ZA949752B - Naphtalene derivatives processes for their preparation and the pharmaceutical compositions which contain them - Google Patents
Naphtalene derivatives processes for their preparation and the pharmaceutical compositions which contain themInfo
- Publication number
- ZA949752B ZA949752B ZA949752A ZA949752A ZA949752B ZA 949752 B ZA949752 B ZA 949752B ZA 949752 A ZA949752 A ZA 949752A ZA 949752 A ZA949752 A ZA 949752A ZA 949752 B ZA949752 B ZA 949752B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- substd
- cycloalkyl
- alkoxy
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/61—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/46—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9314630A FR2713636B1 (fr) | 1993-12-07 | 1993-12-07 | Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA949752B true ZA949752B (en) | 1995-08-17 |
Family
ID=9453623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA949752A ZA949752B (en) | 1993-12-07 | 1994-12-07 | Naphtalene derivatives processes for their preparation and the pharmaceutical compositions which contain them |
Country Status (13)
Country | Link |
---|---|
US (2) | US5591775A (xx) |
EP (1) | EP0662471B1 (xx) |
JP (1) | JP2688179B2 (xx) |
AT (1) | ATE163919T1 (xx) |
AU (1) | AU677868B2 (xx) |
CA (1) | CA2137445C (xx) |
DE (1) | DE69408962T2 (xx) |
DK (1) | DK0662471T3 (xx) |
ES (1) | ES2116555T3 (xx) |
FR (1) | FR2713636B1 (xx) |
GR (1) | GR3026634T3 (xx) |
NZ (1) | NZ270082A (xx) |
ZA (1) | ZA949752B (xx) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849769A (en) | 1994-08-24 | 1998-12-15 | Medivir Ab | N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection |
ATE193700T1 (de) * | 1994-09-12 | 2000-06-15 | Takeda Chemical Industries Ltd | Benzozykloalkenverbindungen, deren herstellung und verwendung |
FR2734814B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2734815B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
US5708005A (en) * | 1995-06-27 | 1998-01-13 | Takeda Chemical Industries, Ltd. | Quinolines, their production and use |
EP0885210B2 (en) | 1996-03-08 | 2008-06-18 | Takeda Pharmaceutical Company Limited | Tricylic compounds having binding affinity for melatonin receptors, their production and use |
US6034239A (en) * | 1996-03-08 | 2000-03-07 | Takeda Chemical Industries, Ltd. | Tricyclic compounds, their production and use |
US6310085B1 (en) * | 1997-10-03 | 2001-10-30 | Clarencew Pty Ltd. | Method for the treatment of neurological or neuropsychiatric disorders |
US5958964A (en) * | 1997-02-18 | 1999-09-28 | South Alabama Medical Science Foundation | Use of melatonin to prevent cytotoxic effects of amyloid beta protein |
FR2771739B1 (fr) * | 1997-11-28 | 2001-04-20 | Adir | Nouveaux composes naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2778662B1 (fr) * | 1998-05-12 | 2000-06-16 | Adir | Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2791344B1 (fr) * | 1999-03-25 | 2002-02-15 | Adir | Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP1213290B1 (en) | 1999-08-20 | 2005-04-20 | Takeda Pharmaceutical Company Limited | Dihydrobenzofuran derivatives, process for the preparation thereof and agents |
US20080167363A1 (en) * | 2006-12-28 | 2008-07-10 | Braincells, Inc | Modulation of Neurogenesis By Melatoninergic Agents |
US7608737B2 (en) * | 2007-05-01 | 2009-10-27 | Concert Pharmaceuticasl Inc. | Naphthyl(ethyl)acetamides |
FR2918371B1 (fr) * | 2007-07-02 | 2009-08-28 | Servier Lab | Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
FR3014437B1 (fr) * | 2013-12-05 | 2016-12-23 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
CN104230742B (zh) * | 2014-08-14 | 2016-08-24 | 广东东阳光药业有限公司 | 萘衍生物及其在药物上的应用 |
CN104292126B (zh) * | 2014-08-14 | 2016-08-24 | 广东东阳光药业有限公司 | 萘衍生物及其在药物上的应用 |
AU2017260019A1 (en) | 2016-05-06 | 2018-11-22 | Sociétés des Produits Nestlé S.A. | Valerian composition and related methods |
WO2022022542A1 (zh) * | 2020-07-28 | 2022-02-03 | 上海翰森生物医药科技有限公司 | 双环类衍生物调节剂、其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001472A1 (en) * | 1987-08-17 | 1989-02-23 | Nelson Research & Development Co. | Melatonin analogues |
DE3828566A1 (de) * | 1988-08-23 | 1990-03-15 | Thomae Gmbh Dr K | Neue benzolsulfonamido-verbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2680507B1 (fr) * | 1991-08-23 | 1993-10-08 | Adir Cie | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2689124A1 (fr) * | 1992-03-27 | 1993-10-01 | Adir | Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
