AU2002358462A1 - Linear and hairpin oligonucleotide analogues comprising intercalator pseudonucleotides - Google Patents
Linear and hairpin oligonucleotide analogues comprising intercalator pseudonucleotidesInfo
- Publication number
- AU2002358462A1 AU2002358462A1 AU2002358462A AU2002358462A AU2002358462A1 AU 2002358462 A1 AU2002358462 A1 AU 2002358462A1 AU 2002358462 A AU2002358462 A AU 2002358462A AU 2002358462 A AU2002358462 A AU 2002358462A AU 2002358462 A1 AU2002358462 A1 AU 2002358462A1
- Authority
- AU
- Australia
- Prior art keywords
- linear
- oligonucleotide analogues
- hairpin oligonucleotide
- intercalator pseudonucleotides
- pseudonucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
Applications Claiming Priority (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200101897 | 2001-12-18 | ||
DKPA200101900 | 2001-12-18 | ||
DKPA200101898 | 2001-12-18 | ||
DKPA200101897 | 2001-12-18 | ||
DKPA200101898 | 2001-12-18 | ||
DKPA200101899 | 2001-12-18 | ||
DKPA200101899 | 2001-12-18 | ||
DKPA200101900 | 2001-12-18 | ||
US36554502P | 2002-03-20 | 2002-03-20 | |
US60/365,545 | 2002-03-20 | ||
DKPA200201578 | 2002-10-14 | ||
DKPA200201576 | 2002-10-14 | ||
DKPA200201575 | 2002-10-14 | ||
DKPA200201577 | 2002-10-14 | ||
DKPA200201577 | 2002-10-14 | ||
DKPA200201578 | 2002-10-14 | ||
DKPA200201575 | 2002-10-14 | ||
DKPA200201576 | 2002-10-14 | ||
PCT/DK2002/000874 WO2003052132A2 (en) | 2001-12-18 | 2002-12-18 | Linear and hairpin oligonucleotide analogues comprising intercalator pseudonucleotides |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002358462A1 true AU2002358462A1 (en) | 2003-06-30 |
AU2002358462A8 AU2002358462A8 (en) | 2003-06-30 |
Family
ID=27576036
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002358464A Ceased AU2002358464B2 (en) | 2001-12-18 | 2002-12-18 | Pseudonucleotide comprising an intercalator |
AU2002358463A Abandoned AU2002358463A1 (en) | 2001-12-18 | 2002-12-18 | Oligonucleotide analogues comprising intercalator pseudonucleotides |
AU2002358462A Abandoned AU2002358462A1 (en) | 2001-12-18 | 2002-12-18 | Linear and hairpin oligonucleotide analogues comprising intercalator pseudonucleotides |
AU2002361946A Abandoned AU2002361946A1 (en) | 2001-12-18 | 2002-12-18 | Oligonucleotides comprising intercalator pseudonucleotide(s) for detection of nucleic acids and mutants hereof |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002358464A Ceased AU2002358464B2 (en) | 2001-12-18 | 2002-12-18 | Pseudonucleotide comprising an intercalator |
AU2002358463A Abandoned AU2002358463A1 (en) | 2001-12-18 | 2002-12-18 | Oligonucleotide analogues comprising intercalator pseudonucleotides |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002361946A Abandoned AU2002361946A1 (en) | 2001-12-18 | 2002-12-18 | Oligonucleotides comprising intercalator pseudonucleotide(s) for detection of nucleic acids and mutants hereof |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1468007A2 (en) |
CN (1) | CN1653079B (en) |
AU (4) | AU2002358464B2 (en) |
WO (4) | WO2003052133A2 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003900368A0 (en) * | 2003-01-24 | 2003-02-13 | Human Genetic Signatures Pty Ltd | Assay for nucleic acid molecules |
WO2004074503A2 (en) * | 2003-02-21 | 2004-09-02 | Hoser Mark J | Nucleic acid sequencing methods, kits and reagents |
WO2004101816A1 (en) * | 2003-05-15 | 2004-11-25 | Human Genetic Signatures Pty Ltd | Decoys for nucleic acid-binding proteins |
WO2004111266A1 (en) | 2003-06-17 | 2004-12-23 | Human Genetic Signatures Pty Ltd | Methods for genome amplification |
CA2537810C (en) | 2003-09-04 | 2012-12-18 | Human Genetic Signatures Pty Ltd | Nucleic acid detection assay |
