ZA984088B - Antithrombotic compound. - Google Patents

Antithrombotic compound.

Info

Publication number
ZA984088B
ZA984088B ZA9804088A ZA984088A ZA984088B ZA 984088 B ZA984088 B ZA 984088B ZA 9804088 A ZA9804088 A ZA 9804088A ZA 984088 A ZA984088 A ZA 984088A ZA 984088 B ZA984088 B ZA 984088B
Authority
ZA
South Africa
Prior art keywords
antithrombotic compound
antithrombotic
compound
Prior art date
Application number
ZA9804088A
Other languages
English (en)
Inventor
Charles Van Jackson
Kenneth Dean Kurz
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA984088B publication Critical patent/ZA984088B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9804088A 1997-05-15 1998-05-14 Antithrombotic compound. ZA984088B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4658497P 1997-05-15 1997-05-15

Publications (1)

Publication Number Publication Date
ZA984088B true ZA984088B (en) 1999-11-15

Family

ID=21944238

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9804088A ZA984088B (en) 1997-05-15 1998-05-14 Antithrombotic compound.

Country Status (8)

Country Link
US (1) US6214841B1 (fr)
EP (1) EP0884326A3 (fr)
JP (1) JP2001525823A (fr)
AU (1) AU7292398A (fr)
CA (1) CA2289625A1 (fr)
TW (1) TW404948B (fr)
WO (1) WO1998051684A1 (fr)
ZA (1) ZA984088B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
CN102127097A (zh) * 2010-01-15 2011-07-20 首都医科大学 N-（3s-1,2,3,4-四氢异喹啉-3-甲酰基）氨基酸铜络合物及其制备方法和应用
JP6125531B2 (ja) 2011-12-19 2017-05-10 ギャンブリット ゲーミング，エルエルシー 混合ゲームにおける仮想構造のためのクレジットおよび可能化システム
WO2013156861A2 (fr) 2012-04-17 2013-10-24 University College Dublin, National University Of Ireland, Dublin Méthodes et composés de traitement de troubles prolifératifs et d'infections virales
US9388127B2 (en) 2012-04-17 2016-07-12 University College Dublin, National University Of Ireland, Dublin Thromboxane receptor antagonists
ES2858551T3 (es) 2015-06-16 2021-09-30 Atxa Therapeutics Ltd Antagonistas del receptor de tromboxano
AU2018289303B2 (en) 2017-06-20 2023-12-21 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US20190269728A1 (en) 2018-03-02 2019-09-05 Sixfold Bioscience Ltd. Compositions for delivery of cargo to cells
CA3094324A1 (fr) 2018-03-26 2019-10-03 Clear Creek Bio, Inc. Compositions et procedes pour inhiber la dihydroorotate deshydrogenase
WO2020081361A1 (fr) 2018-10-17 2020-04-23 Imbria Pharmaceuticals, Inc. Procédés de traitement de maladies rhumatismales à l'aide de composés à base de trimétazidine
US20210300873A1 (en) 2020-03-20 2021-09-30 Clear Creek Bio, Inc. Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof
JP2023523345A (ja) 2020-04-27 2023-06-02 シックスフォールド バイオサイエンス リミテッド モジュール官能基を有する核酸ナノ粒子を含有する組成物
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
WO2022008515A1 (fr) 2020-07-07 2022-01-13 Atxa Therapeutics Limited Formulations d'antagoniste du récepteur du thromboxane
US11730733B2 (en) 2020-12-10 2023-08-22 Imbria Pharmaceuticals, Inc. Methods of treating non-obstructive hypertrophic cardiomyopathy using modified forms of trimetazidine
US12076318B2 (en) 2020-12-10 2024-09-03 Imbria Pharmaceuticals, Inc. Methods of treating heart failure with hibernating myocardium using modified forms of trimetazidine
US11969422B2 (en) 2020-12-10 2024-04-30 Imbria Pharmaceuticals, Inc. Methods of treating heart failure with reduced ejection fraction using modified forms of trimetazidine
US11793807B2 (en) 2020-12-10 2023-10-24 Imbria Pharmaceuticals, Inc. Methods of treating heart failure with preserved ejection fraction using modified forms of trimetazidine
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430023A (en) 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
IL99527A (en) 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
EP0503203A1 (fr) 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Nouveaux inhibiteurs de la thrombine
US5416093A (en) 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
US5252566A (en) 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
NZ245039A (en) 1991-11-12 1994-12-22 Lilly Co Eli N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions
ZA951618B (en) 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5436229A (en) 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
JPH0820597A (ja) 1994-07-07 1996-01-23 Meiji Seika Kaisha Ltd トロンビン阻害作用を有する複素環カルボニル化合物
WO1996030396A1 (fr) 1995-03-24 1996-10-03 Molecumetics Ltd. IMITATEURS DE FEUILLETS β ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PROTEASE
FR2734273B1 (fr) 1995-05-19 1997-07-04 Rhone Poulenc Chimie Dispersion aqueuse a base de silicones et de latex de (co)polymere(s) organique(s) pour la preparation d'elastomere silicone a translucidite reglable
GB9510716D0 (en) 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5827860A (en) 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5827866A (en) 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
US6069232A (en) 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
IL119466A (en) 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
EP1007544A1 (fr) 1996-02-13 2000-06-14 Akzo Nobel N.V. Inhibiteurs de la serine protease
IL120310A (en) 1996-03-01 2002-02-10 Akzo Nobel Nv Serine protease inhibitors and pharmaceuticals containing them
TW523513B (en) 1996-03-01 2003-03-11 Akzo Nobel Nv Serine protease inhibitors
AU3232597A (en) 1996-06-18 1998-01-07 Warner-Lambert Company Pyrrolo{1,2-a}pyrazine-1,4-dione serine protease inhibitors

Also Published As

Publication number Publication date
JP2001525823A (ja) 2001-12-11
EP0884326A3 (fr) 1999-12-01
AU7292398A (en) 1998-12-08
EP0884326A2 (fr) 1998-12-16
TW404948B (en) 2000-09-11
CA2289625A1 (fr) 1998-11-19
US6214841B1 (en) 2001-04-10
WO1998051684A1 (fr) 1998-11-19

Similar Documents

Publication Publication Date Title
ZA989767B (en) Novel compounds.
ZA9711092B (en) Novel compounds.
ZA9610858B (en) Heteroclyclic compounds.
ZA987489B (en) Fungicidal 2-methoxybenzophenones.
ZA984849B (en) Compositions.
HK1016976A1 (en) Resorcinyl-triazine.
ZA984088B (en) Antithrombotic compound.
EP0664969A3 (fr) Chaussure de ski.
ZA9711567B (en) Compounds.
ZA981926B (en) Detergent--package combination.
ZA200203799B (en) Antithrombotic compound.
ZA987055B (en) Substituted 4-benzoylpyrazoles.
PL345238A1 (en) Antithrombotic compounds
ZA987058B (en) Substituted 4-benzoylpyrazoles.
ZA975861B (en) Bromotiacumicin compounds.
ZA9811758B (en) Novel compounds.
ZA9811503B (en) Novel compounds.
HK1017834A1 (en) Bodyshaper.
ZA992899B (en) Novel compound.
ZA964560B (en) Anit-viral compounds.
ZA983705B (en) Pregnan-3-ol-20-ones.
ZA98868B (en) Novel compounds.
ZA987B (en) Substituted 4-benzoylpyrazoles.
ZA988206B (en) Piperidinylmethyloxazolidinone derivative.
GB9711118D0 (en) Compound