JP2002068953A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new, safe and effective melanin formation inhibitor active oxygen scavenger and lipoperoxide formation inhibitor and a cosmetic composition which ameliorates dry skin, eczema or skin roughening by utilizing them and gives gloss or tension to the skin or hair. SOLUTION: This melanin formation inhibitor, active oxygen scavenger and lipoperoxide formation inhibitor are obtained by including an extract from Smallanthus sonchifolia and/or an extract from Citrus Junos as an active ingredient. The cosmetic composition is prepared by including these agents.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel cosmetic effect of a yacon extract and / or a yuzu extract and application to a cosmetic composition based thereon.

[0002] The melanin production inhibitor, active oxygen scavenger, lipid peroxide production inhibitor and the cosmetic composition containing them according to the present invention include pigmentation such as spots and freckles,
It refers to all external preparations for preventing or improving troubles such as rough skin and rough skin.

[0003]

2. Description of the Related Art The color of human skin is determined by the amount of melanin in the epidermis,
Capillary blood flow, food-derived pigment (carotene), the thickness of the stratum corneum and the like have an effect, and among them, melanin pigment has been reported as the most important factor. The so-called liver spots (spots), sparrow egg spots (buckwheat), and pigmentation caused by sunlight are the ones in which the production of melanin pigments is remarkably enhanced by the activation of pigment cells existing in the skin. It is one of the big troubles.

[0004] The melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the process of melanin pigment production, tyrosine is activated by tyrosine in pigment cells (melanocytes) to oxidize tyrosine,
It is converted to dopa and dopaquinone, further autoxidized, polymerized via dopachrome and 5,6-dihydroxyindole, and finally turned into a melanin pigment. The melanin thus produced is secreted from the dendrites of pigment cells (melanocytes) to basal cells, and the basal cells divide, become spiny cells and rise to reach the stratum corneum. Further, it has been reported that when this melanin is irradiated with ultraviolet rays, the existing melanin is oxidized and becomes black temporarily.

There have been many reports on methods for preventing or improving skin spots (spots), sparrow egg spots (buckwheat) and pigmentation due to pigmentation. It is said that it is effective to prevent melanin from being blackened by lightening, or to lighten the color of melanin already produced. Based on this, various whitening components have been conventionally proposed. For example, arbutin, kojic acid or a derivative thereof, ascorbic acid or a derivative thereof,
Tocopherol or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract and plant extract (arnica, altea, aloe, augon, emmeiso, chamomile, licorice, gardenia, genoshoko, sicon) , Ginger, birch, senkyu, gennoshoko, psycho, sasanqua, toki, calendula, elderberry, safflower, garlic, adlay, reishi, logwood)
Etc. are known.

On the other hand, in recent years, the production of active oxygen in a living body and various effects (diseases) caused thereby have been reported. Generally the active oxygen also called ^{_{Activated oxygens, O 2 -, H}} 2 O 2, · OH, is divided into chemiluminescence, both important to participate in self-defense of biological have potent bactericidal action Is considered to be a substance. For example, when foreign enemies (antigens) such as bacteria, viruses, and foreign substances enter the living body, phagocytic neutrophils, monocytes, and macrophages in the blood first start phagocytosis, and then phagocytes. Active oxygen is produced to dissolve foreign substances phagocytosed in the endoplasmic reticulum. This active oxygen acts on the dissolution of phagocytic foods, and on the other hand, directly exerts a bactericidal action on external enemies such as bacteria and foreign substances, thereby playing a role of protecting the living body from external enemies.

However, if the active oxygen for self-defense is excessively produced and secreted, even normal cells may be lysed and stimulated, resulting in various disorders.
Recently, many diseases and diseases induced by active oxygen have been reported. For example, fats and oils such as cholesterol in the blood are oxidized by active oxygen, and vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.)
And blood flow impairment due to a thrombus or the like at the time of cerebral trauma, or ischemic state (oxygen deficiency) in blood vessels due to sudden transient atrophy.

In particular, since the skin is an organ directly in contact with the outside world, it is easily affected by external environmental factors such as ultraviolet rays.
It is known that various diseases are caused by the active oxygen generated thereby. For example, if the active oxygen continues to be excessive in the skin due to ultraviolet rays or radiation,
It reacts with the unsaturated fatty acids of the phospholipids of biological membranes to generate lipid peroxides, which may cause arteriosclerosis, carcinogenesis, membrane destruction, protein degeneration, skin inflammation, and edema. Is done. In addition, from a cosmetic point of view, a disease caused by an excess of reactive oxygen is only concerned with herpes dermatitis, x-ray dermatitis, burns, trauma, sunshine dermatitis, contact dermatitis, eczema, atopic dermatitis, etc. Instead, it induces an increase in glycosaminoglycan, cross-linkage and reduction of collagen fibers, denaturation of elastic fibers, etc., causing the skin to lose its elasticity, causing external changes such as wrinkles and loosening. It is known that the phenomenon is promoted.

[0009] In order to prevent or ameliorate the above-mentioned diseases, substances such as superoxide dismutase (SOD), catalase, glutathione peroxidase, In addition, tocopherol (vitamin E), oryzanol, plant extract (hamamelis, melissa, emisoso, birch, sage, rosemary, age, basil, ginkgo, psycho, peonies, hange, cahig, tissou, ougon, carrot, licorice, ginger) Its usefulness has been pointed out.

[0010]

However, the above-mentioned whitening component or active oxygen-eliminating substance has poor stability and solubility in a prescription system, and produces an unpleasant odor and color due to sedimentation and decomposition, and also has an adverse effect on living organisms. It was not satisfactory in actual use, for example, the effect at the level was not sufficient, and there were safety problems such as skin irritation.

[0011]

Means for Solving the Problems The present inventors have conducted intensive studies in view of these circumstances, and have found that the yacon extract and / or
Alternatively, the present invention has succeeded in finding that the extract of Yuzu is excellent in usability and has an effective melanin production-suppressing action, an active oxygen scavenging (SOD-like) action and a lipid peroxide production-suppressing action. Further, by using this, a cosmetic composition which improves dry skin, eczema and rough skin, and gives gloss and shine to the skin and hair has been completed.

The present invention relates to a melanin production inhibitor, an active oxygen scavenger and a lipid peroxide production inhibitor containing a Yacon extract and / or a Yuzu extract, or a cosmetic composition containing these.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The plants used in the present invention are as follows. Alternatively, whole plants can be used.

"Yacon" means Polaceae in the Asteraceae family.
ymnia sonchifolia Poepp.et Endl. (= P.edulis Weddel
l.), preferably using leaves or roots.

[0015] "Yuzu (citrus, citron)" refers to Rutaceae.
It is Citrus junos Sieb.ex Tanaka, and seeds are particularly preferably used.

The yacon extract and / or yuzu extract used in the present invention are obtained by extracting various parts of a plant as it is or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin), and ketones such as acetone. , Ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform, etc. can be used alone or in any combination of two or more. Can also be used in a state where.

These extracts can be arbitrarily prepared by drying, concentrating, diluting, or mixing with other components, depending on the dosage form and form to be applied.

The extraction is usually carried out under normal pressure, and may be heated to increase the efficiency. After the extraction, the solution is purified by filtration and / or a column such as an ion exchange resin to obtain a solution, paste, gel, or powder. In many cases, the extract can be used as it is, but if necessary, purification treatment such as deodorization and decolorization can be performed as long as the effects of the present invention are not affected. In addition, as a purification treatment means such as deodorization and decolorization, an activated carbon column or the like can be used.

