ZA983395B - Process for the fermentative production of deacylated cephalosporins - Google Patents

Process for the fermentative production of deacylated cephalosporins

Info

Publication number
ZA983395B
ZA983395B ZA983395A ZA983395A ZA983395B ZA 983395 B ZA983395 B ZA 983395B ZA 983395 A ZA983395 A ZA 983395A ZA 983395 A ZA983395 A ZA 983395A ZA 983395 B ZA983395 B ZA 983395B
Authority
ZA
South Africa
Prior art keywords
fermentative production
deacylated
cephalosporins
deacylated cephalosporins
production
Prior art date
Application number
ZA983395A
Other languages
English (en)
Inventor
Maarten Nieboer
Erik De Vroom
Johannes Lugtenburg
Dirk Schipper
Adrianus Wilhelmus Vollebregt
Roelof Ary Lans Bovenberg
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of ZA983395B publication Critical patent/ZA983395B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA983395A 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins ZA983395B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201197 1997-04-22

Publications (1)

Publication Number Publication Date
ZA983395B true ZA983395B (en) 1999-01-27

Family

ID=8228237

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983395A ZA983395B (en) 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins

Country Status (17)

Country Link
US (1) US6410259B1 (fr)
EP (1) EP0915988B1 (fr)
JP (1) JP2000512512A (fr)
KR (1) KR20000022109A (fr)
CN (1) CN1145703C (fr)
AT (1) ATE231919T1 (fr)
AU (1) AU7909498A (fr)
BR (1) BR9804854A (fr)
DE (1) DE69811039T2 (fr)
ES (1) ES2191313T3 (fr)
ID (1) ID21520A (fr)
PL (1) PL330760A1 (fr)
PT (1) PT915988E (fr)
RU (1) RU2208643C2 (fr)
SI (1) SI0915988T1 (fr)
WO (1) WO1998048035A1 (fr)
ZA (1) ZA983395B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1331751A (zh) * 1998-12-22 2002-01-16 Dsm公司 改进的头孢菌素的体内生产方法
EP2123772A1 (fr) 2008-04-29 2009-11-25 DSM IP Assets B.V. Souches produisant des antibiotiques bêta-lactamines
WO2010015624A1 (fr) 2008-08-05 2010-02-11 Dsm Ip Assets B.V. Souches produisant de l'adipoyl-7-adca
EP2392649A3 (fr) 2008-08-05 2012-01-11 DSM IP Assets B.V. Adipoyl-7-ADCA produisant des souches
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
WO2011161004A1 (fr) 2010-06-22 2011-12-29 Dsm Ip Assets B.V. Procédé de fermentation à bulles d'air
MX343543B (es) 2011-03-03 2016-11-08 Dsm Sinochem Pharm Nl Bv Degradación de compuestos de penicilina.
CN102757999A (zh) * 2011-04-29 2012-10-31 上海医药工业研究院 一种用于生产7-氨基头孢烷酸的发酵培养基及其发酵方法
WO2015091455A1 (fr) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioréacteur

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
PT97116B (pt) 1990-03-23 1998-10-30 Gist Brocades Nv Processo para modular a producao de metabolitos secundarios nomeadamente derivados de beta-lactama
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
CZ288721B6 (cs) * 1991-10-15 2001-08-15 Dsm Gist B. V. Biologický způsob výroby kyseliny 7-aminodeacetylcefalosporanové
WO1995004149A1 (fr) 1993-07-30 1995-02-09 Gist-Brocades B.V. Procede de production efficace de 7-adca par l'intermediaire du 3-(carboxyethylthio)propionyl-7-adca
BR9407108A (pt) * 1993-07-30 1996-08-27 Gist Brocades Nv Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido

Also Published As

Publication number Publication date
PT915988E (pt) 2003-06-30
RU2208643C2 (ru) 2003-07-20
EP0915988A1 (fr) 1999-05-19
DE69811039D1 (de) 2003-03-06
BR9804854A (pt) 1999-09-08
US6410259B1 (en) 2002-06-25
AU7909498A (en) 1998-11-13
JP2000512512A (ja) 2000-09-26
SI0915988T1 (en) 2003-06-30
EP0915988B1 (fr) 2003-01-29
CN1224469A (zh) 1999-07-28
WO1998048035A1 (fr) 1998-10-29
ES2191313T3 (es) 2003-09-01
DE69811039T2 (de) 2004-01-22
KR20000022109A (ko) 2000-04-25
ATE231919T1 (de) 2003-02-15
PL330760A1 (en) 1999-05-24
ID21520A (id) 1999-06-24
CN1145703C (zh) 2004-04-14

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