ZA952289B - Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives - Google Patents
Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivativesInfo
- Publication number
- ZA952289B ZA952289B ZA952289A ZA952289A ZA952289B ZA 952289 B ZA952289 B ZA 952289B ZA 952289 A ZA952289 A ZA 952289A ZA 952289 A ZA952289 A ZA 952289A ZA 952289 B ZA952289 B ZA 952289B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- hypotriglyceridemic
- antiatherosclerotic
- hypocholesterolemic
- disulfide derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21747194A | 1994-03-24 | 1994-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA952289B true ZA952289B (en) | 1996-01-09 |
Family
ID=22811224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA952289A ZA952289B (en) | 1994-03-24 | 1995-03-20 | Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives |
Country Status (18)
Country | Link |
---|---|
US (1) | US6013645A (no) |
EP (1) | EP0751774B1 (no) |
JP (1) | JPH10503468A (no) |
CN (1) | CN1144482A (no) |
AT (1) | ATE246927T1 (no) |
AU (1) | AU688012B2 (no) |
CA (1) | CA2184692C (no) |
DE (1) | DE69531489T2 (no) |
DK (1) | DK0751774T3 (no) |
ES (1) | ES2201100T3 (no) |
FI (1) | FI963784A0 (no) |
HU (1) | HUP9774624A2 (no) |
IL (1) | IL113073A (no) |
NO (1) | NO963988L (no) |
NZ (1) | NZ282565A (no) |
PT (1) | PT751774E (no) |
WO (1) | WO1995025519A1 (no) |
ZA (1) | ZA952289B (no) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
GB0119305D0 (en) * | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
GB1525845A (en) * | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
EP0042100A1 (de) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
ZA833214B (en) * | 1982-05-12 | 1983-12-28 | Hoffmann La Roche | Bicyclic compounds |
US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
HUT40660A (en) * | 1985-04-30 | 1987-01-28 | Lilly Co Eli | Process for production of derivatives of 7-substituated bicyclic pirasilididone |
ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
ZA874107B (no) * | 1986-06-13 | 1987-12-09 | ||
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
AU7168091A (en) * | 1989-12-22 | 1991-07-24 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
EP0459432B1 (en) * | 1990-06-01 | 2000-08-23 | Korth, Ruth, Dr. med. | Treatment of diseases with paf-antagonists and procedure for determining their efficacy |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
CA2057786C (en) * | 1990-12-21 | 2002-06-18 | Gary A. Flynn | Amino and nitro containing tricyclic compounds useful as inhibitors or ace |
FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
SG48855A1 (en) * | 1992-04-20 | 1998-05-18 | Takeda Chemical Industries Ltd | 4,1-benzoxazepin derivatives and their use |
RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
-
1995
- 1995-02-28 NZ NZ282565A patent/NZ282565A/xx unknown
- 1995-02-28 CA CA002184692A patent/CA2184692C/en not_active Expired - Fee Related
- 1995-02-28 EP EP95912630A patent/EP0751774B1/en not_active Expired - Lifetime
- 1995-02-28 DE DE69531489T patent/DE69531489T2/de not_active Expired - Fee Related
- 1995-02-28 US US08/913,006 patent/US6013645A/en not_active Expired - Fee Related
- 1995-02-28 ES ES95912630T patent/ES2201100T3/es not_active Expired - Lifetime
- 1995-02-28 AT AT95912630T patent/ATE246927T1/de not_active IP Right Cessation
- 1995-02-28 PT PT95912630T patent/PT751774E/pt unknown
- 1995-02-28 AU AU19720/95A patent/AU688012B2/en not_active Ceased
- 1995-02-28 WO PCT/US1995/002448 patent/WO1995025519A1/en active IP Right Grant
- 1995-02-28 CN CN95192241A patent/CN1144482A/zh active Pending
- 1995-02-28 JP JP7524645A patent/JPH10503468A/ja not_active Ceased
- 1995-02-28 DK DK95912630T patent/DK0751774T3/da active
- 1995-02-28 HU HU9602602A patent/HUP9774624A2/hu unknown
- 1995-03-20 ZA ZA952289A patent/ZA952289B/xx unknown
- 1995-03-22 IL IL11307395A patent/IL113073A/en not_active IP Right Cessation
-
1996
- 1996-09-23 NO NO963988A patent/NO963988L/no not_active Application Discontinuation
- 1996-09-23 FI FI963784A patent/FI963784A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
DK0751774T3 (da) | 2003-12-08 |
EP0751774A1 (en) | 1997-01-08 |
PT751774E (pt) | 2003-11-28 |
DE69531489T2 (de) | 2004-04-08 |
IL113073A (en) | 2001-03-19 |
FI963784A (fi) | 1996-09-23 |
CA2184692C (en) | 2001-01-02 |
WO1995025519A1 (en) | 1995-09-28 |
HUP9774624A2 (en) | 1997-01-28 |
DE69531489D1 (de) | 2003-09-18 |
AU688012B2 (en) | 1998-03-05 |
US6013645A (en) | 2000-01-11 |
NO963988L (no) | 1996-11-22 |
NZ282565A (en) | 1999-11-29 |
IL113073A0 (en) | 1995-06-29 |
ATE246927T1 (de) | 2003-08-15 |
EP0751774B1 (en) | 2003-08-13 |
HU9602602D0 (en) | 1996-11-28 |
FI963784A0 (fi) | 1996-09-23 |
NO963988D0 (no) | 1996-09-23 |
CA2184692A1 (en) | 1995-09-28 |
CN1144482A (zh) | 1997-03-05 |
JPH10503468A (ja) | 1998-03-31 |
ES2201100T3 (es) | 2004-03-16 |
AU1972095A (en) | 1995-10-09 |
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