CN107157448B - Optoacoustic for superficial place imaging and ultrasonic synchronous imaging system and method - Google Patents
Optoacoustic for superficial place imaging and ultrasonic synchronous imaging system and method Download PDFInfo
- Publication number
- CN107157448B CN107157448B CN201710379974.9A CN201710379974A CN107157448B CN 107157448 B CN107157448 B CN 107157448B CN 201710379974 A CN201710379974 A CN 201710379974A CN 107157448 B CN107157448 B CN 107157448B
- Authority
- CN
- China
- Prior art keywords
- optoacoustic
- signal
- ultrasonic
- echo
- ultrasound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0825—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the breast, e.g. mammography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
- A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
- A61B8/5261—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from different diagnostic modalities, e.g. ultrasound and X-ray
Abstract
The invention discloses the optoacoustics being imaged for superficial place and ultrasonic synchronous imaging system and method, it is related to the technical field of medical test imaging device, including laser and photoacoustic ultrasound bimodal imaging system, the photoacoustic ultrasound bimodal imaging system includes signal control and processing module, photoacoustic ultrasound bimodal image-forming module, image display and hand-held optoacoustic probe, it is additionally provided with ultrasonic transducer in hand-held optoacoustic probe, laser is for exporting laser signal, and signal control and processing module are for exporting ultrasonic signal；Hand-held optoacoustic probe is for conducting laser signal and ultrasonic signal to superficial place to be detected；Photoacoustic ultrasound bimodal image-forming module is sent to image display and is shown for rebuilding ultrasonoscopy and photoacoustic image.High sensitivity of the present invention, imaging depth are big, can be flexibly applied to the imaging of the human bodies superficial place such as mammary gland, sentinel lymph node, thyroid gland, prostate.
Description
Technical field
The present invention relates to the technical fields of medical test imaging device, and in particular to a kind of light for superficial place imaging
Sound and ultrasonic synchronous imaging system and method.
Background technology
By the continuous innovation of engineering in medicine technology for many years, the tumor imaging detecting instrument based on imaging methods obtains
It is widely applied, important foundation is provided for medicine detection, Clinics and Practices.Breast cancers are the higher tumours of the extent of injury
Illness, the main imaging device for being applied to tumor of breast detection in the prior art are respectively provided with different technical characterstics, but also still
So it there is a problem that certain：
1) X-ray mammary gland CT/ analog or digital mammary machines, imaging have health potential using having radioactive X-ray
Harmfulness, and be not suitable for carrying out repeated detection in a short time；To in imaging process breast position and technician operation
Level requirement is higher, is easy to form the blind area of imaging；Wherein analog or digital mammary machine also needs to oppress breast, compressing
For power usually in 50N or more, Patient Experience is more painful；The imaging pair for soft tissue structure is compared with the East Asia women population of horn of plenty
Not higher than degree, specificity is not strong；
2) mammary gland infrared light checking therapeutic equipment, resolution ratio and specificity are very poor, are unfavorable for the identification of lesion；Only has two dimension
Imaging capability, accurate three dimensional local information can not be provided；
3) mammary gland nuclear-magnetism MRI, it is more demanding with operative skill to fixed position with mammary gland CT；The check cost of patient compared with
It is high；Pregnancy women taboo uses；
4) breast ultrasound detector, the resolution ratio and specificity of imaging are all poor；It is early to be difficult to small calcification point etc.
Phase pathological characters.
Photoacoustic imaging is a kind of medical image cutting edge technology developed rapidly in recent years, and existing photoacoustic technique is applied to
The scheme of breast cancer allows disease when detecting such as using the ultrasound transducer array of the annular of specific customization or bowl structure
Breast is placed in one by people using the upright or sleeping posture lain prone, and light irradiation excitation is carried out around it, and receive the light of generation
Acoustical signal.Non- hand-held bowl formula optoacoustic mammary gland device there are it is inconvenient for use the problems such as, doctor's operation and the experience that uses of patient are not
Good, bowl formula device can sacrifice some imaging depths usually nor fitted closely with breast, influence to detect quality.
Chinese patent application CN102512207A discloses a kind of B-ultrasonic probe type photoacoustic imaging breast scanner and its scanning
Method：It ties upper two fiber optic bundle in the Ultrasonic-B probe both sides of B ultrasound ultrasonic imaging device.When scanning, first in Ultrasonic-B probe and tested mammary gland
Upper smearing ultrasonic coupling agent, then opens laser light source, by the fiber optic bundle of Ultrasonic-B probe both sides, before directing the light beam into Ultrasonic-B probe
On the mammary gland at end；Ultrasonic probe acquires the photoacoustic signal that breast is generated by optoacoustic effect, and is transmitted in computer and believes through correlation
Number, real-time two-dimensional imaging after image procossing.The patent application disclose B-ultrasonic probe type photoacoustic imaging breast scanner and its scannings
Photoacoustic imaging is applied in breast imaging by method, but photoacoustic technique is applied in conjunction with ripe ultrasonic system, needs to overcome one
A little key technical problems, such as the control and acquisition of photoacoustic signal, the processing of signal, and with the coupling of ultrasonic signal etc., it is practical
There are larger technical difficulty in operation.