The yacon extract and / or yuzu extract of the present invention can be used as a melanin production inhibitor, an active oxygen scavenger, a lipid peroxide production inhibitor, or a raw material to be incorporated into a cosmetic composition. The content is based on the type of applied dosage form,
Depending on the method of use and the expected degree of action, the solid content is usually 0.001% by weight or more (hereinafter expressed as%), preferably about 0.01 to 20%.

The melanin production inhibitor, active oxygen scavenger and lipid peroxide production inhibitor or cosmetic composition according to the present invention may be used in addition to the above-mentioned essential extracts, in a range that does not impair the effects of the present invention. It can be produced by arbitrarily selecting and using the components and additives exemplified below.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopropanol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or alkylene such as chitosan, ethylene oxide (C2-C4)
Hydroxyalkyl to which an oxide is added (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol) ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

In foods and drinks, nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and other healthy and cosmetic effects, improvement in taste, provision of color tone, aroma and gloss, stabilization, It can be used for the purpose of thickening, preserving, etc. Furthermore, in addition to this, various cosmetic and pharmacological effects of each known raw material are expected, and by combining these, the intended effect is enhanced,
Alternatively, it is possible to provide a product that is expected to have a multifunctional effect.

Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akashoma (Akamasa), Akasuri `` fruit '', Red clover, Red grape, Akaminoki (Logwood), Red moss (Red bud), Red moss (Akane grass root), Red moss Ground yellow), Agi (Awei), Aki Larch, Akinire (Latinaceae),
Aguay Guacu, Aguahe (Omitengu palm),
Akebi (Kidori), Asa (Jin Asako), Malva Asagao or Asagao (Toshibushi), Hydrangea (hydrangea), Ashitaba (Asahi),
Azuki (red azuki), acerola, asenyaku (Asenyaku), acira (shokuyoukanna), anise, abiu, abiurana, rape, avemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), Amana (Kikomiko), Amaranthus (Amaranthus), Amaranthus hippochondriacus, Haribiyu, Amaranthus hippochondriacus, Amigasa lily or Bimo (shellfish),
Aristolomeria (Yurizisen), Arcana (Alcanna), Algarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Souduq), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azusa), Yellow sapote , Ikakozorina (ground bile head), Epimedium or Epimedium
(Inyokaku), Igusa (Wicked grass), Knotweed (Tiger root),
Strawberry (first place), strawberry, fig (Fig.
Leaf)), Ichihatsu (first time), Ichibi (Fruit Aoi), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimemegi (Enshi), Carob, Inu-zuna (Telelexi), Inubeyu (Sorainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwatsuchi-chi), iwahiba or iwamatsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (miyoko) ), Uguisukagura "fruit",
Himeuikyo, Turmeric (Utsukin), Duckweed (Floating), Usubasaishin or Keirinsaishin or Shousaisaishin (Spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer dry grass), Udo or Shishiudo (Qang, Independent, Tang Independent) ), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Urajirogashi, Uwaurushi (Kusakokomomo), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezogoka), Echinashi (Hosobamurasakikirengiku) , Enishida, Enokitake (Enotake), Ebisugusa or Cassia Tora (Kyoko), Elcampre, Elderberry `` fruit '', Elemi, Elingy or Prelotus elinge, Endu (Solanaceae, Sophoraceae rice), Ogi or Kibanaugi (yellow) Hoki), Ousei (Naruko lily, Kagi Kurumabanarukoyuri), OuHisasa Yuki or Sasanoyuki, Coptis (Coptis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil engineering incense), giant Tsudzurafuji
(Self-defense), plantain (car front child, car front grass), psyllium thistle
(Keju Leak, Hakuto Okina), Toucan (Haruko), Toucan cactus, Oobanokera or Okera (white juku), Oobansarusubari (Banaba), Oobayashibashi "fruit", Ooishigusa (cereal grass), Oumiacatetsu, Omihacateshi or Omihasabi Hawthorn (Yamako), Barley (barley), Oka, Okazeri (Snake bed), Okra `` fruit '', Oguruma (turnover), Oculli higotai (Yushu sashimi, indigo head), Panax ginseng or Ginseng (carrot), St. John's wort or St. John's wort or St. John's wort (St. edulis), St. John's wort (interrupted), Onomimomi (Blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara
(Tianma), Oni lily or Sasa lily or Hakata lily (Yuri),
Ononis, Halibut (hihayu), Ominaeshi (losing sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch honeysuckle, olives "fruits, seeds, leaves", oregano,
Orange `` fruit, pericarp '', calyxio (ripe yellow), cacao `` fruit, pericarp, seeds '', oyster (persimmon `` leaves ''), kagikazura (cho Tsukuto), persimmon or perilla (lotenso),
Gaku hydrangea, cassia, casino (Kozomi `` fruits ''), gajutsu (shajutsu), Kashiwa (shaki, kayoha), cascallilla, caskarasagrada, gypsophila, senso, kanikusa (kinsato), kaniwa, carnation, kanokosou ( Valerian root), birch or weeping birch (birch), gerbera, pumpkin, capoknoki `` seed '', kahokusansho (shopper), gama (bamboo), chamomile or roman chamomile, chamomile (tobacco), camucam (duckweed), color, Calla salmon, calla uri or china cucumber cucumber (roasted melon), crow sabishaw (midsummer), oak wheat, guarana `` seeds '', karahoo (thick), karaya, galu, karin (cucumber), garcinia, kawamidori, kawara saico (course (White grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawarani Carrot (Aoha),
Japanese mugwort (inchinko), kansui (sweet), licorice
(Licorice), cantaraasa, candelilla, cantola, canna, raspberry (ezo strawberry, strawberry strawberry, shrimp strawberry, pear strawberry, maple strawberry, european strawberry), kiwi `` fruit, leaf '', kiwi sap (urorone), kikyo (bellflower, bellflower) ), Chrysanthemum (chrysanthemum, sycamore, narcissus), chrysanthemum, catalpa (Azumitsu), sagebrush (yotei), pheasant (kinkumi), kizuta, kidachi aloe, edachi mint, kina, chinoki (shincona, red linden), quinoa (quinoa) , Yellowfin (yellow),
Gymnema sylvesta, kimmenkaku, cabbage, cabbage `` immature fruit '', cucumber, gyoryu (Nishikawayanagi, teriyaki), Kiraja saponaria, Kiraya, Kiranso (golden pesticide), kumquat `` fruit '', ginsekai, kimbusen,
Betel, golden hibiscus (following herbs), guapeba vermelha, guava `` fruits '', guayule, quelux infectria (gallicate), cucuinuts, wolfberry
Gugiko, gugi leaf, skeletal bark), kusagi kazura (tenmon winter),
Kudzu (Kakkon), camphor tree, gooseberry `` fruit '', ginseng (yellow flower), cutie river, gardenia (garden garden), kunugi (bokusou), cupuas, kumazasa, kumamatsura (horse whip grass), clara (bitter) , Cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black crocodile mochi (rescue rescue), kurobana hinokiokoshi or hinokiokoshi (extended life grass), clove (clove, Dingka), Gumbai Nazuna (Sekimei, Sekimeishi), Kaigai (Insect, Ichinaku spike), Keito (Rooster corolla, Chicken copter), Gekkavidin, Bayberry (Laurex), Kenashisarutoribara (Tokubukuryo, Mountain return), Gentiana, Gennoshoko (Older) Grass), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Obenimikan, Fukuromi , Sagami koji, ponkan, santara (tachibana skin)), koushinbara (monthly flower), kouzi mint, kouzo `` fruit '', kocha (tea), kohone (river bone), kouhon (straw and kara straw), kouriang, kouriyo Kyou (Kogaro), Cilantro (fruit), Kourouen (Kohren), Koganebana (Yellow Gon), Cowberry (Koshibachi), Coconut `` Fruit '', Goshuyu (Gusyuyu), Goshoichigo (Ubonashi), Pepper (pepper), Cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame ragweed (gensen), goji (gomiko), scallop or binankazura or matsubusa , Wheat (wheat),
Rice or rice bran `` red bran, white bran '', rice oil, cola acuminata `` seed '', cola vera `` seed '', colony llah, fenugreek `` fruit '', colombo, kondurango, kelp, konjac, comfrey (finnari grass), Sisal (Sisal Asa), Sakisima button or Sina button or Shina sensou (Sacred Reaper), Sakura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohagan, Sakuraza Fruit, bark (cherry bark) ''), cherries, pomegranate, sasa, sasanqua, sajimodaka (sawaka), sweet potato, sugarcane,
Sugar beet, Sun jujube (acid jujube), saffron
(Red safflower, western safflower), sapodilla, sapotea mariyo, pomelo `` fruit '', saponso, salmon berry `` fruit '', sarashinasho (masuma), saransitou (sand sashimi head), salvia (sage), sawagikyo (sangansai) , Sawagurumi (Salmon walnut), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sansin ginseng (Seven carrots), Sanshuyu (Susyuyu), Sansho (Sanshuyu), Sandscon (Yamazone), Shea ( (Karite), cyanoki `` fruit '', shiitake mushroom (shiitake), shion (shion), dikitaris, shikunshi (shikunshi), perilla or aodiso or chirimenjiso or katamendiso (perilla leaves, perilla), rosewood, linden, cinnamonium, cinnamon ( Forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, ossiloyshimeji, bunashimeji, honjimesi, shirotamogitake), shimoku Emissions (fist), Shimotsukesou, potatoes, peony (peony),
