CY1121999T1 - Φαρμακοτεχνικες μορφες συνδυασμου δαρουναβιρης - Google Patents
Φαρμακοτεχνικες μορφες συνδυασμου δαρουναβιρηςInfo
- Publication number
- CY1121999T1 CY1121999T1 CY20171101267T CY171101267T CY1121999T1 CY 1121999 T1 CY1121999 T1 CY 1121999T1 CY 20171101267 T CY20171101267 T CY 20171101267T CY 171101267 T CY171101267 T CY 171101267T CY 1121999 T1 CY1121999 T1 CY 1121999T1
- Authority
- CY
- Cyprus
- Prior art keywords
- darunavir
- combination
- pharmaceutical forms
- forms
- pharmaceutically acceptable
- Prior art date
Links
- CJBJHOAVZSMMDJ-HEXNFIEUSA-N darunavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 CJBJHOAVZSMMDJ-HEXNFIEUSA-N 0.000 title abstract 2
- 229960005107 darunavir Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
Αυτή η εφεύρεση σχετίζεται με στέρεες από του στόματος δοσολογικές μορφές του αναστολέα HIV Δαρουναβίρης και/ή ένα φαρμακευτικώς αποδεκτό άλας ή επιδιαλυτωμένο σύμπλοκο αυτής, και με φαρμακοτεχνικές μορφές συνδυασμού αυτής.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11173067 | 2011-07-07 | ||
PCT/EP2012/063249 WO2013004818A1 (en) | 2011-07-07 | 2012-07-06 | Darunavir combination formulations |
EP12738060.8A EP2729130B1 (en) | 2011-07-07 | 2012-07-06 | Darunavir combination formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121999T1 true CY1121999T1 (el) | 2020-07-31 |
Family
ID=46551505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171101267T CY1121999T1 (el) | 2011-07-07 | 2017-12-05 | Φαρμακοτεχνικες μορφες συνδυασμου δαρουναβιρης |
Country Status (23)
Country | Link |
---|---|
US (3) | US20140142070A1 (el) |
EP (1) | EP2729130B1 (el) |
JP (1) | JP6122427B2 (el) |
KR (1) | KR102058097B1 (el) |
CN (1) | CN103826616B (el) |
AU (1) | AU2012280198B2 (el) |
BR (1) | BR112014000290B1 (el) |
CA (1) | CA2838659C (el) |
CY (1) | CY1121999T1 (el) |
DK (1) | DK2729130T3 (el) |
EA (1) | EA026587B1 (el) |
ES (1) | ES2651212T3 (el) |
HR (1) | HRP20171889T1 (el) |
HU (1) | HUE035241T2 (el) |
IL (1) | IL229933A (el) |
LT (1) | LT2729130T (el) |
MX (1) | MX343689B (el) |
NO (1) | NO2729130T3 (el) |
PL (1) | PL2729130T3 (el) |
PT (1) | PT2729130T (el) |
RS (1) | RS56667B1 (el) |
SI (1) | SI2729130T1 (el) |
WO (1) | WO2013004818A1 (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE035241T2 (en) | 2011-07-07 | 2018-05-02 | Janssen Sciences Ireland Uc | Darunavir combination products |
WO2013130766A1 (en) * | 2012-03-01 | 2013-09-06 | Gilead Sciences, Inc. | Spray dried formulations |
CA3012242C (en) | 2012-12-21 | 2021-11-02 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
EP3632415A1 (en) | 2015-11-09 | 2020-04-08 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
US20190175509A1 (en) * | 2016-08-08 | 2019-06-13 | Hetero Labs Limited | High Drug Loaded Tablet Composition for Treating HIV |
EP3496719B1 (en) * | 2016-08-08 | 2023-06-14 | Hetero Labs Limited | A multi-class anti-retroviral composition |
WO2018029561A1 (en) | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | Anti-retroviral compositions |
US20180085387A1 (en) * | 2016-09-27 | 2018-03-29 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
US10786518B2 (en) * | 2017-07-20 | 2020-09-29 | Janssen Sciences Ireland Uc | Compositions and methods of treating HIV |
US20200101093A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Sciences Ireland Unlimited Company | Methods of Treating and Preventing Neuropsychiatric and/or Neurocognitive Complications in Patients Infected with HIV |
WO2021180963A1 (en) | 2020-03-13 | 2021-09-16 | Janssen Sciences Ireland Unlimited Company | A protease inhibitor regimen for treating subjects infected with hiv |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
ES2127938T3 (es) | 1993-08-24 | 1999-05-01 | Searle & Co | Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. |
AU771780B2 (en) | 1998-06-23 | 2004-04-01 | Board Of Trustees Of The University Of Illinois, The | Fitness assay and associated methods |
TWI286476B (en) | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
