DE60234053D1 - Racemisierung und enantiomerentrennung von clopidogrel - Google Patents

Racemisierung und enantiomerentrennung von clopidogrel

Info

Publication number
DE60234053D1
DE60234053D1 DE60234053T DE60234053T DE60234053D1 DE 60234053 D1 DE60234053 D1 DE 60234053D1 DE 60234053 T DE60234053 T DE 60234053T DE 60234053 T DE60234053 T DE 60234053T DE 60234053 D1 DE60234053 D1 DE 60234053D1
Authority
DE
Germany
Prior art keywords
clopidogrel
enantiomer
racemization
enantiomers
hydrocarbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60234053T
Other languages
English (en)
Inventor
Valeriano Merli
Paola Daverio
Stefano Bianchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60234053D1 publication Critical patent/DE60234053D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60234053T 2002-08-02 2002-11-22 Racemisierung und enantiomerentrennung von clopidogrel Expired - Lifetime DE60234053D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40073802P 2002-08-02 2002-08-02
PCT/US2002/037680 WO2004013147A1 (en) 2002-08-02 2002-11-22 Racemization and enantiomer separation of clopidogrel

Publications (1)

Publication Number Publication Date
DE60234053D1 true DE60234053D1 (de) 2009-11-26

Family

ID=31495866

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60234053T Expired - Lifetime DE60234053D1 (de) 2002-08-02 2002-11-22 Racemisierung und enantiomerentrennung von clopidogrel

Country Status (10)

Country Link
US (1) US6737411B2 (de)
EP (2) EP1483269B1 (de)
AT (1) ATE445621T1 (de)
AU (1) AU2002350250A1 (de)
CA (1) CA2494528C (de)
DE (1) DE60234053D1 (de)
ES (1) ES2332773T3 (de)
IL (1) IL166593A0 (de)
MX (1) MXPA05001319A (de)
WO (1) WO2004013147A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2363053C (en) * 2001-11-09 2011-01-25 Bernard Charles Sherman Clopidogrel bisulfate tablet formulation
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
WO2004106344A2 (en) 2003-04-25 2004-12-09 Cadila Healthcare Limited Salts of clopidogrel and process for preparation
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
US7446200B2 (en) * 2004-10-04 2008-11-04 Usv, Ltd. Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I
AU2005327776A1 (en) * 2005-02-15 2006-08-24 Usv Limited Rapid resolution process for clopidogrel base and a process for preparation of Clopidogrel bisulfate polymorph - Form I
TW200640932A (en) * 2005-02-24 2006-12-01 Teva Pharma Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
CZ299213B6 (cs) * 2005-03-08 2008-05-21 Zentiva, A. S Zpusob racemizace R(-) izomeru methylesteru kyseliny (2-chlorfenyl)-6,7-dihydro-thieno[3,2-c]pyridin-5(4H)-octové
CN101212954A (zh) * 2005-05-10 2008-07-02 伊兰制药国际有限公司 纳米粒氯吡格雷制剂
CN101237868A (zh) * 2005-06-13 2008-08-06 伊兰制药国际有限公司 纳米粒氯吡格雷和阿司匹林组合制剂
JP4834333B2 (ja) * 2005-06-27 2011-12-14 アルプス薬品工業株式会社 光学活性ベンジルアミン誘導体の製造方法
KR20070094230A (ko) * 2006-03-17 2007-09-20 한미약품 주식회사 클로피도그렐 캄파술폰산염 또는 이의 결정다형을 함유하는약학 조성물
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
KR100834967B1 (ko) 2006-08-11 2008-06-03 에스케이케미칼주식회사 여액의 라세미화 반응에 의한 ｓ-(＋)-클로피도그렐의고수율 제조방법
DK2064217T3 (da) 2006-09-04 2011-05-09 Ranbaxy Lab Ltd Forbedret fremgangsmåde til fremstilling af clopidogrel og dets farmaceutisk acceptable salte
SI22383A (sl) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
PL380849A1 (pl) * 2006-10-17 2008-04-28 Adamed Spółka Z Ograniczoną Odpowiedzialnością Krystaliczna postać racemicznego -(2-chlorofenylo)-6,7-dihydrotieno[3,2-c]pirydylo-5(4H)-octanu metylu, sposób jej wytwarzania i zastosowanie
BRPI0803101A2 (pt) * 2007-04-18 2014-04-22 Teva Pharma Processos melhores para preparação de clopidogrel
KR20160033792A (ko) 2007-04-27 2016-03-28 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
WO2008146249A1 (en) * 2007-05-30 2008-12-04 Wockhardt Research Centre Processes for the preparation of clopidogrel
KR100887655B1 (ko) 2007-08-01 2009-03-11 (주)바이오켐넷 클로피도그렐의 제조방법
HUP0700809A2 (en) * 2007-12-14 2009-11-30 Richter Gedeon Nyrt Racemisation process for producing methyl (r,s)-(+)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4h)-acetate hydrogene sulfate intermediate
EP2107061A1 (de) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Herstellungsverfahren für optisch angereichertes Clopidogrel
EP2346879A1 (de) * 2008-10-24 2011-07-27 Sandoz AG Verfahren zur herstellung von s-clopidogrel
US8137356B2 (en) * 2008-12-29 2012-03-20 Zimmer Spine, Inc. Flexible guide for insertion of a vertebral stabilization system
US8236782B2 (en) 2009-05-13 2012-08-07 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN101695496A (zh) * 2009-10-15 2010-04-21 苏春华 一种含有三氟柳和氯吡格雷的药物组合物
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
JP5695797B2 (ja) * 2011-04-14 2015-04-08 グァンツォ ハース ファーマ デベロップメント シーオー．，エルティーディー． 新規抗血小板化合物の付加塩
CN106518732B (zh) * 2016-09-30 2018-01-16 厦门欣赛科技有限公司 一种樟脑磺酸合成母液回收利用的方法
CN106496077B (zh) * 2016-09-30 2018-01-16 厦门欣赛科技有限公司 一种从樟脑磺酸合成母液回收樟脑磺酸的方法
CN107383055A (zh) * 2017-08-03 2017-11-24 江苏汉斯通药业有限公司 硫酸氢氯吡格雷的合成方法
US20230059869A1 (en) 2021-08-03 2023-02-23 Liqmeds Worldwide Limited Oral pharmaceutical solution of clopidogrel