Shajin (Shasan), Jasmine (Matsurika), Janohige
(Bakumon winter), Gypsophila paniculata, Skull chamitsu (sand sand, sand compaction), Juzudama, palm `` fruit '', ginger (ginger), jadean hydrangea (Tsuneyama), shobu (iris, iris root), shozuku `` fruit '''', Shirakashi `` seed '', Shirogoshi butterfly `` seed '', white clover (clover), white adzuki (chicken bone), white squirrel (small iris), white savannatata `` flower '', white scented minami (minamitenmi), cinchona sacrifula, jinchoge (mizuka) , Mizuka, Shencho), cinnamon, cinnammom cassia (cinnamon bark), watermelon (watermelon), honeysuckle (gold and silver flower, Shinobi winter), sorrel (acid model), swimberry "fruit", star apple, stevia, strawberry "fruit", Suzu Psycho (Lord Xu Chang), Horsetail (Thorn),
Purslane (horse tongue, horse tooth tongue), plum "fruit",
Pinus sylvestris "cone", larch larch, edible walnuts, edible walnuts, hawthorn, dandelion, European horse chestnut (malonie), pear "fruit", euonymus japonica, elderberry
(Elder), Atlantic shrew (Juniper, Juniper), Achillea millefolium (Mirfoil), Atlantic rose, Atlantic anemone butterfly, Atlantic mistletoe, Atlantic mint or Atlantic mint, Horseradish, Sekisho
(Iris), Sekoku (Ishimasu), Cedron (Bowshukuboku), Zeniaoi, Hirohasenega, Senega, Seri, Celery, Sengoku (Raw Kyu), Sengshinren (Shoushinren), Sengdan, Sengin cactus, Senna `` Fruits, leaves '', Senninsou (Dai Tate), Sengoku (Drug), Soka (Grass), Elephant Chestnut, Soshinwabai, Buckwheat `` seed '', Somei potato, Rhubarb (Ohio), Radish, Soybean, Daidai (orange peel, Kikomi), Takasago Rurigotai ( (Southeast indigo sashimi), Takasaburo (Dried lotus grass), Takatodai (Daigyo), Takawarabi (Inu spine),
Dark sweet cherry "fruit", hollyhock, hollyhock (thyme, morika), hollyhock (hiki), hollyhock, tamarind "seed", onion, tamashiba
(Spicy), Tara tree `` Fruits, leaves, root bark '', Dahlia (Tengiku button), Talwi, Tanshichiwa, Tanjin (Dan ginseng), Dandelion (Gabiko) or Shirobana dandelion or Moko dandelion, Danmar, Cherry `` Fruits '', Chigaya `` Fruits '' , Roots, buds '', carrots (bamboo carrots), chicory,
Chancapiedra (Kidachiko Mikansou), Korean Radish (Rhuanghuang), Korean Radish (Wuyi), Korean Artemisia (Aiba), Choreimaitake (Irei), Chologi, Tsukimisou, Tsukuritake (Mushroom), Camellia, Camellia, Tsumekusa (lacquer) Ginkgo), asiatica (duckweed), vine adzuki
(Red azuki bean), tsuldokudami (what crow), tsuruna (banan), tsujin carrot (four leaf ginseng), tsuwabuki, deiko, teuchigurumi,
Duberry "fruit", tulip, chocolate stay,
Tengsa, Tencha (Tencha), Tendai Yaku (Wakayaku), Pepper (Winter Gourd), Touoka Kazura, Pepper (Pan pepper), Touki (Tokyo), Tokinsenka (Marigold), Touna Bena (River), Maize or Corn Hair (Southern barb hair), Ligustrum beech (Female Sadako), Toudondo or Korean Rosemary (Ryubin), Tokusa (pirate), Dokudami (Jyuku), Tokonon (sore root), Toshishi or Mamedaoshi or Pearhead, Eucommia (Tonaka `` bark) , Leaves, roots "), ash
(Qinhide), tomato, tragacanth, triacanthus `` seed '', eustoma, tormentilla, dronoki, trolo-mallow, Niseria berry `` fruit '', potato or yam (herbal medicine), squid (butcher bloom), naginata koji, nazuna, rape, Nut bean or mandarin (sword bean), jujube, jujube (daijutsu), nanawaibara
(Kanekurako), Navena (intermittent), Nameko, Narco lily (Yoshimi),
Peanut (peanut), Nanten (Minami Tenmi), Namban Karamushi (ramie), Niois violet, Nigaki (Makiki), Nigamogi (Grasshopper), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabnikkei (Chicago) or Keishi (Katsushige) ), Chinese chive
(Niriko), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nurde (five times), leek, nemoki or neb or nebi or nemuriki or digokbana (health), thistle (Oji) , Noibara (real fruit), Nozenkazura (Ryoshohana),
Lacewing, Yarrow, Sawdust (Maehu), Nobara, Nomomo, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hirindou,
Hauchiwa, Pau Doce, Hakamauraboshi (bone crushing supplement), Hakusen (ringworm skin), Huckleberry `` fruit '', Hakobe (proliferation), hazel (Haruko), Hashiridekoro (roto root), basil, lotus (lotus, lotus, (Renko), parsley (Netherlands jelly), naked mussels, batata, bees or medakes (bamboo-boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimochimo), banana, hana mint, hanabishi (swordfish, Shititsuri), vanilla bins, papaya, japonicus
(Mouse malt grass), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hamago or honeysuckle
(Kazuke), Hamabishi (Situriko), Hamanas (Maikai flower), Hamabo fu (Hama wind), Hamamelis, Palm, Rose (Roses), Ballata, Balata gum tree, Haratake (Haratake, Shirooharatake, Usukimori nokasa), Haran, Paliurus ( (Prunus avium), Parietalia,
Balsamina (Tsurureishi, Nigari), Harunile (Yellow, Yuhakuh, Yuba), Barbasco, Harindou, Handaikai (Greaper Sea), Breadfruit, Hiougi (shadow), Lycopodium ginseng (partisan), Pecan nut, Lycopodium (stone) Hirugaru, Tuzusha Hana, Higurumadaria, Higotai, Hishi (Hisami), Pistachio, Beet, Hitotsuba (Ishire), Hitotsubenienida, Daisies (Daisy), Hinata Kozuchi (cow knees), Hinoki, Hiba, Himashi, Sunflower, bell pepper, Himeuzu (Tamaoi), Himegama (incense blossom), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Bjakuyu, Hiyu `` Fruit '', Belodo oyster, Hiroo Okinagusa (Hakuto Okina), Loquat `` Fruit, Leaf, stem ", betel nut (large clothing skin, betel nut), puerh tea (pu-cha), sprout kazura (southern rattan), butterflies, coltsfoot (winter flowers) , Winter leaf), fujibakama (orchid grass), fuji bean (flat beans), fujimokiki
(Chaojizakura, Shinka), grapes `` fruit, peel, seeds,
Leaf '', beech, sycamore mushroom (Cycanoderma), Brazilian liquorice, Brazilian carrot, black currant `` fruit '', blackberry, blagnen, plum `` fruit '', flucellaria, blueberry (Prunus avium), prune, floral blanka, Blond psyllium, bundou (mung beans), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '',
Persea, Perbianberg, Pereschia grandifolia, Benikea or duckweed (Keiten), Boysenberry `` fruit '', Broomweed or Elderweed or Nendow or Hawakigi Kokia (Skinkoshi), Baldwink (Fengxian, acute child, osteophyte) , Potteria sapota, potteria lukuma, spinach, boufu (windbreak), spinach, physalis (toro root), honoki (wakopoku, park), bokeh (gourd), hosobaaburagiku (bittery), hosobaoguruma, hosobananaokera ), Japanese pine tree (Shinjing Sanshichi), Japanese lantern, bodaiju (Bodai tree), button (peony `` flower, leaf,
Stalks, bark ''), buttonpi (peony bark), hops, jojoba, borage (ruriticsha), bordeaux, white berry `` fruit '', hon-oniku (meat jiyo, daitei), honsekkoku (iron bark stone, sparrow mountain stone) , Maizul Tennan Shaw (Tennan Star), Maitake (Maitake), Ephedra (Masochism), Maca, Macadamia Nuts, Margaret (Mokshungiku), Macri (Seaweed), Magwa (Mulberry White Bark, Bark, Leaves), Magnolia・ Splengeri, Masaranpouba, Masaranzuba de Ceara, Masaira de Boi, Masahua (Tamanousenhallen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, pine `` leaves, bark, roots '', Matta Olho, Matsuhod (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanozadin (Bittersweet), Mulberry "Fruit", Quince, Malein (Below Mow) Watermelon), Mango, Mangosteen, Mansagna (Andesca Mitsure), Mansugurumi, Mandarin `` fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokokushi (half-edge lotus), Mihohagi (Chisatsuna), Mycian willow or Japanese willow (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Miyoka, Miracle fruit `` fruit '', Myrrh, Mirobaran, Mugiwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, Purple (purple root), Purple or purple
(Purple pearl), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, mehajiki (mother grass), mebougi, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), mock berry (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry `` fruit '', Moroheiya (Burlap), yakawamurasakiimo, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yashabushi (arrow wheel) or himeyashabushi or giant yashabushi `` fruit, peel, fruit ear '', yayagi, yatsude (octagon metal plate), mistletoe (Willow parasitism), willow (river willow, tachiyanagi, weeping willow,
Red Willow, Pussy Willow, Pussy Willow, Kinuyanagi, Kolyanagi, Unryuyanagi, Miyayamayanagi, Palm, Yamayanagi, Obanyanagi, Tairikkinyanagi,
(Sweaty willow, bonin), willow leaf `` leaves and stems '', yabugarashi, yabukouji (purple gold beef), yabu tobacco (crane squirrel, tenna sperm), pokeweed (commercial land), yamahannoki (yamaharu), yamamomo (yang plum skin), yamamomogi, Eucalyptus, Saxifraga (tiger ear grass), Yucca or Flefifolia, Lily, Yorugusa, Artemisia (Aiba), Lygan (Rainuma), Lime `` fruit '',
Rye, Lacanca `` fruit '', raspberry `` leaves, fruit '', latania (clameria), raccoon or shallots (scallop), lavender, longan (longan meat), agave (Aon agave, fukurin agave), ryocha (green tea), apple `` fruit '' , Seeds, leaves,
Root, gentian, rubus or suavisimus, sweet potato thistle (Urajirohigotai, Xinjiang indigo head), reishi
(Lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (serial forsythia), astragalus, waxy bean, wax palm, rocon (reed, Rone),
Loganberry "Fruit", Rosemary (Mannenrow), Rosehip (Nobara), Wasabi, Cottonweed
(Ming Monka), Waremoko (Jiyu) and the like.

