AU697486B2 - Combination preparations comprising a quinoxaline and a nucleoside - Google Patents

Combination preparations comprising a quinoxaline and a nucleoside

Info

Publication number
AU697486B2
AU697486B2 AU80421/94A AU8042194A AU697486B2 AU 697486 B2 AU697486 B2 AU 697486B2 AU 80421/94 A AU80421/94 A AU 80421/94A AU 8042194 A AU8042194 A AU 8042194A AU 697486 B2 AU697486 B2 AU 697486B2
Authority
AU
Australia
Prior art keywords
nucleoside
quinoxaline
combination preparations
formulae
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU80421/94A
Other versions
AU8042194A (en
Inventor
Martin Blunck
Jorg-Peter Kleim
Christoph Meichsner
Arno Paessens
Gunther Riess
Manfred Rosner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU8042194A publication Critical patent/AU8042194A/en
Application granted granted Critical
Publication of AU697486B2 publication Critical patent/AU697486B2/en
Assigned to AVENTIS PHARMA DEUTSCHLAND GMBH reassignment AVENTIS PHARMA DEUTSCHLAND GMBH Alteration of Name(s) in Register under S187 Assignors: HOECHST AKTIENGESELLSCHAFT
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A combination product containing at least one nucleoside and a compound of the formulae I and/or Ia, <IMAGE> or the physiologically tolerated salts thereof, where the symbols X and n, and the substituents R<1>-R<5>, have the stated meanings, display antiviral activity.
AU80421/94A 1993-12-09 1994-12-08 Combination preparations comprising a quinoxaline and a nucleoside Ceased AU697486B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4342024 1993-12-09
DE4342024A DE4342024A1 (en) 1993-12-09 1993-12-09 Combination preparations containing a quinoxaline and a nucleoside

Publications (2)

Publication Number Publication Date
AU8042194A AU8042194A (en) 1995-06-15
AU697486B2 true AU697486B2 (en) 1998-10-08

Family

ID=6504591

Family Applications (1)

Application Number Title Priority Date Filing Date
AU80421/94A Ceased AU697486B2 (en) 1993-12-09 1994-12-08 Combination preparations comprising a quinoxaline and a nucleoside

Country Status (12)

Country Link
EP (1) EP0657166B1 (en)
JP (1) JPH07196511A (en)
KR (1) KR950016754A (en)
CN (1) CN1108935A (en)
AT (1) ATE236642T1 (en)
AU (1) AU697486B2 (en)
CA (1) CA2137605A1 (en)
DE (2) DE4342024A1 (en)
HU (1) HU221498B (en)
IL (1) IL111909A0 (en)
NZ (1) NZ270088A (en)
ZA (1) ZA949785B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437406A1 (en) * 1994-10-19 1996-04-25 Hoechst Ag Quinoxalines, process for their preparation and their use
DE19703131A1 (en) * 1997-01-29 1998-07-30 Bayer Ag Use of quinoxaline in a combination of three with protease inhibitors and reverse transcriptase inhibitors as medicaments for the treatment of AIDS and / or HIV infections
DE19727117A1 (en) * 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkyl derivatives, pharmaceutical compositions containing them and processes for their preparation
WO1999025327A2 (en) * 1997-11-14 1999-05-27 Warner-Lambert Company Small molecule intervention in hiv-1 replication
WO2000000478A1 (en) * 1998-06-26 2000-01-06 Bristol-Myers Squibb Pharma Company Substituted quinoxalin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
GB9821000D0 (en) * 1998-09-28 1998-11-18 Glaxo Group Ltd Antiviral combinations
GB9911887D0 (en) * 1999-05-21 1999-07-21 Glaxo Group Ltd Methods and medicaments for post exposure prophylaxis of an hiv infection
WO2005018531A2 (en) * 2003-08-26 2005-03-03 'chemical Diversity Research Institute', Ltd. Pharmaceutical compositions, azo-heterocyclic compounds and method for the production and use thereof
MXPA06003578A (en) * 2003-09-30 2006-08-31 Johnson & Johnson Quinoxaline compounds.
US7351709B2 (en) 2004-06-09 2008-04-01 Wyeth Estrogen receptor ligands
WO2015007730A1 (en) 2013-07-15 2015-01-22 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Spiroquinoxaline derivatives as inhibitors of non-apoptotic regulated cell-death
EP3217982A1 (en) 2014-11-10 2017-09-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death
DE102017005089A1 (en) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituted 3,4-dihydroquinoxaline-2 (1H) -one
DE102017005091A1 (en) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituted 3,4-dihydropyrido [2,3-b] pyrazine-2 (1H) -one

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59209965D1 (en) * 1991-04-15 2002-10-17 Aventis Pharma Gmbh Quinoxalines, process for their preparation and their use

Also Published As

Publication number Publication date
HU221498B (en) 2002-10-28
DE59410271D1 (en) 2003-05-15
IL111909A0 (en) 1995-03-15
HUT70037A (en) 1995-09-28
EP0657166B1 (en) 2003-04-09
ATE236642T1 (en) 2003-04-15
DE4342024A1 (en) 1995-06-14
JPH07196511A (en) 1995-08-01
HU9403518D0 (en) 1995-02-28
KR950016754A (en) 1995-07-20
CN1108935A (en) 1995-09-27
AU8042194A (en) 1995-06-15
EP0657166A1 (en) 1995-06-14
NZ270088A (en) 1998-04-27
ZA949785B (en) 1995-07-12
CA2137605A1 (en) 1995-06-10

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH

Free format text: FORMER OWNER WAS: HOECHST AKTIENGESELLSCHAFT

MK14 Patent ceased section 143(a) (annual fees not paid) or expired