CN110037654A - A kind of noninvasive cerebral function imaging helmet and imaging method - Google Patents
A kind of noninvasive cerebral function imaging helmet and imaging method Download PDFInfo
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- CN110037654A CN110037654A CN201910223299.XA CN201910223299A CN110037654A CN 110037654 A CN110037654 A CN 110037654A CN 201910223299 A CN201910223299 A CN 201910223299A CN 110037654 A CN110037654 A CN 110037654A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
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Abstract
The present invention relates to a kind of noninvasive cerebral function imaging helmet and imaging methods, including central node: connecting with each item measurement arm one end, is connect by multicore cable with host；A plurality of measurement arm: strip, one end are connect with central node, have certain elasticity, can be bonded skull placement, and the lower surface that measurement arm is in contact with skull has along the band-like light emitting and light transmission module in brachium direction and the transmitting of band-like ultrasonic phase array and receiving module；Band-like light emitting and light transmission module: it is fixed in measurement arm by fixed card slot, band-like ultrasonic phase array transmitting and receiving module: it is fixed in measurement arm by fixed card slot, host: it is connect through central node with the band-like light emitting and light transmission module and the transmitting of band-like ultrasonic phase array and receiving module measured in arm by multicore cable, compared with prior art, the cerebral function imaging helmet of the invention is convenient to be fixed on head, subject is not influenced to move freely, the psychological burden for mitigating subject can be used for the detection imaging of brain neuroblastoma.
Description
Technical field
The present invention relates to medical imaging device technical fields, more particularly, to a kind of noninvasive cerebral function imaging helmet and imaging
Method.
Background technique
Photoacoustic imaging be a kind of imaging method of emerging development in recent years, it can be achieved that tissue physicochemical properties at
Picture.It combine pure optical imagery high contrast and pure ultrasonics high-penetration the advantages of, can provide high contrast and
High axial resolution is with a wide range of applications in functional imaging field.
If detection while the bimodal of ultrasound and photoacoustic may be implemented, and then it is imaged, then can both provide higher
The structure imaging of resolution ratio, and the tissue physical chemistry of high-resolution and high contrast can be provided on the basis of structural information
The functional imaging of property.
Existing imaging device volume is excessively huge, operates inconvenient, and example MRI application conditions are more harsh, when inspection
All metals cannot participate in, and CT and PET have radioactivity, not be suitable for pregnant woman or child；And during imaging, greatly
More technologies need to guarantee subject head with probe do not relatively move, subject be mostly in the state of anesthesia carry out at
Picture cannot be move freely；At present also lack in skull brain carry out ultrasound, optoacoustic while non-destructive testing device and side
Method, mostly individually detection, do not form integrated detection equipment, or use optical means, can only carry out to cerebral cortex close red
Outer Brian Imaging cannot carry out structure imaging where a certain specific position of determination to brain in skull.
If Chinese patent CN 104545814A discloses a kind of animal wear-type opto-acoustic imaging devices, the shortcomings that this device
It is that can only carry out photoacoustic imaging, inorganized physical structure information to animal brain；108056777 A of Chinese patent CN is public
A kind of device for measuring oxygen-containing hemoglobin and deoxyhemoglobin and Near-infrared Brain imaging device are opened, however this device lacks
Point is can only to carry out Near-infrared Brain imaging to cerebral cortex, and it is a certain specific with determination cannot to carry out structure imaging to brain in skull
Where position.
Summary of the invention
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art and provide a kind of noninvasive brain function at
As the helmet and imaging method.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of noninvasive cerebral function imaging helmet, comprising:
Central node: it connect with one end of a plurality of measurement arm, for assembling ultrasonic phase array and light in each item measurement arm
The cable of transmitting module, and connect by multicore cable with host；
A plurality of measurement arm: the shapes of all measurement arms are strip, one end of every measurement arm respectively with
The central node is connected, and is additionally provided on every measurement arm and receives band for the transmitting through pulsed light and ultrasound；
Band-like light emitting and light transmission module: it is fixed in the measurement arm by fixed card slot, for sending out into skull
Pulsed light passes through transmitting reception band irradiation brain tissue regions to be imaged and generates photoacoustic signal out；
Band-like ultrasonic phase array transmitting and receiving module: it is fixed in the measurement arm by fixed card slot, for sending out
It penetrates ultrasonic signal and passes through transmitting reception band irradiation brain tissue regions to be imaged, and receive the ultrasonic signal and brain tissue being reflected back
The photoacoustic signal of generation；
Host: it is by multicore cable through the central node and the band-like light emitting and light transmission in every measurement arm
Module emits with band-like ultrasonic phase array and receiving module is connected, and for driving transmitting laser and ultrasonic signal, and receives production
Raw photoacoustic signal and the ultrasonic signal being reflected back are imaged.