In addition, other seawaters, for example, seawater salt, dried seawater, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic or Pacific Ocean, sea mud or mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaonori, Hosoedaoonori), Anaaousa (Aousa) and the seaweed [Aosa] Kinds: Kombu (macomb, risicombu, hosomekombu, mishitsembo), wakame, hirome, blue sea turtle, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata, umiuchiwa, usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], algae , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Juniperus giraffe, Tsunomata, Obatsunomata, Tochaka (Yahatsunonomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas spp .: Chlamydomonas sp., Akayukimo, Dunaliella spp .: Dunaliella spp. Spirogyra: Hizaori, Spirogyra, Tsurugimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: boletus japonicus, asamidorigusuga, kawashiogusa, marimo, baronia genus: tamagobaronia, tamabaronia, magnum: agatamagu, iwata: husaiwata, suricogita, heraiwata, crocodile, crocus Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, genus Genus genus, genus Colecaete, genus genus tsutsumo, genus cynomolgus genus: genus primrose, genus genus: human enthusiasts, genus phyllo, enthusiastic genus, mothine enthusiast, genus Genus, genus genus, sumiremo, etc.

Cyanobacteria (Genus Lynch: L., L., L., L .;
(Hassay, genus genus, genus racenmo (spirulina): spirulina, genus trichodesmium (aiakacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomid spp .: Naganami spp., Isogrape spp .: Isogrape,
Isogawara genus: Isogawara, Kurogashira genus: Gunsenkurogashira, Kashirazaki genus: Kashirazaki, Muchimo genus: Muchimo, Hiramutimo, Kebelligsa, Amidigusa genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukuromamiji, Common genus, Common genus Artemisia spp.
Genus genus: genus pine, genus genus: agamatsu, genus okinawa, genus okinawazuku, genus nov., Genus genus: nov. Ishige, Irolo, Icmegasa: Icmegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Betula genus, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Fennel, Turmo Genus: Turmo, Aname Genus: Aname, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Ligustrum, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochidumi-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombe genus: Kikuishicomb, Nejirekombu: Nekorecome, Kuroshiomeko genus : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hamawara, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitoranoo, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Ooban-moku, Genus genus:
Bulukimo, genus Kayamono: Kayamonoli etc.).

Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acacia sylvestris, Ochryllus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattle genus: rattle, hiragaragara, hirohatamatamaki genus: hirohatamaitadaki, tamayitadaki Genus: hibiroudo, himehibiroudo,
Genus Isomomedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekigusa genus: Nisekarekigusa, Okitsubara genus: Oba-okitsubara, Akaba: Akaba, Malva-acaba, Naminohanamina
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: etsukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, moss, moss , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabokintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Suzukito, Fukutokite, Fukutokite Nagaobabane: Nagaobabane,
Genus Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa genus: Kalexigusa, Tosakamaki Genus: Hosobanotosakamakiki, Hirohanokasakamukido, Yatsudegatatosakamokiki, Kurosakamokado, Nezashinotokamukado, Yukasakanokado, Hana Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenia, hohono genus: honoo, lycopodium genus: lycopodium, genus genus, nikunobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobori, Kijino-io Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikenori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, scutellaria genus: scutellaria, Simi genus: genitalia, saimi, squirrel, lotus genus:
Lotus spiders, genus genus: Ikanoashi, Hosoibonori,
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishiburokuro, Madaragusa: Pleurotus terrestris, Echinacea purpurea, Taoyagousou: Genus Taoyanagi, Hanasakura, Asperidae , Hirata goat: Hirata goat, Darus: Darus, Masagoshibari, Anadalus, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushigusa: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi and Snapdragons: Snapdragons, Snapdragons, Species: igis, keiigis, crickets, nigiri, amixa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usveni: Usveni, Hasuginu: Hasuginu, Nagakonohori: Nagakonosugino, Sugisugina, Genus Yaleusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki genus: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia: Enashidazia, Shimadada: Isohagi, Shimadada, Dazimodoki: Dazimomodoki, Itogusa: Moleutogusa, Futonigusa, Makuri: Makuri, Yanaginori: Hanayanagi, Yuna, Yanaginori, Motsurenagina, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshigu, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Hatakesakinokokihiba, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

Axle algae (Characta spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flassica: Himegrass, Chaboflas, Tripera, etc., Yellow algae (Hikarimo: Hikarimo, etc.) and the like.

Materials derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow stomach, a duodenum or an intestinal extract or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products and trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono
Glyceryl-2-ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (eg, magnesium phosphate of vitamin C, vitamin C glucoside), hydroquinone or a derivative thereof (eg, hydroquinone benzyl ether), kojic acid or a derivative thereof, vitamin E or a derivative thereof Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, corn, waremokou, clara, mugwort, Honeysuckle, yellowfin, amberjack, matsuhodo, adlay, dragonflies, hops, hawthorn, eucalyptus, achillea millefolium, althea, calyx, mankeishi, hamamelis, yamaguwa, enmeisou, bellflower, toshishi, seizoko, sun dried, mao, senkyu Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Promoting action of turnover / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Tokinsenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Tenmi,
Ages, ginkgo, green tea).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Bacillus natto extract, Loofah water, Birch (birch) or Akamatsu sap

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, Gennoshoko, comfrey, sage, seaweed, bollige, buttonpi), seaweed extract and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones, etc.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate, and the like.

(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives and anti-binders, fresheners, stabilizers, emulsifiers, animal and plant proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral preparations, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The melanin production inhibitor, active oxygen scavenger and lipid peroxide production inhibitor or cosmetic composition of the present invention may be in any dosage form, such as capsules, powders, granules, solids,
It can be in the form of a liquid, gel, air bubble, emulsion, cream, ointment, sheet or the like.

[0078] Specifically, for example, basic preparations such as medicinal preparations for external use, lotions, emulsions, creams, ointments, lotions, oils, packs, etc .; , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling products, perm agents, hair tonics, hair dyes, hair growth and hair growth products, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
Various products such as deodorants, sanitary cotton, and wet tissues can be used, and can be blended into general foods and drinks.

The method of adding the melanin production inhibitor, active oxygen scavenger and lipid peroxide production inhibitor of the present invention to the cosmetic composition may be added in advance or during the production. It may be appropriately selected in consideration of workability.

[0080]

EXAMPLES The present invention will now be described with reference to Production Examples, Test Examples and Formulation Examples, but the present invention is not limited thereto.

(Production Example 1) Each dried product of yacon and yuzu 10
0 g is extracted with warming in purified water (about 80 ° C.) for about 5 hours, filtered, and the extract (dry solid content: about 0.1 to 3.0%) is extracted to about 1.0 to 3.0 kg.
obtain.

(Production Example 2) Each dried product of yacon and yuzu 10
0 g is immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to extract (dry solid content: about 0.3 to 3.5%)
About 1.0-3.0 kg.

(Production Example 3) Each dried product of yacon and yuzu 10
0 g was gently warm-extracted with 1 L of an equal volume mixture of a 30% propylene glycol solution and a 30% 1,3-butylene glycol solution at 50 ° C. for 6 hours, and suction-filtered to obtain an extract (dry solid content: 0.1%).
2 to 2.5%).

(Production Example 4) Each dried product of yacon and yuzu 10
0g was immersed in 70% ethanol solution or 30% 1,3-butylene glycol solution, or 60% propylene glycol solution, or purified water (about 30 ° C), extracted at room temperature for 5 days and nights, and then filtered to extract. (Dry solids: about 0.3-2.5%) about 1.0-
Get 3.0kg.

(Test 1) Melanin production inhibitory test "Test method and evaluation method" B16 melanoma cells were cultured for 24 hours, and this culture solution was replaced with a culture solution containing a sample. At this time, a solvent in which the sample was dissolved was added to the blank. After culturing for 3 days, the cells were treated with trypsin, and dissolved by heating in a 1N-NaOH solution containing 10% DMSO.
The absorbance at 20 nm was measured. At the same time, the MTT reduction method (Tim Mosmann; Journal of Immunological Methods p5
5-63 (1983)), the number of cells was measured, and after confirming that there was no difference in the number of surviving cells between the blank group and the sample-added group, the suppression rate (%) of the blank cells against the amount of melanin production
Was determined by Equation 1. The results are shown in FIG.

"Sample" The sample was prepared by adjusting the active ingredient of the present invention obtained in Production Example 1 so that the solid content in the culture solution was 25 ppm. As a comparative sample, arbutin manufactured by Sigma was prepared under the same conditions and subjected to a test.

<Equation 1> Melanin production inhibition rate (%) = {1- (sample melanin amount / blank melanin amount)} × 100

(Test Results) As shown in FIG. 1, the production of melanin was significantly suppressed in the sample-added system, and it was confirmed that the active ingredient of the present invention had a high melanin production inhibitory action. Although almost the same effect was observed, though not as much as arbutin, which is a known active ingredient, the product of the present invention is considered to be useful as a whitening agent.

(Test 2) Active oxygen elimination (SOD-like activity)
Action test In recent years, many diseases and diseases induced by active oxygen have been reported, and it has been pointed out that removal and elimination of active oxygen leads to prevention of tissue damage. In this test,
The active ingredient of the present invention obtained in Production Example 1 was evaluated for its ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system using the nitro blue tetrazolium method (Lipid peroxide experiment method, p. Publishing Co., Ltd.)
It was examined by.

