ES2189163T3 - Nitro-benzamidas utiles como agentes anti-arritmicos. - Google Patents

Nitro-benzamidas utiles como agentes anti-arritmicos.

Info

Publication number
ES2189163T3
ES2189163T3 ES98920498T ES98920498T ES2189163T3 ES 2189163 T3 ES2189163 T3 ES 2189163T3 ES 98920498 T ES98920498 T ES 98920498T ES 98920498 T ES98920498 T ES 98920498T ES 2189163 T3 ES2189163 T3 ES 2189163T3
Authority
ES
Spain
Prior art keywords
provides
nitro
benzamidas
arritmic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98920498T
Other languages
English (en)
Inventor
Graham Ralph Smithkline Slater
Paul Jeffrey Smithkline Westlake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2189163T3 publication Critical patent/ES2189163T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

Hidrocloruro hidratado de N-{[}3-{[}{[}2-{(}3,4- dimetoxifenil{etil]amino{]}propil{]}-4-nitro benzamida que se caracteriza porque: (i) comprende agua en el intervalo entre 1,7 a 2,4equivalentes molares; y/o (ii) tiene un punto de fusión por encima de 145ºC y/o (iii) proporciona un espectro infrarrojo que contiene picos a 3510, 3342, 3076, 1665, 1598, 1343, 1330, 1216 y 801 cm{sup,-1}; y/o (iv) proporciona un espectro de resonancia magnética nuclear en estado sólido que contiene desplazamientos químicos tal y como se representa en la Tabla I; y/o (v) proporciona una configuración de refracción de polvo de rayos X (XRPD) tal y como se representa en la Tabla II; un procedimiento de preparación de dicho compuesto, una composición farmacéutica que lo comprende y la utilización de dicho compuesto en medicina.
ES98920498T 1997-03-27 1998-03-24 Nitro-benzamidas utiles como agentes anti-arritmicos. Expired - Lifetime ES2189163T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9706376.2A GB9706376D0 (en) 1997-03-27 1997-03-27 Novel pharmaceutical

Publications (1)

Publication Number Publication Date
ES2189163T3 true ES2189163T3 (es) 2003-07-01

Family

ID=10809958

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98920498T Expired - Lifetime ES2189163T3 (es) 1997-03-27 1998-03-24 Nitro-benzamidas utiles como agentes anti-arritmicos.

Country Status (37)

Country Link
US (1) US20040092771A1 (es)
EP (1) EP0971882B1 (es)
JP (1) JP2001518088A (es)
KR (1) KR20010005566A (es)
CN (1) CN1257478A (es)
AP (1) AP1205A (es)
AT (1) ATE228997T1 (es)
AU (1) AU741476B2 (es)
BG (1) BG103829A (es)
BR (1) BR9809054A (es)
CA (1) CA2285197A1 (es)
DE (1) DE69809891T2 (es)
DK (1) DK0971882T3 (es)
DZ (1) DZ2452A1 (es)
EA (1) EA002439B1 (es)
EG (1) EG21226A (es)
ES (1) ES2189163T3 (es)
GB (1) GB9706376D0 (es)
HK (1) HK1025089A1 (es)
HU (1) HUP0001683A3 (es)
ID (1) ID22787A (es)
IL (1) IL132042A0 (es)
IN (1) IN188180B (es)
MA (1) MA26477A1 (es)
NO (1) NO994682D0 (es)
NZ (1) NZ337794A (es)
OA (1) OA11200A (es)
PE (1) PE61799A1 (es)
PL (1) PL335879A1 (es)
PT (1) PT971882E (es)
SK (1) SK283056B6 (es)
TR (1) TR199902356T2 (es)
TW (1) TW518318B (es)
UA (1) UA57066C2 (es)
UY (1) UY24937A1 (es)
WO (1) WO1998043947A1 (es)
ZA (1) ZA982558B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923933D0 (en) * 1999-10-08 1999-12-08 Smithkline Beecham Lab Novel pharmaceutical
GB9923934D0 (en) * 1999-10-08 1999-12-08 Smithkline Beecham Plc Novel pharmaceutical
US8483008B2 (en) * 2008-11-08 2013-07-09 Westerngeco L.L.C. Coil shooting mode

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2726267B1 (fr) * 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer

Also Published As

Publication number Publication date
SK130299A3 (en) 2000-05-16
BG103829A (bg) 2000-04-28
UA57066C2 (uk) 2003-06-16
DE69809891D1 (de) 2003-01-16
OA11200A (en) 2003-05-21
EA002439B1 (ru) 2002-04-25
HK1025089A1 (en) 2000-11-03
PE61799A1 (es) 1999-09-10
NO994682L (no) 1999-09-24
HUP0001683A3 (en) 2002-11-28
DE69809891T2 (de) 2003-07-24
IL132042A0 (en) 2001-03-19
BR9809054A (pt) 2000-08-01
AP1205A (en) 2003-09-17
CA2285197A1 (en) 1998-10-08
TR199902356T2 (xx) 2000-01-21
MA26477A1 (fr) 2004-12-20
AP9901651A0 (en) 1999-09-30
AU7334198A (en) 1998-10-22
GB9706376D0 (en) 1997-05-14
HUP0001683A2 (hu) 2000-09-28
JP2001518088A (ja) 2001-10-09
EG21226A (en) 2001-03-31
US20040092771A1 (en) 2004-05-13
AU741476B2 (en) 2001-11-29
SK283056B6 (sk) 2003-02-04
KR20010005566A (ko) 2001-01-15
NZ337794A (en) 2001-06-29
EP0971882B1 (en) 2002-12-04
DK0971882T3 (da) 2003-03-31
UY24937A1 (es) 2000-12-29
TW518318B (en) 2003-01-21
PL335879A1 (en) 2000-05-22
NO994682D0 (no) 1999-09-24
WO1998043947A1 (en) 1998-10-08
EA199900879A1 (ru) 2000-04-24
IN188180B (es) 2002-08-31
ZA982558B (en) 1999-09-27
EP0971882A1 (en) 2000-01-19
CN1257478A (zh) 2000-06-21
ATE228997T1 (de) 2002-12-15
ID22787A (id) 1999-12-09
DZ2452A1 (fr) 2003-01-18
PT971882E (pt) 2003-04-30

Similar Documents

Publication Publication Date Title
EA200200571A1 (ru) Новая композиция и ее применение
SE8700499D0 (sv) Novel pharmacologically active compounds
YU6303A (sh) Nova heterociklična jedinjenja, njihovo dobijanje i njihova upotreba kao medikamenata, a naročito kao anti-bakterijskih agenasa
IS2600B (is) Ný tríasólpýrimídínefnasambönd
ES539076A0 (es) Procedimiento para preparar piridin-2-eteres o piridin-2-tioeteres
EP0237200A3 (en) Stabilized pharmaceutical composition comprising a benzimidazole compound, its production and its use as an antiulcer agent
DK1193270T3 (da) Pyrrolobenzodiazepiner
SE8804629A (es)
HUP0400932A3 (en) Pharmaceutical composition containing nateglinide and another antidiabetic compound, process for its preparation and for use the same
EE200000595A (et) Toimeaine viimine kandjamaatriksisse
GEP20043179B (en) Halogenated Amidino Amino Acid Derivatives Useful as Nitric Oxide Synthase Inhibitors
HUP0203431A3 (en) Novel heterocyclic compounds and salts thereof and pharmaceutical compositions containing and use of the same
DK537389D0 (da) Glycosidase-inhibitoren salbostatin, dens fremstilling og anvendelse
ES2056692T3 (es) Triacinas y pirimidinas trisustituidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
ES8800161A1 (es) Procedimiento para la fabricacion de derivados quinolilglicinamidas
SE8904298D0 (sv) New compounds
ES2189163T3 (es) Nitro-benzamidas utiles como agentes anti-arritmicos.
GB9108629D0 (en) Heterocyclic pharmaceutical compounds,preparation and use
DE3688087T2 (de) Cephemverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
IT1303793B1 (it) "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)"
HUP0401862A3 (en) Novel heterocyclic compound and medicinal use thereof and pharmaceutical compositions containing them
MX9100593A (es) Mejoras en o relativas a derivados de propilamina
IT1302022B1 (it) Metodo per eseguire schermografie di parti del corpo di un pazientecon tecnica slot liberamente programmabili e dispositivo per la
GB2135997B (en) N-(m-trifluoromethylphenyl)-n'-propargylpiperazine
IL159493A0 (en) Pharmaceutical formulation containing an ltb4 antagonist