Invention content
In view of the deficiencies of the prior art, the purpose of the present invention is intended to provide the optoacoustic being imaged for superficial place and ultrasound is same
Walk imaging system and method, by photoacoustic imaging technology and optoacoustic-ultrasonic double-mode state imaging system be combined into a kind of high sensitivity, at
As the imaging system that depth is big and sweep speed is fast, enable to be flexibly applied to mammary gland, sentinel lymph node, thyroid gland, preceding
In the imaging of the human bodies superficial place such as row gland.
To achieve the above object, the present invention adopts the following technical scheme that：
Optoacoustic for superficial place imaging and ultrasonic synchronous imaging system, including the laser and optoacoustic-that are connected are super
Sound bimodal imaging system, the optoacoustic-ultrasonic double-mode state imaging system include that signal control and processing module, optoacoustic-ultrasound are double
Modality module, image display and hand-held optoacoustic are popped one's head in, and are provided with ultrasonic transducer in hand-held optoacoustic probe, ultrasound
Energy converter includes multiple piezoelectric chip array elements：
Laser is generated for exporting by the ultrasonic transducer for exporting laser signal, signal control and processing module
Ultrasonic signal；Hand-held optoacoustic is popped one's head in for conducting laser signal and ultrasonic signal to superficial place to be detected, and will
Optoacoustic echo-signal and ultrasound echo signal from superficial place are sent to optoacoustic-ultrasonic double-mode state image-forming module；Optoacoustic-is super
Sound bimodal image-forming module is used to rebuild ultrasonoscopy by ultrasound echo signal and rebuilds optoacoustic figure by optoacoustic echo-signal
Picture, and ultrasonoscopy and photoacoustic image are sent to image display and shown, optoacoustic-ultrasonic double-mode state image-forming module is rebuild
The method of photoacoustic image is specially：For every frame optoacoustic echo-signal, according to the space coordinate and hand of every bit in imaging region
It holds the relative position relation of the upper array element coordinate of formula optoacoustic probe, calculate the ultrasound biography that each point in the imaging frame reaches each array element
Between sowing time, and utilize the reconstruction of following formula progress each point optoacoustic echo-signal：
Wherein, i is the number of piezoelectric chip array element in hand-held optoacoustic probe,Refer in space coordinateThe weight at place
Build rear optoacoustic strength signal；Pi(ti,j) indicate in the optoacoustic echo-signal that i-th of array element receives, be located at (ti,j) moment it is strong
Angle value, (ti,j) it is meant that space coordinateUltrasound propagation time of the position to i-th of piezoelectric chip array element.
Further, the method for optoacoustic-ultrasonic double-mode state image-forming module reconstruction ultrasonoscopy is specially：Respectively to each
Scan line corresponding position emits the ultrasonic signal focused in some depth location, and the ultrasound that each array element is received is returned
The position coordinates of each spatial point in scan line of the wave signal according to required dynamic focusing, calculate under the conditions of same-phase from hair
It is mapped to after reaching the phase delay that each array element signals need and carries out delayed addition, obtain the scan line rebuild, finally again
The complete ultrasonoscopy of one frame is constructed by the scan line reconstruction signal of a plurality of non-overlapping copies.
For optimization system performance, signal control and processing module include front-end control submodule and ultrasound control
Module, wherein the ultrasound control submodule is for exporting the ultrasonic signal generated by the ultrasonic transducer, front-end control
Module is used to control the synchronism output of laser signal and ultrasonic signal.
Further, ultrasonic control submodule be also used as ultrasonic transducer and optoacoustic-ultrasonic double-mode state image-forming module it
Between terminal：Receive ultrasound echo signal from ultrasonic transducer and optoacoustic echo-signal, and to ultrasound echo signal with
Optoacoustic echo-signal carries out preliminary treatment, and the content of preliminary treatment includes filtering, amplification and Wave beam forming, then by preliminary treatment
Ultrasound echo signal and optoacoustic echo-signal be sent to optoacoustic-ultrasonic double-mode state image-forming module.
In order to improve the quality of exported pulsed laser signal, the laser signal of laser output passes through optical focus module
Enter hand-held optoacoustic afterwards to pop one's head in.
In order to further increase the output quality of laser signal, it is provided with details in a play not acted out on stage, but told through dialogues excitation light path in hand-held optoacoustic probe,
Laser signal is used by entering the details in a play not acted out on stage, but told through dialogues excitation light path in hand-held optoacoustic probe, the details in a play not acted out on stage, but told through dialogues excitation light path after optical focus module
Superficial place to be detected is uniformly projected by the angle of setting, shape after by laser signal shaping.