Preferably, solid to be formed by connection set-up mode different between the central node and measurement arm described in every
The noninvasive cerebral function imaging helmet of fixed pattern and the noninvasive cerebral function imaging helmet of slidingtype；
Between the central node is fixedly connected with measurement arm one end described in every, and every measurement arm is to set
Every distribution, the fixed noninvasive cerebral function imaging helmet is formed；
Alternatively, the central node is flexibly connected with measurement arm one end described in every, set between the adjacent measurement arm
It is equipped with stuck point, for limiting every measurement arm between adjacent stuck point to slide within the scope of set angle, forms slidingtype
The noninvasive cerebral function imaging helmet.
Preferably, the band-like light emitting and light transmission module include the light-pulse generator set gradually along optical path, beam shaping
Mirror and light guide plate, the light-pulse generator are connect by multicore cable with the host.
Preferably, the light-pulse generator includes embedded LED array light source and external laser transmitting laser light source, is used for
Emit the pulsed light of multiple and different wavelength.
Preferably, the band-like ultrasonic phase array transmitting and receiving module include array element plate and ultrasonic sound head, the array element
The top of plate is connect by multicore cable with the host, and the bottom end connection ultrasonic sound head, the ultrasound sound head includes pressure
Electroceramics, matching layer and acoustic lens.
Preferably, which further includes for receiving the transparent water sealed layer with offer protection to the transmitting.
Preferably, pass through the band-like light emitting and light transmission module and the band-like ultrasonic phase array transmitting and receiving module
Different connection set-up modes gives optical mode noninvasive brain function to form unilateral side to the noninvasive cerebral function imaging helmet of optical mode and bilateral
The helmet can be imaged.
Preferably, the band-like light emitting and light transmission module and the band-like ultrasonic phase array transmitting and receiving module are distinguished
To be individually juxtaposed on the left and right sides that the transmitting receives band, and the band-like ultrasonic phase array transmitting and receiving module
In array element plate received with the transmitting and form 50 °~80 ° between the normal of band and be obliquely installed, formed unilateral noninvasive to optical mode
The cerebral function imaging helmet.
Preferably, the two sides of the band-like ultrasonic phase array transmitting and receiving module be provided with the band-like light emitting and
Light transmission module, the band-like ultrasonic phase array transmitting and array element plate in receiving module and transmitting reception band are vertically arranged,
Forming bilateral gives optical mode the noninvasive cerebral function imaging helmet.
The present invention also provides a kind of imaging methods using the noninvasive cerebral function imaging helmet, comprising the following steps:
Step 1: according to the pumping signal of host described in photoacoustic ultrasound bimodal synchronous imaging system, controlling multiple channels
Ultrasonic wave of the transmitting after Beam synthesis simultaneously irradiates brain test serum region through skull；
Step 2: the light-pulse generator in band-like light emitting and light transmission module emits pulsed light, band-like light emitting and light transmission module
In beam shaping mirror and light guide plate will after laser shaping, through skull be transmitted to and band-like ultrasonic phase array transmitting and receiving module
The same test serum region of covering generates photoacoustic signal；
Step 3: the ultrasonic signal of band-like ultrasonic phase array transmitting and receiving module reception Tissue reflectance is triggered through pulsed light
Afterwards, by delay, photoacoustic signal is received；
Step 4: the received ultrasonic signal of institute and photoacoustic signal being transferred to the host by multicore cable, realize skull
The synchronous optoacoustic ultrasonic double-mode state imaging simultaneously of interior brain tissue.
Compared with prior art, the invention has the following advantages that
1) it optoacoustic, ultrasound while real-time detection: uses the optical transmitter module of light-pulse generator, channel ultrasonic probe incorporated
Mode together, detection while realizing optoacoustic, ultrasonic two kinds of signals, and examined by using same probe apparatus
It surveys, may be implemented to obtain in real time while the ultrasound and photoacoustic information of brain in skull.
