BE1003255A5 - Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzo-furannyl)-acetiques et leurs esters mucoregulateurs et anti-ischemiques et procede pour les preparer. - Google Patents
Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzo-furannyl)-acetiques et leurs esters mucoregulateurs et anti-ischemiques et procede pour les preparer. Download PDFInfo
- Publication number
- BE1003255A5 BE1003255A5 BE8900822A BE8900822A BE1003255A5 BE 1003255 A5 BE1003255 A5 BE 1003255A5 BE 8900822 A BE8900822 A BE 8900822A BE 8900822 A BE8900822 A BE 8900822A BE 1003255 A5 BE1003255 A5 BE 1003255A5
- Authority
- BE
- Belgium
- Prior art keywords
- dihydro
- acids
- acetics
- trimethylbenzofurannyl
- acyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Les acides (RS)-2-(2,3-dihydro-5-hydroxy-4,6,7 triméthylbenzofurannyl) acétiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7 triméthylbenzofurannyl) acétiques, de même que leurs esters, sont des substances antioxydantes convenant comme agents thérapeutiques pour le traitement de l'emphyzème pulmonaire et des processus inflammatoires des muqueuses de l'appareil respiratoire, de même que pour le traitement des séquelles de l'infarctus cérébral ou cardiaque. Ils sont préférés comme mucolytiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8821603A IT1229482B (it) | 1988-08-01 | 1988-08-01 | Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici. |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1003255A5 true BE1003255A5 (fr) | 1992-02-11 |
Family
ID=11184201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8900822A BE1003255A5 (fr) | 1988-08-01 | 1989-08-01 | Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzo-furannyl)-acetiques et leurs esters mucoregulateurs et anti-ischemiques et procede pour les preparer. |
Country Status (15)
Country | Link |
---|---|
US (2) | US4999350A (fr) |
JP (1) | JPH0278675A (fr) |
KR (1) | KR0129526B1 (fr) |
CN (1) | CN1034574C (fr) |
BE (1) | BE1003255A5 (fr) |
CA (1) | CA1324134C (fr) |
CH (1) | CH679583A5 (fr) |
DE (1) | DE3925496A1 (fr) |
ES (1) | ES2014188A6 (fr) |
FR (1) | FR2634766A1 (fr) |
GB (1) | GB2221463B (fr) |
HK (1) | HK48693A (fr) |
IT (1) | IT1229482B (fr) |
SE (1) | SE469652B (fr) |
SG (1) | SG26693G (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1231341B (it) * | 1989-08-18 | 1991-11-28 | Foscama Biomed Chim Farma | 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche. |
IT1239946B (it) * | 1990-03-12 | 1993-11-27 | Biomedica Foscama Industria Chimicofarmaceutica | Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici |
US5240956A (en) * | 1990-11-07 | 1993-08-31 | Cortech, Inc. | Ester inhibitors |
EP0550292A1 (fr) * | 1992-01-02 | 1993-07-07 | Merrell Dow Pharmaceuticals Inc. | Analogues de tocophérol de protection des tissus |
US5510373A (en) * | 1992-04-06 | 1996-04-23 | Merrell Pharmaceuticals Inc. | Cardioprotective agents |
EP0635009B1 (fr) * | 1992-04-06 | 1997-09-17 | Merrell Pharmaceuticals Inc. | Nouveaux derives de 2,3-dihydro-2,2,4,6,7-pentaalkyl-5-benzofuranols |
US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
TW393475B (en) * | 1992-10-16 | 2000-06-11 | Chugai Pharmaceutical Co Ltd | 4-alkoxyl-2,6-di-t-butyl phenol derivatives |
IT1289494B1 (it) * | 1996-12-20 | 1998-10-15 | Biomedica Foscana Ind Chimico | Acidi 5-idrossi- e 5-acilossi-2,3-diidro-4,6,7-trimetil-2- benzofuranaceti e loro esteri per il trattamento e la prevenzione |