Preferably, two groups of details in a play not acted out on stage, but told through dialogues excitation light paths are respectively arranged in ultrasonic transducer both sides in hand-held optoacoustic probe, swashed
The laser signal of light device output is by being coupled into two groups of multimode fibres after optical focus module, two groups of multimode fibres are by laser
Signal is directed respectively into two groups of details in a play not acted out on stage, but told through dialogues excitation light paths, and as a preferred embodiment of the present invention, every group of details in a play not acted out on stage, but told through dialogues excitation light path includes column
Face mirror, speculum and concave mirror.
Traditional optoacoustic-ultrasonic double-mode state imaging system information source is single, though existing ultrasound and photoacoustic imaging system
Enrich imaging data, but the effective rate of utilization of data is still to be improved, in order to improve information utilization, obtain more fully at
As a result, optoacoustic-ultrasonic double-mode state image-forming module is additionally operable to scheme the photoacoustic image of reconstruction with ultrasound by image registration algorithm
As carrying out fusion superposition, obtaining synthetic image；Image display is additionally operable to display synthetic image.
Optoacoustic-ultrasonic double-mode state imaging system and laser are related to numerous components and circuit, in order to allow system operation more
Stablize, imaging system in the prior art is usually fixedly installed in specified region, is not easy to mobile and is overhauled, in order in not shadow
This defect, optoacoustic-ultrasonic double-mode state imaging system and laser is overcome to be respectively arranged at first under the premise of acoustic system stability
On instrument cab and the second instrument cab；Be additionally provided with water-cooling circulating system on second instrument cab, for provide flowed through by pipeline it is sharp
Circulating cooling liquid inside light device.
Optoacoustic for superficial place imaging and ultrasonic synchronous imaging method, include the following steps：
S1, ultrasonic signal and laser signal reach superficial place to be detected through hand-held optoacoustic probe respectively；
Ultrasonic transducer in S2, hand-held optoacoustic probe receives ultrasound echo signal and optoacoustic time from superficial place
Wave signal, and ultrasound echo signal and optoacoustic echo-signal are respectively converted into after electric signal and are sent to optoacoustic-ultrasonic double-mode state
Image-forming module；
S3, optoacoustic-ultrasonic double-mode state image-forming module rebuild ultrasonoscopy by ultrasound echo signal and pass through optoacoustic echo
Signal reconstruction photoacoustic image, the method that the optoacoustic-ultrasonic double-mode state image-forming module rebuilds photoacoustic image are specially：For every frame light
Sound echo-signal, according to the relative position of the space coordinate of every bit in imaging region and the upper array element coordinate of hand-held optoacoustic probe
Relationship calculates the ultrasound propagation time that each point in the imaging frame reaches each array element, and carries out each point light using following formula
The reconstruction of sound echo-signal：
Wherein, i is the number of piezoelectric chip array element in hand-held optoacoustic probe,Refer in space coordinateThe weight at place
Build rear optoacoustic strength signal；Pi(ti,j) indicate in the optoacoustic echo-signal that i-th of array element receives, be located at (ti,j) moment it is strong
Angle value, (ti,j) it is meant that space coordinateUltrasound propagation time of the position to i-th of piezoelectric chip array element；
S4, image display show ultrasonoscopy and ultrasonoscopy.
Further, in S3, optoacoustic-ultrasonic double-mode state image-forming module rebuilds the side of ultrasonoscopy by ultrasound echo signal
Method is specially：The ultrasonic signal focused in some depth location is emitted to each scan line corresponding position respectively, and will be every
The position coordinates of each spatial point, calculate in scan line of the reflection echo that a array element receives according to required dynamic focusing
Delayed addition is carried out after the phase delay for being emitted to each array element signals needs of arrival under the conditions of same-phase, is rebuild
Good scan line, finally constructs the complete ultrasonoscopy of a frame by the scan line reconstruction signal of a plurality of non-overlapping copies again.
Further, two groups of details in a play not acted out on stage, but told through dialogues exciting lights are respectively arranged in ultrasonic transducer both sides in hand-held optoacoustic probe
Road, in S1, the laser signal of laser output is by being coupled into two groups of multimode fibres, two groups of multimode light after optical focus module
Laser signal is directed respectively into two groups of details in a play not acted out on stage, but told through dialogues excitation light paths by fibre, and details in a play not acted out on stage, but told through dialogues excitation light path will press the angle of setting after laser signal shaping
Degree, shape project superficial place to be detected.
The beneficial effects of the present invention are：Compared to conventional imaging techniques, it is real-time, clever that the present invention has both ultrasonic imaging
Activity height and imaging depth is big and the high sensitivity of photoacoustic imaging, sweep speed are high and the picture characteristics of high resolution, and
It is radiationless, so as to quickly and easily apply in each superficial place imaging of human body, drenched especially for mammary gland/outpost
Bar/screenings of the superficials such as thyroid gland/prostate, the present invention has the foreground promoted the use of.