2) abundant information: optoacoustic is particularly sensitive to blood vessel, has unique advantage in blood oxygen saturation context of detection, in conjunction with super
Acoustic imaging can obtain the physical structure information and histochemistry's information of brain in skull, so that tissue signal detected simultaneously
Information is more abundant.
3) removable by bed: this device is helmet-type, and safety is light, and subject can wear it and move freely, and carry out by bed
Detection, mitigates the psychological burden of subject.
4) space foot: when one group of band-like optical transmitter module and light transmission module is arranged, array element plate is obliquely installed, Ke Yiliu
The band-like optical transmitter module of enough space layouts and light transmission module out, so as to reduce size.
5) Effect on Detecting is good: two groups of band-like optical transmitter modules of configuration and light transmission module, and is located at array element plate two sides, can
To improve Effect on Detecting.
Detailed description of the invention
Fig. 1 is the first visual angle of overall structure schematic diagram of the invention；
Fig. 2 is the second visual angle of overall structure schematic diagram of the invention；
Fig. 3 is overall structure third visual angle schematic diagram of the invention；
Fig. 4 is that bilateral gives optical mode top view in the embodiment of the present invention；
Fig. 5 is the unilateral right side of the embodiment of the present invention to optical mode top view；
Fig. 6 is the unilateral left side of the embodiment of the present invention to optical mode top view；
The band-like optical transmitter module and light transmission that Fig. 7 is the optical transmitter module of the embodiment of the present invention when being embedded LED light source
Module index path；
In figure, 1, central node, 2, measurement arm, 3, band-like light emitting and light transmission module, 4, the transmitting of band-like ultrasonic phase array
And receiving module, 5, multicore cable, 6, LED array light source, 7, beam shaping mirror, 8, light guide plate, 9, array element plate, 10, backing,
11, FPC flexible circuit board, 12, piezoelectric ceramics, 13, matching layer, 14, acoustic lens, 15, fixed card slot, 16, transparent water sealed layer.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiment is a part of the embodiments of the present invention, rather than whole embodiments.Based on this hair
Embodiment in bright, those of ordinary skill in the art's every other reality obtained without making creative work
Example is applied, all should belong to the scope of protection of the invention.
Embodiment
The present invention provides a kind of noninvasive cerebral function imaging helmet, and ultrasound and photoacoustic detection is integrated in same probe apparatus,
The present invention is combined together by popping one's head in channel ultrasonic with the optical transmitter module that can emit multi-Wavelength Pulses light, is realized same
Step, the real-time acquisition with position to ultrasound and photoacoustic signal, can obtain the physical structure information and chemical constituent of brain in skull
Information realizes noninvasive cerebral function imaging, can be used for the detection and imaging of brain neuroblastoma network activity.
Specifically, as shown in FIG. 1 to 3, which includes:
Central node 1: connecting with each item measurement 2 one end of arm, to assemble ultrasonic phase array and light hair in each item measurement arm 2
The cable for penetrating module is connect by multicore cable 5 with host；
Further include:
A plurality of measurement arm 2: strip, one end are connected with central node 1, and the surface that measurement arm 2 is in contact with skull has
Band is received for the transmitting through pulsed light and ultrasound along brachium direction, every measurement arm 2 has certain elasticity, can be bonded
Skull is placed；
Band-like light emitting and light transmission module 3 are all set in measurement arm 2 at least provided with one group and side setting are emitting
Reception takes, and receives the tissue regions generation to be imaged of band irradiation brain across transmitting to issue uniform pulsed light into skull
Photoacoustic signal；
The transmitting of band-like ultrasonic phase array and receiving module 4, are located in measurement arm 2 and side and setting in transmitting receive band
On, for emitting ultrasonic signal, and reception ultrasonic signal and photoacoustic signal.
The connection type of central node 1 and a plurality of measurement 2 one end of arm includes fixed and slidingtype, and concrete composition mode is such as
Under:
1) fixed situation: central node 1 and the link position of each item measurement arm 2 are fixed, and a plurality of measurement arm 2 is with determination
It is spaced apart；
2) the case where slidingtype: central node 1 and each item measure 2 link position on-fixed of arm, set between adjacent measurement arm 2
A stuck point is set, every measurement arm 2 is limited and is slided within the scope of the certain angle between adjacent stuck point.