Family Cites Families (21)

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FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
DE3873162D1 (de) 1987-05-15 1992-09-03 Ciba Geigy Ag Verfahren zur abtragenden bearbeitung von optischen koerpern aus vernetzten polymeren.
FR2652575B1 (fr) 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664276B1 (fr) 1990-07-04 1992-10-23 Sanofi Sa Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.
FR2664596B1 (fr) 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
US5576328A (en) 1994-01-31 1996-11-19 Elf Sanofi Method for the secondary prevention of ischemic events
FR2751540B1 (fr) 1996-07-26 1998-10-16 Sanofi Sa Composition pharmaceutique antithrombotique
FR2760456B1 (fr) 1997-03-05 2000-05-12 Sanofi Sa Procede de preparation de derives de 2-thienyl-ethylamine
FR2760452B1 (fr) 1997-03-05 1999-05-28 Sanofi Sa Procede d'obtention d'enantiomeres d'acides alpha-amines et sels diastereoisomeriques intermediaires
HU225504B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
HU225503B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU222283B1 (hu) 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
DE19721580A1 (de) 1997-05-23 1998-11-26 Dresden Arzneimittel Verwendung von 1-Ar(alk)yl-imidazolin-2-one zur Behandlung von Angst- und Spannungszuständen
FR2769313B1 (fr) 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
HU226421B1 (en) 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
FR2792836B3 (fr) 1999-04-30 2001-07-27 Sanofi Sa Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel
EP1343791A2 (de) * 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Substituierte tetrazyklische pyridoindole als serotonin agonisten und antagonisten
CN100338068C (zh) 2001-01-24 2007-09-19 卡地拉健康护理有限公司 制备氯吡格雷的方法
IN191030B (de) 2001-01-24 2003-09-13 Cadila Healthcare Ltd

Also Published As

Publication number Publication date
WO2004013147A1 (en) 2004-02-12
EP2168969A3 (de) 2011-02-09
US6737411B2 (en) 2004-05-18
EP1483269A4 (de) 2006-08-02
MXPA05001319A (es) 2005-04-28
EP1483269B1 (de) 2009-10-14
AU2002350250A1 (en) 2004-02-23
ES2332773T3 (es) 2010-02-12
IL166593A0 (en) 2006-01-15
EP2168969A2 (de) 2010-03-31
US20040024011A1 (en) 2004-02-05
ATE445621T1 (de) 2009-10-15
EP1483269A1 (de) 2004-12-08
CA2494528C (en) 2009-09-01
CA2494528A1 (en) 2004-02-12

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