Description of the drawings
Fig. 1 is the structure diagram of the optoacoustic and ultrasonic synchronous imaging system for superficial place imaging in the present invention；
Fig. 2 is the structural schematic diagram of laser signal output par, c in the present invention；
Fig. 3 is the flow diagram of the optoacoustic and ultrasonic synchronous imaging method for superficial place imaging in the present invention.
Reference numeral：1, laser；2, optical focus module；3, multimode fibre；4, details in a play not acted out on stage, but told through dialogues excitation light path；5, hand-held light
Sonic probe；6, ultrasonic transducer.
Specific implementation mode
In the following, in conjunction with attached drawing and specific implementation mode, the present invention is described further：
Embodiment 1
As shown in Figures 1 and 2, it is used for the optoacoustic of superficial place imaging and ultrasonic synchronous imaging system, including be connected
Laser 1 and optoacoustic-ultrasonic double-mode state imaging system, laser 1 is for exporting laser signal to generate optoacoustic echo-signal；Light
Sound-ultrasonic double-mode state imaging system includes that signal control and processing module, optoacoustic-ultrasonic double-mode state image-forming module, image are shown
Device and hand-held optoacoustic probe 5, signal control and processing module include front-end control submodule and ultrasonic control submodule,
Include analog voltage modulation circuit, signal acquisition circuit, isolation circuit, preposition amplification and filtered electrical in ultrasonic control submodule
Road, probe option board and channel plate, for exporting the ultrasonic signal generated by the ultrasonic transducer to generate ultrasonic echo letter
Number, it is additionally operable to receive optoacoustic echo-signal and ultrasound echo signal, and carry out just optoacoustic echo-signal and ultrasound echo signal
The content of step processing, preliminary treatment includes filtering, amplification and Wave beam forming, receiving front-end control submodule passages through which vital energy circulates impulse photocontrol
Circuit connecting laser 1, the synchronism output for controlling laser signal and ultrasonic signal；It is also set up in hand-held optoacoustic probe 5
It includes multiple piezoelectric chip array elements to have ultrasonic transducer 6, ultrasonic transducer 6.In ultrasonic transducer 6 in hand-held optoacoustic probe 5
Both sides are respectively arranged with two groups of details in a play not acted out on stage, but told through dialogues excitation light paths 4, and the laser signal that laser 1 exports passes through coupling after an optical focus module 2
It closes and enters two groups of multimode fibres 3, which is directed respectively into two groups of details in a play not acted out on stage, but told through dialogues excitation light paths 4 by laser signal, and every group dark
Field excitation light path 4 preferably comprises cylindrical mirror, speculum and concave mirror, and details in a play not acted out on stage, but told through dialogues excitation light path 4 is used for will be after laser signal shaping
Superficial place to be detected is uniformly projected by the angle of setting, shape, ultrasonic transducer 6 is for receiving from superficial place
Optoacoustic echo-signal and ultrasound echo signal, and optoacoustic echo-signal is passed as electronic signals respectively with ultrasound echo signal
It send to ultrasonic control submodule and carries out preliminary treatment；Optoacoustic-ultrasonic double-mode state image-forming module is for finishing receiving preliminary treatment
Ultrasound echo signal and optoacoustic echo-signal, and respectively by ultrasound echo signal and optoacoustic echo-signal rebuild ultrasonoscopy and
Photoacoustic image, the method that optoacoustic-ultrasonic double-mode state image-forming module rebuilds ultrasonoscopy are specially：Respectively to each scan line pair
The ultrasonic signal that transmitting is focused in some depth location at position is answered, and the reflection echo that each array element is received is according to institute
The position coordinates for needing each spatial point in the scan line of dynamic focusing calculate each from arrival is emitted under the conditions of same-phase
Delayed addition is carried out after the phase delay that array element signals need, the scan line rebuild is obtained, is not weighed mutually by a plurality of again finally
Folded scan line reconstruction signal constructs the complete ultrasonoscopy of a frame；Excitation per frame photoacoustic signal be disposably entirely at
As, by a laser irradiation completion, not needing to be rebuild along different scan lines as ultrasound in range, because
This optoacoustic reconstruction time is smaller than ultrasonic reconstruction time, and optoacoustic-ultrasonic double-mode state image-forming module rebuilds the method tool of photoacoustic image
Body is：For every frame optoacoustic echo-signal, gone into battle according to the space coordinate of every bit in imaging region and hand-held optoacoustic probe 5
The relative position relation of first coordinate calculates the ultrasound propagation time that each point in the imaging frame reaches each array element, and utilize with
Lower formula carries out the reconstruction of each point optoacoustic echo-signal：
Wherein, i is the number of piezoelectric chip array element in hand-held optoacoustic probe 5,Refer in space coordinateThe weight at place
Build rear optoacoustic strength signal；Pi(ti,j) indicate in the optoacoustic echo-signal that i-th of array element receives, be located at (ti,j) moment it is strong
Angle value, (ti,j) it is meant that space coordinateUltrasound propagation time of the position to i-th of piezoelectric chip array element；Optoacoustic-
Ultrasonic double-mode state image-forming module is additionally operable to ultrasonoscopy merge to the photoacoustic image of reconstruction by image registration algorithm folded
Add, obtain synthetic image；Image display is for showing ultrasonoscopy, photoacoustic image and synthetic image.