Host: by multicore cable 5 through central node 1 and the band-like light emitting and light transmission module 3 and band-like in measurement arm 2
Ultrasonic phase array transmitting and receiving module 4 connect, and to drive transmitting laser and ultrasonic signal, and receive the photoacoustic signal of generation
It is imaged with the ultrasonic signal being reflected back.
As shown in Figure 4 to 7,
The optical transmitter module of band-like light emitting and light transmission module 3 emit different wave length pulsed light, band-like light emitting and thoroughly
Pulsed light is transmitted in the brain tissue in skull by the light transmission module of optical module 3, band-like ultrasonic phase array transmitting and reception mould
Block 4 includes at least ultrasonic sound head, array element plate 9, phased array cable, for emitting ultrasonic signal, and receive ultrasonic signal and
Photoacoustic signal, each item measurement arm 2 that one end is connect with central node 1 realize brain in skull for accommodating other all modules
The noninvasive cerebral function imaging of ultrasonic photoacoustic bimodal of tissue.
Light-pulse generator includes but is not limited to embedded LED array light source 6 and external laser transmitting laser light source, for sending out
The pulse laser of multiple wavelength is penetrated, the length of light-pulse generator is longer than the length of beam shaping mirror 7 and light guide plate 8, guarantees transmitting
Pulse laser covers entire transmission region.
Band-like ultrasonic phase array transmitting and receiving module 4 include array element plate 9, phased array cable and ultrasonic sound head, array element
One end of plate 9 is connect with phased array cable, and the other end is connect with ultrasonic sound head, receives the trigger signal for carrying out driving circuit,
Emit ultrasonic signal, and successively receives after certain delay the ultrasonic signal of longitudal section Tissue reflectance and the optoacoustic letter of generation
Number.Wherein, conventional sound head, including piezoelectric ceramics, matching layer 13 and acoustic lens 14 can be selected in ultrasonic sound head in the present embodiment.
Measuring arm 2 has certain elasticity, comprising fixed card slot 15 and for protecting ultrasonic sound head and band-like light emitting and thoroughly
The transparent water sealed layer 16 of optical module 3, fixed card slot 15 is in measurement arm 2, for fixed ultrasonic sound head, band-like light emitting and thoroughly
Band-like optical transmitter module and light transmission module in optical module 3.
It, can be with for the set-up mode of band-like optical transmitter module and light transmission module in band-like light emitting and light transmission module 3
It is divided into unilateral side to optical mode and bilateral to optical mode, two ways has their own advantages, and concrete composition mode is as follows:
1) unilateral in optical mode, band-like light emitting and light transmission module 3 are equipped with one group altogether, and array element plate 9 and transmitting receive band
At an oblique angle, and its one end for receiving band far from transmitting is arranged far from band-like optical transmitter module and light transmission module, it is preferred that probe
Inside area of space on probe cross section is divided into left and right two parts, and wherein array element plate 9 is within the scope of 50~80 degree with a constant inclination
Oblique angle is placed, enable pop one's head in the internal other side place band-like optical transmitter module in band-like light emitting and light transmission module 3 and
Light transmission module, fixed card slot 15 divide for two parts, are respectively used to fixed ultrasonic sound head and light-transmitting plate, realize laser from ultrasonic sound head
Side penetrate, through skull irradiate brain test serum region；The commutative placement of module in two parts region of left and right；
2) bilateral is in optical mode, and the internal area of space on probe cross section of probe is divided into three parts, wherein array element plate 9
It is placed in intermediate region and receives band-like light emitting mould of the band at a right angle, in two groups of band-like light emittings and light transmission module 3 with transmitting
Block and light transmission module are respectively placed in 9 two sides of array element plate, and fixed card slot 15 divides for three parts, the ultrasonic sound being respectively used among fixed
The light guide plate 8 of head and two sides, realizes that laser is penetrated from the two sides of ultrasonic sound head, irradiates brain test serum region through skull；
Light transmission module in band-like light emitting and light transmission module 3 includes beam shaping mirror 7 and light guide plate 8, beam shaping mirror 7
It is arranged in optical path from after going to light guide plate 8, and light guide plate 8 is fixed on measurement arm 2, light beam is whole via beam shaping mirror 7
After shape, to external exposure after further being homogenized by light guide plate 8.Light beam after light guide plate 8 homogenizes is irradiated to band-like ultrasound phase-control
Paroxysm, which is penetrated, meets equation for generating photoacoustic signal with the same test serum region of receiving module covering:
Wherein p (r, t) is acoustic pressure, and H (r, t) is the heat source function that incident laser is excited in imaging region, H (r, t)=A
(r) I (t), A (r) are the light absorption distributions of tissue, and I (t) is irradiation light intensity, and β is thermal expansion coefficient, CpFor specific heat capacity, c is group
The velocity of sound is knitted,For Laplace operator, r is imaging point to the distance of incidence point, and t is the time.
