ZA952382B - Naphthalamides as central nervous system agents - Google Patents

Naphthalamides as central nervous system agents

Info

Publication number
ZA952382B
ZA952382B ZA952382A ZA952382A ZA952382B ZA 952382 B ZA952382 B ZA 952382B ZA 952382 A ZA952382 A ZA 952382A ZA 952382 A ZA952382 A ZA 952382A ZA 952382 B ZA952382 B ZA 952382B
Authority
ZA
South Africa
Prior art keywords
naphthalamides
nervous system
central nervous
agents
system agents
Prior art date
Application number
ZA952382A
Other languages
English (en)
Inventor
Shelly Ann Glase
Suzanne Ross Kesten
Lawrence David Wise
Jonathan Wright
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ZA952382B publication Critical patent/ZA952382B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Liquid Carbonaceous Fuels (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
ZA952382A 1994-03-24 1995-03-23 Naphthalamides as central nervous system agents ZA952382B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/217,395 US5395835A (en) 1994-03-24 1994-03-24 Naphthalamides as central nervous system agents

Publications (1)

Publication Number Publication Date
ZA952382B true ZA952382B (en) 1996-01-10

Family

ID=22810896

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA952382A ZA952382B (en) 1994-03-24 1995-03-23 Naphthalamides as central nervous system agents

Country Status (23)

Country Link
US (1) US5395835A (fr)
EP (1) EP0751939B9 (fr)
JP (1) JP3771581B2 (fr)
KR (1) KR100366175B1 (fr)
AT (1) ATE219068T1 (fr)
AU (1) AU683358B2 (fr)
BG (1) BG62887B1 (fr)
CZ (1) CZ284377B6 (fr)
DE (1) DE69527053T2 (fr)
DK (1) DK0751939T5 (fr)
ES (1) ES2178668T4 (fr)
FI (1) FI113370B (fr)
HU (1) HUT76058A (fr)
MX (1) MX9602517A (fr)
NO (1) NO306779B1 (fr)
NZ (1) NZ281824A (fr)
PH (1) PH31335A (fr)
PL (1) PL181270B1 (fr)
PT (1) PT751939E (fr)
RO (1) RO117452B1 (fr)
RU (1) RU2157370C2 (fr)
WO (1) WO1995025727A1 (fr)
ZA (1) ZA952382B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
PT732332E (pt) * 1995-03-17 2002-06-28 Aventis Pharma Inc Benzotienilpiperazinas substituidas sua utilizacao como medicamentos e processos para a sua preparacao
FR2738569B1 (fr) * 1995-09-12 1997-11-28 Pf Medicament Nouveaux derives naphtamide de 3 beta-amino azabicyclo octane ou nonane, leur procede de preparation, leur utilisation a titre de medicament antipsychotique
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
FR2742149B1 (fr) * 1995-12-11 1998-02-13 Inst Nat Sante Rech Med Nouveaux derives de 2-naphtamides et leurs applications therapeutiques
US5710274A (en) * 1996-02-28 1998-01-20 Neurogen Corporation N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands
US5703235A (en) * 1996-03-21 1997-12-30 Neurogen Corporation N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands
US5763609A (en) 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5703083A (en) * 1996-04-15 1997-12-30 Neurogen Corporation N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
US5703237A (en) * 1996-04-18 1997-12-30 Neurogen Corporation N-Aminoalkyl-2-anthraquinonecarboxamides; new dopamine receptor subtype specific ligands
US5688950A (en) * 1996-04-23 1997-11-18 Neurogen Corporation Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands
US5892041A (en) * 1996-08-12 1999-04-06 Neurogen Corporation Fused indolecarboxamides: dopamine receptor subtype specific ligands
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6291425B1 (en) * 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
AU9297998A (en) * 1998-05-15 1999-12-06 Guilford Pharmaceuticals Inc. Carboxamide compounds, compositions, and methods for inhibiting parp activity
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
ATE402704T1 (de) * 2000-03-27 2008-08-15 Abbott Gmbh & Co Kg Dopamin-d3-rezeptor-liganden zur behandlung von sucht
WO2001090077A1 (fr) 2000-05-19 2001-11-29 Guilford Pharmaceuticals, Inc. Derives de sulfonamide et de carbamide de 6(5h) phenanthridinones et utilisations de ceux-ci
WO2001091796A2 (fr) 2000-06-01 2001-12-06 Guilford Pharmaceuticals Inc. Methodes, composes et compositions permettant de traiter la goutte
US6545011B2 (en) 2000-07-13 2003-04-08 Guilford Pharmaceuticals Inc. Substituted 4,9-dihydrocyclopenta[imn]phenanthridine-5-ones, derivatives thereof and their uses
JP4497814B2 (ja) * 2001-02-16 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド 新規複素環式尿素誘導体およびドーパミンｄ３受容体リガンドとしてのそれらの使用
EP1361875A2 (fr) * 2001-02-16 2003-11-19 Aventis Pharmaceuticals Inc. Nouveaux derives heterocycliques d'amides et leur utilisation comme ligands du recepteur de la dopamine d3
BR0306625A (pt) * 2002-05-23 2006-04-18 Abbott Lab acetamidas e benzamidas que são úteis no tratamento de disfunção sexual
EP1870405A1 (fr) * 2006-06-22 2007-12-26 Bioprojet (Aza)cyclohexanes carbonylées comme ligands du récepteur D3 de la dopamine
KR20230001660U (ko) 2022-02-08 2023-08-16 주식회사 승진피엘에스 옷걸이용 지주 고정장치

