AU8042194A - Combination preparations comprising a quinoxaline and a nucleoside - Google Patents

Combination preparations comprising a quinoxaline and a nucleoside

Info

Publication number
AU8042194A
AU8042194A AU80421/94A AU8042194A AU8042194A AU 8042194 A AU8042194 A AU 8042194A AU 80421/94 A AU80421/94 A AU 80421/94A AU 8042194 A AU8042194 A AU 8042194A AU 8042194 A AU8042194 A AU 8042194A
Authority
AU
Australia
Prior art keywords
nucleoside
quinoxaline
combination preparations
formulae
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU80421/94A
Other versions
AU697486B2 (en
Inventor
Martin Blunck
Jorg-Peter Kleim
Christoph Meichsner
Arno Paessens
Gunther Riess
Manfred Rosner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of AU8042194A publication Critical patent/AU8042194A/en
Application granted granted Critical
Publication of AU697486B2 publication Critical patent/AU697486B2/en
Assigned to AVENTIS PHARMA DEUTSCHLAND GMBH reassignment AVENTIS PHARMA DEUTSCHLAND GMBH Alteration of Name(s) in Register under S187 Assignors: HOECHST AKTIENGESELLSCHAFT
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A combination product containing at least one nucleoside and a compound of the formulae I and/or Ia, <IMAGE> or the physiologically tolerated salts thereof, where the symbols X and n, and the substituents R<1>-R<5>, have the stated meanings, display antiviral activity.
AU80421/94A 1993-12-09 1994-12-08 Combination preparations comprising a quinoxaline and a nucleoside Ceased AU697486B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4342024A DE4342024A1 (en) 1993-12-09 1993-12-09 Combination preparations containing a quinoxaline and a nucleoside
DE4342024 1993-12-09

Publications (2)

Publication Number Publication Date
AU8042194A true AU8042194A (en) 1995-06-15
AU697486B2 AU697486B2 (en) 1998-10-08

Family

ID=6504591

Family Applications (1)

Application Number Title Priority Date Filing Date
AU80421/94A Ceased AU697486B2 (en) 1993-12-09 1994-12-08 Combination preparations comprising a quinoxaline and a nucleoside

Country Status (12)

Country Link
EP (1) EP0657166B1 (en)
JP (1) JPH07196511A (en)
KR (1) KR950016754A (en)
CN (1) CN1108935A (en)
AT (1) ATE236642T1 (en)
AU (1) AU697486B2 (en)
CA (1) CA2137605A1 (en)
DE (2) DE4342024A1 (en)
HU (1) HU221498B (en)
IL (1) IL111909A0 (en)
NZ (1) NZ270088A (en)
ZA (1) ZA949785B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437406A1 (en) * 1994-10-19 1996-04-25 Hoechst Ag Quinoxalines, process for their preparation and their use
DE19703131A1 (en) * 1997-01-29 1998-07-30 Bayer Ag Use of quinoxaline in a combination of three with protease inhibitors and reverse transcriptase inhibitors as medicaments for the treatment of AIDS and / or HIV infections
DE19727117A1 (en) * 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkyl derivatives, pharmaceutical compositions containing them and processes for their preparation
AU9318298A (en) * 1997-11-14 1999-06-07 Warner-Lambert Company Small molecule intervention in hiv-1 replication
AU4719699A (en) * 1998-06-26 2000-01-17 Du Pont Pharmaceuticals Company Substituted quinoxalin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
GB9821000D0 (en) * 1998-09-28 1998-11-18 Glaxo Group Ltd Antiviral combinations
GB9911887D0 (en) * 1999-05-21 1999-07-21 Glaxo Group Ltd Methods and medicaments for post exposure prophylaxis of an hiv infection
WO2005018531A2 (en) * 2003-08-26 2005-03-03 'chemical Diversity Research Institute', Ltd. Pharmaceutical compositions, azo-heterocyclic compounds and method for the production and use thereof
JP2007507514A (en) * 2003-09-30 2007-03-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Quinoxaline compounds
US7351709B2 (en) 2004-06-09 2008-04-01 Wyeth Estrogen receptor ligands
CN105611930B (en) * 2013-07-15 2021-03-02 亥姆霍兹慕尼黑中心-德国环境与健康研究中心（股份有限公司） Spiro quinoxaline derivatives as non-apoptotic regulated cell death inhibitors
EP3217982A1 (en) 2014-11-10 2017-09-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death
DE102017005091A1 (en) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituted 3,4-dihydropyrido [2,3-b] pyrazine-2 (1H) -one
DE102017005089A1 (en) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituted 3,4-dihydroquinoxaline-2 (1H) -one

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164639T3 (en) * 1991-04-15 2002-03-01 Aventis Pharma Gmbh QUINOXALINAS, PROCEDURE FOR PREPARATION AND EMPLOYMENT.

Also Published As

Publication number Publication date
IL111909A0 (en) 1995-03-15
ZA949785B (en) 1995-07-12
NZ270088A (en) 1998-04-27
KR950016754A (en) 1995-07-20
DE4342024A1 (en) 1995-06-14
AU697486B2 (en) 1998-10-08
DE59410271D1 (en) 2003-05-15
HU221498B (en) 2002-10-28
CA2137605A1 (en) 1995-06-10
HU9403518D0 (en) 1995-02-28
EP0657166A1 (en) 1995-06-14
JPH07196511A (en) 1995-08-01
HUT70037A (en) 1995-09-28
EP0657166B1 (en) 2003-04-09
ATE236642T1 (en) 2003-04-15
CN1108935A (en) 1995-09-27

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH

Free format text: FORMER OWNER WAS: HOECHST AKTIENGESELLSCHAFT

MK14 Patent ceased section 143(a) (annual fees not paid) or expired