JP4397659B2 (en) * | 2003-09-11 | 2010-01-13 | 独立行政法人科学技術振興機構 | DNA detection method using molecular beacon using switching between monomer emission and excimer emission of fluorescent molecules |
US8168777B2 (en) | 2004-04-29 | 2012-05-01 | Human Genetic Signatures Pty. Ltd. | Bisulphite reagent treatment of nucleic acid |
ATE476439T1 (en) * | 2004-09-10 | 2010-08-15 | Human Genetic Signatures Pty | AMPLIFICATION BLOCKERS COMPRISING INTERCALATING NUCLEIC ACIDS (INA) CONTAINING INTERCALATING PSEUDONUCLEOTIDES (IPN) |
EP1799853A2 (en) | 2004-09-24 | 2007-06-27 | Universität Bern | Molecular beacons |
EP1828411B1 (en) | 2004-12-03 | 2012-11-07 | Human Genetic Signatures PTY Ltd | Methods for simplifying microbial nucleic acids by chemical modification of cytosines |
ES2436760T3 (en) * | 2005-05-25 | 2014-01-07 | Tina Holding Aps | Stable and selective formation of triple helices and double Hoogsteen type propellers using torsion intercalating nucleic acids (TINA) and procedure for the preparation of TINA |
JP2008541705A (en) | 2005-05-26 | 2008-11-27 | ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド | Isothermal strand displacement amplification using primers containing non-standard bases |
ATE531820T1 (en) | 2005-09-14 | 2011-11-15 | Human Genetic Signatures Pty | HEALTH CONDITION TEST |
WO2007104318A2 (en) * | 2006-03-16 | 2007-09-20 | Pentabase Aps | Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids |
EP1845166A1 (en) * | 2006-04-13 | 2007-10-17 | BioSpring GmbH | Nucleic acid probes with covalently bound intercalating fluorescent dyes for hybridization with target nucleic acids |
WO2009027978A1 (en) | 2007-08-30 | 2009-03-05 | Hadasit Medical Research Services & Development Ltd. | NUCLEIC ACID SEQUENCES COMPRISING NF-ϰB BINDING SITE WITHIN O(6)-METHYLGUANINE-DNA-METHYLTRANSFERASE (MGMT) PROMOTER REGION AND USES THEREOF FOR THE TREATMENT OF CANCER AND IMMUNE-RELATED DISORDERS |
EP2215250B1 (en) | 2007-11-27 | 2013-02-27 | Human Genetic Signatures Pty Ltd | Enzymes for amplification and copying bisulphite modified nucleic acids |
EP2229457A4 (en) | 2007-12-14 | 2011-01-26 | Minitube America Inc | Gender-specific separation of sperm cells and embryos |
WO2011032034A2 (en) | 2009-09-10 | 2011-03-17 | University Of Idaho | Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids |
CN102933720B (en) * | 2010-05-07 | 2015-03-18 | 昆特拜克股份公司 | Method for generating a double stranded nucleic acid with a single stranded overhang |
RU2014106024A (en) | 2011-07-19 | 2015-08-27 | Юниверсити Оф Айдахо | OPTIONS FOR IMPLEMENTING THE PROBE AND METHODS OF DIRECTED ACTION FOR NUCLEIC ACIDS |
NZ622418A (en) | 2011-09-07 | 2014-12-24 | Human Genetic Signatures Pty | Molecular detection assay |
DK3350347T3 (en) | 2015-09-14 | 2021-04-19 | Pentabase Aps | Methods and materials for detection of mutations |
WO2018013999A1 (en) | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
AU2019282789A1 (en) * | 2018-06-08 | 2020-12-17 | Carnegie Mellon University | Modified nucleobases with uniform H-bonding interactions, homo- and hetero-basepair bias, and mismatch discrimination |
CN112601825B (en) * | 2018-07-09 | 2023-11-28 | 青岛华大智造科技有限责任公司 | Nucleic acid sequencing method |
CN114286865A (en) | 2019-05-13 | 2022-04-05 | 潘塔贝斯公司 | Melting temperature methods, kits and reporter oligonucleotides for detecting variant nucleic acids |
CN111073884A (en) * | 2020-02-14 | 2020-04-28 | 昆明理工大学 | Method for improving accuracy of SNP locus detection with functional effect in SNP with distance of non-coding region less than 50bp |
