for acne.

(Test 2) Safety test (1) Primary skin irritation test The whey and each plant extract obtained in Production Examples 1 to 4 were prepared so that the solid content concentration was about 2.0%. Was applied to the skin of 2 × 2 cm ² squares of the skin of Japanese white rabbits (female, 3 birds per group, weighing about 2.3 kg) whose back was shaved. Judgment was carried out 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed, and the animals were determined to be negative.

(Test 3) Safety Test (2) Skin Cumulative Irritation Test The whey obtained in Production Examples 1 to 4 and each plant extract were purified water-purified so that the solid content concentration was about 2.0%. Once prepared, this was applied to the skin of a Hartley-type guinea pig (female, 3 per group, weighing about 320 g) whose shank was shaved (2 × 4 cm ² ) once a day.
0.5 mL / animal was applied 5 times a week. Application was over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and on the day after the last application day, using primary irritancy scoring as an index of erythema and edema. as a result,
In all animals, for 2 weeks after application,
No erythema and edema were recognized, and the result was judged to be negative.

(Test 4) Safety test (3) Single dose toxicity test 12.5% of the whey and each plant extract powder obtained in Production Examples 1 to 4
Adjust with purified water to a concentration of 16mL / kg per animal
Before the test, the dose was orally administered to a ddy mouse (male and female, 5 mice, 5 weeks old, 5 weeks old) which had been fasted for 16 hours, and the appearance and extent of toxic symptoms were observed over time. .
As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD50 is 2,
It was 000 mg / kg or more, and it was judged as a safe substance.

(Prescription examples) Preparation of acne remedy, acne formation inhibitor, cosmetic composition The following formulation examples are shown below according to the above evaluation results. It may be manufactured, and only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. A: Whey of Production Example 1 B: Oubaku extract of Production Example 2 * Any one of A and B extracts 2.0 10. C: Extract of the pentagon of Production Example 2 D: Comfrey extract of Production Example 2 E: Soybean extract of Production Example 2 * Any one of extracts C to E 3.0 11. Preservative (paraoxybenzoate) Acid ester) Appropriate amount 12. Residual water to 100

(Formulation Example 2) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Whey 3.0 6. Touki hot water extract 1.0 7. Butylhydroxyanisole 0.1 8. Preservative (benzalkonium chloride) proper amount 9. Perfume (yuzu water) proper amount 10. Purified water 100 residue

(Formulation Example 3) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Oubak 50% ethanol extraction Liquid 2.0 6. Perilla 50% ethanol extract 1.0 7. Peony 50% ethanol extract 1.0 8. Appropriate amount of antibacterial and preservative (thiamine lauryl sulfate) 9. Appropriate amount of fragrance (fonilla water) 10. Purified water 100

(Formulation Example 4) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Whey aqueous solution 3.0 5. Comfrey 50% ethanol extract 2.0 6. Green tea 50 % Ethanol extract 1.0 7. Hamamelis 50% ethanol extract 1.0 8. Allantoin 0.2 9. Astringent (zinc sulfocarbonate) 0.2 10. Antibacterial and preservative (thiamine lauryl sulfate) qs 11. Fragrance (thin water) qs 12 .Remaining amount of purified water 100

(Formulation Example 5) Two-layer lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Extraction of oak in Production Example 2 Liquid 2.0 6. Spicy 30% ethanol extract 1.0 7. Grapefruit 30% ethanol extract 1.0 8. Ascorbic acid 0.2 9. Astringent (sodium sulfocarbonate) 0.2 10. Preservative (phenoxyethanol) qs 11. Perfume (lavender water) ) Appropriate amount 12. Residual water with 100 purified water

(Formulation Example 6) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. Oubak 50% propylene glycol extract 3.0 8. Stevia 50% propylene glycol extract 2.0 9. Peach leaf 50% propylene glycol extract 2.0 10. Placenta extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative (photosensitizer) No. 201) Appropriate amount 14.Fragrance (Bodyju water) Appropriate amount 15.Remaining to be 100 purified water

