ZA974802B - Anit-neurodegeneratively effective 10-aminoaliphatyl-dibenz[b,f]oxepine salts - Google Patents

Anit-neurodegeneratively effective 10-aminoaliphatyl-dibenz[b,f]oxepine salts

Info

Publication number
ZA974802B
ZA974802B ZA974802A ZA974802A ZA974802B ZA 974802 B ZA974802 B ZA 974802B ZA 974802 A ZA974802 A ZA 974802A ZA 974802 A ZA974802 A ZA 974802A ZA 974802 B ZA974802 B ZA 974802B
Authority
ZA
South Africa
Prior art keywords
neurodegeneratively
aminoaliphatyl
oxepine
anit
dibenz
Prior art date
Application number
ZA974802A
Other languages
English (en)
Inventor
Kaspar Zimmermann
Silvio Roggo
Claudia Betschart
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA974802B publication Critical patent/ZA974802B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA974802A 1996-05-30 1997-05-30 Anit-neurodegeneratively effective 10-aminoaliphatyl-dibenz[b,f]oxepine salts ZA974802B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH135296 1996-05-30

Publications (1)

Publication Number Publication Date
ZA974802B true ZA974802B (en) 1998-11-30

Family

ID=4208469

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA974802A ZA974802B (en) 1996-05-30 1997-05-30 Anit-neurodegeneratively effective 10-aminoaliphatyl-dibenz[b,f]oxepine salts

Country Status (10)

Country Link
AR (1) AR008371A1 (es)
AU (1) AU3030397A (es)
CO (1) CO5080765A1 (es)
CZ (1) CZ296134B6 (es)
ID (1) ID18178A (es)
PE (1) PE70398A1 (es)
PL (1) PL191728B1 (es)
TR (1) TR199802482T2 (es)
WO (1) WO1997045422A1 (es)
ZA (1) ZA974802B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7355042B2 (en) 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
AU2003235799A1 (en) * 2002-01-08 2003-07-24 Nordic Bioscience A/S Modulation of iamt (pimt or pcmt) in immune system
JP2006516580A (ja) * 2003-01-29 2006-07-06 ノバルティス アクチエンゲゼルシャフト 眼の変性疾患の処置のための１０−アミノアリファチル−ジベンズ［ｂ，ｆ］オキセピンの使用
AR046320A1 (es) * 2003-11-06 2005-11-30 Novartis Ag Composiciones farmaceuticas estabilizadas de dibenzo-oxepina.
US20060063755A1 (en) 2004-09-21 2006-03-23 Edgar Dale M Loxapine analogs and methods of use thereof
WO2006049734A2 (en) 2004-10-29 2006-05-11 Hypnion, Inc. Quetiapine analogs and methods of use thereof
EP1757284A1 (en) 2005-08-25 2007-02-28 Santhera Pharmaceuticals (Schweiz) AG Use of N-(dibenz(b,f)oxepin-10ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of muscular dystrophy
EP1842539A1 (en) 2006-04-05 2007-10-10 Santhera Pharmaceuticals (Schweiz) AG Use of N- (dibenz(b,f)oxepin-10-ylmethyl)N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of congenital muscular dystrophy or myopathy resulting from collagen VI deficiency
US9937144B2 (en) 2013-01-30 2018-04-10 The Johns Hopkins University Treatment of drug abuse by preventing GAPDH nitrosylation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3100207A (en) * 1959-07-08 1963-08-06 Smith Kline French Lab 10-aminoalkylbenzo[b,f]thiepin and -dibenz[b,f]oxepin derivatives
DE1493782B1 (de) * 1964-06-29 1969-12-11 Geigy Ag J R Basisch substituierte Dibenzo[b,f]-oxepine und deren nicht-toxische Salze
CH585747A5 (es) * 1973-06-08 1977-03-15 Hoffmann La Roche
PT726265E (pt) * 1995-02-08 2001-12-28 Novartis Ag 10-amino-alifatil-dibenzo¬b,f| oxepinas com accao antineurodegenerativa

Also Published As

Publication number Publication date
AU3030397A (en) 1998-01-05
WO1997045422A1 (en) 1997-12-04
TR199802482T2 (xx) 1999-02-22
PE70398A1 (es) 1998-11-09
CO5080765A1 (es) 2001-09-25
PL191728B1 (pl) 2006-06-30
AR008371A1 (es) 2000-01-19
CZ387898A3 (cs) 1999-02-17
ID18178A (id) 1998-03-12
PL330238A1 (en) 1999-05-10
CZ296134B6 (cs) 2006-01-11

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