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1543944A (fr) * 1967-03-10 1968-10-31 Bruneau & Cie Lab Dérivés amidés de l'acide salicylique et leur préparation
US3846430A (en) * 1968-01-12 1974-11-05 Bruneau & Cie Lab 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
US4975439A (en) * 1987-09-25 1990-12-04 Janssen Pharmaceutical N.V. Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
IL90279A (en) * 1988-05-24 1995-03-30 American Home Prod History of piperazinyl carboxamide, their preparation and the pharmaceutical preparations containing them
US5010078A (en) * 1988-05-24 1991-04-23 American Home Products Corporation Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity
JP2671059B2 (ja) * 1990-11-30 1997-10-29 富士レビオ株式会社 ナフトエ酸誘導体
FR2682953B1 (fr) * 1991-10-23 1995-04-21 Inst Nat Sante Rech Med Nouveaux derives de naphtamides, leur procede de preparation et leur application dans le domaine therapeutique.
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
FR2693722B1 (fr) * 1992-07-16 1994-10-14 Meram Lab Dérivés de la N-cycloalkylpipérazine, procédé d'obtention et compositions pharmaceutiques les contenant.
GB9218113D0 (en) * 1992-08-26 1992-10-14 Lilly Industries Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
RO117452B1 (ro) 2002-03-29
EP0751939A1 (fr) 1997-01-08
ATE219068T1 (de) 2002-06-15
KR100366175B1 (ko) 2003-04-08
DE69527053D1 (de) 2002-07-18
BG62887B1 (bg) 2000-10-31
NO963996D0 (no) 1996-09-23
NO963996L (no) 1996-09-23
AU1877495A (en) 1995-10-09
RU2157370C2 (ru) 2000-10-10
NZ281824A (en) 1997-10-24
NO306779B1 (no) 1999-12-20
PL181270B1 (pl) 2001-07-31
ES2178668T3 (es) 2003-01-01
PT751939E (pt) 2002-11-29
FI963294A0 (fi) 1996-08-23
HU9602605D0 (en) 1996-11-28
ES2178668T4 (es) 2003-06-16
HUT76058A (en) 1997-06-30
WO1995025727A1 (fr) 1995-09-28
CZ276896A3 (en) 1997-04-16
DK0751939T5 (da) 2004-11-08
BG100830A (en) 1997-10-31
JPH09511503A (ja) 1997-11-18
US5395835A (en) 1995-03-07
CZ284377B6 (cs) 1998-11-11
EP0751939B9 (fr) 2003-01-02
PL316313A1 (en) 1997-01-06
PH31335A (en) 1998-07-06
FI963294A (fi) 1996-08-23
DE69527053T2 (de) 2003-01-02
DK0751939T3 (da) 2002-10-07
AU683358B2 (en) 1997-11-06
FI113370B (fi) 2004-04-15
EP0751939B1 (fr) 2002-06-12
JP3771581B2 (ja) 2006-04-26
MX9602517A (es) 1997-05-31

Similar Documents

Publication Publication Date Title
HU9602605D0 (en) Naphthylamides as central nervous system agents
SI0725779T1 (fr)
MY107728A (en) Substituted cyclohexanols as central nervous system agents.
HUP9701096A3 (en) Use of benzenesulfonamides for the preparation of pharmaceutical compositions treating disorders of the central nervous system, novel derivatives, process for their preparation and pharmaceutical compositions containing them
BR0309875A (pt) métodos e composições para tratamento de distúrbios do sistema nervoso periférico e novos compostos úteis para isto
YU38801A (sh) Azabicikloalkani kao modulatori ccr5
BR9917038A (pt) Composto, composição farmacêutica, método de modulação da atividade receptora de quimocinas, método de tratamento ou prevenção de doenças inflamatórias, método de tratamento ou prevenção de asma e método de tratamento ou prevenção de disfunções inflamatórias
SI0751129T1 (en) Substituted dihydrodibenzo(b,f)azepines, method for their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them
NZ313606A (en) Benzo[g]quinoline derivatives and pharmaceutical compositions thereof for treating depression, anxiety and bipolar disorders
GR3019782T3 (en) Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
WO1992007832A3 (fr) Piperazines substituees utilisees comme agents de traitement du systeme nerveux central
CA2284551A1 (fr) Nouvelles combinaisons therapeutiques de la mirtazapine et d'agents antipsychotiques pour le traitement ou la prophylaxie de psychoses
HUP0103832A3 (en) Triazolopyridines for the treatment of thrombosis disorders, pharmaceutical compositions containing the same and process for preparation thereof
AU6770190A (en) Substituted cyclohexenes as central nervous system agents
PL310950A1 (en) Novel imidazole quinoxalinones, method of obtaining them and their application
CA2180155A1 (fr) Naphtylamides comme agents actifs sur le systeme nerveux central
TW374085B (en) Novel piperidine derivatives, their preparation, pharmaceutical formulation and medical use
EA200200656A1 (ru) НОВЫЕ ТЕРАПЕВТИЧЕСКИЕ КОМБИНАЦИИ (S)-2-(БЕНЗИЛАМИНОМЕТИЛ)-2,3,8,9-ТЕТРАГИДРО-7H-1,4-ДИОКСИН [2,3-е]ИНДОЛ-8-ОНА И НЕЙРОЛЕПТИКОВ ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРЕДОТВРАЩЕНИЯ ПСИХОТИЧЕСКИХ РАССТРОЙСТВ
PT950053E (pt) Novos derivados de benzoilalquil-1,2,3,6-tetra-hidropiridinas
TR200000916T2 (tr) İkameli piperidin türevleri.