In the present invention, signal control and processing module, optoacoustic-ultrasonic double-mode state image-forming module are set in a host, should
Host is connected with image display, and the ultrasonic probe interface for connecting hand-held optoacoustic probe 5, host are provided on host
It is set to the first instrument cab, image display is set to through Universal arm on the first instrument cab；Laser 1, optical focus module 2 with
One water-cooling circulating system is set to jointly on the second instrument cab, and circulating cooling liquid caused by water-cooling circulating system is flowed through through pipeline
Inside laser 1.
Embodiment 2
As shown in Figures 2 and 3, it is used for the optoacoustic of superficial place imaging and ultrasonic synchronous imaging method, is included the following steps：
S1, receiving front-end control submodule control laser 1 and ultrasonic control submodule synchronism output laser signal and surpass
Acoustical signal, ultrasonic signal and laser signal reach superficial place to be detected through hand-held optoacoustic probe 5 respectively, and wherein laser is believed
Number by being coupled into two groups of multimode fibres 3 after optical focus module 2, laser signal is directed respectively into two by two groups of multimode fibres 3
Group details in a play not acted out on stage, but told through dialogues excitation light path 4, details in a play not acted out on stage, but told through dialogues excitation light path 4 uniformly projects angle, the shape by setting after laser signal shaping to be checked
The superficial place of survey, details in a play not acted out on stage, but told through dialogues excitation light path 4 preferably comprise cylindrical mirror, speculum and concave mirror；
Ultrasonic transducer 6 in S2, hand-held optoacoustic probe 5 receives ultrasound echo signal and optoacoustic from superficial place
Echo-signal, and ultrasound echo signal and optoacoustic echo-signal are respectively converted into after electric signal and are sent to ultrasound control submodule
Block, ultrasonic control submodule are sent to optoacoustic-ultrasound pair after carrying out preliminary treatment to ultrasound echo signal and optoacoustic echo-signal
The content of modality module, preliminary treatment includes filtering, amplification and Wave beam forming；
S3, optoacoustic-ultrasonic double-mode state image-forming module are based on ultrasound echo signal and rebuild ultrasonoscopy, specially：It is right respectively
Each scan line corresponding position emits the ultrasonic signal focused in some depth location, and each array element is received
The position coordinates of each spatial point in scan line of the reflection echo according to required dynamic focusing, calculate under the conditions of same-phase from
It is emitted to after reaching the phase delay that each array element signals need and carries out delayed addition, obtain the scan line rebuild, finally
The complete ultrasonoscopy of a frame is constructed by the scan line reconstruction signal of a plurality of non-overlapping copies again；Optoacoustic-ultrasonic double-mode state imaging
Module is based on optoacoustic echo-signal and rebuilds photoacoustic image, specially：For every frame optoacoustic echo-signal, according to every in imaging region
The space coordinate of any and hand-held optoacoustic pop one's head in upper array element coordinate relative position relation, calculate each point in the imaging frame and arrive
Up to the ultrasound propagation time of each array element, and utilize the reconstruction of following formula progress each point optoacoustic echo-signal：
Wherein, i is the number of piezoelectric chip array element in hand-held optoacoustic probe 5,Refer in space coordinateThe weight at place
Build rear optoacoustic strength signal；Pi(ti,j) indicate in the optoacoustic echo-signal that i-th of array element receives, be located at (ti,j) moment it is strong
Angle value, (ti,j) it is meant that space coordinateUltrasound propagation time of the position to i-th of piezoelectric chip array element；Optoacoustic-
Ultrasonic double-mode state image-forming module also with ultrasonoscopy merge by image registration algorithm to the photoacoustic image of reconstruction to be superimposed, obtains
To synthetic image；
S4, image display show ultrasound-optoacoustic bimodal realtime graphic and have merged photoacoustic image and ultrasonoscopy
Synthetic image.
It will be apparent to those skilled in the art that technical solution that can be as described above and design, make various other
Corresponding change and deformation, and all these changes and deformation should all belong to the protection domain of the claims in the present invention
Within.
Claims (8)
1. the optoacoustic for superficial place imaging and ultrasonic synchronous imaging system, which is characterized in that including the laser being connected
With optoacoustic-ultrasonic double-mode state imaging system, the optoacoustic-ultrasonic double-mode state imaging system include signal control and processing module,
Optoacoustic-ultrasonic double-mode state image-forming module, image display and hand-held optoacoustic are popped one's head in, and ultrasound is provided in hand-held optoacoustic probe
Energy converter, ultrasonic transducer include multiple piezoelectric chip array elements：
The laser is generated for exporting by the ultrasonic transducer for exporting laser signal, signal control and processing module
Ultrasonic signal；It is provided with details in a play not acted out on stage, but told through dialogues excitation light path in the hand-held optoacoustic probe, laser signal passes through an optical focus module
Enter the details in a play not acted out on stage, but told through dialogues excitation light path in hand-held optoacoustic probe afterwards, the details in a play not acted out on stage, but told through dialogues excitation light path be used for by after laser signal shaping by setting
Fixed angle, shape project superficial place to be detected, and the hand-held optoacoustic probe is for believing laser signal and ultrasound
Number conduction to superficial place to be detected, and by from superficial place optoacoustic echo-signal and ultrasound echo signal be sent to light
Sound-ultrasonic double-mode state image-forming module；The optoacoustic-ultrasonic double-mode state image-forming module is used to rebuild ultrasound by ultrasound echo signal
Image and by optoacoustic echo-signal rebuild photoacoustic image, and by ultrasonoscopy and photoacoustic image be sent to image display carry out
It has been shown that, the method that optoacoustic-ultrasonic double-mode state image-forming module rebuilds photoacoustic image are specially：For every frame optoacoustic echo-signal, root
According to the relative position relation of the upper array element coordinate of space coordinate and hand-held optoacoustic probe of every bit in imaging region, calculate this
Each point reaches the ultrasound propagation time of each array element in imaging frame, and the weight of each point optoacoustic echo-signal is carried out using following formula
It builds：
Wherein, i is the number of piezoelectric chip array element in hand-held optoacoustic probe,Refer in space coordinateAfter the reconstruction at place
Optoacoustic strength signal；Pi(ti,j) indicate in the optoacoustic echo-signal that i-th of array element receives, be located at (ti,j) moment intensity
Value, (ti,j) it is meant that space coordinateUltrasound propagation time of the position to i-th of piezoelectric chip array element；
The optoacoustic-ultrasonic double-mode state image-forming module is additionally operable to scheme the photoacoustic image of reconstruction with ultrasound by image registration algorithm
As carrying out fusion superposition, obtaining synthetic image；Image display is additionally operable to display synthetic image.
2. optoacoustic as described in claim 1 and ultrasonic synchronous imaging system, which is characterized in that the optoacoustic-ultrasonic double-mode state
Image-forming module rebuild ultrasonoscopy method be specially：Each scan line corresponding position is emitted in some depth position respectively
The ultrasonic signal of focusing is set, and the ultrasound echo signal that each array element is received is according to the scan line of required dynamic focusing
The position coordinates of upper each spatial point calculate and prolong from the phase for being emitted to each array element signals needs of arrival under the conditions of same-phase
When after carry out delayed addition, the scan line rebuild is obtained, finally again by the scan line reconstruction signal structure of a plurality of non-overlapping copies
Build out the complete ultrasonoscopy of a frame.
3. optoacoustic as described in claim 1 and ultrasonic synchronous imaging system, which is characterized in that the signal control and processing mould
Block includes front-end control submodule and ultrasonic control submodule, wherein the ultrasound control submodule is for exporting by described
The ultrasonic signal that ultrasonic transducer generates, the front-end control submodule are synchronous defeated with ultrasonic signal for controlling laser signal
Go out.
4. optoacoustic as claimed in claim 3 and ultrasonic synchronous imaging system, which is characterized in that the ultrasound control submodule is also
As the terminal between ultrasonic transducer and optoacoustic-ultrasonic double-mode state image-forming module：Receive the ultrasound from ultrasonic transducer
Echo-signal and optoacoustic echo-signal, and preliminary treatment is carried out to ultrasound echo signal and optoacoustic echo-signal, then will tentatively locate
The ultrasound echo signal managed is sent to optoacoustic-ultrasonic double-mode state image-forming module with optoacoustic echo-signal.
5. optoacoustic as described in claim 1 and ultrasonic synchronous imaging system, which is characterized in that in the hand-held optoacoustic probe
Two groups of details in a play not acted out on stage, but told through dialogues excitation light paths are respectively arranged in ultrasonic transducer both sides, the laser signal of laser output passes through optical focus mould
Two groups of multimode fibres are coupled into after block, laser signal is directed respectively into two groups of details in a play not acted out on stage, but told through dialogues excitation light paths by two groups of multimode fibres.