"Testing method and evaluation method" [0108] To 2.5 mL of a 0.05 M sodium carbonate buffer (pH 10.2) containing 1.0 mM xanthine and 3.0 mM disodium ethylenediaminetetraacetate was added.
Add 75 mM nitro blue tetrazolium, 0.15 W / V% bovine serum albumin, and 0.1 mL of each sample solution, and leave at 25 ° C. for 10 minutes. There is a xanthine oxidase aqueous solution 0.1m which was adjusted so that the absorbance change was about 0.3 / 20 minutes in advance.
After L was added and left at 25 ° C. for 20 minutes, the reaction was stopped with a 6 mM CuCl solution, and the absorbance at 560 nm was measured. The control ratio was obtained by adding the solvent of the sample solution instead of the sample as a control, and for each sample and the control, the group containing the reaction stop solution before the addition of xanthine oxidase was used as a blank, and the inhibition rate was calculated by Equation 2. As shown in FIG.

"Sample" As a sample, the product of the present invention obtained in Production Example 2 was adjusted to a solid content concentration of 0.1% and subjected to a test. As controls, a peony extract and a hop extract (both 50% EtO
H extract) adjusted to a solid concentration of 0.1% was used for the test.

<Equation 2> Active oxygen scavenging rate (%) = {1− (sample OD value−blank (sample) OD value) / (control OD value−blank (control) OD value)} ×
100

(Test Results) As shown in FIG. 2, the active oxygen scavenging ability was observed in the product of the present invention. Therefore, the product of the present invention is considered to be useful as an active oxygen scavenger.

(Test 3) Lipid Peroxide Inhibition Test Lipid peroxide is an oxidized unsaturated fatty acid, which damages the cell membrane in vivo, inactivates various enzymes, and denatures biological proteins. And so on. As a result, it is said that various harmful effects are exerted on living tissues, such as acceleration of aging and cancerous changes. In the skin, for example, the accumulation of lipid peroxides caused by the peroxidation of sebum causes changes in the cell membrane and mitochondrial functions of the skin,
It is said to not only induce symptoms such as melasma, primary irritant dermatitis, and atopic dermatitis, but also promote skin aging such as rough skin, wrinkles, and senile pigmentation. Suppression is regarded as important in dermatology. In this test, the amount of peroxide of linolenic acid generated by ultraviolet rays was measured by using the TBA method (Analytical, Biochemistry. Vol. 95, pp. 351-358 (1979)) and obtained in Production Example 1. The antioxidant effect of the active ingredient of the present invention was examined.

"Test method and evaluation method" A solution in which 0.1% linolene was dissolved in 0.8% sodium lauryl sulfate 4.
To 9 mL, add 0.1 mL of the test sample and irradiate with ultraviolet light for 1 hour. 1 mL of this reaction solution is placed in a centrifuge tube containing dibutylhydroxytoluene as a reaction terminator, 1 mL of thiobarbituric acid solution is added thereto, and the mixture is heated at 95 ° C. for 1 hour. After cooling, 4 mL of a butanol solution was added, shaken well, centrifuged, and the absorbance at 532 nm of the butanol layer was measured.
In addition, the solvent to which the solvent was added was used as a control, and a blank which was not irradiated with ultraviolet light was set for each sample and control, and the lipid peroxide production inhibition rate (%) was determined by Equation 3. The results are shown in FIG. "Sample" The sample was prepared by adjusting the active ingredient of the present invention obtained in Production Example 2 so as to have a solid concentration of 0.10%, and was subjected to a test. As a comparative sample, dl-α-tocopherol manufactured by Kishida Chemical was prepared under the same conditions and used for the test.

<Equation 3> Lipid peroxide production inhibition rate (%) = {1− (sample OD value−flank (sample) OD value) / (control OD value−flank (control) OD value)}
× 100

(Test Results) As shown in FIG. 3, the product of the present invention was superior to the control, dl-α-tocopherol, but showed a strong inhibitory effect on lipid peroxide production. Therefore, the product of the present invention is considered to be useful as an antioxidant.

(Test 4) Safety test (1) Skin primary irritation test The active ingredient of the present invention obtained in Production Example 1 was prepared with purified water so that the dry solid concentration was 1.0%, and the back Was applied to the skin of shaved Japanese white rabbits (female, 3 animals per group, weight around 2.3 kg). At 24, 48 and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. The results confirmed that all animals did not show any erythema and edema and were safe with respect to primary skin irritation.

(Test 5) Safety Test (2) Skin Cumulative Irritation Test The active ingredient of the present invention obtained in Production Example 1 was prepared with purified water so that the dry solid content concentration was 1.0%, and the back was Hartley guinea pig with female shaving (female, 3 animals per group, weight 330g)
0.5 mL / animal was applied to the skin before and after) once a day, 5 times a week. Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. The results confirmed that all animals did not show any erythema and edema for 2 weeks and were safe with respect to cumulative skin irritation.

(Test 6) Safety test (3) Single dose toxicity test The active ingredient of the present invention obtained in Production Example 1 was adjusted with purified water to a concentration of 12.5%, and 16 mL / kg per animal. The amount of ddy mice (male and female,
(5 animals per group, 5 weeks old) were orally administered, and the appearance and degree of toxicity symptoms were observed over time. As a result, no abnormality was observed in all the mice for 14 days, and it was confirmed that there was no abnormality in the dissection result. Therefore, the LD50 was considered to be 2,000 mg / kg or more, confirming that the substance was safe.

(Formulation Examples) Production of Various Cosmetic Compositions The following formulation examples are shown in accordance with the above evaluation results. Was.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Sorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. Yacon 50% EtOH extract 5.0 10. Preservative (paraoxybenzoate) qs 11. perfume qs 12. Purified water 100

(Formulation Example 2) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12. Yacon extract of Production Example 3 3.0 13. Yuzu hot water extract 3.0 14. Preservative (p-hydroxybenzoate) appropriate amount 15. Purified water 100 residue

(Formulation Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Grapefruit fruit or leaf hot water extract 3.0 6. Yacon of Production Example 4 Extract 3.0 7. Yuzu extract of Production Example 4 3.0 8. Olive oil 1.0 9. Shea butter 1.0 10. Butylhydroxyanisole 0.1 11. Vitamin E derivative 0.1 12. Preservative (benzalkonium chloride) qs. Water) Appropriate amount 14. Residual water to make purified water 100

(Formulation Example 4) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Yakon 30% ethanol extraction Liquid 1.0 6. Yuzu 30% ethanol extract 1.0 7. Grapefruit fruit or leaf 50% ethanol extract 1.0 8. Kiwi fruit 50% ethanol extract 1.0 9. Antibacterial and preservative (lactoferrin solution) qs 10. Fragrance (Western thin load) Water) Appropriate amount 11. Residual water to make purified water 100

(Formulation Example 5) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Yacon 50% 1,3-butylene glycol extract 2.0 5. Gentian whole plant 50 % Ethanol extract 1.0 6. Sage whole plant 50% ethanol extract 1.0 7. Allantoin 0.2 8. Astringent (zinc sulfocarbonate) 0.2 9. Antibacterial and preservative (thiamine lauryl sulfate) qs 10. Perfume (lavender water) Appropriate amount 11.Purified water 100 residue

(Formulation Example 6) Two-layer lotion (liquid to liquid type) wt% 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Yuzu 30% ethanol extract 2.0 6. Peony 30% glycerin extract 1.0 7. Hawthorn whole plant 30% glycerin extract 1.0 8. Ascorbic acid 0.2 9. Astringent (calamine) 0.1 10. Preservative (phenoxyethanol) qs 11. Spice (lemon water) qs 12.Remaining with purified water 100