-
1993
- 1993-12-07 FR FR9314630A patent/FR2713636B1/fr not_active Expired - Fee Related
-
1994
- 1994-12-05 AU AU80215/94A patent/AU677868B2/en not_active Ceased
- 1994-12-06 CA CA002137445A patent/CA2137445C/fr not_active Expired - Fee Related
- 1994-12-06 US US08/349,914 patent/US5591775A/en not_active Expired - Lifetime
- 1994-12-06 NZ NZ270082A patent/NZ270082A/en not_active IP Right Cessation
- 1994-12-06 ES ES94402789T patent/ES2116555T3/es not_active Expired - Lifetime
- 1994-12-06 DK DK94402789T patent/DK0662471T3/da active
- 1994-12-06 EP EP94402789A patent/EP0662471B1/fr not_active Expired - Lifetime
- 1994-12-06 AT AT94402789T patent/ATE163919T1/de not_active IP Right Cessation
- 1994-12-06 DE DE69408962T patent/DE69408962T2/de not_active Expired - Fee Related
- 1994-12-06 JP JP6301805A patent/JP2688179B2/ja not_active Expired - Fee Related
- 1994-12-07 ZA ZA949752A patent/ZA949752B/xx unknown
-
1995
- 1995-05-23 US US08/447,886 patent/US5552418A/en not_active Expired - Lifetime
-
1998
- 1998-04-14 GR GR980400833T patent/GR3026634T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU677868B2 (en) | 1997-05-08 |
FR2713636A1 (fr) | 1995-06-16 |
US5591775A (en) | 1997-01-07 |
NZ270082A (en) | 1995-07-26 |
DE69408962T2 (de) | 1998-10-08 |
JPH07224017A (ja) | 1995-08-22 |
ES2116555T3 (es) | 1998-07-16 |
JP2688179B2 (ja) | 1997-12-08 |
FR2713636B1 (fr) | 1996-01-05 |
DK0662471T3 (da) | 1998-12-21 |
GR3026634T3 (en) | 1998-07-31 |
EP0662471B1 (fr) | 1998-03-11 |
US5552418A (en) | 1996-09-03 |
EP0662471A2 (fr) | 1995-07-12 |
CA2137445C (fr) | 2000-10-24 |
EP0662471A3 (fr) | 1995-08-02 |
CA2137445A1 (fr) | 1995-06-08 |
AU8021594A (en) | 1995-06-15 |
DE69408962D1 (de) | 1998-04-16 |
ATE163919T1 (de) | 1998-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA949752B (en) | Naphtalene derivatives processes for their preparation and the pharmaceutical compositions which contain them | |
IL101763A (en) | 4-alkylenepiperidine derivatives, their preparation and pharmaceutical compositions containing them | |
AU645867B2 (en) | 2-arylthiazole derivative and pharmaceutical composition containing the same | |
BR9303993A (pt) | Composto, processo para preparar o mesmo e composição farmacêutica | |
DK131893D0 (da) | 2-(substitueret methyl)-4-(substitueret ethoxy)-5-(lavere alkyl)-pyridinforbindelser, farmaceutisk praeparat, som indeholder saadanne samt anvendelse af en saadan forbindelse til fremstilling af et farmaceutisk praeparat | |
NO950009L (no) | Heterocykliske forbindelser som farmasöytika | |
DK0628311T3 (da) | Xanthinderivater som antidepressive midler | |
AR006360A1 (es) | Derivados de 1,2,3,4-tetrahidronaftaleno substituidos, uso de los mismos para la preparacion de medicamentos y procedimiento para su preparacion. | |
DK0630366T3 (da) | Substituerede heterocycliske derivater, der er nyttige som blodpladeaggregeringsinhibitorer | |
FI952550A (fi) | Uudet N-pyridyylikarboksamidit ja johdannaiset, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset | |
ES2167931T3 (es) | Derivados bifenilicos sustituidos por un radical aromatico o heteroaromatico y composiciones farmaceuticas y cosmeticas que los contienen. | |
BR9802212A (pt) | Compostos cromeno um processo para sua preparação e composições farmacêuticas contendo os mesmos | |
NO981814D0 (no) | Nye heterocykliske forbindelser, fremgangsmÕte ved deres fremstilling og farmas÷ytiske sammensetninger som inneholder dem | |
DK447284A (da) | Aminoderivater af 2-(n-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl)),deres fremstilling og anvendelse | |
DK645589D0 (da) | Arolyxopropanolaminotetraliner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem | |
ZA88208B (en) | Sweetening agents derived from guanidinoacetic and ethanamidinoacetic acids,process for sweetening various products,and compositions containing such sweetening agents | |
FI950818A0 (fi) | Uudet substituoidut sulfoniamidit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset | |
SE9401353D0 (sv) | Novel antitumour compounds with antimitotic activity | |
DE69018741T2 (de) | Konjugierte gamma-Hydroxybutenolid-Derivate und sie als aktiver Wirkstoff enthaltende Mittel gegen Magengeschwüre. | |
AU6426386A (en) | Derivatives of 3-imino-pyridazine, process for obtaining them and pharmaceutical compositions containing them | |
NO976101L (no) | Nye ellipticinforbindelser, en fremgangsmÕte ved deres fremstilling, samt farmas°ytiske blandinger som inneholder dem |