(Formulation Example 7) Pack weight% 1. Polyvinyl alcohol 15.0 2. Carboxymethylcellulose sodium 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Oakaku 50% ethanol extract 3.0 6. Calendula 50% ethanol extract 1.0 7. Sodium soap 50% ethanol extract 1.0 8. Preservative (paraoxybenzoate) proper amount 9. Flavor (toque water) proper amount 10. Purified water 100 residue

(Formulation Example 8) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Jasmine essential oil 3.0 8 Whey 3.0 8. Comfrey 50% ethanol extract 2.0 9. Chimpi 50% ethanol extract 1.0 10. Seaweed (Hibamata) 50% ethanol extract 1.0 11. Preservative (paraoxybenzoate) qs 12. Fragrance ( Sage water) Appropriate amount 13. Residual water with 100 purified water

(Formulation Example 9) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 15.0 5. Borax 0.5 6. Oubak hot water extract 3.0 7. Soybean hot water extract 3.0 8. Tormentilla hot water extract 1.0 9. Liquid shea butter 1.0 10. Preservative (acrinol) 0.1 11. Appropriate amount of fragrance (sage water) 12. Purified water 100

(Formulation Example 10) Emollient cream weight% 1. stearic acid 2.0 2. stearyl alcohol 7.0 3. reduced lanolin 2.0 4. squalane 5.0 5. octyldodecanol 6.0 6. polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Oubak 50% 1,3-butylene glycol extract 3.0 10. Ogon 50% 1,3-butylene glycol extract 3.0 11. Melissa 50% 1, 3-Butylene glycol extract 1.0 12. Preservative (paraben) qs 13. perfume (clove water) qs 14. Purified water 100

(Formulation Example 11) Face wash cream wt% 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Extract of oak Liquid 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 8. Soy 50% 1,3-butylene glycol extract 2.0 9. Comfrey 50% 1,3-butylene glycol extract 3.0 10. Loose (Hiff) 50% 1,3-butylene glycol extract 2.0 11. Dipotassium glycyrrhetinate 1.0 12. Royal jelly extract 0.1 13. Preservative (salicylic acid) 0.1 14. Appropriate perfume (sage water) 15. Purified water 100

(Formulation Example 12) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. A: Whey B: Oubak 50% 1,3-butylene glycol extract * Any one of A-B extract 3.0 10. C: Ogon 50% 1,3- Butylene glycol extract D: Comfrey 50% 1,3-butylene glycol extract E: Soybean 50% 1,3-butylene glycol extract * Any one of CE to E extract 3.0 11. Glycyrrhetinic acid 1.0 12 Preservative (salicylic acid) 0.1 13.Perfume (Touki water) Appropriate amount 14.Purified water 100 residue

(Formulation Example 13) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Whey 1.5 5. Comfrey 50% 1,3-butylene glycol extract 1.0 6 Linden 50% 1,3-butylene glycol extract 0.5 7. seaweed (wakame) 50% 1,3-butylene glycol extract 0.5 8. valerian 50% 1,3-butylene glycol extract 0.5 9. polyethylene powder 0.5 10 Amino acids (glycine, glutamine, etc.) 0.5 11. Preservatives (undecylenic acid, phenol) proper amount 12. pH adjuster proper amount 13. Fragrance (shower water) proper amount 14. Purified water 100 residue

(Formulation Example 14) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 99% 1.0 12. Titanium dioxide 5.0 13. Whey 1.0 14. Soy 50 % Ethanol extract 0.5 15. Birch 50% ethanol extract 0.5 16. Oxophila 50% ethanol extract 0.5 17. Preservative (paraben) qs 18. perfume (apple water) qs 19. Purified water 100

(Formulation Example 15) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Obaque water extract 1.0 6 Aqueous water extract 1.0 7. Carrot water extract 0.5 8. Avocado water extract 0.5 9. Antioxidant (butylhydroxytoluene) qs 10. Flavor (toque water) qs

(Formulation Example 16) Cream foundation (O / W type) wt% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11. Kaolin 3.0 12. Talc 3.0 13. Color pigment (iron iron oxide) 1.0 14. Oubak 70% 1,3-butylene glycol extract Dry powder 0.1 15. Dry powder of soybean 70% 1,3-butylene glycol extract 0.1 16. Preservative (paraben) qs 17. flavor (lemon water) qs 18. Purified water 100