(Formulation Example 7) Carmine lotion (liquid to solid)% by weight 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. Yuzu 50% propylene glycol extract 2.0 8. Yacon 50% propylene glycol extract 2.0 9. Panax ginseng root 50% propylene glycol extract 1.0 10. Placenta extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative (photosensitive Element 201 & 401) Suitable amount 14.Fragrance (Bodhi tree water) Appropriate amount 15.Purified water 100 residue

(Formulation Example 8) pack weight% 1. polyvinyl alcohol 15.0 2. sodium carboxymethyl cellulose 5.0 3. propylene glycol 3.0 4. ethanol 10.0 5. yacon 50% ethanol extract 1.0 6. thyme whole plant 50% ethanol extract 1.0 7. 50% ethanol extract of Melissa leaf or stem 1.0 8. Preservative (paraoxybenzoate) qs 9. Fragrance (Tokisui) qs 10. Purified water 100

(Formulation Example 9) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Yacon 30% ethanol Extract 2.0 8. Safflower whole plant 50% ethanol extract 2.0 9. Yuzu fruit 50% ethanol extract 2.0 10. Preservative (paraoxybenzoate) qs 11. perfume (cypress water) qs 12. Purified water 100 Residue

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Yacon extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 9.Yuzu extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10.Birch bark extract 2.0 (ethanol: 1 , 3-butylene glycol = 1: 1 extraction solvent) 11.Liquid shea fat 1.0 12.Preservative (acrinol) 0.1 13.Perfume (sage water) Appropriate amount 14.Purified water 100 residue

(Formulation Example 11) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Hot water extract of Saranshito 3.0 10. Yacon 10% 1,3-butylene glycol extract 3.0 11. Yuzu 30% 1,3-butylene glycol extract 3.0 12. Rosemary leaf or flower 50% 1,3-butylene glycol extract 2.0 13. Preservative (paraben) suitable amount 14. Fragrance (cinch water) proper amount 15. Purified water 100 residue

(Formulation Example 12) Face wash cream weight% 1. myristic acid 25.0 2. stearic acid 5.0 3. tallow fatty acid 5.0 4. propylene glycol 10.0 5. potassium hydroxide 6.0 6. coconut oil fatty acid diethanolamide 6.0 7. yacon extraction Liquid 2.0 (ethanol: 1,3-butylene glycol = 1: 2 extraction solvent) 8. Yuzu hot water extract 2.0 9. Luffa fruit or stem 50% 1,3-butylene glycol extract 2.0 10. Dipotassium glycyrrhetinate 1.0 11 .Preservative (salicylic acid) 0.1 12.Perfume (sage water) appropriate amount 13.Purified water 100 residue

(Formulation Example 13) Face wash cream weight% 1. stearic acid 10.0 2. palmitic acid 10.0 3. myristic acid 12.0 4. lauric acid 4.0 5. oleyl alcohol 1.5 6. lanolin derivative (EO adduct) 1.0 7. glycerin 18.0 8. Potassium hydroxide 6.0 9. Yuzu extract of Production Example 3 5.0 10. Royal jelly extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 11. Glycyrrhetinic acid 1.0 12. Preservative (salicylic acid) 0.1 0.1 13. Perfume (Tokimizu) Appropriate amount 14. Purified water 100 residue

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Whey 1.5 5. 70% yacon 70% 1,3-butylene glycol extract 1.0 6. Yuzu 70% 1,3-butylene glycol extract 0.5 7. Amacha leaf or stem 70% 1,3-butylene glycol extract 0.5 8. Polyethylene powder 0.5 9. Hydroxypropyl chitosan solution 0.5 10. Amino acids (glycine, glutamine, etc.) 0.5 11. Preservative (undecylenic acid, phenol) proper amount 12. pH adjuster proper amount 13. Fragrance (lavender water) proper amount 14. Purified water 100 residue

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 1.0 12. Titanium dioxide 5.0 13. Yacon 50% dipropylene glycol extract 0.5 14. Yuzu 50% dipropylene glycol extract 0.5 15. Honeysuckle whole plant 50% dipropylene glycol extract 0.5 16. Mulberry bark 50% dipropylene glycol extract 0.5 17. Purple root 50% dipropylene glycol extract 0.5 18. Preservative (paraben) qs 19. Fragrance (apple water) qs 20. Purified water 100 residue

(Formulation Example 16) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. 30% Yacon 1,3 -Butylene glycol extract 1.0 6. Yuzu 10% 1,3-butylene glycol extract 1.0 7. Aloe leaf 50% 1,3-butylene glycol extract 0.5 8. Yukinoshita whole plant 30% 1,3-butylene glycol extract 0.5 9. Barley whole plant 50% 1,3-butylene glycol extract 0.5 10. Fencil fruit 30% 1,3-butylene glycol extract 2.0 11. Antioxidant (butylhydroxytoluene) qs 12. Fragrance (bodaiju water) Appropriate amount

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-Dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Color pigment (iron iron oxide) 1.0 15. Yakon hot water extraction Dry powder 0.2 16. Yuzu hot water extraction dry powder 0.2 17. Preservative (paraben) proper amount 18. Fragrance (rose water) proper amount 19. Purified water 100 residue

(Formulation Example 18) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Yakon 20% 2,3-butylene glycol extract 2.0 7. Yuzu 10% 1,4-butylene glycol extract 2.0 8. Hydroxypropyl chitosan solution 2.0 9. Mucopolysaccharide solution 1.0 10. Antibacterial and preservative (photosensitive Element No. 101) Appropriate quantity 11. pH adjuster Appropriate quantity 12. Perfume (sandalwood water) Appropriate quantity 13. Residue to 100 purified water

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Yacon 50% 1,2-butylene glycol extract 1.0 6. Yuzu 50% 1,2-butylene glycol extract 1.0 7. Novara 50% 1,2-butylene glycol extract 1.0 8. Futandanpopo 50% 1,3-butylene glycol extract 1.0 9. Hydroxyethyl chitosan solution 1.0 10. Trehalose solution 1.0 11. Hydrolyzed silk solution 1.0 12. Appropriate amount of antibacterial and preservative (benzalkonium chloride) 13. Appropriate amount of fragrance (lavender water) 14. Residual amount of purified water 100

(Formulation Example 20) Rinse weight% 1. Stearyl trimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Yuzu 50% ethylene glycol extraction Solution 1.0 7. Yacon 50% 1,3-butylene glycol extract 1.0 8. Apricot fruit or leaf 30% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed keratin solution 1.0 11. Antibacterial and preservative (chlorinated) Benzalkonium) Appropriate amount 12. Fragrance (chamois water) Appropriate amount 13. Residual water to be purified water 100

(Formulation Example 21) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Yuzu hot water extract 2.0 6. Yacon 50% ethanol extract 2.0 7. Matsufudo sclerotium 50% ethanol extract 1.0 8. Melissa whole plant 50% ethanol extract 1.0 9. Panax ginseng root 50% ethanol extract 1.0 10. Carpronium chloride 0.3 11. Hinokitiol 0.5 12. Keratin Decomposition solution 1.0 13. Antibacterial and preservative (paraben, benzalkonium chloride) proper amount 14. Fragrance (senkyu water) proper amount 15. Purified water 100 residue

(Formulation Example 22) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Trimethylene glycol 5.0 6. Yuzu 50% Ethanol extract 1.0 7. Parsley whole plant 50% 1,3-butylene glycol extract 0.5 8. Loquat leaf 30% ethanol extract 1.0 9. Azulene 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) qs 11 .Perfume (Touki water) Appropriate amount 12. Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Yacon extract of Production Example 5.0 5. Peony 50% Ethanol extract 3.0 6. Yuzu leaf or fruit 50% ethanol extract 3.0 7. Preservative (paraben) qs 8. Purified water 100 residue