IT1320131B1 (it) * | 2000-12-21 | 2003-11-18 | Foscama Biomed Chim Farma | Uso degli acidi 5-idrossi e 5-acilossi-2,3-diidro-4,6,7-trimetil-2-benzofuranacetici e loro esteri come cicatrizzanti delle lesioni |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0165810A2 (fr) * | 1984-06-20 | 1985-12-27 | Merck Frosst Canada Inc. | Dérivés de benzofuranne et de benzothiophène, leur application pour inhiber la biosynthèse de leucotriène aux mammifères et compositions pharmaceutiques contenant ces dérivés |
JPS6388173A (ja) * | 1986-09-30 | 1988-04-19 | Kuraray Co Ltd | 2,3−ジヒドロベンゾフラン誘導体 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6065063A (ja) * | 1983-09-20 | 1985-04-13 | Matsunaga Kagaku Kogyo Kk | 難燃化剤 |
US4537903A (en) * | 1983-10-12 | 1985-08-27 | Merck & Co., Inc. | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents |
US4918092A (en) * | 1983-12-21 | 1990-04-17 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
EP0273647B1 (fr) * | 1986-12-27 | 1992-03-11 | Takeda Chemical Industries, Ltd. | Dérivés de coumaranne, leur préparation et leur utilisation |
JP2855340B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | 2―置換クマラン誘導体 |
-
1988
- 1988-08-01 IT IT8821603A patent/IT1229482B/it active
-
1989
- 1989-04-13 US US07/337,358 patent/US4999350A/en not_active Expired - Lifetime
- 1989-07-24 CH CH2760/89A patent/CH679583A5/it not_active IP Right Cessation
- 1989-07-26 SE SE8902603A patent/SE469652B/sv not_active IP Right Cessation
- 1989-07-31 CA CA000607022A patent/CA1324134C/fr not_active Expired - Fee Related
- 1989-07-31 JP JP1200164A patent/JPH0278675A/ja active Pending
- 1989-08-01 ES ES8902723A patent/ES2014188A6/es not_active Expired - Lifetime
- 1989-08-01 GB GB8917515A patent/GB2221463B/en not_active Expired - Lifetime
- 1989-08-01 BE BE8900822A patent/BE1003255A5/fr not_active IP Right Cessation
- 1989-08-01 FR FR8910354A patent/FR2634766A1/fr active Granted
- 1989-08-01 CN CN89107028A patent/CN1034574C/zh not_active Expired - Fee Related
- 1989-08-01 KR KR1019890011057A patent/KR0129526B1/ko not_active IP Right Cessation
- 1989-08-01 DE DE3925496A patent/DE3925496A1/de active Granted
-
1990
- 1990-09-17 US US07/583,810 patent/US5041568A/en not_active Expired - Fee Related
-
1993
- 1993-03-11 SG SG266/93A patent/SG26693G/en unknown
- 1993-05-20 HK HK486/93A patent/HK48693A/xx not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0165810A2 (fr) * | 1984-06-20 | 1985-12-27 | Merck Frosst Canada Inc. | Dérivés de benzofuranne et de benzothiophène, leur application pour inhiber la biosynthèse de leucotriène aux mammifères et compositions pharmaceutiques contenant ces dérivés |
JPS6388173A (ja) * | 1986-09-30 | 1988-04-19 | Kuraray Co Ltd | 2,3−ジヒドロベンゾフラン誘導体 |
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS, vol. 110, no. 9, 27 février 1989, page 630, abrégé no. 75294x, Columbus, Ohio, US; & JP-A-63 088 173 (KURARAY CO., LTD) 19-04-1988 * |
Also Published As
Publication number | Publication date |
---|---|
SE8902603D0 (sv) | 1989-07-26 |
SG26693G (en) | 1993-05-21 |
GB8917515D0 (en) | 1989-09-13 |
DE3925496A1 (de) | 1990-02-22 |
JPH0278675A (ja) | 1990-03-19 |
IT1229482B (it) | 1991-09-03 |
HK48693A (en) | 1993-05-27 |
US5041568A (en) | 1991-08-20 |
SE8902603L (sv) | 1990-02-02 |
KR0129526B1 (ko) | 1998-04-09 |
GB2221463B (en) | 1992-03-25 |
ES2014188A6 (es) | 1990-06-16 |
CN1034574C (zh) | 1997-04-16 |
IT8821603A0 (it) | 1988-08-01 |
KR900003145A (ko) | 1990-03-23 |
FR2634766A1 (fr) | 1990-02-02 |
FR2634766B1 (fr) | 1994-08-19 |
DE3925496C2 (fr) | 1992-04-30 |
US4999350A (en) | 1991-03-12 |
CN1042354A (zh) | 1990-05-23 |
GB2221463A (en) | 1990-02-07 |
CH679583A5 (fr) | 1992-03-13 |
SE469652B (sv) | 1993-08-16 |
CA1324134C (fr) | 1993-11-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Effective date: 20050831 |