(Formulation Example 17) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Whey aqueous solution 2.0 7. Thympi 50% ethanol extract 2.0 8. Rosemary 30% ethanol extract 1.0 9. Mucopolysaccharide solution 1.0 10. Antibacterial and preservative (thiamine lauryl sulfate) qs 11. pH adjuster Appropriate amount 12.Fragrance (hamamelis water) Appropriate amount 13.Residual water to be 100

(Formulation Example 18) Rinse weight% 1. Stearyl trimethyl ammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Oubak 50% ethanol extract 1.0 6. Aloe 50 % Ethanol extract 1.0 7. Althea 50% ethanol extract 1.0 8. Trehalose solution 1.0 9. Hydrolyzed silk solution 1.0 10. Antibacterial and preservative (benzalkonium chloride) qs 11. Fragrance (lavender water) qs 12 .Remaining amount of purified water 100

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Whey 2.0 6. Comfrey 50% ethylene glycol Extract 1.0 7. Sodium soap 50% ethylene glycol extract 1.0 8. Trehalose solution 1.0 9. Hydrolyzed silk solution 1.0 10. Appropriate amount of antibacterial and preservative (benzalkonium chloride) 11. Appropriate amount of fragrance (chamomile water) 12. Residue with 100 purified water

(Formulation Example 20) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Oubak hot water extract 2.0 6. Hawthorn hot water extract 1.0 7. Diou hot water extract 1.0 8. Carpronium chloride 0.3 9. Hinokitiol 0.5 10. Keratin decomposition solution 1.0 11. Antibacterial and preservative (paraben, benzalkonium chloride) qs 12. Perfume (chamomile water) Appropriate amount 13. Residual water to be 100

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Oubak 50% ethanol extract 1.0 6. Ogugon 50% ethanol extract 1.0 7. Bukuryo 50% ethanol extract 1.0 8. Seaweed (Hijirimen, Kombu) 50% ethanol extract 1.0 9. Azulene 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) Appropriate amount 11 .Perfume (chamomile water) Appropriate amount 12. Residual water with 100 purified water

(Formulation Example 22) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: whey B: Oubak 60% ethanol extract * A Extract of any one of -B 3.0 5. C: 60% ethanol extract of pentagon D: Comfrey 60% ethanol extract E: 60% ethanol extract of soybean * Extract of any one of CE 3.0 6. Preservative (paraben) appropriate amount 7. Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. oak hot water extract 2.0 7 1. Quince hot water extract 1.0 8. Sodium hyaluronate solution 1.0 9. Carboxymethyl chitin solution 1.0 10. Vitamin E derivative 0.5 11. Antibacterial and preservative (paraben) 0.1 12. Flavor (rose water) qs 13. Purified water 100 And the rest

(Formulation Example 24) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Oubak 50% propylene glycol extract 5.0 3. Ougon 50% propylene glycol extract 2.0 4. Melissa 50% propylene glycol extract 2.0 5. Loquat Leaf 50% propylene glycol extract 1.0 6. Vitamin E derivative 0.5 7. Pepper tincture 0.5 8. Resorcin 0.5 0.5 Glycyrrhizic acid 0.5 10. Hydroxypropyl chitosan solution 0.5 11. Bovine hematin solution 0.5 12. Mucin solution 0.5 13. Amino acid ( (Glycine, glutamine, etc.) 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (rosemary water) qs 16. Purified water 100

(Formulation Example 25) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Whey aqueous solution 5.0 3. Lentinus 50% 1,3-butylene glycol extract 1.0 4. Mulberry bark 50% 1,3-butylene glycol Extract 1.0 5. Cantaritis tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhizic acid 0.5 8. Resorcinol 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Elastin hydrolyzate 0.5 13 .Antimicrobial and preservative (paraben) 0.1 14.Perfume (lavender water) qs 15.Purified water 100 residue

(Formulation Example 26) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. Whey 5.0 5. Powdered hot water extraction powder 5.0 6. Pigment (Gunjo Pink) ) Appropriate amount

