ZA949785B - Combination preparations comprising a quinoxaline and a nucleoside - Google Patents

Combination preparations comprising a quinoxaline and a nucleoside

Info

Publication number
ZA949785B
ZA949785B ZA949785A ZA949785A ZA949785B ZA 949785 B ZA949785 B ZA 949785B ZA 949785 A ZA949785 A ZA 949785A ZA 949785 A ZA949785 A ZA 949785A ZA 949785 B ZA949785 B ZA 949785B
Authority
ZA
South Africa
Prior art keywords
nucleoside
quinoxaline
combination preparations
formulae
substituents
Prior art date
Application number
ZA949785A
Inventor
Christoph Meichsner
Guenther Riess
Joerg-Peter Kleim
Manfred Roesner
Arno Paessens
Martin Blunck
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA949785B publication Critical patent/ZA949785B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

A combination product containing at least one nucleoside and a compound of the formulae I and/or Ia, <IMAGE> or the physiologically tolerated salts thereof, where the symbols X and n, and the substituents R<1>-R<5>, have the stated meanings, display antiviral activity.
ZA949785A 1993-12-09 1994-12-08 Combination preparations comprising a quinoxaline and a nucleoside ZA949785B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4342024A DE4342024A1 (en) 1993-12-09 1993-12-09 Combination preparations containing a quinoxaline and a nucleoside

Publications (1)

Publication Number Publication Date
ZA949785B true ZA949785B (en) 1995-07-12

Family

ID=6504591

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA949785A ZA949785B (en) 1993-12-09 1994-12-08 Combination preparations comprising a quinoxaline and a nucleoside

Country Status (12)

Country Link
EP (1) EP0657166B1 (en)
JP (1) JPH07196511A (en)
KR (1) KR950016754A (en)
CN (1) CN1108935A (en)
AT (1) ATE236642T1 (en)
AU (1) AU697486B2 (en)
CA (1) CA2137605A1 (en)
DE (2) DE4342024A1 (en)
HU (1) HU221498B (en)
IL (1) IL111909A0 (en)
NZ (1) NZ270088A (en)
ZA (1) ZA949785B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437406A1 (en) * 1994-10-19 1996-04-25 Hoechst Ag Quinoxalines, process for their preparation and their use
DE19703131A1 (en) * 1997-01-29 1998-07-30 Bayer Ag Use of quinoxaline in a combination of three with protease inhibitors and reverse transcriptase inhibitors as medicaments for the treatment of AIDS and / or HIV infections
DE19727117A1 (en) * 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkyl derivatives, pharmaceutical compositions containing them and processes for their preparation
AU9318298A (en) * 1997-11-14 1999-06-07 Warner-Lambert Company Small molecule intervention in hiv-1 replication
AU4719699A (en) * 1998-06-26 2000-01-17 Du Pont Pharmaceuticals Company Substituted quinoxalin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
GB9821000D0 (en) * 1998-09-28 1998-11-18 Glaxo Group Ltd Antiviral combinations
GB9911887D0 (en) * 1999-05-21 1999-07-21 Glaxo Group Ltd Methods and medicaments for post exposure prophylaxis of an hiv infection
WO2005018531A2 (en) * 2003-08-26 2005-03-03 'chemical Diversity Research Institute', Ltd. Pharmaceutical compositions, azo-heterocyclic compounds and method for the production and use thereof
JP2007507514A (en) * 2003-09-30 2007-03-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Quinoxaline compounds
US7351709B2 (en) 2004-06-09 2008-04-01 Wyeth Estrogen receptor ligands
CN105611930B (en) * 2013-07-15 2021-03-02 亥姆霍兹慕尼黑中心-德国环境与健康研究中心（股份有限公司） Spiro quinoxaline derivatives as non-apoptotic regulated cell death inhibitors
EP3217982A1 (en) 2014-11-10 2017-09-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death
DE102017005091A1 (en) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituted 3,4-dihydropyrido [2,3-b] pyrazine-2 (1H) -one
DE102017005089A1 (en) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituted 3,4-dihydroquinoxaline-2 (1H) -one

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164639T3 (en) * 1991-04-15 2002-03-01 Aventis Pharma Gmbh QUINOXALINAS, PROCEDURE FOR PREPARATION AND EMPLOYMENT.

Also Published As

Publication number Publication date
IL111909A0 (en) 1995-03-15
NZ270088A (en) 1998-04-27
KR950016754A (en) 1995-07-20
AU8042194A (en) 1995-06-15
DE4342024A1 (en) 1995-06-14
AU697486B2 (en) 1998-10-08
DE59410271D1 (en) 2003-05-15
HU221498B (en) 2002-10-28
CA2137605A1 (en) 1995-06-10
HU9403518D0 (en) 1995-02-28
EP0657166A1 (en) 1995-06-14
JPH07196511A (en) 1995-08-01
HUT70037A (en) 1995-09-28
EP0657166B1 (en) 2003-04-09
ATE236642T1 (en) 2003-04-15
CN1108935A (en) 1995-09-27

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