(Formulation Example 24) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. Yuzu hot water extract 2.0 7 .Yacon 50% ethanol extract 1.0 8. Ogon 50% ethanol extract 1.0 9. Carboxymethyl chitin solution 1.0 10. Vitamin E derivative 0.5 11. Antibacterial and preservative (paraben) 0.1 12. Perfume (sage water) Appropriate amount 13. Residue with 100 purified water

(Formulation Example 25) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Yacon 50% propylene glycol extract 5.0 3. Panax ginseng root 50% propylene glycol extract 2.0 4. Artemisia leaf or stem 50% 1,3- Butylene glycol extract 1.0 5. 50% nuts 1,3 butylene glycol extract 1.0 6. Vitamin E derivative 0.5 7. Pepper tincture 0.5 8. Resorcin 0.5 9. Dipotassium glycyrrhizinate 0.5 10. Carboxymethyl chitin solution 0.5 11 Beef hematin solution 0.5 12. Mucin solution 0.5 13. Amino acids (glycine, glutamine, etc.) 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (rosemary water) qs 16. Purified water 100

(Formulation Example 26) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Yacon 50% 1,3-butylene glycol extract 1.0 3. Yuzu 50% 1,3-butylene glycol extract 1.0 4. Assembly Drugs) Whole plant 60% ethanol extract 1.0 5. Canthari tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhizic acid 0.5 8. Resorcinol 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12 .Antimicrobial and preservative (paraben) 0.1 13.Perfume (lavender water) suitable amount 14.Purified water 100 residue

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. Yuzu hot water extraction dry powder 5.0 5. Eucalyptus whole plant hot water extraction dry powder 5.0 6. Suitable amount of pigment (Gunjo green)

(Formulation Example 28) Granule bath agent% by weight 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Yakon hot water extraction dry powder 2.0 5. Yuzu hot water extraction dry powder 1.0 6. Satsuma mandarin orange 50% ethanol extracted dry powder 1.0 7. Peach leaf 70% ethanol extracted dry powder 1.0 8. Iris leaf or root 70% ethanol extracted dry powder 1.0 9. Apple juice powder 1.0 10. Pigment (Gunjo, chromium hydroxide) 11. Suitable amount of fragrance (grape water)

(Formulation Example 17) Coating Protective Agent A gauze or liniment cloth is impregnated with a prescription liquid obtained by mixing a suitable amount of a 20% ethanol extract of Yacon, an antibiotic, an anti-inflammation, etc. to prepare a protective agent for clothing attached to the wound. Alternatively, the Yuzu hot water extract may be directly applied locally and covered with gauze or the like.

(Test 8) Use effect test A use test was conducted to evaluate the effect of the cosmetic composition of the present invention when actually used. Conditions are stains,
Sobacas, people suffering from dark and dark (34-41 years old, 8 people) and people suffering from dry skin and skin without luster (26-47 years old, 10 people)
Is a paneler, twice daily in the morning and evening, and after washing the face, an appropriate amount of the emulsion (test product) of Formulation Example 2 is applied to the left half of the face. We decided to apply to half. The evaluation was performed according to the following criteria. The results are shown in Tables 1 and 2, and the numbers in the table represent the number of persons. No one complained of skin abnormalities during the use period.

"Stain, freckles, skin color improving effect" Efficacy: Blemish, freckles, and skin blackness were less noticeable (improved) than before. Slightly effective: spots, freckles, and skin darkness were slightly reduced. Ineffective: No change from before use.

[0133]

"Skin quality improving effect" Effective: The gloss and firmness of the skin increased, and the dry skin quality was also improved to a dry skin. Somewhat effective: Skin gloss and tension increased slightly, and dry skin quality was slightly improved. Ineffective: No change from before use.

[0135]

(Test Results) As shown in Tables 1 and 2, the emulsion containing the product of the present invention is effective for significantly improving dry skin, giving the skin a gloss and firmness, and reducing stains and freckles. Confirmed that there is. In addition, there was a case that it was effective in reducing eczema.

(Test 11) Use effect test A use test was conducted to evaluate the effect when the cosmetic composition of the present invention was actually used. The condition is for those who are worried that there is a lot of gloss, lack of tension, split ends and cuts (26 ~
(47 years old, 10 persons) were panelists, and for two weeks after the start of the test, the shampoos and rinses of Formulation Examples 18 and 20 prepared as control products were prepared by removing the active ingredient of the present invention from the shampoos and rinses.
For the next two weeks, the shampoos and rinses (test products) of Formulation Examples 18 and 20 were used every night. The evaluation was performed according to the following criteria. The results are as shown in Table 5, and the numerical values in the table represent the number of persons. No one complained of hair and scalp abnormalities during the use period.

"Hair quality improving effect" Effective: Hair gloss and tension increased, and split ends and cut hairs were improved. Slightly effective: Hair gloss and tension was slightly increased, and split ends and cut hairs were slightly improved. Ineffective: No change from before use.

[0139]

[0140]

Industrial Applicability The melanin production inhibitor, active oxygen scavenger and lipid peroxide production inhibitor or cosmetic composition containing the yacon extract and / or yuzu extract of the present invention have an excellent melanin production inhibitory action. It was confirmed that it had an inhibitory effect on tyrosinase activity, a scavenging effect on active oxygen and an inhibitory effect on lipid peroxide production. Further, the cosmetic composition containing them has an effect of improving spots, freckles, skin color, an effect of improving dry skin, eczema, and rough skin, and a beautiful skin effect of giving gloss and tension to skin and hair, and an antiaging effect.

[Brief description of the drawings]

FIG. 1 is a view showing the results of a melanin production inhibition test of a yacon extract and / or yuzu extract of the present invention.

FIG. 2 is a view showing the results of an active oxygen elimination test of the yacon extract and / or yuzu extract of the present invention.

FIG. 3 is a graph showing the results of a lipid peroxide production inhibition test of the yacon extract and / or yuzu extract of the present invention.

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[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0021

[Correction method] Change

[Correction contents]

The melanin production inhibitor, active oxygen scavenger and lipid peroxide production inhibitor or cosmetic composition of the present invention do not impair the effects of the present invention, if necessary, in addition to the above essential extract. The components and additives exemplified below can be arbitrarily selected and used in combination within the range, and the content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 Q 7/06 7/06 7/075 7/075 7/50 7/50 F-term (reference) 4C083 AA072 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB352 AB432 AB442 AC022 AC062 AC072 AC092 AC102 AC122 AC132 AC182 AC242 AC342 AC352 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC622 AC902 AD272 AD312 AD322 AD412 AD442 AD452 AD512 AD532 AD552 AD642 AD662 CC04 CC05 CC06 CC07 CC23 CC25 CC38 CC39 DD05 DD12 DD21 DD22 DD23 DD27 DD30 DD31 EE06 EE16

Claims (4)

[Claims] 1. A melanin production inhibitor comprising a yacon extract and / or a yuzu extract. 2. An active oxygen scavenger comprising a Yacon extract and / or a Yuzu extract. 3. A lipid peroxide production inhibitor comprising a yacon extract and / or a yuzu extract. 4. The melanin production inhibitor according to claim 1, which contains a yacon extract and / or a yuzu extract, the active oxygen scavenger according to claim 2, and the lipid peroxide production inhibitor according to claim 3. , A cosmetic composition comprising at least one or more.