WO2022002958A1 (en) | 2020-06-29 | 2022-01-06 | Pentabase Aps | Detection of methylation status |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3293820B2 (en) * | 1985-12-13 | 2002-06-17 | エンゾ− バイオケム インコ−ポレイテツド | Novel one-step method and polynucleotide compound for hybridizing to target polynucleotide |
US6031091A (en) * | 1987-09-21 | 2000-02-29 | Gen-Probe Incorporated | Non-nucleotide linking reagents for nucleotide probes |
US5585481A (en) * | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
US5998135A (en) * | 1989-02-24 | 1999-12-07 | Enzo Diagnostics, Inc. | Energy transfer hybridization assay using intercalators and lanthanide metals |
AU7579991A (en) * | 1990-02-20 | 1991-09-18 | Gilead Sciences, Inc. | Pseudonucleosides and pseudonucleotides and their polymers |
US5332659A (en) * | 1992-04-09 | 1994-07-26 | The United States Of America As Represented By The Secretary Of The Navy | Light emission-or absorbance-based binding assays for polynucleic acids |
US5886177A (en) * | 1994-01-11 | 1999-03-23 | Isis Pharmaceuticals, Inc. | Phosphate linked oligomers |
GB9604669D0 (en) * | 1996-03-05 | 1996-05-01 | Ciba Geigy Ag | Chemical compounds |
CA2252048C (en) * | 1996-04-12 | 2008-03-11 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
ATE275573T1 (en) * | 1996-05-15 | 2004-09-15 | Univ Rochester | NEW NUCLEOSIDE ANALOGUES THAT HAVE POLYCYCLIC AROMATIC GROUPS AS SUBSTITUENTS, METHOD FOR THEIR PRODUCTION AND THEIR APPLICATIONS |
US6248518B1 (en) * | 1996-10-29 | 2001-06-19 | Board Of Regents Of University Of Nebraska | Method for detecting point mutations in DNA utilizing fluorescence energy transfer |
US6172209B1 (en) * | 1997-02-14 | 2001-01-09 | Isis Pharmaceuticals Inc. | Aminooxy-modified oligonucleotides and methods for making same |
US6117973A (en) * | 1997-02-24 | 2000-09-12 | Georgia Tech Research Corp. | PNA monomers with electron donor or acceptor |
US6506567B2 (en) * | 2000-01-31 | 2003-01-14 | Fuji Photo Film Co., Ltd. | Water-soluble flourescent intercalator compound |
US20030165837A1 (en) * | 2000-06-14 | 2003-09-04 | The Scripps Research Institute | Method for screening DNA binding |
-
2002
- 2002-12-18 WO PCT/DK2002/000875 patent/WO2003052133A2/en not_active Application Discontinuation
- 2002-12-18 CN CN028282140A patent/CN1653079B/en not_active Expired - Fee Related
- 2002-12-18 EP EP02792708A patent/EP1468007A2/en not_active Withdrawn
- 2002-12-18 AU AU2002358464A patent/AU2002358464B2/en not_active Ceased
- 2002-12-18 AU AU2002358463A patent/AU2002358463A1/en not_active Abandoned
- 2002-12-18 WO PCT/DK2002/000877 patent/WO2003052134A2/en not_active Application Discontinuation
- 2002-12-18 AU AU2002358462A patent/AU2002358462A1/en not_active Abandoned
- 2002-12-18 AU AU2002361946A patent/AU2002361946A1/en not_active Abandoned
- 2002-12-18 WO PCT/DK2002/000874 patent/WO2003052132A2/en not_active Application Discontinuation
- 2002-12-18 WO PCT/DK2002/000876 patent/WO2003051901A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1653079A (en) | 2005-08-10 |
WO2003052133A2 (en) | 2003-06-26 |
AU2002358464B2 (en) | 2006-04-27 |
AU2002358463A1 (en) | 2003-06-30 |
WO2003051901A3 (en) | 2003-11-27 |
AU2002358463A8 (en) | 2003-06-30 |
WO2003052132A2 (en) | 2003-06-26 |
AU2002361946A8 (en) | 2003-06-30 |
CN1653079B (en) | 2010-06-16 |
WO2003052134A2 (en) | 2003-06-26 |
AU2002361946A1 (en) | 2003-06-30 |
AU2002358464A1 (en) | 2003-06-30 |
AU2002358462A8 (en) | 2003-06-30 |
WO2003052134A3 (en) | 2004-03-25 |
WO2003052133A3 (en) | 2003-10-02 |
WO2003051901A2 (en) | 2003-06-26 |
WO2003052132A3 (en) | 2003-10-09 |
EP1468007A2 (en) | 2004-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |