ZA952289B - Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives - Google Patents

Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives

Info

Publication number
ZA952289B
ZA952289B ZA952289A ZA952289A ZA952289B ZA 952289 B ZA952289 B ZA 952289B ZA 952289 A ZA952289 A ZA 952289A ZA 952289 A ZA952289 A ZA 952289A ZA 952289 B ZA952289 B ZA 952289B
Authority
ZA
South Africa
Prior art keywords
pct
hypotriglyceridemic
antiatherosclerotic
hypocholesterolemic
disulfide derivatives
Prior art date
Application number
ZA952289A
Other languages
English (en)
Inventor
Gary A Flynn
John F French
Richard C Dage
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA952289B publication Critical patent/ZA952289B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
ZA952289A 1994-03-24 1995-03-20 Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives ZA952289B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21747194A 1994-03-24 1994-03-24

Publications (1)

Publication Number Publication Date
ZA952289B true ZA952289B (en) 1996-01-09

Family

ID=22811224

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA952289A ZA952289B (en) 1994-03-24 1995-03-20 Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives

Country Status (18)

Country Link
US (1) US6013645A (xx)
EP (1) EP0751774B1 (xx)
JP (1) JPH10503468A (xx)
CN (1) CN1144482A (xx)
AT (1) ATE246927T1 (xx)
AU (1) AU688012B2 (xx)
CA (1) CA2184692C (xx)
DE (1) DE69531489T2 (xx)
DK (1) DK0751774T3 (xx)
ES (1) ES2201100T3 (xx)
FI (1) FI963784A0 (xx)
HU (1) HUP9774624A2 (xx)
IL (1) IL113073A (xx)
NO (1) NO963988L (xx)
NZ (1) NZ282565A (xx)
PT (1) PT751774E (xx)
WO (1) WO1995025519A1 (xx)
ZA (1) ZA952289B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
GB0119305D0 (en) * 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
HUT40660A (en) * 1985-04-30 1987-01-28 Lilly Co Eli Process for production of derivatives of 7-substituated bicyclic pirasilididone
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
ZA874107B (xx) * 1986-06-13 1987-12-09
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
EP0459432B1 (en) * 1990-06-01 2000-08-23 Korth, Ruth, Dr. med. Treatment of diseases with paf-antagonists and procedure for determining their efficacy
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
CA2057786C (en) * 1990-12-21 2002-06-18 Gary A. Flynn Amino and nitro containing tricyclic compounds useful as inhibitors or ace
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
SG48855A1 (en) * 1992-04-20 1998-05-18 Takeda Chemical Industries Ltd 4,1-benzoxazepin derivatives and their use
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Also Published As

Publication number Publication date
DK0751774T3 (da) 2003-12-08
EP0751774A1 (en) 1997-01-08
PT751774E (pt) 2003-11-28
DE69531489T2 (de) 2004-04-08
IL113073A (en) 2001-03-19
FI963784A (fi) 1996-09-23
CA2184692C (en) 2001-01-02
WO1995025519A1 (en) 1995-09-28
HUP9774624A2 (en) 1997-01-28
DE69531489D1 (de) 2003-09-18
AU688012B2 (en) 1998-03-05
US6013645A (en) 2000-01-11
NO963988L (no) 1996-11-22
NZ282565A (en) 1999-11-29
IL113073A0 (en) 1995-06-29
ATE246927T1 (de) 2003-08-15
EP0751774B1 (en) 2003-08-13
HU9602602D0 (en) 1996-11-28
FI963784A0 (fi) 1996-09-23
NO963988D0 (no) 1996-09-23
CA2184692A1 (en) 1995-09-28
CN1144482A (zh) 1997-03-05
JPH10503468A (ja) 1998-03-31
ES2201100T3 (es) 2004-03-16
AU1972095A (en) 1995-10-09

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