HUE034389T2 (en) | 2002-05-16 | 2018-02-28 | Janssen Sciences Ireland Uc | Pseudopolymorphic forms of an HIV protease inhibitor |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
WO2007143422A2 (en) | 2006-05-30 | 2007-12-13 | Janssen Pharmaceutica N.V. | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
US20080039428A1 (en) * | 2006-06-29 | 2008-02-14 | Panacos Pharmaceuticals, Inc. | Antiretroviral combination therapy |
TWI411613B (zh) | 2006-07-07 | 2013-10-11 | Gilead Sciences Inc | 用於改善被細胞色素p450單氧合酶所代謝之治療劑的藥物動力性質之調節劑 |
MX2009004439A (es) * | 2006-10-25 | 2009-05-11 | Mcneil Ppc Inc | Composicion de ibuprofeno. |
MX2009008935A (es) | 2007-02-23 | 2009-11-02 | Gilead Sciences Inc | Moduladores de las propiedades farmacocineticas de productos terapeuticos. |
US20100190809A1 (en) | 2007-06-25 | 2010-07-29 | Jody Firmin Voorspoels | Combination formulations |
AR069539A1 (es) | 2007-07-25 | 2010-02-03 | Tibotec Pharm Ltd | Avances respecto de las formulaciones de comprimidos contra el vih |
NZ584998A (en) | 2007-11-20 | 2012-08-31 | Janssen Pharmaceutica Nv | Cycloalkyloxy-and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor |
GT200800303A (es) * | 2007-12-24 | 2009-09-18 | Combinacion anti-retroviral | |
EA201591353A1 (ru) * | 2008-05-02 | 2016-01-29 | Джилид Сайэнс, Инк. | Применение частиц твердого носителя для улучшения технологических характеристик фармацевтического агента |
PE20110994A1 (es) * | 2009-02-06 | 2012-01-24 | Gilead Sciences Inc | Comprimidos antivirales que comprenden elvitegravir, emtricitabina, disoproxil fumarato de tenofovir y un derivado de tiazol |
CA2776807C (en) * | 2009-09-17 | 2018-10-16 | Mylan Laboratories Limited | An improved process for the preparation of darunavir |
WO2011141921A1 (en) | 2010-05-10 | 2011-11-17 | Hetero Research Foundation | Darunavir compositions |
HUE035241T2 (en) | 2011-07-07 | 2018-05-02 | Janssen Sciences Ireland Uc | Darunavir combination products |
BR112014000195A2 (pt) | 2011-07-07 | 2017-02-21 | Janssen R&D Ireland | formulações de darunavir |
WO2013115916A1 (en) | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Combination therapy comprising gs-7340 and cobicistat for use in the treatment of viral infections |
JP2018502118A (ja) | 2015-01-03 | 2018-01-25 | マイラン・ラボラトリーズ・リミテッドMylan Laboratories Limited | 非晶質ヘミフマル酸テノホビルアラフェナミドおよびその予備混合物を調製するプロセス |
-
2012
- 2012-07-06 HU HUE12738060A patent/HUE035241T2/en unknown
- 2012-07-06 SI SI201231141T patent/SI2729130T1/en unknown
- 2012-07-06 LT LTEP12738060.8T patent/LT2729130T/lt unknown
- 2012-07-06 NO NO12738060A patent/NO2729130T3/no unknown
- 2012-07-06 WO PCT/EP2012/063249 patent/WO2013004818A1/en active Application Filing
- 2012-07-06 US US14/131,282 patent/US20140142070A1/en not_active Abandoned
- 2012-07-06 ES ES12738060.8T patent/ES2651212T3/es active Active
- 2012-07-06 KR KR1020147000092A patent/KR102058097B1/ko active IP Right Grant
- 2012-07-06 JP JP2014517822A patent/JP6122427B2/ja active Active
- 2012-07-06 EP EP12738060.8A patent/EP2729130B1/en active Active
- 2012-07-06 EA EA201490222A patent/EA026587B1/ru unknown
- 2012-07-06 BR BR112014000290-8A patent/BR112014000290B1/pt active IP Right Grant
- 2012-07-06 DK DK12738060.8T patent/DK2729130T3/en active
- 2012-07-06 AU AU2012280198A patent/AU2012280198B2/en active Active
- 2012-07-06 RS RS20171244A patent/RS56667B1/sr unknown
- 2012-07-06 CA CA2838659A patent/CA2838659C/en active Active
- 2012-07-06 PL PL12738060T patent/PL2729130T3/pl unknown
- 2012-07-06 MX MX2013015199A patent/MX343689B/es active IP Right Grant
- 2012-07-06 CN CN201280033554.0A patent/CN103826616B/zh active Active
- 2012-07-06 PT PT127380608T patent/PT2729130T/pt unknown
-
2013
- 2013-12-17 IL IL229933A patent/IL229933A/en active IP Right Grant
-
2017
- 2017-12-05 HR HRP20171889TT patent/HRP20171889T1/hr unknown
- 2017-12-05 CY CY20171101267T patent/CY1121999T1/el unknown
-
2019
- 2019-11-27 US US16/697,888 patent/US11654150B2/en active Active
-
2023
- 2023-05-05 US US18/313,266 patent/US20230302024A1/en active Pending
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