6. the imaging method of optoacoustic as described in claim 1 and ultrasonic synchronous imaging system, which is characterized in that including walking as follows
Suddenly：
S1, ultrasonic signal and laser signal reach superficial place to be detected through hand-held optoacoustic probe respectively；
Ultrasonic transducer in S2, hand-held optoacoustic probe receives ultrasound echo signal and optoacoustic echo letter from superficial place
Number, and ultrasound echo signal and optoacoustic echo-signal are respectively converted into after electric signal and are sent to optoacoustic-ultrasonic double-mode state imaging
Module；
S3, optoacoustic-ultrasonic double-mode state image-forming module rebuild ultrasonoscopy by ultrasound echo signal and pass through optoacoustic echo-signal
Photoacoustic image is rebuild, the method that the optoacoustic-ultrasonic double-mode state image-forming module rebuilds photoacoustic image is specially：For every frame optoacoustic
Echo-signal is closed according to the relative position of the space coordinate of every bit in imaging region and the upper array element coordinate of hand-held optoacoustic probe
It is, calculates the ultrasound propagation time that each point in the imaging frame reaches each array element, and each point optoacoustic is carried out using following formula
The reconstruction of echo-signal：
Wherein, i is the number of piezoelectric chip array element in hand-held optoacoustic probe,Refer in space coordinateAfter the reconstruction at place
Optoacoustic strength signal；Pi(ti,j) indicate in the optoacoustic echo-signal that i-th of array element receives, be located at (ti,j) moment intensity
Value, (ti,j) it is meant that space coordinateUltrasound propagation time of the position to i-th of piezoelectric chip array element；
S4, image display show photoacoustic image and ultrasonoscopy.
7. imaging method as claimed in claim 6, which is characterized in that in S3, optoacoustic-ultrasonic double-mode state image-forming module passes through super
Sound echo-signal rebuild ultrasonoscopy method be specially：Each scan line corresponding position is emitted in some depth respectively
The ultrasonic signal that position focuses, and in scan line of the reflection echo that each array element is received according to required dynamic focusing
The position coordinates of each spatial point calculate under the conditions of same-phase from the phase delay for being emitted to each array element signals needs of arrival
Delayed addition is carried out later, obtains the scan line rebuild, and is finally built again by the scan line reconstruction signal of a plurality of non-overlapping copies
Go out the complete ultrasonoscopy of a frame.
8. imaging method as claimed in claim 6, which is characterized in that in ultrasonic transducer two in the hand-held optoacoustic probe
Side is respectively arranged with two groups of details in a play not acted out on stage, but told through dialogues excitation light paths, and in S1, the laser signal of laser output after optical focus module by coupling
Into two groups of multimode fibres, laser signal is directed respectively into two groups of details in a play not acted out on stage, but told through dialogues excitation light paths, details in a play not acted out on stage, but told through dialogues excitation light path by two groups of multimode fibres
After laser signal shaping superficial place to be detected will be projected by angle, the shape of setting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710379974.9A CN107157448B (en) | 2017-05-25 | 2017-05-25 | Optoacoustic for superficial place imaging and ultrasonic synchronous imaging system and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710379974.9A CN107157448B (en) | 2017-05-25 | 2017-05-25 | Optoacoustic for superficial place imaging and ultrasonic synchronous imaging system and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107157448A CN107157448A (en) | 2017-09-15 |
| CN107157448B true CN107157448B (en) | 2018-09-18 |
Family
ID=59820751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710379974.9A Active CN107157448B (en) | 2017-05-25 | 2017-05-25 | Optoacoustic for superficial place imaging and ultrasonic synchronous imaging system and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107157448B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023056290A1 (en) * | 2021-09-30 | 2023-04-06 | Seno Medical Instruments, Inc. | Optoacoustic probe for prostrate imaging |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107616784B (en) * | 2017-09-19 | 2020-09-22 | 华南师范大学 | Wide-field photoacoustic ultrasonic breast coronal plane scanning imaging device and method based on 1024 linear array detection |
| CN109507117B (en) * | 2018-11-12 | 2020-04-03 | 中国科学技术大学 | Micro-nano imaging detection experimental device based on photoacoustic beam shaping |
| CN109674490B (en) * | 2019-01-17 | 2021-09-10 | 南京大学深圳研究院 | Ultrasonic-guided photoacoustic microscope imaging method with low reflection artifact |
| CN110037779B (en) * | 2019-05-05 | 2020-09-29 | 深圳大学 | Handheld intervention device and use method thereof |
| CN110559016A (en) * | 2019-10-21 | 2019-12-13 | 四川瑞利浦医疗科技有限公司 | thyroid detection device and method based on microwave thermoacoustic and ultrasonic imaging |
