ZA971849B - Oligonucleotide analogues. - Google Patents
Oligonucleotide analogues.Info
- Publication number
- ZA971849B ZA971849B ZA9701849A ZA971849A ZA971849B ZA 971849 B ZA971849 B ZA 971849B ZA 9701849 A ZA9701849 A ZA 9701849A ZA 971849 A ZA971849 A ZA 971849A ZA 971849 B ZA971849 B ZA 971849B
- Authority
- ZA
- South Africa
- Prior art keywords
- attached
- group
- unsubstituted
- cycloalkyl
- alkenyl
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9604669.3A GB9604669D0 (en) | 1996-03-05 | 1996-03-05 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA971849B true ZA971849B (en) | 1997-09-05 |
Family
ID=10789879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9701849A ZA971849B (en) | 1996-03-05 | 1997-03-04 | Oligonucleotide analogues. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6562960B1 (fr) |
| EP (1) | EP0885237B1 (fr) |
| JP (1) | JP2000506849A (fr) |
| CN (1) | CN1212701A (fr) |
| AT (1) | ATE249475T1 (fr) |
| AU (1) | AU1886797A (fr) |
| BR (1) | BR9707918A (fr) |
| CA (1) | CA2247480A1 (fr) |
| DE (1) | DE69724768T2 (fr) |
| GB (1) | GB9604669D0 (fr) |
| WO (1) | WO1997032887A1 (fr) |
| ZA (1) | ZA971849B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6639061B1 (en) * | 1999-07-07 | 2003-10-28 | Isis Pharmaceuticals, Inc. | C3′-methylene hydrogen phosphonate oligomers and related compounds |
| US6414135B1 (en) | 1999-07-07 | 2002-07-02 | Isis Pharmaceuticals, Inc. | C3′-methylene hydrogen phosphonate monomers and related compounds |
| AU2002358462A1 (en) * | 2001-12-18 | 2003-06-30 | Human Genetic Signatures Pty Ltd | Linear and hairpin oligonucleotide analogues comprising intercalator pseudonucleotides |
| FR2858976B1 (fr) * | 2003-08-22 | 2006-02-10 | Isochem Sa | Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane |
| ES2439591T3 (es) * | 2007-08-15 | 2014-01-23 | Isis Pharmaceuticals, Inc. | Análogos de ácido nucleico de tetrahidropirano |
| WO2010064146A2 (fr) | 2008-12-02 | 2010-06-10 | Chiralgen, Ltd. | Procédé pour la synthèse d’acides nucléiques modifiés par des atomes de phosphore |
| KR101885383B1 (ko) | 2009-07-06 | 2018-08-03 | 웨이브 라이프 사이언시스 리미티드 | 신규한 핵산 프로드러그 및 그의 사용 방법 |
| EP2620428B1 (fr) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Groupe auxiliaire asymétrique |
| JP6128529B2 (ja) | 2011-07-19 | 2017-05-17 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | 官能化核酸の合成のための方法 |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | キラル制御 |
| CA2879066C (fr) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Adjuvant d'acide nucleique chiral |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| WO2015108046A1 (fr) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique |
| WO2015108047A1 (fr) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité |
| EP3095459A4 (fr) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Adjuvant d'acide nucléique chiral ayant un effet antitumoral et agent antitumoral |
| SG10201912897UA (en) | 2014-01-16 | 2020-02-27 | Wave Life Sciences Ltd | Chiral design |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4507433A (en) * | 1983-10-07 | 1985-03-26 | The Johns Hopkins University | Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates |
| US4806463A (en) | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
| EP0266099A3 (fr) | 1986-10-28 | 1990-09-19 | The Johns Hopkins University | Alkyl- ou arylphosphonate oligonucléoside capable de réticulation avec des acides nucléiques ou de clevage d'acides nucléiques |
| GB8721442D0 (en) | 1987-09-11 | 1987-10-21 | Ciba Geigy Ag | Process |
| WO1989008146A1 (fr) | 1988-02-26 | 1989-09-08 | Worcester Foundation For Experimental Biology | Inhibition du htlv-iii par des oligonucleotides exogenes |
| DE69034150T2 (de) | 1989-10-24 | 2005-08-25 | Isis Pharmaceuticals, Inc., Carlsbad | 2'-Modifizierte Oligonukleotide |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US5610289A (en) * | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US6033909A (en) * | 1992-01-22 | 2000-03-07 | Hoechst Aktiengesellschaft | Oligonucleotide analogs, their preparation and use |
| US5681747A (en) | 1992-03-16 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof |
| US5625050A (en) | 1994-03-31 | 1997-04-29 | Amgen Inc. | Modified oligonucleotides and intermediates useful in nucleic acid therapeutics |
| US5563255A (en) * | 1994-05-31 | 1996-10-08 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
| GB9417746D0 (en) | 1994-09-03 | 1994-10-19 | Ciba Geigy Ag | Chemical compounds |
-
1996
- 1996-03-05 GB GBGB9604669.3A patent/GB9604669D0/en active Pending
-
1997
- 1997-02-24 BR BR9707918A patent/BR9707918A/pt not_active IP Right Cessation
- 1997-02-24 CA CA002247480A patent/CA2247480A1/fr not_active Abandoned
- 1997-02-24 DE DE69724768T patent/DE69724768T2/de not_active Expired - Lifetime
- 1997-02-24 CN CN97192761A patent/CN1212701A/zh active Pending
- 1997-02-24 AU AU18867/97A patent/AU1886797A/en not_active Abandoned
- 1997-02-24 US US09/142,212 patent/US6562960B1/en not_active Expired - Fee Related
- 1997-02-24 JP JP9531546A patent/JP2000506849A/ja active Pending
- 1997-02-24 EP EP97905245A patent/EP0885237B1/fr not_active Expired - Lifetime
- 1997-02-24 WO PCT/GB1997/000499 patent/WO1997032887A1/fr active IP Right Grant
- 1997-02-24 AT AT97905245T patent/ATE249475T1/de not_active IP Right Cessation
- 1997-03-04 ZA ZA9701849A patent/ZA971849B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2247480A1 (fr) | 1997-09-12 |
| WO1997032887A1 (fr) | 1997-09-12 |
| DE69724768D1 (de) | 2003-10-16 |
| DE69724768T2 (de) | 2004-08-05 |
| EP0885237B1 (fr) | 2003-09-10 |
| JP2000506849A (ja) | 2000-06-06 |
| US6562960B1 (en) | 2003-05-13 |
| EP0885237A1 (fr) | 1998-12-23 |
| GB9604669D0 (en) | 1996-05-01 |
| BR9707918A (pt) | 1999-07-27 |
| CN1212701A (zh) | 1999-03-31 |
| ATE249475T1 (de) | 2003-09-15 |
| AU1886797A (en) | 1997-09-22 |
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