When concrete application of the present invention in embodiment the following steps are included:
Step S1: (Chinese patent CN105395170A can be used to disclose based on photoacoustic ultrasound bimodal synchronous imaging system
System) pumping signal, control multiple channels while emitting ultrasonic wave after Beam synthesis, waited for through skull irradiation brain
Survey tissue regions；
Step S2: the light emitting portion in band-like light emitting and light transmission module 3 emits pulsed light, and light transmission part is whole by laser
The same test serum region covered with the transmitting of band-like ultrasonic phase array and receiving module 4 is transmitted to after shape, for generating optoacoustic
Signal.
Step S3: receiving the pumping signal of photoacoustic ultrasound bimodal synchronous imaging system, the transmitting of band-like ultrasonic phase array and
Receiving module 4 receives the ultrasonic signal of Tissue reflectance, after pulsed light triggers, by certain delay, receives photoacoustic signal.
Step S4: the received ultrasonic signal of institute and photoacoustic signal pass through multicore cable 5 and are transferred to host, realize brain in skull
Portion's synchronous optoacoustic ultrasonic double-mode state imaging simultaneously.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can readily occur in various equivalent modifications or replace
It changes, these modifications or substitutions should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with right
It is required that protection scope subject to.
Claims (10)
1. a kind of noninvasive cerebral function imaging helmet characterized by comprising
Central node (1): it connect with one end of a plurality of measurement arm (2), for assembling ultrasonic phase array in each item measurement arm (2)
With the cable of optical transmitter module, and it is connect with host by multicore cable (5)；
A plurality of measurement arm (2): the shape of all measurements arm (2) is strip, one end point of every measurement arm (2)
It is not connected with the central node (1), is additionally provided on every measurement arm (2) for the transmitting through pulsed light and ultrasound
Receive band；
Band-like light emitting and light transmission module (3): it is fixed in the measurement arm (2) by fixed card slot (15), is used for cranium
Pulsed light is issued in bone receives band irradiation brain tissue regions generation photoacoustic signal to be imaged across transmitting；
Band-like ultrasonic phase array transmitting and receiving module (4): it is fixed in the measurement arm (2) by fixed card slot (15),
Transmitting is passed through for emitting ultrasonic signal and receives band irradiation brain tissue regions to be imaged, and receive the ultrasonic signal that is reflected back and
The photoacoustic signal that brain tissue generates；
Host: it is by multicore cable (5) through the central node (1) and the band-like light emitting in every measurement arm (2)
And light transmission module (3) emits with band-like ultrasonic phase array and receiving module (4) is connected, for driving transmitting laser and ultrasound letter
Number, and the ultrasonic signal for receiving the photoacoustic signal of generation and being reflected back is imaged.
2. a kind of noninvasive cerebral function imaging helmet according to claim 1, which is characterized in that pass through the central node
(1) between measurement arm (2) described in every different connection set-up mode with formed the fixed noninvasive cerebral function imaging helmet and
The noninvasive cerebral function imaging helmet of slidingtype；
The central node (1) is fixedly connected with measurement arm (2) one end described in every, and every measurement arm (2) with
Setting is spaced apart, and forms the fixed noninvasive cerebral function imaging helmet；
Alternatively, the central node (1) is flexibly connected with measurement arm (2) one end described in every, the adjacent measurement arm (2) it
Between be provided with stuck point, for limiting every measurement arm (2) between adjacent stuck point to slide within the scope of set angle, formed
The noninvasive cerebral function imaging helmet of slidingtype.