| CN112022213B (en) * | 2019-10-24 | 2021-07-09 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic image processing method and processing device |
| CN111281344A (en) * | 2020-02-26 | 2020-06-16 | 浙江杜比医疗科技有限公司 | Mammary gland imaging system and mammary gland imaging method |
| CN111772581B (en) * | 2020-06-11 | 2023-03-28 | 华南师范大学 | High-sensitivity photoacoustic/ultrasonic dual-mode imaging device and method based on double-curvature linear array detector |
| CN112603263B (en) * | 2020-12-14 | 2023-09-05 | 华南师范大学 | Palm photoacoustic imaging device and method |
| CN112826521A (en) * | 2020-12-29 | 2021-05-25 | 上海联影医疗科技股份有限公司 | Tomographic imaging system and method |
| CN113080871B (en) * | 2021-04-12 | 2022-09-16 | 北京航空航天大学 | Imaging system |
| CN113749689B (en) * | 2021-08-23 | 2022-05-20 | 华中科技大学 | Bimodal imaging system and method based on array type optical fiber ultrasonic probe |
| CN114028741A (en) * | 2021-11-16 | 2022-02-11 | 上海吾魅科技有限公司 | Probe combining high-intensity focused ultrasound and superficial imaging ultrasound |
| CN117017280B (en) * | 2023-07-24 | 2024-03-19 | 西南交通大学 | Wearable flexible near-infrared photoacoustic/ultrasonic dual-mode imaging system and method |
| CN116942103B (en) * | 2023-09-20 | 2023-12-12 | 杭州励影光电成像有限责任公司 | Dark-field photoacoustic tomography system and method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101472520B (en) * | 2006-06-23 | 2015-06-03 | 皇家飞利浦电子股份有限公司 | Timing controller for combined photoacoustic and ultrasound imager |
| CN102743191B (en) * | 2012-06-28 | 2014-06-25 | 华南师范大学 | Focusing rotary scanning photoacoustic ultrasonic blood vessel endoscope imaging device and focusing rotary scanning photoacoustic ultrasonic blood vessel endoscope imaging method |
| CN105395170B (en) * | 2015-12-15 | 2018-07-27 | 同济大学 | A kind of photoacoustic ultrasound bimodal synchronous imaging system |
| CN105395219B (en) * | 2015-12-15 | 2018-07-24 | 同济大学 | A kind of three modality imaging system of ultrasonic photoacoustic photoacoustic spectrum |
-
2017
- 2017-05-25 CN CN201710379974.9A patent/CN107157448B/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023056290A1 (en) * | 2021-09-30 | 2023-04-06 | Seno Medical Instruments, Inc. | Optoacoustic probe for prostrate imaging |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107157448A (en) | 2017-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107157448B (en) | Optoacoustic for superficial place imaging and ultrasonic synchronous imaging system and method | |
| EP2328480B1 (en) | Low-cost device for c-scan photoacoustic imaging | |
| CN105395170B (en) | A kind of photoacoustic ultrasound bimodal synchronous imaging system | |
| CN100512760C (en) | Method and apparatus for forming an image that shows information about a subject | |
| US20170086788A1 (en) | Non-imaging low frequency ultrasonic testing and diagnostic evaluation system | |
| CN107713990A (en) | A kind of thermoacoustic, optoacoustic, ultrasonic three mode tumor of breast detection means and method | |
| CN104883965B (en) | Subject information obtaining device, display methods, program and processing unit | |
| WO2015016403A1 (en) | Device and method for acquiring fusion image | |
| CN107115098A (en) | Based on one-dimensional non-focusing and the double array scanning imaging devices of focusing ultrasound and method | |
| CA2462378A1 (en) | Non-invasive subject-information imaging method and apparatus | |
| Kumavor et al. | Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system | |
| CN104825180A (en) | Tri-modal breast imaging system and imaging method thereof | |
| US20210052210A1 (en) | Detection device and detection method for fusion of tactile sensing and optical tomography | |
| CN105595964A (en) | Double-focusing ultrasonic probe and sparse array photoacoustic tomography imaging system | |
| Oeri et al. | Hybrid photoacoustic/ultrasound tomograph for real-time finger imaging | |
| CN106618489A (en) | Apparatus and processing method for acquiring detected object information | |
| CN108464817A (en) | A kind of double-mode imaging system and its imaging method | |
| Lee et al. | Panoramic volumetric clinical handheld photoacoustic and ultrasound imaging | |
| CN110037654A (en) | A kind of noninvasive cerebral function imaging helmet and imaging method | |
| CN105249933A (en) | Photo-acoustic molecule three-dimensional image instrument | |
| US20230146520A1 (en) | Dual mode three-dimensional breast imaging device and method | |
| CN207561920U (en) | Moveable desk-top optoacoustic and ultrasonic synchronous imaging device | |
| Zheng et al. | Volumetric tri-modal imaging with combined photoacoustic, ultrasound, and shear wave elastography | |
| US10080550B2 (en) | Ultrasonic apparatus and control method for the same | |
| CN209644941U (en) | A kind of breast imaging device based on CTLM and ultrasonic technology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221021 Address after: Room 015, Room 114, No. 85, Xiangxue Avenue Middle, Huangpu District, Guangzhou, Guangdong 510000 Patentee after: Guangzhou Meishen Biotechnology Co.,Ltd. Address before: 518,000 Nanshan Medical Device Industrial Park BF12, No. 1019, Nanhai Avenue, Nanshan District, Shenzhen, Guangdong Patentee before: RUIXIN LIFE TECHNOLOGIES (SHENZHEN) Co.,Ltd. |