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Oubak 70% ethanol extracted powder 1.0 5. Loquat leaf 70% ethanol extracted powder 1.0 6 .70% ethanol extracted powder from chamomile 1.0 7.70% ethanol extracted powder from mulberry bark 1.08 70% ethanol extracted powder from Novara 1.0 9.orange juice powder 1.0 10.Dye (Gunjo, chromium hydroxide) qs 11.Fragrance (Hamamelis) Water) appropriate amount

(Formulation Example 28) Coating Protective Agent A gauze or liniment cloth is impregnated with a formulation solution containing an appropriate amount of soybean, pentagon, Comfrey hot water mixed extract, antibiotics, anti-inflammatory, etc., and attached to the wound. Alternatively, the oak extract may be directly applied locally and covered with gauze or the like.

(Test 5) Use Effect Test The effect of the cosmetic composition of the present invention actually used was examined. A person suffering from acne or skin inflammation caused by acne, 10 persons aged 15 to 35 years old, as panelists, daily, in the morning and at night, twice a day after washing the face, and applying an appropriate amount of the emulsion of Formulation Example 1 onto the face for 2 weeks It was performed by coating. Incidentally, the control, the whey of the present invention, those containing only one kind of oak extract or each plant extract of the present invention from the milky lotion, or the whey of the present invention, those excluding the oat extract or each plant extract. What was prescribed by the same method was used. The evaluation was performed according to the following criteria. The results are as shown in Tables 3 to 5, and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.

Total cure: No acne or skin irritation caused by acne was eliminated. Significant effect: Significantly reduced symptoms. Effective: Symptoms were reduced. Invalid: No change from before use.

[0123]

[0124]

[0125]

(Test Results) As shown in Tables 3 to 5, one or more selected from whey and oak extracts of the present invention, and one or more plant extracts selected from ogon, comfrey and soybean were used in combination. Emulsion has a significant effect on rough acne or skin inflammation caused by acne,
A preventive effect was also observed. In addition, even when compared with the formulation of the component of the present invention alone (Ougon extract, Comfrey extract, soybean extract), the effect on acne or skin inflammation caused by acne was strongly recognized.

[0127]

EFFECT OF THE INVENTION A remedy for acne and a suppressant for the formation of acne, which are used in combination with one or more plant extracts selected from whey and oak extracts of the present invention, and one or more plant extracts selected from gibbon, comfrey and soybean. Alternatively, the cosmetic composition has an excellent effect on preventing and treating skin diseases such as acne or rough skin due to skin inflammation caused by acne. It is also safe for humans and animals, and can be used for other general foods and drinks.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (reference) A61K 35/78 A61K 35/78 QC J A61P 17/10 A61P 17/10 F term (reference) 4C083 AA071 AA072 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC022 AC072 AC102 AC122 AC132 AC182 AC212 AC242 AC312 AC342 AC392 AC402 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC682 AC692 AC792 AC902 AD022 AD412ADAD ADAD ADAD ADAD AD AD632 AD642 AD662 CC04 CC05 CC06 CC07 CC12 CC19 CC23 CC25 CC32 CC33 CC37 CC38 CC39 DD21 DD27 DD32 EE14 4C087 BB39 CA07 ZA89 4C088 AB12 AB38 AB62 ZA89

Claims (6)

[Claims] 1. A remedy for acne comprising at least one selected from whey and oat extract. 2. A method for suppressing the formation of a foam, which comprises at least one selected from whey and oat extract. 3. A cosmetic composition comprising any one or more of the acne treatment agent and the acne formation inhibitor according to claim 1 or 2. 4. A remedy for acne comprising the following essential components (1) and (2): (1) One or more selected from whey and oak extract. (2) One or more plant extracts selected from burdock, comfrey and soybean. 5. A production inhibitor comprising the following (1) and (2) as essential components: (1) One or more selected from whey and oak extract. (2) One or more plant extracts selected from burdock, comfrey and soybean. 6. A cosmetic composition comprising at least one of the acne treating agent and the acne formation inhibitor according to any one of claims 4 to 5.