3. a kind of noninvasive cerebral function imaging helmet according to claim 1, which is characterized in that the band-like light emitting and thoroughly
Optical module (3) includes the light-pulse generator set gradually along optical path, beam shaping mirror (7) and light guide plate (8), and the light-pulse generator is logical
Multicore cable (5) is crossed to connect with the host.
4. a kind of noninvasive cerebral function imaging helmet according to claim 3, which is characterized in that the light-pulse generator includes interior
Embedded LED array light source (6) and external laser emit laser light source, for emitting the pulsed light of multiple and different wavelength.
5. a kind of noninvasive cerebral function imaging helmet according to claim 1, which is characterized in that the band-like ultrasonic phase array
Transmitting and receiving module (4) include array element plate (9) and ultrasonic sound head, the top of the array element plate (9) by multicore cable (5) and
Host connection, the bottom end connection ultrasonic sound head, the ultrasound sound head include that piezoelectric ceramics, matching layer (13) harmony are saturating
Mirror (14).
6. a kind of noninvasive cerebral function imaging helmet according to claim 1, which is characterized in that the helmet further include for pair
The transmitting receives the transparent water sealed layer (16) with offer protection.
7. a kind of noninvasive cerebral function imaging helmet according to claim 1, which is characterized in that pass through the band-like light emitting
And the connection set-up mode that light transmission module (3) emits from the band-like ultrasonic phase array and receiving module (4) are different is to form list
Side gives optical mode the noninvasive cerebral function imaging helmet to the noninvasive cerebral function imaging helmet of optical mode and bilateral.
8. a kind of noninvasive cerebral function imaging helmet according to claim 7, which is characterized in that the band-like light emitting and thoroughly
Optical module (3) is connect respectively with being individually juxtaposed on the transmitting with the band-like ultrasonic phase array transmitting and receiving module (4)
The left and right sides of take-up, and the array element plate (9) in band-like ultrasonic phase array transmitting and receiving module (4) with the hair
50 °~80 ° of formation is obliquely installed between penetrating the normal for receiving band, is formed unilateral to the noninvasive cerebral function imaging helmet of optical mode.
9. a kind of noninvasive cerebral function imaging helmet according to claim 7, which is characterized in that the band-like ultrasonic phase array
The two sides of transmitting and receiving module (4) are provided with the band-like light emitting and light transmission module (3), the band-like ultrasonic phase array
Array element plate (9) in transmitting and receiving module (4) receives band with the transmitting and is vertically arranged, and forms bilateral and gives optical mode noninvasive brain
The functional imaging helmet.
10. it is a kind of using claim 1~9 its any one of as described in the noninvasive cerebral function imaging helmet imaging method,
Characterized by comprising the following steps:
Step 1: according to the pumping signal of host described in photoacoustic ultrasound bimodal synchronous imaging system, controlling multiple channels simultaneously
Emit the ultrasonic wave after Beam synthesis, irradiates brain test serum region through skull；
Step 2: the light-pulse generator in band-like light emitting and light transmission module (3) emits pulsed light, band-like light emitting and light transmission module
(3) beam shaping mirror (7) and light guide plate (8) in are transmitted to after laser shaping through skull and emit with band-like ultrasonic phase array
And the same test serum region of receiving module (4) covering, generate photoacoustic signal；
Step 3: the ultrasonic signal of band-like ultrasonic phase array transmitting and receiving module (4) reception Tissue reflectance is triggered through pulsed light
Afterwards, by delay, photoacoustic signal is received；
Step 4: the received ultrasonic signal of institute and photoacoustic signal being transferred to the host by multicore cable (5), realize skull
The synchronous optoacoustic ultrasonic double-mode state imaging simultaneously of interior brain tissue.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110548233A (en) * | 2019-09-30 | 2019-12-10 | 上海交通大学 | Portable double-channel transcranial ultrasonic stimulation device for nerve regulation |
| CN110840395A (en) * | 2019-10-21 | 2020-02-28 | 同济大学 | Head band type brain function imaging instrument |
| CN112545457A (en) * | 2020-12-01 | 2021-03-26 | 浙江清华柔性电子技术研究院 | Brain imaging detection device and brain imaging detection method |
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